CN107980909B - Composition, preparation method thereof and product for relieving early pregnancy reaction - Google Patents
Composition, preparation method thereof and product for relieving early pregnancy reaction Download PDFInfo
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- CN107980909B CN107980909B CN201711250838.6A CN201711250838A CN107980909B CN 107980909 B CN107980909 B CN 107980909B CN 201711250838 A CN201711250838 A CN 201711250838A CN 107980909 B CN107980909 B CN 107980909B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
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Abstract
The present invention provides a composition comprising: 20-35 parts of whole milk powder; 15-30 parts of ginger powder; 10-20 parts by weight of honey powder; 5-15 parts of red date powder; 60.001-0.002 parts of vitamin B. The raw materials in the composition provided by the invention are safe and reliable, so that the composition can be taken by vast pregnant women without worry, and the specific raw materials are combined according to a specific proportion, so that the synergistic interaction effect among the raw materials is fully exerted, the effect of relieving the early pregnancy reaction is better, and meanwhile, sufficient nutrition can be provided for the pregnant women.
Description
Technical Field
The invention relates to the field of health care products, in particular to a composition, a preparation method thereof and a product for relieving early pregnancy reaction.
Background
The early pregnancy reaction refers to the phenomena of nausea, vomiting, dizziness, inappetence, lassitude and the like of the pregnant women during the early pregnancy. The sensitivity of the smell to the smell is improved and the pregnancy reaction is shown to different degrees because the hormone level of the female is rapidly increased in the early pregnancy. According to statistics, about 50-90% of the primiparous women have symptoms of nausea, vomiting, anorexia and the like, and when the symptoms are serious, the symptoms are accompanied by weight loss, dehydration and electrolyte imbalance, namely hyperemesis gravidarum, and the incidence rate is about 0.5%.
The early pregnancy reaction not only makes the pregnant woman uncomfortable, causes inconvenience to daily life of the pregnant woman, but also causes insufficient nutrition intake of the pregnant woman due to vomiting, inappetence and the like, and seriously affects the physical health of the pregnant woman and the development of a fetus. Existing antiemetics, such as antihistamines, anticholinergics, dopamine antagonists, 5-hydroxytryptamine (5-HT3) antagonists, gastrointestinal agents, corticosteroids, and the like, while preventing nausea and vomiting during pregnancy, most pregnant women are reluctant to use them because of the risk of adverse reactions to these drugs. Therefore, the development of a product which is safe, can effectively prevent the pregnant woman from vomiting and can supplement nutrition for the pregnant woman is of great significance.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a composition, which can achieve a good effect of alleviating early pregnancy reaction.
The present invention provides a composition comprising:
preferably, the method comprises the following steps:
preferably, one or more of the following raw materials are also included:
preferably, one or more of the following raw materials are also included:
0-19 parts by weight of xylitol;
0-9 parts of erythritol;
the content of the xylitol and the erythritol is not 0 at the same time.
The composition provided by the technical scheme of the invention is applied to preparing a product for relieving early pregnancy reaction.
The invention provides a preparation method of the composition in the technical scheme, which comprises the following steps:
mixing vitamin B6, fructus Jujubae powder, rhizoma Zingiberis recens powder, Mel powder and whole milk powder uniformly to obtain the composition.
The invention provides a product for relieving early pregnancy reaction, which is characterized by comprising the composition according to any one of the technical schemes.
Preferably, the dosage form is one or more of powder, tablets, oral liquid and granules.
Preferably, the powder comprises the composition of any one of the above technical schemes and 0.1-1.5 parts by weight of glidant.
The invention provides a solid beverage for relieving early pregnancy reaction, which comprises:
compared with the prior art, the invention provides a composition, which comprises: 20-35 parts of whole milk powder; 15-30 parts of ginger powder; 10-20 parts by weight of honey powder; 5-15 parts of red date powder; 60.001-0.002 parts of vitamin B. The raw materials in the composition provided by the invention are safe and reliable, so that the composition can be taken by vast pregnant women without worry, and the specific raw materials are combined according to a specific proportion, so that the synergistic interaction effect among the raw materials is fully exerted, the effect of relieving the early pregnancy reaction is better, and meanwhile, sufficient nutrition can be provided for the pregnant women.
Detailed Description
The invention provides a composition, a preparation method thereof and a product for relieving early pregnancy reaction, and the composition and the product can be realized by appropriately modifying components and proportion parameters by the technical personnel in the field with reference to the content. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The present invention provides a composition comprising:
the composition provided by the invention can well relieve early pregnancy reaction. The early pregnancy reaction of the present invention is well known to those skilled in the art, and may specifically include nausea, vomiting, dizziness, lassitude, anorexia, etc.
The composition provided by the invention comprises 20-35 parts by weight of whole milk powder; preferably 25-33 parts by weight of whole milk powder; more preferably 27 to 32 parts by weight of whole milk powder.
The whole milk powder is well known to those skilled in the art, and the brand is not limited.
The whole milk powder contains high-quality protein, fat, multiple vitamins and mineral substances such as calcium, phosphorus, iron and the like, protein clots are fine and soft after spray drying treatment, and are easy to digest compared with fresh milk, so the whole milk powder is a good nutritional product suitable for drinking everyday, can prevent the skin from being dry and dark, and can make the skin white and glossy; can also supplement abundant calcium, and can supplement nutrition for pregnant women with poor appetite caused by vomiting and pregnancy. Further, since the whole milk powder contains a small amount of cholesterol and contains components such as orotic acid and 3-hydroxy-3-methylglutaric acid which reduce cholesterol and inhibit its absorption, the whole milk powder can be taken by a diabetic accompanied by hypertension and coronary heart disease without fear of disappearing milk due to a large amount of fat. The whole milk powder is a balanced food, and modern medical research shows that the milk also contains physiologically active components such as phospholipid, certain unsaturated fatty acid and the like, and has comprehensive effect on human health.
The whole milk powder is preferably sieved by a sieve of 20-30 meshes for later use.
The composition provided by the invention comprises 15-30 parts by weight of ginger powder; preferably, the ginger powder comprises 17-28 parts by weight of ginger powder; more preferably, the ginger powder comprises 18-26 parts by weight of ginger powder.
The ginger powder provided by the invention is the ginger powder well known to those skilled in the art. Can be commercially available or self-made.
The preferable concrete is as follows:
the ginger is cleaned, blanched for 10-20 seconds, juiced, filtered, concentrated, freeze-dried and crushed to 60-80 meshes to obtain ginger powder.
The specific operations of washing, blanching, juicing, filtering, concentrating, freeze-drying and crushing are not limited in the invention and are well known to those skilled in the art.
In a preferred scheme, the ginger powder is further prepared into ginger powder microcapsules. The ginger powder microcapsule is preferably prepared according to the following method: the method comprises the steps of taking chitosan as a wall material and maltodextrin as an auxiliary wall material, dissolving chitosan and maltodextrin in water according to a mass ratio of 3 (0.5-1), preparing a 2.5-3.5% wall material solution, dissolving ginger powder with 70-75% ethanol, dispersing the ginger powder into the wall material solution under a stirring state, and performing spray drying to obtain the ginger powder microcapsule.
The ginger is rich in volatile oil and various nutritional ingredients, such as zingerone, zingiberene, aromatic alcohol, protein, fat, calcium, iron, phosphorus, carotene, vitamin B1, vitamin B2, vitamin C and the like, and has double effects of food therapy and drug therapy. Not only can relieve or eliminate vomiting symptom caused by pregnancy, but also can promote blood circulation and metabolism, and is beneficial to the development of fetus.
The composition provided by the invention comprises 10-20 parts by weight of honey powder; preferably 12-19 parts by weight of honey powder; more preferably 13-18 parts by weight of honey powder.
The honey powder of the present invention is a honey powder well known to those skilled in the art. Can be commercially available or self-made.
The preferable concrete is as follows: spray drying Mel to obtain Mel powder.
The present invention is not limited to the specific parameters of the spray drying, and those skilled in the art will be familiar with the present invention.
Honey is a mixture of fructose, glucose, water, a small amount of protein, vitamins, minerals, phenols and other compounds, is a good nutritional supplement for human bodies, and has good improving effect on glucose tolerance, diabetes and related symptoms.
The composition provided by the invention comprises 5-15 parts by weight of red date powder; preferably, the red date powder comprises 6-14 parts by weight of red date powder; more preferably, the red date powder comprises 7-13 parts by weight of red date powder.
The red date powder is not limited in source, can be commercially available, and can be prepared according to the method of the invention:
cleaning red dates, adding water to 40-60 ℃, ultrasonically extracting for 40-50 min at 100-200W, and filtering to obtain residues and a first extracting solution; adding water into the residue, carrying out ultrasonic extraction at the temperature of 60-80 ℃ and the power of 100-200W for 30-40 min, and filtering to obtain a secondary extracting solution; mixing the two extractive solutions, and drying to obtain fructus Jujubae powder.
The red dates are preferably extracted in an extraction tank.
Wherein the volume ratio of the red dates to the first water addition is 1: (3-6). The volume ratio of the residue to water is 1: (2-3).
The drying is preferably spray drying.
The red dates contain abundant vitamins, proteins and mineral elements, and are very important for forming the tissue structure of a human body, maintaining the body fluid balance of the human body, promoting the development of children and improving intelligence.
The composition provided by the invention comprises 0.001-0.002 parts by weight of vitamin B6. The source of the compound is not limited in the present invention, and may be commercially available.
Vitamin B6 has a close relationship with protein metabolism, and vitamin B6 is an essential substance in energy production, amino acid and fat metabolism, central nervous system activity, and hemoglobin production. The present inventors have found that vitamin B6 supplementation reduces infantile convulsions and vomiting in pregnant women.
In some embodiments of the present invention, the composition comprises:
the present invention provides a composition comprising: 20-35 parts of whole milk powder; 15-30 parts of ginger powder; 10-20 parts by weight of honey powder; 5-15 parts of red date powder; 60.001-0.002 parts of vitamin B. The raw materials in the composition provided by the invention are safe and reliable, so that the composition can be taken by vast pregnant women without worry, and the specific raw materials are combined according to a specific proportion, so that the synergistic interaction effect among the raw materials is fully exerted, the effect of relieving the early pregnancy reaction is better, and meanwhile, sufficient nutrition can be provided for the pregnant women.
In the present invention, the composition preferably further comprises one or more of the following raw materials:
wherein the composition further comprises one of folic acid and/or its derivatives, fructus Lycii powder, rhizoma Dioscoreae powder and milk mineral salt. Preferably, the composition further comprises any one of folic acid and/or derivatives thereof and medlar powder.
The composition may further comprise any two of folic acid and/or its derivatives, Lycium barbarum powder, rhizoma Dioscoreae powder, and milk mineral salts.
In this case, the composition further comprises folic acid and/or derivatives thereof and wolfberry powder; folic acid and/or derivatives thereof and yam flour; folic acid and/or derivatives thereof and milk mineral salts; fructus Lycii powder and rhizoma Dioscoreae powder; medlar powder and milk mineral salt; yam flour and milk mineral salts; preferably folic acid and/or derivatives thereof and medlar powder; folic acid and/or derivatives thereof and yam flour; folic acid and/or derivatives thereof and milk mineral salts.
The composition may comprise any three of folic acid and/or derivatives thereof, lycium barbarum powder, yam flour, and milk mineral salts.
In this case, the composition further comprises folic acid and/or its derivatives, yam powder, and lycium barbarum powder; folic acid and/or derivatives thereof, wolfberry powder and milk mineral salts; fructus Lycii powder, rhizoma Dioscoreae powder and milk mineral salt; preferably folic acid and/or its derivatives, rhizoma Dioscoreae powder and fructus Lycii powder; folic acid and/or derivatives thereof, wolfberry powder and milk mineral salts.
The composition may comprise four of folic acid and/or its derivatives, Lycium barbarum powder, rhizoma Dioscoreae powder, and milk mineral salt.
In the above combination, folic acid and/or derivatives thereof is 0.0001 to 0.0005 part by weight; preferably 0.0002 to 0.0005 parts by weight.
The folic acid derivative is preferably one or more selected from dihydrofolic acid, 5-leucovorin, 5-methyltetrahydrofolic acid, 5, 10-methylenetetrahydrofolic acid, 5, 10-methenyltetrahydrofolic acid, 10-leucotetrahydrofolic acid and tetrahydrofolic acid.
Folic acid, a class of organic substances essential for the maintenance of the normal life processes of organisms, is usually absorbed by the body and then converted into at least 5 active coenzyme forms, which are involved in the transfer of one carbon unit into the body, and have particularly important roles in the biosynthesis of purines, pyrimidines, nucleic acids and proteins and the division and growth of cells. Folic acid can prevent neural tube development deformity. Because folic acid is closely related to DNA synthesis, if a pregnant woman takes folic acid seriously insufficiently, the DNA synthesis of a fetus is obstructed, cell division is weakened, and the development of key parts of the spine is damaged, so that spine rhagadia is caused. If a woman is under folate intake during the first 6 weeks of pregnancy, the likelihood of developing a malformation without brain and meningeal fissures increases by a factor of 4. The lack of folic acid in humans can cause nuclear megaloblastic anemia in infants and megaloblastic anemia in pregnant women. This is because DNA synthesis is inhibited by folic acid deficiency, insufficient nucleoprotein formation, immature erythroid cells newly formed in bone marrow, decreased cell division and proliferation rate, and increased cell volume to give megaerythroid cells. At the same time, folate levels in leukocytes, platelets and serum were also decreased. Anemia can occur in infants and pregnant women, generally due to a simple deficiency of folic acid.
In the combination, the medlar powder accounts for 0 to 9 weight portions; preferably 2 to 9 parts by weight; more preferably 3 to 9 parts by weight; most preferably 3 to 8 parts by weight. The source of the medlar powder is not limited and can be sold in the market, and the preferable extraction method of the medlar powder is consistent with the extraction method of the red date powder and the yam powder.
The preferable concrete is as follows: cleaning the medlar, adding water to 40-60 ℃, ultrasonically extracting for 40-50 min at 100-200W, and filtering to obtain residues and a first extracting solution; adding water into the residue, carrying out ultrasonic extraction at the temperature of 60-80 ℃ and the power of 100-200W for 30-40 min, and filtering to obtain a secondary extracting solution; mixing the two extractive solutions, and drying to obtain fructus Jujubae powder.
The medlar is preferably extracted in an extraction tank.
Wherein, the volume ratio of the medlar to the first water addition is 1: (3-6). The volume ratio of the residue to water is 1: (2-3).
The drying is preferably spray drying.
The medlar has good antioxidant effect, and can increase the antioxidant capacity of the serum of a subject by nearly 10% under normal conditions. Meanwhile, the medlar fruits also contain zeaxanthin, and when the medlar fruits are eaten, the zeaxanthin can be enriched in adipose tissues, particularly in the macular area of retina, so that tissue pathological changes caused by over-sunlight (UV light) and other oxidation processes can be prevented.
In the combination, the yam flour is 0-8 parts by weight; preferably 3 to 8 parts by weight; more preferably 5 to 8 parts by weight. The source of the yam flour is not limited and can be sold in the market, and the yam flour is preferably consistent with the extraction method of the red date powder and the medlar powder. And will not be described in detail herein. In the actual production, the medlar, the red dates and the Chinese yam can be cleaned and placed in an extraction tank, and the subsequent extraction operation is continued; the present invention will not be described in detail herein. Finally preparing the composite powder.
The Chinese yam tuber contains abundant starch, saponin, mucus (mainly mannan, phytic acid and the like), choline, glycoprotein and a plurality of amino acids, and is a famous product used as both medicine and food. Has the pharmacological effects of improving immunity, improving digestion, reducing blood sugar and blood lipid, resisting oxidation, delaying aging, regulating acid-base balance, etc.
In the above combination, the milk mineral salt is 0 to 6 parts by weight; preferably 2 to 6 parts by weight; more preferably 3 to 6 parts by weight.
The milk mineral salt contains calcium phosphate as main ingredient, and also contains abundant nutrients such as protein, lactose, zinc, phosphorus, sodium, potassium, magnesium, etc. The milk mineral salt has calcium content of 23-28%, calcium-phosphorus ratio of 2:1, and is easy to be effectively absorbed and utilized by human body, and the calcium supplementing effect of the milk mineral salt is not reversed, so that the milk mineral salt is an excellent source of calcium, and is helpful for pregnant women to maintain bone health.
The invention creatively discovers that folic acid and/or derivatives thereof and any one or more of medlar, yam and milk mineral salt are added into the composition to generate a synergistic effect, so that the effect of reducing the early pregnancy reaction of the composition is further remarkably improved.
In the present invention, the composition preferably further comprises one or more of the following raw materials:
0-19 parts by weight of xylitol;
0-9 parts of erythritol;
the content of the xylitol and the erythritol is not 0 at the same time.
The composition of the invention preferably further comprises one or more of the following raw materials on the basis of the components; can be any one of xylitol and erythritol; two of xylitol and erythritol are also possible.
Wherein, in the combination, the xylitol accounts for 0 to 19 weight parts; preferably 4 to 18 parts by weight; more preferably 5 to 18 parts by weight; most preferably 7 to 16 parts by weight.
0-9 parts of erythritol; preferably 3 to 9 parts by weight; more preferably 5 to 9 parts by weight; most preferably 5 to 8 parts by weight.
Xylitol is a good sweetener, can be metabolized in vivo without insulin, can synthesize glycogen or oxidize and release energy for organism, does not cause increase of blood sugar concentration, and can be used as saccharide substitute for diabetic patients and gestational diabetes mellitus patients. Moreover, the xylitol is taken by pregnant women to help prevent dental caries, and the probability of infection of children with dental caries bacteria after birth can be reduced.
Erythritol belongs to a filling type sweetener, and has cool mouthfeel, low calorie and high safety. Erythritol has the advantages of independent or less insulin dependent metabolic pathway, no caries, low energy value, high tolerance, no side effect, etc.
The composition provided by the technical scheme of the invention is applied to preparing a product for relieving early pregnancy reaction.
The invention provides a preparation method of the composition in the technical scheme, which comprises the following steps:
mixing vitamin B6, fructus Jujubae powder, rhizoma Zingiberis recens powder, Mel powder and whole milk powder uniformly to obtain the composition.
The invention is preferably prepared by the following two-step method:
vitamin B6 is taken and premixed with part of whole milk powder to obtain composite powder;
mixing fructus Jujubae powder, compound powder, rhizoma Zingiberis recens powder, Mel powder and the rest whole milk powder uniformly to obtain the composition.
The preparation method of the composition of the invention is more preferably as follows:
sieving the whole milk powder with a sieve of 20-30 meshes for later use;
cleaning red dates, adding water to 40-60 ℃, ultrasonically extracting for 40-50 min at 100-200W, and filtering to obtain residues and a first extracting solution; adding water into the residue, carrying out ultrasonic extraction at the temperature of 60-80 ℃ and the power of 100-200W for 30-40 min, and filtering to obtain a secondary extracting solution; mixing the two extractive solutions, and drying to obtain fructus Jujubae powder;
cleaning ginger, blanching for 10-20 seconds, juicing, filtering, concentrating, freeze-drying and crushing to 60-80 meshes to obtain ginger powder;
spray drying Mel to obtain Mel powder;
vitamin B6 is taken and premixed with part of whole milk powder to obtain composite powder;
mixing fructus Jujubae powder, compound powder, rhizoma Zingiberis recens powder, Mel powder and the rest whole milk powder uniformly to obtain the composition.
The specific compositions of the components and the mixing ratios are clearly described above, and are not repeated herein.
The present invention is not limited to the specific operation of the above steps, and those skilled in the art can easily understand the operation.
When the invention also comprises one or more of folic acid, medlar powder, yam powder, milk mineral salt, xylitol and erythritol, the preparation method of the invention preferably comprises the following steps:
respectively sieving the whole milk powder, the xylitol, the erythritol and the milk mineral salt with a 20-30-mesh sieve for later use;
cleaning medlar, red dates and Chinese yam, placing the cleaned medlar, red dates and Chinese yam in an extraction tank, adding 3-6 times of water by weight, carrying out ultrasonic extraction for 40-50 min at 40-60 ℃ and 100-200W, and filtering to obtain a primary extracting solution; adding 2-3 times of water by weight into the residue in the extraction tank, performing ultrasonic extraction at 60-80 ℃ and 100-200W for 30-40 min, and filtering to obtain a secondary extracting solution; mixing the two extracting solutions, and spray drying to obtain composite powder 1;
cleaning ginger, blanching in boiling water for 10-20 seconds, juicing, filtering, concentrating, freeze-drying, and crushing to 60-80 meshes to obtain ginger powder for later use;
in a preferred scheme, the ginger powder is further prepared into ginger powder microcapsules. Preparing a ginger powder microcapsule: dissolving chitosan and maltodextrin in water according to a mass ratio of (0.5-1) of 3 to prepare a wall material solution with the concentration of 2.5-3.5 percent, dissolving ginger powder in 70-75 percent ethanol, dispersing the ginger powder into the wall material solution under a stirring state, and performing spray drying to obtain a ginger powder microcapsule;
spray drying Mel to obtain Mel powder;
vitamin B6, folic acid and partial whole milk powder are taken to be subjected to equal gradient premixing treatment to obtain composite powder 2;
mixing xylitol, erythritol, milk mineral salt, compound powder 1, compound powder 2, rhizoma Zingiberis recens powder, Mel powder, and the rest whole milk powder uniformly to obtain the composition.
The optimal selection of the equal-quantity gradient premixing treatment of the vitamin B6, the folic acid and the partial whole milk powder is as follows:
mixing vitamin B6, folic acid and partial whole milk powder according to the weight ratio of 1: 1, mixing to obtain first premixed powder;
mixing the first premixed powder with part of the whole milk powder according to the weight ratio of 1: 3, mixing to obtain second premixed powder;
mixing the second premixed powder with part of the whole milk powder according to the weight ratio of 1: 5, mixing to obtain a third premixed powder.
The specific mixing mode of the invention ensures that the mixing is more uniform and the effect is better.
The invention provides a product for relieving early pregnancy reaction, which is characterized by comprising the composition in the technical scheme.
In the invention, the product for relieving the early pregnancy reaction is food, medicine or health-care food.
In particular, the food product for alleviating the early pregnancy response comprises the composition of the invention and acceptable ingredients in food products.
The health food for relieving the early pregnancy reaction comprises the composition and acceptable auxiliary materials in the health food.
The medicine for relieving the early pregnancy reaction comprises the composition and pharmaceutically acceptable auxiliary materials.
The dosage form of the product for relieving the early pregnancy reaction is preferably one or more of powder, tablets, oral liquid and granules.
The powder disclosed by the invention comprises the composition and 0.1-1.5 parts by weight of glidant.
The glidant is preferably selected from one or more of silicon dioxide and calcium silicate.
The invention provides a solid beverage for relieving early pregnancy reaction, which comprises:
the preferred proportion of the beverage is the same as the proportion and the components of the composition, and the description is omitted.
In order to further illustrate the present invention, the following examples are provided to describe the compositions provided by the present invention in detail.
Examples 1 to 7 and comparative examples 1 to 3.
(1) Formulation of
(2) Preparation method
The compositions of comparative examples 1 to 3 and examples 1 to 7 were prepared in the following manner, and if no component was included in the composition, no component was added during the preparation.
1) Sieving whole milk powder, xylitol, erythritol and milk mineral salt with 30 mesh sieve respectively.
2) Cleaning medlar, red dates and Chinese yam, placing the cleaned medlar, red dates and Chinese yam in an extraction tank, adding 3-6 times of water by weight, carrying out ultrasonic extraction for 40-50 min at 40-60 ℃ and 100-200W, and filtering to obtain a primary extracting solution; adding 2-3 times of water by weight into the residue in the extraction tank, performing ultrasonic extraction at 60-80 ℃ and 100-200W for 30-40 min, and filtering to obtain a secondary extracting solution; and mixing the two extracting solutions, and performing spray drying to obtain the composite powder 1.
3) Cleaning rhizoma Zingiberis recens, blanching in boiling water for 10 s, squeezing, filtering, concentrating, lyophilizing, and pulverizing to 80 mesh to obtain rhizoma Zingiberis recens powder.
4) Spray drying Mel to obtain Mel powder.
5) Collecting vitamin B6And performing equal gradient premixing treatment on folic acid and part of the whole milk powder to obtain the composite powder 2.
6) Mixing xylitol, erythritol, milk mineral salt, compound powder 1, compound powder 2, rhizoma Zingiberis recens powder, Mel powder and the rest whole milk powder uniformly to obtain the composition.
The preparation process of example 7 was identical except for step 3). The preparation of example 7 is as follows except for step 3):
cleaning rhizoma Zingiberis recens, blanching in boiling water for 10 s, squeezing, filtering, concentrating, lyophilizing, and pulverizing to 80 mesh to obtain rhizoma Zingiberis recens powder. Dissolving chitosan and maltodextrin in a mass ratio of 3:1 in water to prepare a 3.5% wall material solution, dissolving the ginger powder in 75% ethanol, dispersing the solution in the wall material solution under stirring, and performing spray drying to obtain the ginger powder microcapsule.
Solid beverages were prepared by adding 0.5% calcium silicate to the compositions of comparative examples 1 to 3 and examples 1 to 7.
(3) Evaluation of Effect
1) The effect of relieving symptoms such as dizziness, lassitude, anorexia and the like during pregnancy is as follows:
pregnant women with early pregnancy reactions such as dizziness, listlessness, anorexia and the like are selected to participate in the eating trial test, and 20 pregnant women are grouped according to the number of solid beverage samples. The dosage and the frequency of eating the solid beverage by each group of pregnant women are the same: it is administered 1 bag (5 g/bag) each time, 3 times daily for 2 weeks.
The effect evaluation comprises two aspects of the relieving effect and the mouthfeel of the early pregnancy reaction.
Evaluation standard of remission effect of early pregnancy reaction:
the effect is shown: the symptoms of dizziness, lassitude, anorexia, etc. basically disappear.
The method has the following advantages: symptoms such as dizziness, lassitude, anorexia and the like are obviously improved;
and (4) invalidation: symptoms such as dizziness, lassitude and anorexia are not improved.
The total effective rate (%) - (effective number + significant number)/total number.
Grading standard of mouthfeel:
and 5, dividing: the ginger has moderate spicy taste, fresh aroma, moderate sweet taste, fineness and smoothness
And 4, dividing: has pungent taste of rhizoma Zingiberis recens, moderate fragrance, slight sweet and soft and smooth
And 3, dividing: light piquancy or sweetness, light fragrance and fine and smooth
And 2, dividing: the sweet and spicy taste is not obvious, basically no fragrance exists, and the taste is general
1 minute: the sweet and spicy taste is too strong and the granules feel
The average score was calculated based on the subject's score for mouthfeel of the solid beverage sample.
The results of the measurements are given in the following table:
2) effect on nausea and vomiting during pregnancy:
and selecting early-stage pregnant women with the age of 24-35, the number of weeks of pregnancy of 7-8 and the pregnancy vomiting times of 4-6/day to participate in a dietary test, and grouping according to the number of solid beverage samples, wherein 20 persons are in each group. The dosage and the frequency of eating the solid beverage by each group of pregnant women are the same: the number of pregnancy and vomiting per day in one week is counted, wherein the number of pregnancy and vomiting per day is 1 bag (5 g/bag) per time and 3 times per day.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A composition, comprising:
20-35 parts of whole milk powder;
15-30 parts of ginger powder;
10-20 parts by weight of honey powder;
5-15 parts of red date powder;
60.001-0.002 parts by weight of vitamin B;
0.0001-0.0005 parts by weight of folic acid and/or derivatives thereof;
0-9 parts of wolfberry powder;
0-8 parts of yam flour;
0-6 parts of milk mineral salt.
2. The composition as claimed in claim 1, comprising:
25-33 parts of whole milk powder;
17-28 parts of ginger powder;
12-19 parts of honey powder;
6-14 parts of red date powder;
60.001-0.002 parts of vitamin B.
3. The composition of claim 1, further comprising one or more of the following materials:
0-19 parts by weight of xylitol;
0-9 parts of erythritol.
4. Use of a composition according to any one of claims 1 to 3 in the manufacture of a product for alleviating an early pregnancy response.
5. A product for alleviating early pregnancy reactions, comprising a composition according to any one of claims 1 to 3.
6. The product of claim 5, in a dosage form selected from the group consisting of powder, tablet, oral liquid, and granule.
7. The product according to claim 6, wherein the powder comprises the composition of any one of claims 1 to 3 and 0.1 to 1.5 parts by weight of a glidant.
8. A solid beverage for alleviating early pregnancy reactions, comprising: the composition of claim 1;
0-19 parts by weight of xylitol;
0-9 parts of erythritol;
0-1.5 parts of a flow aid.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859280A (en) * | 2014-03-11 | 2014-06-18 | 同福碗粥股份有限公司 | Health-care porridge for pregnant women and preparation method of porridge |
| CN103999941A (en) * | 2014-06-04 | 2014-08-27 | 李卫平 | Milk tea powder for pregnant women |
| CN105231214A (en) * | 2015-11-05 | 2016-01-13 | 叶芳 | Composite fruit and vegetable beverage capable of relieving morning sickness symptom of pregnant women at earlystage and preparation method of composite fruit and vegetable beverage |
| CN105326038A (en) * | 2015-11-10 | 2016-02-17 | 劲膳美生物科技股份有限公司 | Pregnant-woman pregnancy-vomiting total-nutrient formula food |
| CN106173572A (en) * | 2015-04-30 | 2016-12-07 | 北京斯利安药业有限公司 | A kind of maternal nutritional fortified compositions and preparation method thereof |
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2017
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859280A (en) * | 2014-03-11 | 2014-06-18 | 同福碗粥股份有限公司 | Health-care porridge for pregnant women and preparation method of porridge |
| CN103999941A (en) * | 2014-06-04 | 2014-08-27 | 李卫平 | Milk tea powder for pregnant women |
| CN106173572A (en) * | 2015-04-30 | 2016-12-07 | 北京斯利安药业有限公司 | A kind of maternal nutritional fortified compositions and preparation method thereof |
| CN105231214A (en) * | 2015-11-05 | 2016-01-13 | 叶芳 | Composite fruit and vegetable beverage capable of relieving morning sickness symptom of pregnant women at earlystage and preparation method of composite fruit and vegetable beverage |
| CN105326038A (en) * | 2015-11-10 | 2016-02-17 | 劲膳美生物科技股份有限公司 | Pregnant-woman pregnancy-vomiting total-nutrient formula food |
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