CN107952783A - A kind of processing method and its application containing antibiotic substance - Google Patents
A kind of processing method and its application containing antibiotic substance Download PDFInfo
- Publication number
- CN107952783A CN107952783A CN201711205843.5A CN201711205843A CN107952783A CN 107952783 A CN107952783 A CN 107952783A CN 201711205843 A CN201711205843 A CN 201711205843A CN 107952783 A CN107952783 A CN 107952783A
- Authority
- CN
- China
- Prior art keywords
- antibiotic substance
- processing method
- containing antibiotic
- conditioning agent
- livestock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 77
- 239000000126 substance Substances 0.000 title claims abstract description 35
- 238000003672 processing method Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 35
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 26
- 230000003750 conditioning effect Effects 0.000 claims abstract description 24
- 235000010855 food raising agent Nutrition 0.000 claims abstract description 15
- 230000008569 process Effects 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 12
- 244000005700 microbiome Species 0.000 claims abstract description 11
- 239000007800 oxidant agent Substances 0.000 claims abstract description 9
- 230000001590 oxidative effect Effects 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 8
- 239000000428 dust Substances 0.000 claims abstract description 8
- 239000002585 base Substances 0.000 claims abstract description 7
- 150000007513 acids Chemical group 0.000 claims abstract description 6
- 239000010902 straw Substances 0.000 claims abstract description 6
- 239000002023 wood Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 3
- 210000003608 fece Anatomy 0.000 claims description 41
- 241000894006 Bacteria Species 0.000 claims description 37
- 244000144972 livestock Species 0.000 claims description 27
- 244000144977 poultry Species 0.000 claims description 27
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 239000010871 livestock manure Substances 0.000 claims description 12
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 239000004098 Tetracycline Substances 0.000 claims description 7
- 235000019364 tetracycline Nutrition 0.000 claims description 7
- 150000003522 tetracyclines Chemical class 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims description 5
- 241000287828 Gallus gallus Species 0.000 claims description 5
- 229930182555 Penicillin Natural products 0.000 claims description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 229960003276 erythromycin Drugs 0.000 claims description 5
- 229940049954 penicillin Drugs 0.000 claims description 5
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 claims description 4
- 229940126575 aminoglycoside Drugs 0.000 claims description 4
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 4
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical group CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 claims description 4
- 229960005287 lincomycin Drugs 0.000 claims description 4
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 4
- 150000007660 quinolones Chemical class 0.000 claims description 4
- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 claims description 4
- -1 sulfapryidine Chemical compound 0.000 claims description 4
- 229960002180 tetracycline Drugs 0.000 claims description 4
- 229930101283 tetracycline Natural products 0.000 claims description 4
- 150000003952 β-lactams Chemical class 0.000 claims description 4
- 241000272525 Anas platyrhynchos Species 0.000 claims description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 3
- 241001494479 Pecora Species 0.000 claims description 3
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 claims description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000292 calcium oxide Substances 0.000 claims description 3
- 229940087373 calcium oxide Drugs 0.000 claims description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 3
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 3
- 229960004475 chlortetracycline Drugs 0.000 claims description 3
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 3
- 235000019365 chlortetracycline Nutrition 0.000 claims description 3
- 238000000855 fermentation Methods 0.000 claims description 3
- 230000004151 fermentation Effects 0.000 claims description 3
- 229940063650 terramycin Drugs 0.000 claims description 3
- 229940040944 tetracyclines Drugs 0.000 claims description 3
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims description 2
- UQVADGKRJSPTBY-UHFFFAOYSA-N 4-benzyl-5-methoxypyrimidin-2-amine Chemical compound O(C)C=1C(=NC(=NC1)N)CC1=CC=CC=C1 UQVADGKRJSPTBY-UHFFFAOYSA-N 0.000 claims description 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 2
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 claims description 2
- 229930195503 Fortimicin Natural products 0.000 claims description 2
- 239000004182 Tylosin Substances 0.000 claims description 2
- 229930194936 Tylosin Natural products 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 2
- 229960003022 amoxicillin Drugs 0.000 claims description 2
- 229960000723 ampicillin Drugs 0.000 claims description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 2
- BIDUPMYXGFNAEJ-APGVDKLISA-N astromicin Chemical compound O[C@@H]1[C@H](N(C)C(=O)CN)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 BIDUPMYXGFNAEJ-APGVDKLISA-N 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 claims description 2
- 229940106164 cephalexin Drugs 0.000 claims description 2
- 229960003405 ciprofloxacin Drugs 0.000 claims description 2
- 229960002626 clarithromycin Drugs 0.000 claims description 2
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims description 2
- 229960000740 enrofloxacin Drugs 0.000 claims description 2
- 229960001180 norfloxacin Drugs 0.000 claims description 2
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims description 2
- 229960001699 ofloxacin Drugs 0.000 claims description 2
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960005224 roxithromycin Drugs 0.000 claims description 2
- 229960000973 sulfadimethoxine Drugs 0.000 claims description 2
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 claims description 2
- 229960002135 sulfadimidine Drugs 0.000 claims description 2
- QPPBRPIAZZHUNT-UHFFFAOYSA-N sulfamerazine Chemical compound CC1=CC=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 QPPBRPIAZZHUNT-UHFFFAOYSA-N 0.000 claims description 2
- 229960002597 sulfamerazine Drugs 0.000 claims description 2
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 claims description 2
- 229960005404 sulfamethoxazole Drugs 0.000 claims description 2
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 claims description 2
- 229960004059 tylosin Drugs 0.000 claims description 2
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 claims description 2
- 235000019375 tylosin Nutrition 0.000 claims description 2
- WMPXPUYPYQKQCX-UHFFFAOYSA-N Sulfamonomethoxine Chemical compound C1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 WMPXPUYPYQKQCX-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229950003874 sulfamonomethoxine Drugs 0.000 claims 1
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- 239000003895 organic fertilizer Substances 0.000 abstract description 15
- 239000003516 soil conditioner Substances 0.000 abstract description 7
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- 239000007789 gas Substances 0.000 description 5
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- 235000013619 trace mineral Nutrition 0.000 description 5
- 239000011573 trace mineral Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- 238000011017 operating method Methods 0.000 description 4
- 239000002893 slag Substances 0.000 description 4
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- 241000233866 Fungi Species 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000005416 organic matter Substances 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 239000003546 flue gas Substances 0.000 description 2
- 239000000446 fuel Substances 0.000 description 2
- 235000009973 maize Nutrition 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000002910 solid waste Substances 0.000 description 2
- 208000031295 Animal disease Diseases 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
- 229960001544 sulfathiazole Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/78—Recycling of wood or furniture waste
Landscapes
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Fertilizers (AREA)
Abstract
The present invention provides a kind of processing method containing antibiotic substance and its application, the processing method containing antibiotic substance includes the following steps：(A) antibiotic substance will be contained to be stirred with conditioning agent, raising agent is added again to stir to form mixture, the conditioning agent is acids, bases, oxidant and specified microorganisms preparation, and the raising agent is Chinese medicine dreg, the one of which in straw, wood dust；(B) system temperature is preheated to more than 100 DEG C, adds the mixture and carry out 30 1200s of high temperature high pressure process, between 150 230 DEG C, pressure controls between 1.8 2.4MPa temperature control, you can.The processing method containing antibiotic substance of the embodiment of the present invention is widely used in the numerous areas such as medical production, animal husbandry, processing method is easy to operate, it is environmentally protective, cost is low easy, and material after treatment can also be recycled, as organic fertilizer, soil conditioner or other nutriments.
Description
Technical field
The present invention relates to solid waste processing recycling field, in particular to a kind of place containing antibiotic substance
Manage method and its application.
Background technology
Antibiotic is a kind of medicine for having and killing or inhibit bacteria growth.Natural antibiotics are the metabolism productions of microorganism
Thing, some of which are peptides.Antibiotic is that the microorganisms such as bacterium, fungi produce in growth course for struggle for existence needs
Chemical substance, this material can ensure its own existence, while can also kill or suppress other bacteriums.Antibiotic extensive use
In veterinary clinic, in control and treatment livestock and poultry infection, bacterial infectious disease plays fruitful effect.
Pharmaceutical factory can generally produce substantial amounts of bacteria residue during antibiotic is produced, and the main component of bacteria residue is mycelia
Body, remaining culture medium, metabolic intermediate, organic solvent and a small amount of remaining antibiotic.Bacteria residue is full of nutrition, can be follow-up
Recycled as organic fertilizer or nutriment, but because of the presence of residual antibiotic, significantly limit its recycling profit
With.
The main methods for the antibiotic bacterium dregs that country allows are burning, landfill at present.Burning method can be big in the short time
Amplitude reduces bacteria residue volume, while eliminates harmful substance therein.But since fresh bacteria residue moisture content is high, it need to be dried
Dry disposal, needs addition fuel auxiliary to burn in burning process, high energy consumption in disposal process, and the burning expense of bacteria residue per ton is
3500-4000 members.In addition, bacteria residue burning is improper, incineration flue gas, bioxin and flying dust can be produced.Landfill is a kind of confrontation
The disposal options of raw element bacteria residue minimizing, are also second of the method for disposal approved except the outer China of burnings at present.But bacteria residue produces
It is high to measure big water content, landfill can take substantial amounts of land resource, and the improper percolate that can produce of landfill disposal causes underground water and soil
Earth pollutes, and causes pollution transportation, therefore, the processing of antibiotic bacterium dregs is the great difficult problem that current pharmaceutical industry faces.
In addition, feces of livestock and poultry includes pig manure, cow dung, sheep manure, chicken manure, duck excrement, rabbit excrement, horsehit etc..In recent years, due to China
Livestock-raising total amount constantly rises, and the feces of livestock and poultry total amount of corresponding generation is also more and more.During livestock-raising, in order to control
Treat Animal diseases and accelerate growth of animal, this antibiotic is generally widely used in animal husbandry, and most of antibiotic can remain
Excreted with animals urine and excrement., may if being directly used for agricultural production using untreated animal dung as organic fertilizer
The microecological balance around plant rhizosphere can be destroyed, causes soil antibiotic to pollute, jeopardizes agricultural product security.
So destruction of the feces of livestock and poultry to microecological balance in order to prevent, is generally pocessed by the way of compost.But
In composting process, the pH of windrow, moisture content, temperature, organic matter initial concentration etc. can all influence compost effect, and composting method pair
The removal effect of antibiotic residue is relatively low, can not reduce the risk of antibiotic residue completely.
Be related in the prior art be to other effective treating methods containing antibiotic substance, such as number of patent application
A kind of method processing tetracycline bacterial dreg with metal ion catalysis ozone oxidation has been recorded in 201610039015.8 patent
Method, number of patent application are to have recorded to handle feces of livestock and poultry using one plant of tetracycline degradation bacteria in 201710200022.6 patent
Method, generally or the method using more traditional compost or microbial degradation, and removal efficiency is general for the above method
All over being not very high.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of processing method containing antibiotic substance, which passes through confrontation
Raw element class material carries out high temperature and pressure harmless treatment, and processing method is easy to operate, environmentally protective, and cost is low easy, and passes through
The material crossed after processing can also be recycled, and as organic fertilizer, soil conditioner or other nutriments, improve this
The added value of class solid waste, there is extensive recommendation to be worth very much.
The second object of the present invention is to provide a kind of extensive use of above-mentioned processing method, can apply raw in medicine
The numerous areas such as production, animal husbandry, contain antibiotic substance for high-content, can be handled in method using the present invention,
Using very extensive.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
The present invention provides a kind of processing method containing antibiotic substance, include the following steps：
(A) antibiotic substance will be contained to be stirred with conditioning agent, then adds raising agent and stir to form mixture, the adjusting
Agent is acids, bases, oxidant and specified microorganisms preparation, and the raising agent is Chinese medicine dreg, in straw, wood dust
One of which；
(B) system temperature is preheated to more than 100 DEG C, adds the mixture and carry out high temperature high pressure process 30-1200s,
Between 150-230 DEG C, pressure controls between 1.8-2.4MPa temperature control, you can.
Preferably, it is described to include macrolide, aminoglycoside, beta-lactam, woods gram acid amides containing antibiotic substance
One of which in class, Tetracyclines, quinolones and sulfamido；
Preferably, the macrolide includes wherein one in erythromycin, roxithromycin, tylosin, clarithromycin
Kind is several；
Preferably, the Tetracyclines includes the one or more in tetracycline, terramycin, aureomycin, fortimicin；
Preferably, the aminoglycoside includes streptomysin, the one of which in streptomycin sulphate or several；
Preferably, the beta-lactam includes wherein one in Amoxicillin, ampicillin, penicillin, cefalexin
Kind is several；
Preferably, the woods gram amide-type is lincomycin；
It is phonetic that the sulfamido includes sulfamethoxazole, sulfamerazine, methoxybenzyl aminopyrimidine, sulfadimidine, methoxy
One of which in pyridine, sulphathiazole, sulfapryidine, sulfadimethoxine；
The quinolones is included in Enrofloxacin, Ciprofloxacin, Ofloxacin, fleraxacin, Norfloxacin wherein
It is a kind of；
Preferably, the acids is hydrochloric acid, and the bases is in calcium oxide, calcium hypochlorite, carbon acid calcium and sodium hydroxide
One of which or several.
It can be seen that the scope for the antibiotic that the present invention is included can include Multiple Classes of Antibiotics type than wide.
In the prior art, antibiotic is generally present in after pharmaceutical factory produces in remaining bacteria residue, or in the excrement of livestock and poultry,
But the residual of antibiotic can cause bacteria residue or excrement to carry out resource reutilization, it is therefore desirable to which bacteria residue, excrement are carried out
Harmless treatment, and in the prior art universal method for innocent treatment use more to burn, filling or the mode of compost,
But since fresh bacteria residue moisture content is high, drying disposal need to be carried out, need addition fuel auxiliary to burn in burning process, disposed
High energy consumption in journey, and bacteria residue burning is improper, can produce incineration flue gas, bioxin and flying dust.In composting process, windrow
PH, moisture content, temperature, organic matter initial concentration etc. can all influence compost effect, and remove remaining to antibiotic of composting method is imitated
Fruit is relatively low, can not reduce the risk of antibiotic residue completely.Traditional aerobic compost is all by certain decomposed time, not
The antibiotic residue in bacteria residue and feces of livestock and poultry can be removed completely, and removal rate is uneven.
Therefore, in order to solve above-mentioned technical problem, the present invention provides a kind of processing side to such antibiotic
Method, not only whole processing procedure energy conservation and environmental protection, but also the removal rate of antibiotic can be up to more than 99%, processing method is simple,
The removal rate of any type processing method than in the prior art is all high, and should be widely promoted application.State is produced every year at present
The antibiotic bacterium quantity of slag, feces of livestock and poultry amount is huge, therefore need to look for a kind of more inexpensive, efficient processing method right and wrong
Often it is badly in need of the technical problem solved.
In the step (A) of the present invention, since antibiotic is unstable in alkaline condition, preferably contain antibiotic by such
Material is stirred to mix with conditioning agent (conditioning agent is the mixture of acids, bases, oxidant and specified microorganisms preparation) to be added
Add, it is therefore an objective to manufacture alkaline environment, antibiotic is departed from its ph stability scope, antibiotic has hygroscopicity, Neng Gouchong in addition
Point the moisture content containing antibiotic substance is reduced, in addition the oxidation susceptibility of conditioning agent changes the stability of titer of antibodies, can be
Follow-up link is easier to change its molecular structure, and inventor is by the composition for conditioning agent of making rational planning for reach more excellent place
Manage effect.
Preferably, the mass percent for adding conditioning agent is the 0.1-8% of the material of antibiotic, is more preferably 0.2-4%,
Such as can also be 0.3%, 1%, 3% etc..
Moisture content is preferably controlled between 50-80wt% after addition conditioning agent, to reach reduction moisture content, ensures follow-up step
The rapid effect smoothly implemented.
After with the addition of conditioning agent, it is also necessary to add a certain amount of raising agent, raising agent can increase the loose of mixture
Degree, reduces moisture, supplementary carbon source, raising agent is Chinese medicine dreg, the one of which in straw, wood dust, is in addition fed suitable
Sequence need especially to notice, it is necessary to first addition conditioning agent add raising agent again because on the premise of acid-base property is changed with it is loose
Agent mixing can more give full play to its effect, reach loose, supplementary carbon source effect.
Preferably, the additive amount of raising agent is that the material total mass ratio of conditioning agent and antibiotic is (0.1-1)：1, more preferably
For (0.5-0.7)：1, such as mass ratio can also be 0.6：1,0.8：1,0.9：1 etc..
Preferably, after with the addition of raising agent, moisture content can be reduced further, and general control is between 40-65wt%.
In the present invention, the material containing antibiotic preferably includes one or both of antibiotic bacterium dregs, feces of livestock and poultry, more
The excellent mixing for both antibiotic bacterium dregs and feces of livestock and poultry, mass ratio between the two are preferably controlled in 1：Between (0-10), example
Such as can also be 1：0.2、1：0.4、1：0.5、1：Why both are carried out mix and match by 0.6, because containing in antibiotic bacterium dregs
There is abundant albumen, nitrogen content is high；Containing abundant carbon source in feces of livestock and poultry, the content of organic matter is high, the two is mixed harmless
Change the carbon-nitrogen ratio that product disclosure satisfy that Institute of Micro-biology needs in fermentation, it is not necessary to which the extra other nutritional ingredients of addition can be subject to
Utilize, it is very convenient, it is therefore preferred that both mixtures of selection contain antibiotic substance as pending, certainly therebetween
It is to have what certain quality proportioning required, because if mass ratio control is improper, the product by harmless treatment can not expire
Normal demand of the foot as nutritional ingredient, it is also necessary to other nutritional ingredients are additionally added, it is of high cost to also increase operation difficulty, institute
Preferably needing burden control proper.
Preferably, feces of livestock and poultry includes the one of which in pig manure, chicken manure, cow dung, sheep manure, horsehit, duck excrement and rabbit excrement.
Before treatment, the moisture content of antibiotic bacterium dregs is preferably controlled between 60-95wt%, the moisture content of feces of livestock and poultry
It is preferably controlled between 40-85wt%, by adding conditioning agent, raising agent to reduce water content.
It is that the mixture mixed in step (A) is subjected to high temperature high pressure process in the step (B) of the present invention, first will
System temperature is preheated to more than 120 DEG C, it is more excellent be 130-140 DEG C between.
By said mixture high temperature high pressure process 30-1200s after preheating, temperature control is between 180-230 DEG C, pressure control
System is between 1.8-2.4MPa, by high temperature high pressure process, can decompose containing antibiotic substance in mixture, so as to reach
The effect of harmless treatment.
In addition, the time of high temperature high pressure process can also be 100-1000s, the temperature of high temperature high pressure process can also be
Between 200-220 DEG C, pressure can be controlled between 2.0-2.3MPa, pass through antibiosis in the product of the harmless treatment of the present invention
Plain residual quantity is less than 1%, and removal effect is good.Meanwhile roundworm egg in feces of livestock and poultry and colibacillus of excrement also can efficiently be gone
Remove, reach really innoxious.
Finally, innoxious product is fermented according to compost method, obtains organic fertilizer raw material full of nutrition.Pass through to
Strain, trace element etc. are wherein added, can be made into the various high nutrition products such as biological organic fertilizer, soil conditioner.
Well should as it can be seen that the processing method containing antibiotic substance of the present invention is respectively provided with terms of pharmacy industry, animal husbandry
With using very extensive.
Compared with prior art, beneficial effects of the present invention are：
(1) antibiotic bacterium dregs of the invention and feces of livestock and poultry mixed processing, remove antibiosis therein while targeted
Element residual, removal efficiency is up to more than 99%, and processing method is easy to operate, environmentally protective, and cost is low easy, and after treatment
Material can also be recycled；
(2) antibiotic bacterium dregs can complement one another with both feces of livestock and poultry nutritional ingredient, be provided for follow-up microbial fermentation
Carbon source, the nitrogen source of abundance；
(3) present invention mixture nutritional ingredient after treatment, can do organic fertilizer raw material, at the same solve aquaculture,
Pharmaceutical industry a technical problem to be solved urgently.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person, the condition suggested according to normal condition or manufacturer carry out.Reagents or instruments used without specified manufacturer, is
The conventional products that can be obtained by commercially available purchase.
Embodiment 1
The processing method of lincomycin fungi residues is as follows：
1) the fresh lincomycin fungi residues that moisture content is 60wt% are tentatively mixed in mixer, is then being mixed
The conditioning agent (hydrochloric acid, calcium oxide, oxidant and specified microorganisms preparation) of 0.1wt% is added in thing, alkaline environment is manufactured, makes woods
Can mycin depart from its ph stability scope, moisture content is between 60-95wt%；
2) said mixture and wood dust are pressed 1：1 ratio mixing, fully mixes, obtains pending material, moisture content
For 40wt%, wood dust can increase the gas porosity of mixture, reduce moisture, supplementary carbon source；
3) high temperature and pressure harmless treatment is carried out to mixture using Steam explosive machine：Cylinder is preheated to steam first
More than 120 DEG C, pending material is added into feed bin, then carries out being warming up to 180 DEG C.The steam explosion dwell time is set as 30s, is pressed
Power is 1.8MPa, then slowly opens steam valve, carries out steam explosion, innoxious product is obtained after steam explosion；
Antibiotic residual quantity is less than 1% in innoxious product, and for removal rate more than 99%, removal effect is good；
4) innoxious product is fermented according to compost method, obtains organic fertilizer raw material full of nutrition.By to its
Middle addition strain, trace element etc., can be made into the various high nutrition products such as biological organic fertilizer, soil conditioner.
Embodiment 2
The processing method that erythromycin bacterium slag is mixed with feces of livestock and poultry is as follows：
1) by the fresh erythromycin bacterium slag that moisture content is 95wt% and the feces of livestock and poultry horsehit that moisture content is 40wt% by 1：
10 ratio is tentatively mixed in mixer, then in said mixture add 8wt% conditioning agent (calcium hypochlorite,
Oxidant and specified microorganisms preparation), alkaline environment is manufactured, erythromycin is departed from its ph stability scope, moisture content is in 50-
Between 80wt%；
2) said mixture and maize straw are pressed 1：0.5 ratio mixing, fully mixes, obtains pending material, contain
Water rate is 65wt%, and stalk can increase the gas porosity of mixture, reduce moisture, supplementary carbon source；
3) high temperature and pressure harmless treatment is carried out to mixture using Steam explosive machine：Cylinder is preheated to steam first
More than 130 DEG C, pending material is added into feed bin, then carries out being warming up to 230 DEG C.The steam explosion dwell time is set as 1200s,
Pressure is 2.4MPa, then slowly opens steam valve, carries out steam explosion, innoxious product is obtained after steam explosion；
Antibiotic residual quantity is less than 1% in innoxious product, and for removal rate more than 99%, removal effect is good；
4) innoxious product is fermented according to compost method, obtains organic fertilizer raw material full of nutrition.By to its
Middle addition strain, trace element etc., can be made into the various high nutrition products such as biological organic fertilizer, soil conditioner.
Embodiment 3
The processing method that streptomycin sulphate bacteria residue is mixed with feces of livestock and poultry is as follows：
1) feces of livestock and poultry (horse for being 70wt% with moisture content by the fresh sulfuric acid streptomysin bacteria residue that moisture content is 80wt%
The mixing of excrement, chicken manure) press 1：3 ratio is tentatively mixed in mixer, and 0.2wt% is then added in said mixture
Conditioning agent (calcium hypochlorite, oxidant and specified microorganisms preparation), manufacture alkaline environment, streptomycin sulphate is departed from its soda acid
Stability range, moisture content is between 50-80wt%；
2) said mixture and maize straw are pressed 1：0.7 ratio mixing, fully mixes, obtains pending material, contain
Water rate is 50wt%, and stalk can increase the gas porosity of mixture, reduce moisture, supplementary carbon source；
3) high temperature and pressure harmless treatment is carried out to mixture using Steam explosive machine：Cylinder is preheated to steam first
140 DEG C, pending material is added into feed bin, then carries out being warming up to 200 DEG C.The steam explosion dwell time is set as 1000s, pressure
For 2.3MPa, steam valve is then slowly opened, steam explosion is carried out, innoxious product is obtained after steam explosion；
Antibiotic residual quantity is less than 1% in innoxious product, and for removal rate more than 99%, removal effect is good；
4) innoxious product is fermented according to compost method, obtains organic fertilizer raw material full of nutrition.By to its
Middle addition strain, trace element etc., can be made into the various high nutrition products such as biological organic fertilizer, soil conditioner.
Embodiment 4
The processing method that penicillin mushroom dregs are mixed with feces of livestock and poultry is as follows：
1) feces of livestock and poultry (pig manure, the chicken manure for being 60wt% with moisture content by the penicillin mushroom dregs that moisture content is 80wt%
Mixing) press 1：2 ratio is tentatively mixed in mixer, and the conditioning agent (salt of 4wt% is then added in said mixture
Acid, calcium hypochlorite, carbon acid calcium, oxidant and specified microorganisms preparation) penicillin is departed from its ph stability scope, moisture content
In 60wt%；
2) said mixture and soybean stalk are pressed 1：0.7 ratio mixing, fully mixes, obtains pending material, contain
Water rate is 40-50wt%, and stalk can increase the gas porosity of mixture, reduce moisture, supplementary carbon source；
3) high temperature and pressure harmless treatment is carried out to mixture using Steam explosive machine：Cylinder is preheated to steam first
More than 135 DEG C, pending material is added into feed bin, then carries out being warming up to 220 DEG C.The steam explosion dwell time is set as 100s,
Pressure is 2.0MPa, then slowly opens steam valve, carries out steam explosion, innoxious product is obtained after steam explosion；
Antibiotic residual quantity is less than 1% in innoxious product, and for removal rate more than 99%, removal effect is good；
4) innoxious product is fermented according to compost method, obtains organic fertilizer raw material full of nutrition.By to its
Middle addition strain, trace element etc., can be made into the various high nutrition products such as biological organic fertilizer, soil conditioner.
Embodiment 5
Other operating procedures are consistent with embodiment 4, and conditioning agent (hydrochloric acid, the hypochlorous acid of 3wt% are simply added in step 1)
Calcium, carbon acid calcium, oxidant and specified microorganisms preparation), last removal rate is more than 99%.
Embodiment 6
Other operating procedures are consistent with embodiment 4, and simply the bacteria residue in step 1) is terramycin, aureomycin mixture bacterium
Slag, last removal rate is more than 99%.
Embodiment 7
Other operating procedures and embodiment 4 are consistent, simply only feces of livestock and poultry in step 1), last removal rate 99% with
On.
Embodiment 8
Other operating procedures are consistent with embodiment 4, and said mixture and Chinese medicine dreg 2) simply are pressed 1：0.6 ratio is mixed
Close, fully mix, obtain pending material, moisture content 40-50wt%, Chinese medicine dreg can increase the gas porosity of mixture, drop
Low moisture, supplementary carbon source, last removal rate is more than 99%.
Comparative example 1
Concrete operation step and embodiment 4 are consistent, simply add conditioning agent with adding the order of soybean stalk in no particular order,
Unified addition mixing, it is 98% finally to detect removal rate.
Comparative example 2
Concrete operation step is consistent with embodiment 4, and simply in step 3), the steam explosion dwell time is 10s, and finally detection removes
Rate is 98%.
Comparative example 3
Concrete operation step is consistent with embodiment 4, and simply in step 3), steam explosion pressure is 1.2MPa, and finally detection removes
Rate is 98%.
Comparative example 4
Concrete operation step is consistent with embodiment 4, and simply in step 3), the temperature of steam explosion is 130 DEG C, and finally detection removes
Rate is 98%.
Although being illustrated and the invention has been described with specific embodiment, but will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of processing method containing antibiotic substance, it is characterised in that include the following steps：
(A) antibiotic substance will be contained to be stirred with conditioning agent, then adds raising agent and stir to form mixture, the conditioning agent is
Acids, bases, oxidant and specified microorganisms preparation, the raising agent is Chinese medicine dreg, straw, in wood dust wherein
It is a kind of；
(B) system temperature is preheated to more than 100 DEG C, adds the mixture and carry out high temperature high pressure process 30-1200s, temperature
Between 150-230 DEG C, pressure is controlled between 1.8-2.4MPa for control, you can；
Preferably, it is described to include macrolide, aminoglycoside, beta-lactam, woods gram amide-type, four containing antibiotic substance
One of which in ring element class, quinolones and sulfamido；
Preferably, the macrolide include erythromycin, roxithromycin, tylosin, the one of which in clarithromycin or
It is several；
Preferably, the Tetracyclines includes the one or more in tetracycline, terramycin, aureomycin, fortimicin；
Preferably, the aminoglycoside includes streptomysin, the one of which in streptomycin sulphate or several；
Preferably, the beta-lactam include Amoxicillin, ampicillin, penicillin, the one of which in cefalexin or
It is several；
Preferably, the woods gram amide-type is lincomycin；
The sulfamido includes sulfamethoxazole, sulfamerazine, methoxybenzyl aminopyrimidine, sulfadimidine, Sulfamonomethoxine, sulphur
One of which in amine thiazole, sulfapryidine, sulfadimethoxine；
The quinolones includes the one of which in Enrofloxacin, Ciprofloxacin, Ofloxacin, fleraxacin, Norfloxacin；
Preferably, the acids is hydrochloric acid, and the bases is its in calcium oxide, calcium hypochlorite, carbon acid calcium and sodium hydroxide
Middle one or more.
2. the processing method according to claim 1 containing antibiotic substance, it is characterised in that described in the step (A)
Include one or both of antibiotic bacterium dregs, feces of livestock and poultry containing antibiotic substance；
Preferably, feces of livestock and poultry includes the one of which in pig manure, chicken manure, cow dung, sheep manure, horsehit, duck excrement and rabbit excrement；
Preferably, described containing antibiotic substance is antibiotic bacterium dregs and feces of livestock and poultry, both mass ratioes are 1：(0-10)；
Preferably, the moisture control of antibiotic bacterium dregs is between 60-95wt%；
Preferably, the moisture control of feces of livestock and poultry is between 40-85wt%.
3. the processing method according to claim 1 or 2 containing antibiotic substance, it is characterised in that in the step (A),
The mass percent for adding conditioning agent is the 0.1-8% containing antibiotic substance, more preferably 0.2-4%；
Preferably, moisture control is between 50-80wt% after adding conditioning agent.
4. the processing method according to claim 1 or 2 containing antibiotic substance, it is characterised in that in the step (A),
The additive amount of raising agent is conditioning agent and the total mass ratio containing antibiotic substance is (0.1-1)：1, more preferably (0.5-0.7)：
1；
Preferably, after adding raising agent, the moisture control of the mixture is between 40-65wt%.
5. the processing method according to claim 1 or 2 containing antibiotic substance, it is characterised in that in the step (B),
System temperature is preheated to more than 120 DEG C.
6. the processing method according to claim 5 containing antibiotic substance, it is characterised in that the system temperature is 130-
Between 140 DEG C.
7. the processing method according to claim 6 containing antibiotic substance, it is characterised in that in the step (B), high temperature
HIGH PRESSURE TREATMENT 100-1000s.
8. the processing method according to claim 6 containing antibiotic substance, it is characterised in that in the step (B), temperature
Between 200-220 DEG C, pressure is controlled between 2.0-2.3MPa for control.
9. the processing method according to claim 1 or 2 containing antibiotic substance, it is characterised in that in the step (B),
The step of fermentation is further included after high temperature high pressure process is to obtain the nutriment that can be recycled.
10. processing method of the claim 1-9 any one of them containing antibiotic substance answering in terms of pharmacy industry, animal husbandry
With.
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| CN110125146A (en) * | 2019-05-28 | 2019-08-16 | 周天舒 | A kind of method of antibiotic bacterium dregs disposal of resources reuse fermenting and producing |
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