CN107875222B

CN107875222B - Traditional Chinese medicine preparation for preventing and treating lamb dysentery and preparation method thereof

Info

Publication number: CN107875222B
Application number: CN201711252308.5A
Authority: CN
Inventors: 何碧柔
Original assignee: Daxin Science & Technology Information Research Institute
Current assignee: Daxin Science & Technology Information Research Institute
Priority date: 2017-12-01
Filing date: 2017-12-01
Publication date: 2021-03-26
Anticipated expiration: 2037-12-01
Also published as: CN107875222A

Abstract

The invention relates to the field of veterinary medicines, in particular to a traditional Chinese medicine preparation for preventing and treating lamb dysentery and a preparation method thereof, wherein the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 20-25 parts of kapok; 15-20 parts of purslane; 10-15 parts of dark plum; 16-18 parts of liquorice; 10-16 parts of Chinese pulsatilla root; 15-18 parts of fructus forsythiae; 12-14 parts of poria cocos; 15-17 parts of dried orange peel; 8-10 parts of scutellaria baicalensis; 6-10 parts of bighead atractylodes rhizome; 5-10 parts of costustoot and 10-20 parts of dandelion. The traditional Chinese medicine preparation prepared by the invention has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery, relieving diarrhea with astringents, resisting viruses and the like, and can be taken by lambs to enhance the disease resistance of the lambs, effectively prevent and treat the lamb dysentery, improve the survival rate and reduce the breeding risk. The traditional Chinese medicine preparation prepared by the invention has an obvious curative effect on lamb dysentery, and the cure rate of lamb dysentery is up to more than 96%.

Description

Traditional Chinese medicine preparation for preventing and treating lamb dysentery and preparation method thereof

Technical Field

The invention relates to the field of veterinary medicines, in particular to a traditional Chinese medicine preparation for preventing and treating lamb dysentery and a preparation method thereof.

Background

Sheep is a general term of the ovineidae family, mammalia, artiodactyla, bovidae, ovineidae, and is one of the human domestic animals. Hairy ruminants, the main source of wool, are the four legged ruminants. The hair color is mainly white. The goat and the sheep are mainly raised in China. Lamb, the lamb being the lamb, is a sheep not full of one year of age or not developing permanent teeth, which is infested with various diseases during feeding, wherein lamb dysentery is an acute toxemia of newborn lambs, and is characterized by severe diarrhea and ulcer in small intestine. The disease can cause massive lamb death, and brings great loss to the sheep industry. Lamb dysentery mainly damages lambs within 7 days of age, wherein the disease is the most at 2-3 days of age, and the disease is rarely suffered at more than 7 days of age. The pathogeny of the disease is clostridium welchii type B. Within the days of the lamb, clostridium welchii can enter the digestive tract of the lamb by sucking milk from the lamb, the hands of a breeder and the excrement of the lamb. Under the conditions of external adverse inducement such as malnutrition of ewes in pregnancy, lean lamb physique, cold climate, lamb freezing, improper lactation, lamb hunger and satiety, lamb resistance weakening and the like, bacteria breed in a large quantity to generate toxin.

The incubation period of the lamb dysentery natural infection is 1-2 days. The main clinical manifestations are: at the beginning of illness, the affected sheep have a sallow spirit and do not want to eat milk; subsequent diarrhea, odor; in the later stage, some lambs have blood in the feces until they become bloody stool. Diseased lambs are gradually weak and cannot stand up in lying place, if the diseased lambs are not treated in time, the diseased lambs usually die within l-2d, and only a few lambs with mild diseases can be self-healed. Some lambs have diarrhea, i.e. the lambs begin to turn yellow, sticky or milky white, bubble-bearing and smelly feces within hours to days after birth, and then the feces turn yellow green, dark green or greenish white, bubble-bearing and watery diarrhea; some lambs had blood and mucous membranes. Due to severe dehydration, the affected lambs are emaciated and mentally committed, and the body temperature rises to more than 41 ℃, and the lambs are usually dead within 1-2 days. Some diseased lambs have neurological symptoms, quadriplegia, lying on the ground, shortness of breath, white foam in mouth, final coma, head backward, and body temperature drop, and die in hours to tens of hours if not firmly cured. Due to the fact that basic facilities for breeding sheep in a plurality of regions are weak, the improved breeding degree of sheep is low, the breeding technology is backward and the like, the incidence rate of lamb dysentery can reach more than 50% at most, and the incidence rate of lamb dysentery in most regions is more than 20% on average. Therefore, lamb dysentery is one of the main diseases harming sheep raising industry.

Different prevention and treatment measures are selected by different sheep farms (households), and a unified prevention and treatment method is not available at present. Generally, oxytetracycline is drenched for prevention within 12 hours after the birth of lambs, sulfaguanidine, tannase, furazolidone and the like are taken orally when the disease is developed, but the methods have common effects and the drug effect is reduced due to long-term large-dose use. Some sheep farms (households) mainly rely on the administration of antibiotics to newborn lambs to prevent lamb dysentery, western medicines or antibiotics are mainly used for treating lamb dysentery, the phenomena of multiple dependence on antibiotics and abuse of antibiotics exist, and the risk of increasing the drug resistance of pathogenic bacteria exists. At present, lamb dysentery becomes one of the main diseases faced by the sheep raising industry, the incidence rate is high, the death is fast, and huge economic losses are often caused. Meanwhile, the digestion and absorption and the emergency capacity of the lambs are poor, and western medicines are used to cause the obvious side effects of vomiting, no eating and the like, so that the subsequent growth of the recovered lambs is not facilitated. In addition, the resistance of the lambs is low, the intestines and the stomach are weak, the applicability of the medicine is not as good as that of the adult goats, and therefore more cautions should be taken during treatment.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine preparation for preventing and treating lamb dysentery and a preparation method thereof, the traditional Chinese medicine preparation is prepared by taking a plurality of Chinese herbal medicines as raw materials, integrates the effects of the plurality of Chinese herbal medicines, has the effects of clearing heat, removing toxicity, aiding digestion, preventing and treating lamb dysentery and the like, has no pollution, no residue and obvious medicine effect, can enhance the disease resistance of lambs, can play an effective prevention and treatment role on lamb dysentery, enhances the immunity of the lambs, has no toxic or side effect, is beneficial to improving the survival rate of the lambs and reducing the breeding risk.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine preparation for preventing and treating lamb dysentery comprises the following raw materials in parts by weight:

20-25 parts of kapok; 15-20 parts of purslane; 10-15 parts of dark plum; 16-18 parts of liquorice; 10-16 parts of Chinese pulsatilla root; 15-18 parts of fructus forsythiae; 12-14 parts of poria cocos; 15-17 parts of dried orange peel; 8-10 parts of scutellaria baicalensis; 6-10 parts of bighead atractylodes rhizome; 5-10 parts of costustoot and 10-20 parts of dandelion; the traditional Chinese medicine preparation is oral liquid, powder, soft extract or other oral dosage forms.

The preparation method of the oral liquid of the traditional Chinese medicine preparation for preventing and treating lamb dysentery comprises the following steps:

(1) weighing the medicines: weighing kapok, purslane, dark plum, liquorice, Chinese pulsatilla root, weeping forsythia, tuckahoe, dried orange peel, scutellaria, atractylodes, costus root and dandelion in parts by weight for later use;

(2) water extraction: putting the standby traditional Chinese medicinal materials into a traditional Chinese medicine extraction tank, adding 13-15 times of water by weight, heating and boiling for 1.5-2 hours, discharging liquid medicine, filtering, adding 5-6 times of water into dregs, heating and boiling for 0.5 hour, discharging dregs, filtering the liquid medicine, and combining the obtained liquid medicine for two times;

(3) mixing with appropriate amount of sucrose to obtain syrup, mixing with the above medicinal liquid, adding appropriate amount of antiseptic, standing, filtering, and packaging to obtain oral liquid.

The application method of the prepared traditional Chinese medicine oral liquid for preventing and treating lamb dysentery comprises the following steps: the affected lambs are taken 2 times a day, 25 milliliters of the medicine is taken each time, and 2 days are 1 course of treatment.

The preparation method of the powder of the traditional Chinese medicine preparation for preventing and treating lamb dysentery comprises the following steps: pulverizing dried kapok, purslane, dark plum, liquorice, Chinese pulsatilla root, fructus forsythiae, poria cocos, dried orange peel, scutellaria baicalensis, bighead atractylodes rhizome, elecampane and dandelion to below lOO meshes in parts by weight, and then carrying out vacuum packaging by using a plastic bag to obtain powder. The application method of the prepared traditional Chinese medicine powder for preventing and treating lamb dysentery comprises the following steps: the composition is administered to affected lambs 5mg each time, 2 times daily, and 2 days as 1 treatment course.

The preparation method of the traditional Chinese medicine preparation for preventing and treating lamb dysentery, namely the decocted extract, comprises the following steps:

(1) weighing dried common bombax flower, purslane, dark plum, dried tangerine peel and dandelion in parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 5-10 times of water in parts by weight, heating and boiling for 1-2 hours, discharging the liquid medicine, filtering, adding 5-7 times of water in the dregs of a decoction, heating and boiling for 0.5-1.0 hour, discharging the dregs of a decoction, filtering the liquid medicine, combining the obtained two liquid medicines, and concentrating to obtain concentrated solution A;

(2) weighing liquorice, Chinese pulsatilla root, fructus forsythiae, poria cocos, scutellaria baicalensis, bighead atractylodes rhizome and elecampane according to parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 5-10 times of 80% ethanol according to the weight, heating and boiling for 1-2.5 hours, discharging liquid medicine, filtering, adding 4-6 times of 70% ethanol into dregs of a decoction, heating and boiling for 0.5 hour, filtering, combining the obtained two liquid medicines, concentrating and steaming the ethanol to obtain concentrated solution B;

(3) mixing the concentrated solution A and the concentrated solution B, concentrating at 60-100 ℃ under reduced pressure to obtain fluid extract with relative density of 1.20-1.30 at 55 ℃, adding refined sugar or refined honey, heating to relative density of 1.3-1.5, and collecting to obtain paste.

The application method of the prepared traditional Chinese medicine decoction for preventing and treating lamb dysentery comprises the following steps: 8mg is taken for each lamb, 2 times a day, and 2 days are 1 treatment course.

The traditional Chinese medicine preparation for preventing and treating lamb dysentery prepared by the invention has the following traditional Chinese medicine properties:

kapok is a flower of kapok family, the total length of the flower is 5-8 cm, the flower shrinks when being dry, and the flower is irregular block-shaped and mostly does not have ovary and flower stalk; latin learning name: bombax ceiba Linnaeus, Bombax malabaricum DC; alias: the Chinese medicinal composition comprises Ganoderma, hero, Panzhihua, Jibei, and bee flame. The common bombax flower is a good food material for removing dampness among Guangdong people, has the effects of removing dampness, and is flat and moist, and also has the effects of removing heat and toxic materials, cooling blood and stopping dysentery; the juice of flos Bombacis Malabarici can be used for treating dysentery, and can be used as a medicine for clearing heat and eliminating dampness, and can be used for treating bacillary dysentery, enteritis, and stomachache.

Herba Portulacae (its scientific name: Portulaca oleracea L.) is used as a whole herb. The functional indications are as follows: clear heat and promote diuresis, cool blood and remove toxicity. Can be used for treating bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, hemorrhoid hemorrhage, and leucorrhea; it is used externally to treat furuncle, eczema and herpes zoster. Purslane contains abundant vitamin A-like substances, so that the physiological function of epithelial cells can be promoted to be normal, and the healing of ulcer can be promoted. Herba Portulacae has inhibitory effect on Escherichia coli, Bacillus dysenteriae and Bacillus typhi; it also has inhibitory effect on common pathogenic dermatophytes. The medical condition is as follows: the whole herb treats dysentery, enteritis and diarrhea, sore throat, toothache and innominate toxic swelling, which is recorded in Gui Yao Shu (Osmanthus drug Manual). Inverting the velvet table: the whole herb is used for treating enteritis, diarrhea, dysentery, nephritis, urinary tract infection edema, ulcer, hemorrhoid hemorrhage, sore throat, toothache, innominate toxic swelling, and carbuncle sore & lt & gt Dian Yao Lu (records on Dian medicine).

Mume fructus is a nearly mature fruit of Prunus mume (Sieb.) Sieb. et Zucc. of Rosaceae. [ FUNCTIONS ] can astringe lung, astringe intestine, promote fluid production, and relieve ascaris. Can be used for treating chronic cough due to lung deficiency; asthenic fever with polydipsia; chronic malaria; chronic diarrhea; dysentery; hematochezia; hematuria; metrorrhagia; colic and abdominal pain due to ascariasis; vomiting; ancylostomiasis. The dark plum has the function of disinfection and also prevents food from decaying in intestines and stomach. [ discussions of the respective households ] 1, Ben Cao Shi Yi: it can remove phlegm, primarily malaria, quench thirst, regulate middle energizer, remove cold and hot dysentery, and stop vomiting and adverse flow of qi. 2. The bibliography: stop diarrhea, dry mouth with saliva. To promote the circulation of the muscles and tendons and remove arthralgia. The New plains of materia Medica: wu Mei is indicated for dysentery and malaria, and it is quick-acting.

Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L, which is a dried root of Glycyrrhiza uralensis Fisch. The functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. Licorice root, radix Glycyrrhizae is neutral in nature and sweet in flavor, entering twelve meridians. Has the pharmacological actions of detoxification, phlegm elimination, pain relief, spasmolysis and cancer resistance. In traditional Chinese medicine, liquorice tonifies spleen and qi, nourishes cough and moistens lung, relieves urgency and detoxifies, and regulates a plurality of medicines. Clinical applications are divided into unprocessed and honey-processed. Unprocessed can be used for mainly treating swollen sore throat, deep-rooted carbuncle, pyocutaneous disease, gastrointestinal ulcer, drug toxicity removal, food poisoning and the like; stir-baked with honey is mainly indicated for hypofunction of spleen and stomach, loose stool, weakness, fever, cough, palpitation, etc. The Glycyrrhrizae radix preparation has effects in promoting stomach mucus formation and secretion, prolonging epithelial cell life, and resisting inflammation, and can be used for treating chronic ulcer and duodenal ulcer; the flavone of Glycyrrhrizae radix has antiinflammatory, spasmolytic and antacid effects; licorice root is also one of the main raw materials of Rendan.

Pulsatilla chinensis (Bge.) Regel, dried root of Pulsatilla chinensis (Pulsatilla chinensis, Pulsati. Bitter in property and cold in nature. The meridian tropism enters stomach and large intestine meridians. The functions are mainly to clear away heat and toxic material, cool blood and stop dysentery. Can be used for treating dysentery with heat-toxin and blood, pudendal pruritus, leukorrhagia, and amebic dysentery. Pulsatilla chinensis is the essential drug for amebic dysentery, and has the effect when used singly in a large dose. The Chinese medicine holds that the pulsatilla chinensis has the effects of clearing heat and removing toxicity, cooling blood and stopping dysentery, improving eyesight, eliminating dampness and killing parasites; it is used for treating dysentery due to heat-toxin, epistaxis, hemorrhoid, leukorrhagia, pudendal pruritus, carbuncle, sore, and lymphoid tuberculosis. The fresh juice and decoction of the Chinese pulsatilla root have obvious inhibition effect on various bacteria, and the soup and the four medicines thereof have obvious inhibition effect on various enteric pathogenic bacteria such as dysentery bacillus.

Forsythia suspensa (Latin's name: Forsythia subspensa) is dried fruit of Vahl, Forsythia subspensa (Thunb.) of Oleaceae. Bitter in property and slightly cold in nature. Meridian tropism enters lung, heart and small intestine meridians.

The functional indications are as follows: clear heat and remove toxicity, resolve swelling and dissipate nodulation. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, macula, and stranguria with heat. Discussion of each house 1. Shen nong Ben Cao Jing: cold and heat, atrophy of mouse, scrofula, abscess, swelling and sore, goiter and fever. 2. Treatise on herb Property: mainly relieve stranguria, promote urination, and remove heart heat. 3. Rihuazi Bencao: unblocking small intestine and draining pus. For sores and furuncles, it can alleviate pain and dredge menstruation.

Poria is dried sclerotium of Wolf of Poria cocos (Schw.) belonging to Polyporaceae. The functional indications are as follows: excreting dampness and promoting diuresis, invigorating spleen and stomach, calming heart and tranquilizing; it is indicated for difficulty in micturition, edema, abdominal distention, expectoration, emesis, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia. The main component of Poria is pachyman with high content. Has inhibitory effect on various bacteria; can reduce gastric acid, and has prophylactic effect on digestive tract ulcer; has obvious protective effect on liver injury and anti-tumor effect; the immune function can be adjusted in multiple ways; can accelerate the return of leucopenia caused by chemotherapy; and has tranquilizing effect. The Poria decoction has inhibitory effect on Staphylococcus aureus, Escherichia coli, and Proteus. The ethanol extract kills leptospira, while the water decoction is ineffective. Immune enhancement effect: the pachyman has effects of enhancing immunity of normal and tumor-bearing mice, and enhancing phagocytic function of macrophage of mice. Pachyman has obvious anti-tumor effect; has diuretic effect, and can increase discharge of electrolyte such as potassium, sodium, and chlorine; has tranquilizing, liver protecting, ulcer inhibiting, blood sugar lowering, and radioprotective effects.

Pericarpium Citri Tangerinae is dry mature pericarp of Citrus reticulata Blanco of Rutaceae and its cultivar, and can be used for treating spleen deficiency, anorexia, dyspepsia, nausea and emesis. The product has effects of eliminating dampness, invigorating spleen and promoting appetite, and is suitable for spleen and stomach weakness, diet reduction, dyspepsia, diarrhea, etc., and is often combined with Ginseng radix, Atractylodis rhizoma, Poria, etc. Because it can tonify spleen and regulate qi, it is often used as an adjuvant to qi tonics to make tonics without stagnation, so it can prevent swelling. The bitter substances of pericarpium Citri Tangerinae are "limonoids" represented by limonin and bitter principle, which have mild taste, are easily dissolved in water, and are helpful for digestion of food. The pericarpium Citri Tangerinae contains volatile oil, hesperidin, vitamin B, C, etc., and the volatile oil has mild irritation effect on gastrointestinal tract, and can promote secretion of digestive juice, eliminate intestinal tract pneumatosis and stimulate appetite. The dried orange peel is also a common traditional Chinese medicine and has the effects of ventilating, strengthening spleen, eliminating dampness and phlegm, removing grease and retaining fragrance, and calming adverse-rising energy and preventing vomiting.

Radix Scutellariae is also named as herba Camelliae Japonicae root or radix Seu folium Eupatorii chinensis. Is prepared from Scutellaria baicalensis Georgi (Scutellaria baicalensis Georgi) of Labiatae by root. Has the effects of clearing heat, eliminating dampness, cooling blood, preventing miscarriage and detoxifying. It can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore. Has the effects of clearing heat, eliminating dampness, cooling blood, preventing miscarriage and detoxifying. The clinical application of the scutellaria baicalensis has better antibacterial property than the coptis chinensis, and the scutellaria baicalensis does not generate drug resistance.

The Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae. The functions are mainly used for strengthening spleen and replenishing qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, and spontaneous perspiration. Rhizoma atractylodis macrocephalae strengthens the spleen and stomach, and is used for treating spleen deficiency, anorexia, diarrhea, loose stool and threatened abortion.

Radix aucklandiae is dried root of Aucklandia lappa Decne of Compositae. The functional indications are as follows: move qi and alleviate pain, warm the middle-jiao and harmonize stomach. It is indicated for middle-cold and qi stagnation, chest and abdomen distending pain, vomiting, diarrhea, tenesmus, and hernia of cold type. [ COMPLEMENTARY APPLICATION ] distending pain in the abdomen, indigestion and indigestion: is combined with amomum fruit, bitter orange and white atractylodes rhizome. Abdominal pain in diarrhea, tenesmus: it is combined with coptis root, areca seed, bitter orange, rhubarb, etc. Spleen deficiency, indigestion, abdominal distension and diarrhea: it is combined with dangshen, white atractylodes rhizome, dried orange peel, etc.

Herba Taraxaci is whole plant with root of Taraxacum mongolicum hand-Mazz of Compositae. Dandelion is sweet in nature and taste, slightly bitter and cold. It enters liver and stomach meridians. Has diuretic, laxative, jaundice treating, and gallbladder promoting effects. It is used to treat heat-toxin, carbuncle, pyocutaneous disease, internal carbuncle, conjunctival congestion, swelling and pain, damp-heat, jaundice, stranguria with urine, furuncle, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, damp-heat jaundice, and stranguria with pain. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection. The dandelion can be eaten raw, fried and used as soup, is a plant used as both medicine and food [ pharmacological research ] and has the functions of resisting pathogenic microorganism, resisting tumor, resisting gastric ulcer, benefiting gallbladder and protecting liver, directly excites the heart of the frog in vitro at low concentration, and has an inhibiting effect at high concentration.

The invention has the beneficial effects that:

1. the traditional Chinese medicine preparation for preventing and treating lamb dysentery disclosed by the invention adopts natural Chinese herbal medicines as raw materials, the Chinese herbal medicines have a very strong treatment effect, and also contain a plurality of nutrient substances such as various vitamins and the like, and the traditional Chinese medicine preparation has the advantages of wide sources, no pollution, low price, low residue, no pollution, small toxic and side effects, difficulty in generating drug resistance and the like. Compared with the traditional Chinese medicine preparation for preventing and treating lamb dysentery, which is prepared by taking western medicines such as antibiotic medicines (oxytetracycline and the like) for lambs, the traditional Chinese medicine preparation has the characteristics of no residue and no toxic or side effect.

2. The traditional Chinese medicine preparation for preventing and treating lamb dysentery is prepared by taking multiple Chinese herbal medicines as raw materials, and integrates the effects of the multiple Chinese herbal medicines of kapok, purslane, dark plum fruit, liquorice, Chinese pulsatilla root, fructus forsythiae, poria cocos, dried orange peel, scutellaria baicalensis, bighead atractylodes rhizome, elecampane and dandelion, wherein kapok, purslane and the Chinese pulsatilla root have the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery; dark plum astringes lung and intestines, and stops dysentery and malaria; the liquorice and the forsythia have the effects of tonifying spleen and qi, diminishing inflammation and detoxifying; poria, Scutellariae radix and herba Taraxaci have antibacterial and antiinflammatory effects; the bighead atractylodes rhizome and the costustoot have the effects of tonifying spleen and promoting appetite, the effects of clearing away heat and toxic materials, cooling blood and stopping diarrhea, resisting bacteria and diminishing inflammation, and tonifying spleen and supplementing qi of all the medicines are comprehensively utilized, the compatibility is scientific, the combined effect of dialectical treatment of a traditional Chinese medicine prescription is reserved, so that the prepared traditional Chinese medicine preparation can play the roles of clearing away heat and toxic materials, cooling blood and stopping diarrhea, astringing intestines and stopping diarrhea, resisting viruses and the like, and the prepared traditional Chinese medicine preparation for preventing and treating lamb dysentery is taken by lambs, the disease resistance of the lambs can be enhanced, the lamb dysentery is effectively prevented and treated, the survival rate is.

3. The traditional Chinese medicine preparation for preventing and treating lamb dysentery disclosed by the invention is simple in preparation method, rich in raw material source, low in price and low in production cost, and compared with the method of preventing and treating lamb dysentery by taking western medicines such as antibiotic medicines (oxytetracycline and the like) for lambs, the traditional Chinese medicine preparation for preventing and treating lamb dysentery disclosed by the invention mainly uses Chinese herbal medicines as raw materials, so that the residues of toxic medicines can be greatly reduced, the quality of mutton is improved, the purpose of healthy breeding is achieved, and the traditional Chinese medicine preparation is easy to popularize and apply. After the traditional Chinese medicine preparation for preventing and treating lamb dysentery is taken by lambs suffering from dysentery, the effect can be achieved by eating the preparation for 1-2 times, diarrhea, dehydration and vomiting caused by lamb dysentery can be rapidly relieved, and symptoms are obviously relieved. The traditional Chinese medicine preparation is taken for the lamb suffering from dysentery for 2 times every day, can effectively cure the lamb dysentery after being taken normally, is safe and free of toxic and side effects, and can play roles in enhancing the body immunity of the lamb, inhibiting bacteria and preventing and treating the lamb dysentery. The traditional Chinese medicine preparation prepared by the invention has an obvious curative effect on lamb dysentery, and the cure rate of lamb dysentery is up to more than 96%.

Detailed Description

Example 1

A preparation method of a traditional Chinese medicine preparation for preventing and treating lamb dysentery comprises the following steps:

(1) weighing the medicines: weighing 20 parts of dried kapok according to the parts by weight; 15 parts of purslane; 10 parts of dark plum; 16 parts of liquorice; 10 parts of Chinese pulsatilla root; 15 parts of fructus forsythiae; 12 parts of poria cocos; 15 parts of dried orange peel; 8 parts of scutellaria baicalensis; 6 parts of bighead atractylodes rhizome; 5 parts of costustoot and 10 parts of dandelion; standby;

(3) mixing with appropriate amount of sucrose to obtain syrup, mixing with the above medicinal liquid, adding appropriate amount of antiseptic, standing, filtering, and packaging to obtain oral liquid. The use method of the prepared oral liquid comprises the following steps: the affected lambs are taken 2 times a day, 25 milliliters of the medicine is taken each time, and 2 days are 1 course of treatment.

Example 2

A preparation method of a traditional Chinese medicine preparation for preventing and treating lamb dysentery is as follows: 22 parts of kapok with the dried water content of less than 15 percent by weight; 18 parts of purslane; 13 parts of dark plum; 17 parts of liquorice; 14 parts of Chinese pulsatilla root; 16 parts of fructus forsythiae; 13 parts of poria cocos; 16 parts of dried orange peel; 9 parts of scutellaria baicalensis; 8 parts of bighead atractylodes rhizome; 7 parts of costustoot and 15 parts of dandelion; pulverizing to below lOO mesh, and vacuum packaging with plastic bag to obtain powder; the using method of the prepared powder comprises the following steps: the composition is administered to affected lambs 5mg each time, 2 times daily, and 2 days as 1 treatment course.

Example 3

A preparation method of a traditional Chinese medicine preparation for preventing and treating lamb dysentery, namely a soft extract, comprises the following steps:

(1) weighing 25 parts of dried common bombax flower, 20 parts of purslane, 15 parts of dark plum, 17 parts of dried orange peel and 20 parts of dandelion in parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 5-10 times of water in parts by weight, heating and boiling for 1-2 hours, discharging liquid medicine, filtering, adding 5-7 times of water in dregs of a decoction, heating and boiling for 0.5-1.0 hour, discharging dregs of a decoction, filtering the liquid medicine, combining the obtained two liquid medicines, and concentrating to obtain concentrated solution A;

(2) weighing 18 parts of liquorice, 16 parts of Chinese pulsatilla root, 18 parts of weeping forsythia, 14 parts of poria cocos, 10 parts of scutellaria baicalensis, 10 parts of bighead atractylodes rhizome and 10 parts of costustoot according to parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 5-10 times of 80% ethanol according to the weight, heating and boiling for 1-2.5 hours, discharging liquid medicine, filtering, adding 4-6 times of 70% ethanol into dregs of a decoction, heating and boiling for 0.5 hour, filtering, combining the obtained two liquid medicines, concentrating and steaming the ethanol to obtain concentrated solution B;

The application method of the prepared soft extract comprises the following steps: 8mg is taken for each lamb, 2 times a day, and 2 days are 1 treatment course.

Example 4

(1) weighing 21 parts of dried common bombax flower, 17 parts of purslane, 12 parts of dark plum, 15 parts of dried orange peel and 17 parts of dandelion in parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 10 times of water in parts by weight, heating and boiling for 2 hours, discharging liquid medicine, filtering, adding 7 times of water in dregs of a decoction, heating and boiling for 1.0 hour, discharging dregs of a decoction, filtering the liquid medicine, combining the obtained two liquid medicines, and concentrating to obtain concentrated solution A;

(2) weighing 16 parts of liquorice, 14 parts of Chinese pulsatilla root, 17 parts of weeping forsythia, 13 parts of poria cocos, 9 parts of scutellaria baicalensis, 8 parts of bighead atractylodes rhizome and 8 parts of costustoot according to parts by weight, putting the medicinal materials into a traditional Chinese medicine extraction tank, adding 10 times of 80% ethanol according to the weight, heating and boiling for 2.5 hours, discharging liquid medicine, filtering, adding 6 times of 70% ethanol into dregs, heating and boiling for 0.5 hour, filtering, combining the obtained two liquid medicines, concentrating and steaming to remove ethanol to obtain concentrated solution B;

Application effects

Test conditions:

the test was performed on 200 lambs with diarrhea, 100 ewes and 100 rams. The 200 sheep were equally divided into 2 groups, each group having 50 ewes and 50 rams. The first group of lambs with diarrhea was treated with the following schedule: 0.2 to 0.3 g of oxytetracycline and 0.2 to 0.3 g of pepsin are added with a proper amount of warm boiled water to be taken orally for sick lambs for 2 times a day and for 4 to 5 days continuously. A second group of lambs with diarrhea, the treatment regimen was: the oral liquid prepared in the embodiment 1 of the invention is orally taken by sick lambs for 2 times a day, 25 milliliters of the oral liquid is taken every time, and 2 days are 1 course of treatment.

And (3) test results:

after the first group takes the oxytetracycline for the sick sheep, the sick sheep are continuously taken for 5 days, the third day stops diarrhea, the 7 th day is fed and recovered, the cure rate is 87 percent, and 8 dead sheep die. After the oral liquid prepared in the embodiment 1 of the invention is taken by the sick sheep in the second group for three days, the diarrhea basically disappears on the second day after the oral liquid is taken, the feces is normal on the third day, the ingestion is normal, the repeated phenomenon does not occur after the oral liquid is taken out, the death phenomenon does not occur, all other sheep are completely cured except 1 lamb with serious symptoms after the oral liquid is taken for 3 days, and the cure rate is 99%. And the cured sheep has good appetite and enhanced immunity, and does not have dysentery or other diseases until slaughtering. Compared with the method for treating the lamb with dysentery by adopting antibiotic drugs, the traditional Chinese medicine preparation for preventing and treating the lamb dysentery disclosed by the invention adopts natural plants as raw materials, is wide in medicine source and low in cost, can play an effective prevention and treatment role on the lamb dysentery, and can enhance the immunity of the lamb; the traditional Chinese medicine preparation for preventing and treating lamb dysentery prepared by the invention has the characteristics of good curative effect on lamb dysentery, no residue and no toxic or side effect, and is in line with the development of the breeding industry.

Claims

1. The traditional Chinese medicine preparation for preventing and treating lamb dysentery is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:

20-25 parts of kapok; 15-20 parts of purslane; 10-15 parts of dark plum; 16-18 parts of liquorice; 10-16 parts of Chinese pulsatilla root; 15-18 parts of fructus forsythiae; 12-14 parts of poria cocos; 15-17 parts of dried orange peel; 8-10 parts of scutellaria baicalensis; 6-10 parts of bighead atractylodes rhizome; 5-10 parts of costustoot and 10-20 parts of dandelion; the traditional Chinese medicine preparation is oral liquid, powder or soft extract;

the preparation method of the oral liquid comprises the following steps:

(3) preparing syrup from sucrose, mixing with the above medicinal liquid, adding antiseptic, standing, filtering, and packaging to obtain oral liquid;

the preparation method of the powder comprises the following steps:

pulverizing dried kapok, purslane, dark plum, liquorice, Chinese pulsatilla root, fructus forsythiae, poria cocos, dried orange peel, scutellaria baicalensis, bighead atractylodes rhizome, elecampane and dandelion to be less than 100 meshes according to the weight percentage, and then carrying out vacuum packaging by using a plastic bag to obtain powder;

the preparation method of the soft extract comprises the following steps: