CN107815851A - 基于氧化锌纳米棒功能棉织物的生物传感器 - Google Patents
基于氧化锌纳米棒功能棉织物的生物传感器 Download PDFInfo
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title claims abstract description 122
- 239000011787 zinc oxide Substances 0.000 title claims abstract description 61
- 239000002073 nanorod Substances 0.000 title claims abstract description 38
- 229920000742 Cotton Polymers 0.000 claims abstract description 48
- 239000000758 substrate Substances 0.000 claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 102
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 22
- 229910021641 deionized water Inorganic materials 0.000 claims description 22
- 239000004744 fabric Substances 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 18
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 18
- -1 alcohol ether mono sulfosuccinates Chemical class 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 239000013078 crystal Substances 0.000 claims description 10
- HFQQZARZPUDIFP-UHFFFAOYSA-M sodium;2-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O HFQQZARZPUDIFP-UHFFFAOYSA-M 0.000 claims description 10
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 9
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 9
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 9
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 238000005507 spraying Methods 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 125000000129 anionic group Chemical group 0.000 claims description 7
- 238000012986 modification Methods 0.000 claims description 7
- 230000004048 modification Effects 0.000 claims description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 5
- 229940098773 bovine serum albumin Drugs 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000001027 hydrothermal synthesis Methods 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 238000011068 loading method Methods 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- VWSUVZVPDQDVRT-UHFFFAOYSA-N phenylperoxybenzene Chemical compound C=1C=CC=CC=1OOC1=CC=CC=C1 VWSUVZVPDQDVRT-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- AGGKEGLBGGJEBZ-UHFFFAOYSA-N tetramethylenedisulfotetramine Chemical compound C1N(S2(=O)=O)CN3S(=O)(=O)N1CN2C3 AGGKEGLBGGJEBZ-UHFFFAOYSA-N 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- 238000002242 deionisation method Methods 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 238000007306 functionalization reaction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- YFDKVXNMRLLVSL-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid;sodium Chemical class [Na].CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O YFDKVXNMRLLVSL-UHFFFAOYSA-N 0.000 description 1
- 241000549556 Nanos Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
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- 230000008021 deposition Effects 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000002520 smart material Substances 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
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Abstract
本发明公开了一种基于氧化锌纳米棒功能棉织物的生物传感器，将包覆在BSA中间的ZnO纳米棒沉积到棉布上，然后制备了包括氧化锌纳米棒功能棉织物、导线和柔性基底在内的压电式生物传感器。该传感器具有非常高的灵敏度、辨识度和优异的耐用性能，在柔性可穿戴器件领域具有广阔的应用前景。
Description
技术领域
本发明涉及一种基于氧化锌纳米棒功能棉织物的生物传感器，属功能纳米材料和传感器领域。
背景技术
传统的传感器大多是基于半导体和金属材料，其便携性、柔韧性较差。而随着科学技术的发展和进步，微型技术、无线通信、低能耗设计和柔性传感等技术走进人们的生活，新型智能传感器件提高了使用者的舒适度和安全度。衣服和纺织品类基本覆盖了人体90%的表皮皮肤，由于其可再生、可穿戴、柔性、来源广泛、价格便宜、制备简单的特点，因而基于纺织品的可穿戴智能传感器越来越受到人们的喜爱和关注。
2006年，佐治亚理工学院王中林课题组首次研制成功了纳米发电机，通过AFM拨动氧化锌纳米线，可将机械能转化为电能。受到纳米发电机的启发，将ZnO纳米发电机结合高导电蚕丝纤维，不仅可以实现为柔性可穿戴器件提供电源，同时可检测人体生理参数。西南大学毛翠萍以制备好的导电蚕丝为基底，通过电沉积方式将ZnO沉积到蚕丝上，制备传感器。监测其随人体手指折叠、扭曲、拉伸等模拟机械运动过程的变化情况。将其贴于颈部动脉位置，检测该传感器对人体因心跳和呼吸引起皮肤微小振动的感应，通过导线连接电化学工作站收集电信号，实时检测信号变化以达到测试目的。他们的工作展示了ZnO纳米棒阵列修饰蚕丝在可穿戴生理传感方面的应用潜力（毛翠萍. 纳米功能化蚕丝织物的制备及其在可穿戴领域的应用研究[D].西南大学,2016）。中国发明专利CN201410145112.6将氧化锌纳米棒有序致密的包裹在蚕丝表面，将机械能转化成电能，因此可用于制备传感器。但是上述文献中ZnO纳米棒与基底材料之间缺乏有效的结合力，因而制备的生物传感器耐用程度和使用周期有待进一步提高。
发明内容
本发明针对上述不足，提供了一种基于氧化锌纳米棒功能棉织物的生物传感器。
本发明通过下述技术方案予以实现：
（1）将棉织物置于质量分数为10-18％的氢氧化钠溶液中，浴比1:50，70℃反应180min，用去离子水反复洗至中性，烘干后得到氢氧化钠改性棉；然后将上述氢氧化钠改性棉分散于乙醇中，浴比1:50，80℃氮气保护条件下冷凝回流60min，加入醇醚磺基琥珀酸单酯二钠盐，匀速搅拌60min后，加入偶氮二异庚腈和过氧化二苯甲酰，继续搅拌反应1-12h，过滤后使用乙醇、去离子水反复清洗，真空烘干后得到阴离子化棉织物；所述醇醚磺基琥珀酸单酯二钠盐与氢氧化钠改性棉的质量比为1:1-1:3，所述偶氮二异庚腈的质量为氢氧化钠改性棉的0.01%-0.5%，所述过氧化二苯甲酰的质量为氢氧化钠改性棉的0.01%-0.5%。（2）将上述阴离子化棉织物浸渍在60℃的质量分数0.1-1%的牛血清白蛋白（BSA）溶液中10-60min，得到BSA改性棉织物。（3）将上述BSA改性棉织物浸渍在0.1-1mol/L的硝酸锌溶液中1-6h，真空干燥后，浸入到0.1-1mol/L的氢氧化钠溶液中，混合搅拌1h后，移至反应釜中150℃反应1-6h，用乙醇和去离子水反复清洗、离心、干燥处理后得到负载氧化锌晶种的棉织物；将0.1-1mol/L的硝酸锌、0.1-1mol/L的六次甲基四胺混合均匀后得到氧化锌种子生长液，其中所述硝酸锌和所述六次甲基四胺的质量比为1:1-1:5，将上述负载氧化锌晶种的棉织物浸渍在所述氧化锌种子生长液中1h，然后缓慢加入十二烷基苯磺酸钠（SDBS），所述SDBS和硝酸锌的质量比为2:1-1:2，移至反应釜中180℃水热反应1-12h，反应结束后，用乙醇和去离子水反复清洗、离心、干燥处理后得到氧化锌纳米棒改性棉织物。（4）将上述氧化锌纳米棒改性棉织物浸渍在60℃的质量分数0.1-1%的BSA溶液中10-60min，用去离子水反复清洗、干燥处理得到氧化锌纳米棒功能棉织物。（5）所述生物传感器包括氧化锌纳米棒功能棉织物、导线和柔性基底；在所述氧化锌纳米棒功能棉织物的一端喷金1-5min；所述氧化锌纳米棒功能棉织物的两端分别与导线两端连接形成回路，并通过导电胶固定于柔性基底上。
详细的生物传感器的制备步骤可参考中国发明专利CN201410145112.6氧化锌纳米棒矩阵修饰蚕丝的制备方法及其产品；西南大学毛翠萍的硕士论文（纳米功能化蚕丝织物的制备及其在可穿戴领域的应用研究[D].西南大学,2016）；Mao CP, et al. Flexibleand wearable electronic silk fabrics for human physiological monitoring,Smart Materials and Structures, 2017, 26(9): 095033。
与现有技术相比，本发明的优点在于：将氧化锌纳米棒包覆在BSA中间，大大提高了氧化锌纳米棒的结合牢度。然后制备了包括氧化锌纳米棒功能棉织物、导线和柔性基底的压电式生物传感器。该传感器具有非常高的灵敏度、辨识度，在智能可穿戴领域具有巨大的应用前景，而且该传感器还具有优异的耐用性能和使用周期。
具体实施方式
下面结合具体实施方式，进一步阐述本发明。
实施例1：
（1）将棉织物置于质量分数为10％的氢氧化钠溶液中，浴比1:50，70℃反应180min，用去离子水反复洗至中性，烘干后得到氢氧化钠改性棉；然后将上述氢氧化钠改性棉分散于乙醇中，浴比1:50，80℃氮气保护条件下冷凝回流60min，加入醇醚磺基琥珀酸单酯二钠盐，匀速搅拌60min后，加入偶氮二异庚腈和过氧化二苯甲酰，继续搅拌反应1h，过滤后使用乙醇、去离子水反复清洗，真空烘干后得到阴离子化棉织物；所述醇醚磺基琥珀酸单酯二钠盐与氢氧化钠改性棉的质量比为1:1，所述偶氮二异庚腈的质量为氢氧化钠改性棉的0.03%，所述过氧化二苯甲酰的质量为氢氧化钠改性棉的0.01%。（2）将上述阴离子棉织物浸渍在60℃的质量分数0.1%的牛血清白蛋白（BSA）溶液中10min，得到BSA改性棉织物。（3）将上述BSA改性棉织物浸渍在0.1mol/L的硝酸锌溶液中1h，真空干燥后，浸入到0.1mol/L的氢氧化钠溶液中，混合搅拌1h后，移至反应釜中150℃反应1h，用乙醇和去离子水反复清洗、离心、干燥处理后得到负载氧化锌晶种的棉织物；将0.1mol/L的硝酸锌、0.1mol/L的六次甲基四胺混合均匀后得到氧化锌种子生长液，其中所述硝酸锌和所述六次甲基四胺的质量比为1:1，将上述负载氧化锌晶种的棉织物浸渍在所述氧化锌种子生长液中1h，然后缓慢加入十二烷基苯磺酸钠（SDBS），所述SDBS和硝酸锌的质量比为2:1，移至反应釜中180℃水热反应1h，反应结束后，用乙醇和去离子水反复清洗、离心、干燥处理后得到氧化锌纳米棒改性棉织物。（4）将上述氧化锌纳米棒改性棉织物浸渍在60℃的质量分数0.1%的BSA溶液中10min，用去离子水反复清洗、干燥处理得到氧化锌纳米棒功能棉织物。（5）将氧化锌纳米棒功能棉织物用铝箔遮住棉布一端，然后在磁控下溅射喷金1min，将喷金后的棉布用导线连接，然后用导电胶固定在柔性基底上得到生物传感器。
实施例2：
（1）将棉织物置于质量分数为15％的氢氧化钠溶液中，浴比1:50，70℃反应180min，用去离子水反复洗至中性，烘干后得到氢氧化钠改性棉；然后将上述氢氧化钠改性棉分散于乙醇中，浴比1:50，80℃氮气保护条件下冷凝回流60min，加入醇醚磺基琥珀酸单酯二钠盐，匀速搅拌60min后，加入偶氮二异庚腈和过氧化二苯甲酰，继续搅拌反应6h，过滤后使用乙醇、去离子水反复清洗，真空烘干后得到阴离子化棉织物；所述醇醚磺基琥珀酸单酯二钠盐与氢氧化钠改性棉的质量比为1:2，所述偶氮二异庚腈的质量为氢氧化钠改性棉的0.1%，所述过氧化二苯甲酰的质量为氢氧化钠改性棉的0.15%。（2）将上述阴离子棉织物浸渍在60℃的质量分数0.5%的牛血清白蛋白（BSA）溶液中30min，得到BSA改性棉织物。（3）将上述BSA改性棉织物浸渍在0.5mol/L的硝酸锌溶液中3h，真空干燥后，浸入到0.5mol/L的氢氧化钠溶液中，混合搅拌1h后，移至反应釜中150℃反应3h，用乙醇和去离子水反复清洗、离心、干燥处理后得到负载氧化锌晶种的棉织物；将0.5mol/L的硝酸锌、0.5mol/L的六次甲基四胺混合均匀后得到氧化锌种子生长液，其中所述硝酸锌和所述六次甲基四胺的质量比为1:2，将上述负载氧化锌晶种的棉织物浸渍在所述氧化锌种子生长液中1h，然后缓慢加入十二烷基苯磺酸钠（SDBS），所述SDBS和硝酸锌的质量比为1:1，移至反应釜中180℃水热反应6h，反应结束后，用乙醇和去离子水反复清洗、离心、干燥处理后得到氧化锌纳米棒改性棉织物。（4）将上述氧化锌纳米棒改性棉织物浸渍在60℃的质量分数0.5%的BSA溶液中30min，用去离子水反复清洗、干燥处理得到氧化锌纳米棒功能棉织物。（5）将氧化锌纳米棒功能棉织物用铝箔遮住棉布一端，然后在磁控下溅射喷金3min，将喷金后的棉布用导线连接，然后用导电胶固定在柔性基底上得到生物传感器。
实施例3：
（1）将棉织物置于质量分数为18％的氢氧化钠溶液中，浴比1:50，70℃反应180min，用去离子水反复洗至中性，烘干后得到氢氧化钠改性棉；然后将上述氢氧化钠改性棉分散于乙醇中，浴比1:50，80℃氮气保护条件下冷凝回流60min，加入醇醚磺基琥珀酸单酯二钠盐，匀速搅拌60min后，加入偶氮二异庚腈和过氧化二苯甲酰，继续搅拌反应12h，过滤后使用乙醇、去离子水反复清洗，真空烘干后得到阴离子化棉织物；所述醇醚磺基琥珀酸单酯二钠盐与氢氧化钠改性棉的质量比为1:3，所述偶氮二异庚腈的质量为氢氧化钠改性棉的0.2%，所述过氧化二苯甲酰的质量为氢氧化钠改性棉的0.45%。（2）将上述阴离子棉织物浸渍在60℃的质量分数1%的牛血清白蛋白（BSA）溶液中60min，得到BSA改性棉织物。（3）将上述BSA改性棉织物浸渍在1mol/L的硝酸锌溶液中6h，真空干燥后，浸入到1mol/L的氢氧化钠溶液中，混合搅拌1h后，移至反应釜中150℃反应6h，用乙醇和去离子水反复清洗、离心、干燥处理后得到负载氧化锌晶种的棉织物；将1mol/L的硝酸锌、1mol/L的六次甲基四胺混合均匀后得到氧化锌种子生长液，其中所述硝酸锌和所述六次甲基四胺的质量比为1:5，将上述负载氧化锌晶种的棉织物浸渍在所述氧化锌种子生长液中1h，然后缓慢加入十二烷基苯磺酸钠（SDBS），所述SDBS和硝酸锌的质量比为1:2，移至反应釜中180℃水热反应12h，反应结束后，用乙醇和去离子水反复清洗、离心、干燥处理后得到氧化锌纳米棒改性棉织物。（4）将上述氧化锌纳米棒改性棉织物浸渍在60℃的质量分数1%的BSA溶液中60min，用去离子水反复清洗、干燥处理得到氧化锌纳米棒功能棉织物。（5）将氧化锌纳米棒功能棉织物用铝箔遮住棉布一端，然后在磁控下溅射喷金5min，将喷金后的棉布用导线连接，然后用导电胶固定在柔性基底上得到生物传感器。
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无法对所有的实施方式予以穷举。凡是属于本发明的技术方案所引申出的显而易见的变化或变动仍处于本发明的保护范围之列。
Claims (2)
1.基于氧化锌纳米棒功能棉织物的生物传感器，其特征在于，
所述氧化锌纳米棒功能棉织物的制备方法，包括以下步骤：（1）将棉织物置于质量分数为10-18％的氢氧化钠溶液中，浴比1:50，70℃反应180min，用去离子水反复洗至中性，烘干后得到氢氧化钠改性棉；然后将上述氢氧化钠改性棉分散于乙醇中，浴比1:50，80℃氮气保护条件下冷凝回流60min，加入醇醚磺基琥珀酸单酯二钠盐，匀速搅拌60min后，加入偶氮二异庚腈和过氧化二苯甲酰，继续搅拌反应1-12h，过滤后使用乙醇、去离子水反复清洗，真空烘干后得到阴离子化棉织物；所述醇醚磺基琥珀酸单酯二钠盐与氢氧化钠改性棉的质量比为1:1-1:3，所述偶氮二异庚腈的质量为氢氧化钠改性棉的0.01%-0.5%，所述过氧化二苯甲酰的质量为氢氧化钠改性棉的0.01%-0.5%；（2）将上述阴离子化棉织物浸渍在60℃的质量分数0.1-1%的牛血清白蛋白（BSA）溶液中10-60min，得到BSA改性棉织物；（3）将上述BSA改性棉织物浸渍在0.1-1mol/L的硝酸锌溶液中1-6h，真空干燥后，浸入到0.1-1mol/L的氢氧化钠溶液中，混合搅拌1h后，移至反应釜中150℃反应1-6h，用乙醇和去离子水反复清洗、离心、干燥处理后得到负载氧化锌晶种的棉织物；将0.1-1mol/L的硝酸锌、0.1-1mol/L的六次甲基四胺混合均匀后得到氧化锌种子生长液，其中所述硝酸锌和所述六次甲基四胺的质量比为1:1-1:5，将上述负载氧化锌晶种的棉织物浸渍在所述氧化锌种子生长液中1h，然后缓慢加入十二烷基苯磺酸钠（SDBS），所述SDBS和硝酸锌的质量比为2:1-1:2，移至反应釜中180℃水热反应1-12h，反应结束后，用乙醇和去离子水反复清洗、离心、干燥处理后得到氧化锌纳米棒改性棉织物；（4）将上述氧化锌纳米棒改性棉织物浸渍在60℃的质量分数0.1-1%的BSA溶液中10-60min，用去离子水反复清洗、干燥处理得到氧化锌纳米棒功能棉织物。
2.根据权利要求1所述的基于氧化锌纳米棒功能棉织物的生物传感器，其特征在于：所述生物传感器包括氧化锌纳米棒功能棉织物、导线和柔性基底，在所述氧化锌纳米棒功能棉织物的一端喷金1-5min；所述氧化锌纳米棒功能棉织物的两端分别与导线两端连接形成回路，并通过导电胶固定于柔性基底上。
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| CN112587128A (zh) * | 2020-11-16 | 2021-04-02 | 江南大学 | 一种基于氧化锌纳米棒结构的织物基底压电传感器及其制备方法 |
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