CN107922392B - 1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 - Google Patents

1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 Download PDF

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CN107922392B
CN107922392B CN201680009724.XA CN201680009724A CN107922392B CN 107922392 B CN107922392 B CN 107922392B CN 201680009724 A CN201680009724 A CN 201680009724A CN 107922392 B CN107922392 B CN 107922392B
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alkyl
haloalkyl
cycloalkyl
disorder
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CN107922392A (zh
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安东尼·埃斯特拉德
马修·沃尔格拉夫
陈慧芬
亚历山大·科列斯尼科夫
伊莱沙·维尔缪
维沙尔·维尔马
王兰
丹尼尔·肖尔
史蒂芬·多
袁步伟
胡百华
吴国胜
林星雨
陆爱军
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F Hoffmann La Roche AG
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680009724.XA 2015-02-15 2016-02-12 1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 Active CN107922392B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2015073102 2015-02-15
CNPCT/CN2015/073102 2015-02-15
CN2015076318 2015-04-10
CNPCT/CN2015/076318 2015-04-10
CNPCT/CN2016/071061 2016-01-15
CN2016071061 2016-01-15
PCT/EP2016/052950 WO2016128529A1 (en) 2015-02-15 2016-02-12 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists

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CN107922392A CN107922392A (zh) 2018-04-17
CN107922392B true CN107922392B (zh) 2020-07-21

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US (1) US10179782B2 (enExample)
EP (1) EP3256463B1 (enExample)
JP (1) JP6700291B2 (enExample)
KR (1) KR20170118166A (enExample)
CN (1) CN107922392B (enExample)
AU (1) AU2016217851A1 (enExample)
BR (1) BR112017017052A2 (enExample)
CA (1) CA2975196A1 (enExample)
CL (1) CL2017001987A1 (enExample)
CO (1) CO2017007679A2 (enExample)
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PE (1) PE20180177A1 (enExample)
PH (1) PH12017501478A1 (enExample)
PT (1) PT3256463T (enExample)
SG (1) SG11201706451TA (enExample)
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