CN108025018B - 用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 - Google Patents

用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 Download PDF

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CN108025018B
CN108025018B CN201680043989.1A CN201680043989A CN108025018B CN 108025018 B CN108025018 B CN 108025018B CN 201680043989 A CN201680043989 A CN 201680043989A CN 108025018 B CN108025018 B CN 108025018B
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cancer
tumor
seq
cpg
oligonucleotide
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CN108025018A (zh
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Y.于
A.E.登克
S.萨德科瓦
U.T.范
R.A.卡斯特莱因
D.R.考夫曼
R.L.科夫曼
C.奎杜奇
R.S.詹森
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Tesalas Life Sciences
Merck Sharp and Dohme BV
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Texales Life Sciences Shenhuo Pharmaceutical Co ltd
Merck and Co Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201680043989.1A 2015-05-29 2016-05-26 用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 Active CN108025018B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562168449P 2015-05-29 2015-05-29
US62/168449 2015-05-29
US201562169309P 2015-06-01 2015-06-01
US62/169309 2015-06-01
PCT/US2016/034275 WO2016196173A1 (en) 2015-05-29 2016-05-26 Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer

Publications (2)

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CN108025018A CN108025018A (zh) 2018-05-11
CN108025018B true CN108025018B (zh) 2021-08-17

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US (2) US10751412B2 (https=)
EP (2) EP3302501B1 (https=)
JP (2) JP6893608B2 (https=)
KR (1) KR20180014009A (https=)
CN (1) CN108025018B (https=)
AU (1) AU2016271018A1 (https=)
BR (1) BR112017025562A2 (https=)
CA (1) CA2986126A1 (https=)
ES (1) ES2985394T3 (https=)
MA (1) MA44699A (https=)
MX (1) MX2017015308A (https=)
RU (1) RU2017145558A (https=)
WO (1) WO2016196173A1 (https=)

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MX2017015308A (es) 2018-07-06
JP7236483B2 (ja) 2023-03-09
CA2986126A1 (en) 2016-12-08
ES2985394T3 (es) 2024-11-05
EP3302501A1 (en) 2018-04-11
KR20180014009A (ko) 2018-02-07
US11918648B2 (en) 2024-03-05
JP6893608B2 (ja) 2021-06-23
US20180169229A1 (en) 2018-06-21
EP3892284A1 (en) 2021-10-13
JP2021102627A (ja) 2021-07-15
RU2017145558A (ru) 2019-07-01
WO2016196173A1 (en) 2016-12-08
MA44699A (fr) 2021-05-05
EP3302501B1 (en) 2021-09-22
AU2016271018A1 (en) 2017-11-30
EP3892284B1 (en) 2024-05-22
US20210196819A1 (en) 2021-07-01
BR112017025562A2 (pt) 2018-08-07
HK1252652A1 (zh) 2019-05-31
JP2018516911A (ja) 2018-06-28
US10751412B2 (en) 2020-08-25
EP3302501A4 (en) 2019-02-27
CN108025018A (zh) 2018-05-11

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