CN107849013B - 作为dub抑制剂用于治疗癌症的氰基吡咯烷类 - Google Patents

作为dub抑制剂用于治疗癌症的氰基吡咯烷类 Download PDF

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CN107849013B
CN107849013B CN201680040161.0A CN201680040161A CN107849013B CN 107849013 B CN107849013 B CN 107849013B CN 201680040161 A CN201680040161 A CN 201680040161A CN 107849013 B CN107849013 B CN 107849013B
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pyrrolidine
cyano
carbonyl
carbonitrile
carboxamide
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CN107849013A (zh
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M·肯普
M·施托克利
A·琼斯
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Mission Therapeutics Ltd
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Mission Therapeutics Ltd
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680040161.0A 2015-07-14 2016-07-14 作为dub抑制剂用于治疗癌症的氰基吡咯烷类 Active CN107849013B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1512270.8A GB201512270D0 (en) 2015-07-14 2015-07-14 Novel Compounds
GB1512270.8 2015-07-14
GBGB1604642.7A GB201604642D0 (en) 2016-03-18 2016-03-18 Novel compounds
GB1604642.7 2016-03-18
PCT/GB2016/052130 WO2017009650A1 (en) 2015-07-14 2016-07-14 Cyanopyrrolidines as dub inhibitors for the treatment of cancer

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CN107849013A CN107849013A (zh) 2018-03-27
CN107849013B true CN107849013B (zh) 2022-03-29

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US (2) US10669234B2 (https=)
EP (2) EP3322702B1 (https=)
JP (1) JP6802251B2 (https=)
CN (1) CN107849013B (https=)
ES (1) ES2773046T3 (https=)
WO (1) WO2017009650A1 (https=)

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US10669234B2 (en) 2020-06-02
EP3800186A1 (en) 2021-04-07
US11319287B2 (en) 2022-05-03
JP6802251B2 (ja) 2020-12-16
JP2018524367A (ja) 2018-08-30
EP3800186B1 (en) 2024-10-02
CN107849013A (zh) 2018-03-27
EP3322702B1 (en) 2019-11-20
US20180194724A1 (en) 2018-07-12
ES2773046T3 (es) 2020-07-09
EP3322702A1 (en) 2018-05-23
US20200231542A1 (en) 2020-07-23
WO2017009650A1 (en) 2017-01-19

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