CN107929631A - A kind of pharmaceutical composition for treating chronic gastritis and preparation method thereof - Google Patents

A kind of pharmaceutical composition for treating chronic gastritis and preparation method thereof Download PDF

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Publication number
CN107929631A
CN107929631A CN201711133554.9A CN201711133554A CN107929631A CN 107929631 A CN107929631 A CN 107929631A CN 201711133554 A CN201711133554 A CN 201711133554A CN 107929631 A CN107929631 A CN 107929631A
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parts
pharmaceutical composition
prepared
active ingredient
erythrina
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王缉华
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Hua Chunfu Family Farm In Bobai County Guangxi
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Hua Chunfu Family Farm In Bobai County Guangxi
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/50—Methods involving additional extraction steps
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Abstract

The present invention relates to treat a kind of pharmaceutical composition of chronic gastritis and preparation method thereof.The pharmaceutical composition is prepared by the Chinese medicine material of following parts by weight：Black tiger, erythrina indica, Flos Ilicis Asprellae, iron holly bark, longan parasitism tea, false-yellowflower milkwort root or herb, obstinate pudendal sore, wrinkled giant hyssop, radix fici simplicissimae, Poria cocos, Chinese fanpalm seed, in one's early teens, cross bee saage, dried orange peel, Cortex Magnoliae Officinalis, erythrina bark, caulis piperis futokadsurae, hairyvein agrimony, serissa serissoide.Pharmaceutical composition of the present invention can effectively treat middle epigastric discomfort caused by chronic gastritis, and middle upper abdomen dull pain, burning pain is glutted, loss of appetite, belch, pantothenic acid, the clinical symptoms such as nausea.

Description

A kind of pharmaceutical composition for treating chronic gastritis and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines for the treatment of, and in particular to a kind of pharmaceutical composition for treating chronic gastritis and its preparation Method.
Background technology
Chronic gastritis is the disease that stomach lining is in chronic chronic inflammation, is digestive system common disease, is belonged in chronic gastritis It is a kind of.Can be because being addicted to drink, drink espresso, bile regurgitation, or because helicobacter pylori infections etc. cause.Patient can have different degrees of disappear Change ill symptoms, such as epigastric discomfort, secret anguish after feeding, with belch, nausea, pantothenic acid, occasionally there is vomiting.
Common treatment method has：
1. eliminate the cause of disease
2. drug therapy
（1）The protection common medicine of stomach lining medicine has colloidal bismuth citrate（CBS）, ulcerlmin, dioctahedral smectite, Marzulene-S, hydrogen Alumina gel, gastric mucin and gavirin tablet etc..
（2）Adjust gastrointestinal motility function medicine Abdeminal pain metoclopramide or domperidone etc..Hiccup, abdominal distension have reflux Phenomenon is main person, can use medicine for stomach dynamic, such as metoclopramide, dompendone, not husky Billy.
（3）If antibiotic gastrocopy finds Helicobacter pylori, antibiotic, clarithromycin, amoxycillin should be taken Penicillin etc., plays the role of removing Hp, general to can be selected two kinds, often with gastric mucosa protective agent and antiacid use in conjunction.
（4）The common medicine of antiacid has Cimetidine, ranitidine, famotidine, sodium acid carbonate（Sodium bicarbonate）, hydrogen-oxygen Change magnesium, gel aluminum hydroxide, gavirin tablet etc..
（5）Anodyne Upper abdominal pain is compared with the orally available atropine of severe one, pro-banthine, Semen daturae tablet or 654-2, to reduce hydrochloric acid in gastric juice Secretion and alleviation colic symptoms.
（6）It also can use digestant such as pancreatin, aluzyme, alctasin, Dimethicone etc..Acid suppression can be also used if any sour regurgitation phenomenon Such as safe stomach U.S. of medicine, ranitidine, famotidine.Prevent bile regurgitation from can take Hydrotalcite, cholestyramine to adsorb bile；Have and vomit Bloody stool blood person, cimetidine take orally.
The content of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for treating chronic gastritis；
It is a further object of the present invention to provide a kind of preparation method for the pharmaceutical composition for treating chronic gastritis.
The purpose of the present invention is what is realized by following technical solution：
The pharmaceutical composition for the treatment of chronic gastritis of the present invention, it is prepared by the raw material of following parts by weight：
Black tiger 25-35 parts, 25-35 parts of erythrina indica, 25-35 parts of Flos Ilicis Asprellae, 25-35 parts of iron holly bark, 25-35 parts of longan parasitism tea, 25-35 parts of false-yellowflower milkwort root or herb, 25-35 parts of obstinate pudendal sore, 15-25 parts of wrinkled giant hyssop, 15-25 parts of radix fici simplicissimae, 15-25 parts of Poria cocos, Chinese fan palm It is 15-25 parts sub-, 15-25 parts in one's early teens, cross 15-25 part of bee saage, be 15-25 parts of dried orange peel, 15-25 parts of Cortex Magnoliae Officinalis, 8-15 parts of erythrina bark, extra large 8-15 parts of wind rattan, 8-15 parts of hairyvein agrimony, 8-15 parts of serissa serissoide；
Preferably, it is to be prepared by the raw material of following parts by weight：
Black 30 parts of tiger, 30 parts of erythrina indica, 30 parts of Flos Ilicis Asprellae, 30 parts of iron holly bark, 30 parts of longan parasitism tea, 30 parts of false-yellowflower milkwort root or herb, 30 parts of obstinate pudendal sore, 20 parts of wrinkled giant hyssop, 20 parts of radix fici simplicissimae, 20 parts of Poria cocos, 20 parts of Chinese fanpalm seed, 20 parts in one's early teens, cross 20 parts of bee saage, old 20 parts of skin, 20 parts of Cortex Magnoliae Officinalis, 10 parts of erythrina bark, 10 parts of caulis piperis futokadsurae, 10 parts of hairyvein agrimony, 10 parts of serissa serissoide.
It is the crude drug source and primary efficacy of Chinese medicine preparation of the present invention below：
Black tiger, is Schisandraceae Plant kadsurae coccineae Kadsura coccinea (Lem.) A.C.Smith [K.chinensisHance ex Benth；K.hainanensisMerr. root] and viticula..It is pungent；Slight bitter；It is warm-natured.Promoting the circulation of qi is lived Blood, swelling and pain relieving.For arthralgia pain due to rheumatism, stomachache, dysmenorrhoea, the postpartum product stasis of blood, traumatic injury swelling and pain.
Erythrina indica leaf, is legume erythrina indica Erythrina variegata L. and himalayan coralbean herb Erythrina The leaf of arborescens Roxb..
Flos Ilicis Asprellae, Aquifoliaceae Holly leaf of plum Chinese ilex Ilex asprella（Hook. et Arn.） Champ. ex Benth., it is used as medicine with root, leaf.It is bitter, sweet, it is cool.It is clearing heat and detoxicating, promote the production of body fluid to quench thirst.For catching a cold, hyperpyrexia polydipsia, tonsillitis, throat Inflammation, tracheitis, pertussis, enteritis, dysentery, catarrhal jaundice, wild gill fungus, arsenic intoxication.For herbal tea primary raw material；Leaf external application, which is controlled, falls Beat damage, carbuncle furuncle poison.
Iron holly bark, the bark of Aquifoliaceae Holly ilexrotunda Ilex rotunda Thunb.（Double-layer fur）, leaf, root Also can be used as medicine.Hardship, it is cool.It is clearing heat and detoxicating, swelling and pain relieving.For catching a cold, tonsillitis, abscess of throat, acute gastroenteritis, rheumatic bone Bitterly；Traumatic injury, carbuncle furuncle sore, traumatic hemorrhage, burn and scald are controlled in external application.
Longan is parasitic, Santalales, Loranthaceae, shrub.Parasitize Fagaceae, Theaceae, moraceae plants or sweetgum, oil In the various plants such as paulownia, Chinese fir.It is sweet；It is bitter；It is mild-natured；Wind-damp dispelling；Filling liver kidney；Promoting blood circulation and stopping pain；Cough-relieving；Stop dysentery.Main arthralgia pain due to rheumatism；Waist Knee joint soreness；Have a dizzy spell；Alopecia；Traumatic injury；Hemorrhoid gall；Cough；Hemoptysis；Dysentery
Radix fici simplicissimae, is Moraceae ficus species ficus simplicissima Ficus simplicissima Lour. [F. hirta Vahl var. palmatiloba （Merr.）Chum], it is used as medicine with root.It is sweet, tepor.Invigorating the spleen for eliminating dampness, promoting the circulation of qi resolving sputum, relaxing tendons and activating collaterals.For lung knot Core is coughed, chronic bronchitis, rheumatic arthritis, waist-leg pain, insufficiency of the spleen edema, after being ill night sweat, leukorrhea.
False-yellowflower milkwort root or herb, Polygalaceae polygala false-yellowflower milkwort root or herb Polygala aureocauda Dunn, is entered with root Medicine.Sweet, slight bitter, puts down.Tonifying Qi and blood, invigorating spleen to remove dampness, promoting blood circulation for regulating menstruation.For physically weak after being ill, soreness of waist and knee joint, traumatic injury, jaundice Type hepatitis, nephritic dropsy, the prolapse of uterus, leukorrhea, irregular menstruation.
Chinese fanpalm seed, is the seed of babassu Chinese fan palm.It is sweet in flavor；It is bitter；It is mild-natured；Mild toxicity；It is promoting blood circulation and removing blood stasis；Softening and resolving hard mass.It is main Chronic hepatitis；A lump in the abdomen causing distension and pain
In one's early teens, it is the nearly mature seed of drying of zingiberaceous plant Alpinia katsumadai Hayata in one's early teens.It is acrid in flavour and warm in nature. Returns spleen, stomach.It is drying damp and strengthening spleen, warm stomach preventing or arresting vomiting.For internal retention of cold wetness, abdominal fullness and distention crymodynia, belch is vomitted inverse, do not feel like eating.
Obstinate pudendal sore, the herb of Piperaceae plant Hance Pepper Stem and Leaf Piper hancei Maxim..Acrid flavour, it is mild-natured.Dispelling wind and eliminating dampness, by force Waist and knee, swelling and pain relieving.Cure cold cough, asthma, stomach abdomen tremble with fear pain, treating rheumatic ostealgia, numb in every limb, waist-leg weakness, muscular atrophy, fall Play damage.
Caulis piperis futokadsurae, is the drying rattan of Piperaceae plant wind rattan Piper kadsura (Choisy) 0hwi.Acrid flavour, hardship, Slightly warm in nature.Return liver warp.Wind-damp dispelling, degrading the channel, stopping numbness pain.For wind-cold-dampness arthralgia, podomere pain, muscle arteries and veins contraction, joint stuffiness.
Bee saage is crossed, also known as kind young fragrant, false camphor tree son.The woody section medicinal herbs of Rutaceae Clausena.Latin name Clausena Excavata Burm. f. are antipyretic, removing toxic substances, admittedly lung channel, to control rheumatism, arthritis good medicine, can go miasma, control abdominal pain, and poison One of Chinese drugs for snakebites of snake bite.
Dried orange peel, is the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and its variety Skin.It is bitter, acrid in flavour and warm in nature.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Wrinkled giant hyssop, there is Pogostemon cablin Pogostemon cablin (Blanco)) dry aerial parts of Benth..Tepor.Return Spleen, stomach, lung channel.Eliminate dampness with aromatics, and middle preventing or arresting vomiting, deliver relieving summer-heat.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian is vomitted, summer-heat and damp exterior syndrome, at the beginning of damp-warm syndrome Rise, burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and abdominal pain is vomited and diarrhoea, nasosinusitis headache.
Poria cocos, is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.It is sweet in flavor, light, it is mild-natured. The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the heart It is refreshing uneasy, insomnia of palpitating with fear.
Cortex Magnoliae Officinalis, is Magnoliacea plant Cortex Magnoliae Officinalis Magnolia officinalis Rehd. et Wils. or Magnolia bilola The drying dry hide of Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., root skin And branch skin.It is bitter, acrid in flavour and warm in nature.Returns spleen, stomach, lung, large intestine channel.Eliminating dampness dissolving phlegm, lower gas removes full.For in humidity hysteresis wound, abdominal swelling and diarrhea, to eat Pneumatosis is stagnant, abdominal distention constipation, sputum cough.
Erythrina bark, the bark or root skin of pulse family himalayan coralbean herb Erythrina indica Lam..Hardship, puts down.Return liver and kidney channel. Wind-damp dispelling, channels sootheing and network vessel quickening.For rheumatic numbness, Leg muscles pain, traumatic injury；Various stubborn dermatitis are controlled in external application.
Serissa serissoide, is Rubiaceae serissa serissoide platymiscium serissa serissoide Serissa serissoides（DC.）Druce, with complete Strain is used as medicine.Light, micro-pungent, it is cool.Expelling wind to resolve the exterior, clearing heat and promoting diuresis, relaxing tendons and activating collaterals.For catching a cold, cough, toothache, acute tonsillitis, Sphagitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, Hypertension Complicated Headache, antimigraine, rheumatic arthralgia, leukorrhea；Stem Ashing eye droppings controls mist.
Hairyvein agrimony, is the dry aerial parts of rosaceous plant hairyvein agrimony Agrimonia pilosa Ledeb..Bitter, It is puckery, put down.Converge to heart and liver channels.Astringing to arrest bleeding, preventing malaria, stop dysentery, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, bloody flux, takes off power Internal lesion caused by overexertion, carbuncle sore tumefacting virus, under pruritus vulvae band.
Another aspect of the present invention there is provided the preparation method of the active ingredient of pharmaceutical composition of the present invention, and this method is Carried using water or the ethanol of 40-80% concentration expressed in percentage by volume extracts.Specific preparation method is as follows：
Scheme one：Whole medicinal materials, extracting in water 2-3 times are taken, each amount of water carries every time equivalent to 6-12 times of medicinal material gross weight Take the time for 1-3 it is small when, merge extracting solution, filtration, when filtrate is concentrated into 70-80 DEG C relative density be 1.10-1.25 clear cream, Up to active ingredient.
Scheme two：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often When secondary extraction time is 1-3 small, merge extracting solution, filtration, relative density is 1.05-1.20's when filtrate is concentrated into 70-80 DEG C Clear cream, adds ethanol, and it is 40-70% to make alcohol content, when standing 12-24 is small, filtration, and relative density when filtrate is concentrated into 70-80 DEG C For the medicinal extract of 1.10-1.25, up to active ingredient.
Scheme three：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is medicinal material total amount 4-10 times, when extraction time is 1-3 small, merge extracting solution, filtering, relative density is 1.10- when filtrate is concentrated into 60-80 DEG C 1.25 medicinal extract, up to active ingredient.
It is of the present invention treatment chronic gastritis pharmaceutical composition, can with pharmaceutically acceptable carrier combination, Various common dosage forms, such as tablet, granule, capsule, syrup are made.
The pharmaceutically acceptable carrier of the present invention includes but not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Spleen and stomach damp-heat type patient's retention of damp-heat in the interior, heat-clearing easily help wet, the easy heat of clearing damp, thus treatment get up it is more intractable, it is past Toward taking, effect is slower.In the selection of medicine, it should be noted that select the product of eliminating dampness and heat, use the medicine of fragrant dry clearing damp and heavy dose of heat-clearing with caution The agent of removing toxic substances.
The black tiger energy promoting flow of qi and blood circulation of the present invention, swelling and pain relieving；Erythrina indica anti-inflammatory analgetic；Flos Ilicis Asprellae is clearing heat and detoxicating, anti-inflammatory；Iron holly bark It is clearing heat and detoxicating, dampness removing analgesic；Longan parasitism mental-tranquilization, anti-inflammatory, promoting blood circulation, alleviate long-pending dissipating bind；False-yellowflower milkwort root or herb clearing heat and eliminating phlegm；Water Banyan parasitism clearing heat and expelling damp, detoxicating and fighting cancer；Wrinkled giant hyssop qi-restoratives moistening lung, strengthening tendons are active；Radix fici simplicissimae tonifies Qi of the kidney, consolidates foster body；Fu Siberian cocklebur Yin nourishing and lung moistening；Chinese fanpalm seed astringing to arrest bleeding；Hidroschesis；Dry temperature dispelling cold in one's early teens, eliminating phlegm preventing malaria, invigorating the spleen warm stomach；Cross bee saage it is antipyretic, solution Poison, solid lung channel；Dried orange peel regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm；Cortex Magnoliae Officinalis：It is clearing heat and detoxicating, it is inducing diuresis and reducing edema；Erythrina bark inducing diuresis to remove edema；Caulis piperis futokadsurae Stagnation resolvation diuresis；Oldenlandia diffusa inducing diuresis to remove edema, promoting blood circulation and stopping pain；Hairyvein agrimony astringing to arrest bleeding；Wrinkled giant hyssop is eliminated dampness with aromatics, and middle preventing or arresting vomiting；Six The moon avenges reinforcing stomach reg fluid, nourishing Yin and clearing heat.Full side's collocation is scientific and reasonable, meets System of Chinese medicine, mutually collaboration so that of the invention Chinese medicine has good clearing away heat and eliminating dampeness, invigorating the spleen qi-regulating and stomach stagnation resolvation effect.
A kind of pharmaceutical composition for treating chronic gastritis provided by the invention has the following advantages：
1st, pharmaceutical composition provided by the invention has good clearing away heat and eliminating dampeness, invigorating the spleen qi-regulating and stomach stagnation resolvation effect, can effectively control Treat damp-heat type chronic gastritis, total effective rate 89.5%
2nd, pharmaceutical composition preparation method of the invention is simple and practicable, is adapted to basic medical unit or producer to produce in enormous quantities.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that the embodiment of the present invention is to be used to illustrate The present invention rather than limitation of the present invention.The simple modifications that essence carries out the present invention according to the present invention belong to the present invention Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution Volume ratio.
Embodiment 1：
Take black tiger 30g, erythrina indica 30g, Flos Ilicis Asprellae 30g, iron holly bark 30g, longan parasitism tea 30g, false-yellowflower milkwort root or herb 30g, small intestine Wind 30g, wrinkled giant hyssop 20g, radix fici simplicissimae 20g, Poria cocos 20g, in one's early teens Chinese fanpalm seed 20g, 20g, excessively bee saage 20g, dried orange peel 20g, Cortex Magnoliae Officinalis 20g, erythrina bark 10g, caulis piperis futokadsurae 10g, hairyvein agrimony 10g, serissa serissoide 10g, extracting in water 2 times, amount of water is respectively medicinal material twice 10 times, 8 times of gross weight, when extraction time is respectively 2 small twice, 1 it is small when, merge extracting solution, filtration, filtrate is concentrated into 80 DEG C When relative density be 1.10 medicinal extract.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir evenly, and syrup is made Agent.
Embodiment 2：
Take black tiger 25g, erythrina indica 25g, Flos Ilicis Asprellae 25g, iron holly bark 25g, longan parasitism tea 25g, false-yellowflower milkwort root or herb 25g, small intestine Wind 25g, wrinkled giant hyssop 15g, radix fici simplicissimae 15g, Poria cocos 15g, in one's early teens Chinese fanpalm seed 15g, 15g, excessively bee saage 15g, dried orange peel 15g, Cortex Magnoliae Officinalis 15g, erythrina bark 8g, caulis piperis futokadsurae 8g, hairyvein agrimony 8g serissa serissoide 8g, are extracted 3 times with 40% alcohol reflux, each ethanol consumption difference 10 times, 8 times, 4 times for medicinal material total amount, when extraction time difference 3 is small, 2 it is small when, 1 it is small when, merge extracting solution, filtering, filtrate is dense Relative density is 1.25 medicinal extract when being reduced to 60 DEG C, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
Embodiment 3：
Take black tiger 25g, erythrina indica 35g, Flos Ilicis Asprellae 25g, iron holly bark 35g, longan parasitism tea 25g, false-yellowflower milkwort root or herb 35g, small intestine Wind 25g, wrinkled giant hyssop 15g, radix fici simplicissimae 25g, Poria cocos 15g, in one's early teens Chinese fanpalm seed 25g, 15g, excessively bee saage 25g, dried orange peel 15g, Cortex Magnoliae Officinalis 25g, erythrina bark 8g, caulis piperis futokadsurae 15g, hairyvein agrimony 15g, serissa serissoide 15g, extracting in water 3 times, amount of water is respectively equivalent to medicine three times 12 times, 8 times, 6 times of material gross weight, when each extraction time difference 3 is small, 2 it is small when, 1 it is small when, merge extracting solution, filtration, filtrate Relative density is 1.20 clear cream when being concentrated into 70 DEG C, adds ethanol, and it is 40% to make alcohol content, when standing 24 is small, filtration, and filtrate Relative density is 1.10 medicinal extract when being concentrated into 70 DEG C, and addition purified water ad pond om is 3 times of medicinal material gross weight, filling, i.e., Obtain mixture of the present invention.
Embodiment 4：
Take black tiger 35g, erythrina indica 25g, Flos Ilicis Asprellae 35g, iron holly bark 25g, longan parasitism tea 35g, false-yellowflower milkwort root or herb 25g, small intestine Wind 35g, wrinkled giant hyssop 15g, radix fici simplicissimae 25g, Poria cocos 15g, in one's early teens Chinese fanpalm seed 25g, 15g, excessively bee saage 25g, dried orange peel 15g, Cortex Magnoliae Officinalis 25g, erythrina bark 8g, caulis piperis futokadsurae 15g, hairyvein agrimony 15g serissa serissoide 15g, are extracted 2 times with alcohol reflux, each concentration of alcohol difference For 80%, 60%, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, when extraction time is respectively 4 small, 3 it is small when, merge Extracting solution, filtering, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, adds supplementary product starch, ethanol, talcum powder, system Obtain tablet.
Embodiment 5：
Take black tiger 30g, erythrina indica 25g, Flos Ilicis Asprellae 30g, iron holly bark 25g, longan parasitism tea 30g, false-yellowflower milkwort root or herb 25g, small intestine Wind 30g, wrinkled giant hyssop 15g, radix fici simplicissimae 20g, Poria cocos 15g, in one's early teens Chinese fanpalm seed 20g, 15g, excessively bee saage 20g, dried orange peel 15g, Cortex Magnoliae Officinalis 20g, erythrina bark 10g, caulis piperis futokadsurae 8g, hairyvein agrimony 8g, serissa serissoide 8g, extracting in water 3 times, amount of water is respectively medicinal material gross weight three times Amount 12 times, 8 times, 6 times, when extraction time is respectively 3 small three times, 2 it is small when, 1 it is small when, merge extracting solution, filtration, filtrate concentration To the clear cream that relative density at 70 DEG C is 1.25, supplementary product starch, ethanol, dextrin, magnesium stearate are added, loads capsule shells, be made Capsule.
Embodiment 6：
Take black tiger 35g, erythrina indica 35g, Flos Ilicis Asprellae 35g, iron holly bark 35g, longan parasitism tea 35g, false-yellowflower milkwort root or herb 35g, small intestine Wind 35g, wrinkled giant hyssop 25g, radix fici simplicissimae 25g, Poria cocos 25g, in one's early teens Chinese fanpalm seed 25g, 25g, excessively bee saage 25g, dried orange peel 25g, Cortex Magnoliae Officinalis 25g, erythrina bark 15g, caulis piperis futokadsurae 15g, hairyvein agrimony 15g, serissa serissoide 15g, extracting in water 2 times, each amount of water is respectively equivalent to 12 times, 10 times of medicinal material gross weight, when each extraction time is respectively 3 small, 2 it is small when, merge extracting solution, filtration, filtrate concentration Relative density is 1.05 clear cream to 80 DEG C, adds ethanol, and it is 70% to make alcohol content, when standing 12 is small, filtration, and filtrate concentration To the medicinal extract that relative density at 70 DEG C is 1.25, auxiliary material Icing Sugar, starch, dextrin, ethanol are added, granule is made.
Embodiment 7：
Weigh black tiger 30g, erythrina indica 30g, Flos Ilicis Asprellae 30g, iron holly bark 30g, longan parasitism tea 30g, false-yellowflower milkwort root or herb 30g, small Intestines wind 30g, wrinkled giant hyssop 20g, radix fici simplicissimae 20g, Poria cocos 20g, in one's early teens Chinese fanpalm seed 20g, 20g, excessively bee saage 20g, dried orange peel 20g, thickness Plain 20g, erythrina bark 10g, caulis piperis futokadsurae 10g, hairyvein agrimony 10g, serissa serissoide 10g, clean, dry, crushing, up to pulvis of the present invention.
Embodiment 8
Tablet prepared by the embodiment of the present invention 4, gives Patients with Chronic Gastritis and takes orally, 2 every time, 3 times a day, bfore meals, Clinical data is as follows：
Disorder class Illness number of cases The course of disease Treatment time Efficiently individual quantity Total effective rate
Chronic gastritis 57 - 7 years 2 years 10-15 days 51 people 89.5%
Embodiment 9
Stone XX, 58 years old, man.Uncomfortable nearly 2 years of gastral cavilty portion, when beginning, feel that upper abdomen has a dull ache, and abdominal fullness and distention, diet is bad, Gradually aggravated afterwards to abdominal distension, hiccup frequency is made, and the rear feeling of fullness received aggravates, when have heartburn, sour regurgitation, body sleepiness power, starts to see the doctor for treatment then, begins Western medicine symptom is taken still to mitigate, but afterwards and repeatedly, and it is dissatisfied through multi-treatment, curative effect.The embodiment of the present invention 6 is given to control Treat, abdominal distension, gastral cavilty turgor slightly mitigate after 3 days, do not occur heartburn, sour regurgitation；Abdominal distension, gastral cavilty turgor unobvious after 10 days；Diet Increase, it is comfortable in stomach after food；Stool is not once a day, not dry dilute；Without hiccup, heartburn, sour regurgitation symptom.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed Scope.

Claims (7)

1. a kind of pharmaceutical composition for treating chronic gastritis, it is characterised in that it is prepared by the raw material of following parts by weight 's：Black tiger 25-35 parts, it is 25-35 parts of erythrina indica, 25-35 parts of Flos Ilicis Asprellae, 25-35 parts of iron holly bark, 25-35 parts of longan parasitism tea, yellow 25-35 parts of omei meadowrue herb of flower, 25-35 parts of obstinate pudendal sore, 15-25 parts of wrinkled giant hyssop, 15-25 parts of radix fici simplicissimae, 15-25 parts of Poria cocos, Chinese fanpalm seed 15-25 parts, 15-25 parts in one's early teens, cross 15-25 parts of bee saage, 15-25 parts of dried orange peel, 15-25 parts of Cortex Magnoliae Officinalis, 8-15 parts of erythrina bark, sea wind 8-15 parts of rattan, 8-15 parts of hairyvein agrimony, 8-15 parts of serissa serissoide.
2. pharmaceutical composition according to claim 1, it is characterised in that it is prepared by the raw material of following parts by weight 's：It is black 30 parts of tiger, 30 parts of erythrina indica, 30 parts of Flos Ilicis Asprellae, 30 parts of iron holly bark, 30 parts of longan parasitism tea, 30 parts of false-yellowflower milkwort root or herb, small 30 parts of intestines wind, 20 parts of wrinkled giant hyssop, 20 parts of radix fici simplicissimae, 20 parts of Poria cocos, 20 parts of Chinese fanpalm seed, 20 parts in one's early teens, cross 20 parts of bee saage, dried orange peel 20 parts, 20 parts of Cortex Magnoliae Officinalis, 10 parts of erythrina bark, 10 parts of caulis piperis futokadsurae, 10 parts of hairyvein agrimony, 10 parts of serissa serissoide.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that its active ingredient is to be carried using water or 40-80% What the ethanol extraction of concentration expressed in percentage by volume was prepared.
4. pharmaceutical composition as claimed in claim 3, it is characterised in that its active ingredient be prepared by the following method and Into：Whole medicinal materials are taken, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time For 1-3 it is small when, merge extracting solution, filtration, when filtrate is concentrated into 70-80 DEG C relative density be 1.10-1.25 clear cream, to obtain the final product The active ingredient.
5. pharmaceutical composition as claimed in claim 3, it is characterised in that its active ingredient be prepared by the following method and Into：Whole medicinal materials are taken, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time For 1-3 it is small when, merge extracting solution, filtration, when filtrate is concentrated into 70-80 DEG C relative density be 1.05-1.20 clear cream, add second Alcohol, it is 40-70% to make alcohol content, and when standing 12-24 is small, filtration, relative density is 1.10-1.25 when filtrate is concentrated into 70-80 DEG C Medicinal extract, up to the active ingredient.
6. pharmaceutical composition as claimed in claim 3, it is characterised in that its active ingredient be prepared by the following method and Into：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is 4-10 times of medicinal material total amount, is extracted When time is 1-3 small, merge extracting solution, filtering, relative density is the medicinal extract of 1.10-1.25 when filtrate is concentrated into 60-80 DEG C, i.e., Obtain the active ingredient.
A kind of 7. pharmaceutical composition for treating chronic gastritis, by the pharmaceutical composition of the treatment chronic gastritis of claim 1 or 2 It is prepared into acceptable carrier combination in pharmaceuticals industry.
CN201711133554.9A 2017-11-16 2017-11-16 A kind of pharmaceutical composition for treating chronic gastritis and preparation method thereof Pending CN107929631A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102949685A (en) * 2012-09-26 2013-03-06 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating chronic gastritis
CN103330914A (en) * 2013-06-27 2013-10-02 柳晖 Traditional Chinese medicine composition for treating chronic gastritis
CN104107387A (en) * 2014-07-24 2014-10-22 王浩 Traditional Chinese medicinal composition for treating chronic gastritis
CN104367913A (en) * 2014-10-30 2015-02-25 张恩荣 Pharmaceutical composition for treating superficial gastritis as well as preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102949685A (en) * 2012-09-26 2013-03-06 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating chronic gastritis
CN103330914A (en) * 2013-06-27 2013-10-02 柳晖 Traditional Chinese medicine composition for treating chronic gastritis
CN104107387A (en) * 2014-07-24 2014-10-22 王浩 Traditional Chinese medicinal composition for treating chronic gastritis
CN104367913A (en) * 2014-10-30 2015-02-25 张恩荣 Pharmaceutical composition for treating superficial gastritis as well as preparation method thereof

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