CN107848964B - Ebna1抑制剂和使用其的方法 - Google Patents

Ebna1抑制剂和使用其的方法 Download PDF

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CN107848964B
CN107848964B CN201680041102.5A CN201680041102A CN107848964B CN 107848964 B CN107848964 B CN 107848964B CN 201680041102 A CN201680041102 A CN 201680041102A CN 107848964 B CN107848964 B CN 107848964B
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indol
compound
route
benzoic acid
certain embodiments
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CN107848964A (zh
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T·E·麦塞科
G·R·史密斯
A·B·瑞兹
P·M·利伯曼
M·E·麦克唐纳
Y·张
M·卡森
S·陈
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Wistar Institute of Anatomy and Biology
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Wistar Institute of Anatomy and Biology
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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BR112017024481B1 (pt) 2015-05-14 2020-11-17 The Wistar Institute Of Anatomy And Biology composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo
WO2018220149A1 (en) 2017-06-02 2018-12-06 F. Hoffmann-La Roche Ag Compounds
UA126452C2 (uk) * 2017-06-02 2022-10-05 Ф. Хоффманн-Ля Рош Аг Похідні ізоіндолу
TW201946919A (zh) 2018-05-17 2019-12-16 威斯塔研究所 Ebna1抑制劑晶形、其製備方法及其使用方法
PE20211388A1 (es) 2018-06-29 2021-07-27 Hoffmann La Roche Compuestos
CN109336857A (zh) * 2018-11-13 2019-02-15 南方医科大学 一种含取代联苯的黄酮及其应用
MA56507A (fr) 2019-06-21 2022-04-27 Hoffmann La Roche Nouveaux inhibiteurs d'egfr
IL288522B2 (en) 2019-06-21 2025-02-01 Hoffmann La Roche EGFR inhibitor for cancer treatment
CN113754541B (zh) * 2020-06-02 2025-01-03 深圳湾实验室 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用
CN116135850A (zh) 2021-11-16 2023-05-19 深圳湾实验室 抗鼻咽癌的小分子抑制剂、化合物的制备方法及其应用
WO2024050408A1 (en) * 2022-08-30 2024-03-07 The Wistar Institute Of Anatomy And Biology Development of a novel ebna-1 degrader targeting through mdm2
CN117586230B (zh) * 2023-10-20 2024-09-24 南方医科大学深圳医院 降解ebna1的protac化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007002587A2 (en) * 2005-06-24 2007-01-04 The Brigham And Women's Hospital, Inc. Inhibitors of epstein barr virus nuclear antigen 1
WO2015073864A1 (en) * 2013-11-15 2015-05-21 The Wisar Institute Of Anatomy And Biology Ebna1 inhibitors and their method of use

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56117398A (en) 1980-02-18 1981-09-14 Nec Corp Data processor
HU190007B (en) 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
DE3936297A1 (de) 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von symmetrischen diarylacetylenen
DE4039448A1 (de) 1990-12-11 1992-06-17 Rhein Chemie Rheinau Gmbh Polyurethan-katalysatoren
US5356919A (en) 1991-05-30 1994-10-18 G. D. Searle & Co. Leukotriene B4 synthesis inhibitors
US6166028A (en) 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
OA12274A (en) 2000-05-22 2006-05-09 Aventis Pharma Inc Arylmethylamine derivatives for use as tryptase inhibitors.
DK1302461T3 (da) 2000-05-31 2008-01-28 Santen Pharmaceutical Co Ltd TNF-alfa-produktionsinhibitorer
US6811983B2 (en) 2001-07-26 2004-11-02 Wisconsin Alumni Research Foundation Method of identifying inhibitors of EBNA-1
CN1505603A (zh) * 2001-09-17 2004-06-16 ��һ��������ҩ��ʽ���� 具有nf-kb抑制作用的取代苯甲酸衍生物
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US20040044041A1 (en) 2002-08-06 2004-03-04 Kuduk Scott D. 2-(Biarylalkyl)amino-3-(cyanoalkanoylamino)pyridine derivatives
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
CN1288117C (zh) 2004-04-02 2006-12-06 中国科学院上海有机化学研究所 端基炔烃和芳基卤化物的偶联反应
WO2006002474A1 (en) * 2004-07-02 2006-01-12 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
WO2006019831A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
AU2005268893B2 (en) 2004-08-05 2011-10-13 F. Hoffmann-La Roche Ag Indole, indazole or indoline derivatives
EP1879898A2 (en) 2005-05-12 2008-01-23 Wyeth a Corporation of the State of Delaware Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists
UA95244C2 (ru) 2005-06-22 2011-07-25 Плексикон, Инк. Соединения и способ модулирования активности киназ, и показания для их применения
WO2007023242A1 (en) 2005-08-24 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
US8022217B2 (en) 2006-07-31 2011-09-20 Cadila Healthcare Limited Compounds suitable as modulators of HDL
US7956216B2 (en) 2006-12-21 2011-06-07 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
JP5773877B2 (ja) 2008-10-22 2015-09-02 アキュセラ インコーポレイテッド 眼の疾患及び障害を治療する化合物
CA2751260A1 (en) 2009-02-12 2010-08-19 Stefano Crosignani Phenoxy acetic acid derivatives
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
WO2010118009A1 (en) 2009-04-06 2010-10-14 Ptc Therapeutics, Inc. Hcv inhibitor and therapeutic agent combinations
US20100273772A1 (en) 2009-04-23 2010-10-28 Wyeth Llc Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
EA022445B1 (ru) 2009-05-04 2016-01-29 Прометик Байосайенсиз Инк. Замещенные ароматические соединения, композиции на их основе и их фармацевтические применения
WO2011090738A2 (en) * 2009-12-29 2011-07-28 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
WO2011082098A1 (en) 2009-12-30 2011-07-07 The Rockefeller University Lysine and arginine methyltransferase inhibitors for treating cancer
CA2788363A1 (en) 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US9024021B2 (en) 2011-01-21 2015-05-05 Sun Pharma Advanced Research Company Ltd. Diarylacetylene hydrazide containing tyrosine kinase inhibitors
WO2012162291A1 (en) 2011-05-24 2012-11-29 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN104603138A (zh) 2012-07-12 2015-05-06 艾伯维公司 Hcv抑制剂的晶形
US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
BR112017024481B1 (pt) 2015-05-14 2020-11-17 The Wistar Institute Of Anatomy And Biology composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007002587A2 (en) * 2005-06-24 2007-01-04 The Brigham And Women's Hospital, Inc. Inhibitors of epstein barr virus nuclear antigen 1
WO2015073864A1 (en) * 2013-11-15 2015-05-21 The Wisar Institute Of Anatomy And Biology Ebna1 inhibitors and their method of use

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