CN107789282A - A kind of skin care item containing dendrobium candidum extract and plant whitening element and its preparation method and application - Google Patents
A kind of skin care item containing dendrobium candidum extract and plant whitening element and its preparation method and application Download PDFInfo
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- CN107789282A CN107789282A CN201711171891.7A CN201711171891A CN107789282A CN 107789282 A CN107789282 A CN 107789282A CN 201711171891 A CN201711171891 A CN 201711171891A CN 107789282 A CN107789282 A CN 107789282A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention provides a kind of skin care item containing dendrobium candidum extract and plant whitening element and its preparation method and application, skin care item of the present invention are with dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extract, and plant whitening element and other effects material is raw material, not only composition is natural, and can play good whitening, anti-acne and wrinkle removing effect.Meanwhile preparation method simple process of the present invention, suitable for large-scale production.
Description
Technical field
The present invention relates to cosmetic field, contains dendrobium candidum extract and plant whitening element in particular to one kind
Skin care item and its preparation method and application.
Background technology
Ultraviolet is divided into UVA, UVB, UVC and UVD, wherein, UVA wave bands can go directly the skin corium of skin, destroy elasticity
Fiber and stirring azelon, produce wrinkle, make cutis laxa aging；UVB ultraviolets have erythema effect to human body, it is long-term or
Excessive exposure can make skin tanning, and cause red and swollen decortication, can also cause to burn when serious.In daily life, we can not keep away
The meeting exempted from is injured by ultraviolet, causes the skin problems such as red swelling of the skin allergy, tanned decortication.
And acne is then one of most commonly seen skin problem, more than 50% people is throughout the year with " whelk ".Acne is
A kind of infective inflammation of pilosebaceous follicle, sebaceous glands are opened on follicular orifice more, if follicular orifice blocks, due to excessive sebum
The effect of the propionibacterium acnes of hyper-proliferative, can make in the stimulation of excess fat acid caused by metabolism and enclosed environment
Obtain skin and produce inflammatory reaction, lipase caused by propionibacterium acnes decomposes sebum generation free fatty, while chemotactic inflammation
Cell and medium, finally induce and aggravate inflammatory reaction.Therefore the performance of small pox is from gently to being hoary hair's blackhead, inflammatory mound again
Rash and warts, tumour and tubercle, and bacterium infection phenomenon be present in small pox explanation that is rubescent and suppurating.
Existing whitening and product for resolving poxes are more, however, the action effect of these products is more single, and have concurrently whitening,
The product of acne-removal function is more rare.Meanwhile in the product of commercially available prod, more to synthesize whitening composition or anti-virus activities bactericide as work(
Composition is imitated, although certain whitening that these compositions can play and anti-acne effect, however, long-term use of can give skin tape
Carry out larger stimulation, and be also easy to, to accelerating skin aging, blocking pore, destroy the micro-ecological environment of skin, on the contrary cause
Skin is in easy infection state, can not realize due whitening anti-acne effect.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of skin care item containing dendrobium candidum extract and plant whitening element, institute
The skin care item stated are with dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extract, Yi Jizhi
Thing whitening element and other effects material is raw material, and not only composition is natural, and can play good whitening, anti-acne and wrinkle removing effect.
The second object of the present invention is to provide a kind of described shield containing dendrobium candidum extract and plant whitening element
The preparation method of skin product, preparation method of the present invention have simple process, the advantages that suitable for large-scale production.
The third object of the present invention is to improve a kind of described shield containing dendrobium candidum extract and plant whitening element
The application of skin product.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of skin care item containing dendrobium candidum extract and plant whitening element, it is described to contain dendrobium candidum extract and plant
The raw material of skin care articles of thing whitening element includes：Dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel
Extract, plant whitening element, water, aqueous phase auxiliary material, oil phase auxiliary material, preservative, and spices；Preferably, the skin care item are shield
Skin breast.
Preferably, in the skin care item of the present invention containing dendrobium candidum extract and plant whitening element, the plant
Whitening element includes：One or more in ophiopogon japonicus extract, oriental cherry extract, and hyperici,herba extract.
Preferably, in the skin care item of the present invention containing dendrobium candidum extract and plant whitening element, the aqueous phase
Auxiliary material includes：One or more in glycerine, propane diols, Sodium Hyaluronate, and carbomer.
Preferably, in the skin care item of the present invention containing dendrobium candidum extract and plant whitening element, the oil phase
Auxiliary material includes：Saualane, cyclomethicone, stereth -2, stereth -21, cetostearyl alcohol, butter fruit
Set fruit fatty oil, glycerine polymethacrylates, Gantrez AN-119, PAA/sodium acryloyldimethyl taurate copolymers,
The smooth oleate of isohexadecane, sorb, and the one or more in triethanolamine.
Preferably, in the skin care item of the present invention containing dendrobium candidum extract and plant whitening element, the anti-corrosion
Agent includes：One or more in Butylated Hydroxytoluene, methylisothiazolinone, and iodine propilolic alcohol butyl mephenesin Carbamate.
Preferably, in the skin care item of the present invention containing dendrobium candidum extract and plant whitening element, the spices
Including essence.
Preferably, in parts by weight, the shield of the present invention containing dendrobium candidum extract and plant whitening element
Skin product raw material includes：20~30 parts of dendrobium candidum extract, 5~10 parts of oat kernel extract, 2~5 parts of dried tremella extract, turn round thorn
2~5 parts of Cactus Pedicel extract, 20~30 parts of plant whitening element, 30~60 parts of water, 1~20 part of aqueous phase auxiliary material, oil phase auxiliary material 1
~20 parts, 0.1~1 part of preservative, and 0.5~2 part of spices.
Meanwhile present invention also offers the preparation of the skin care item containing dendrobium candidum extract and plant whitening element
Method, the preparation method comprise the following steps：
(a) by water and the heating mixing of aqueous phase auxiliary material, it is completely dissolved to Aqueous Phase Raw Material；
(b) oil phase auxiliary material is heated and mixed, it is well mixed to the dissolving of oil phase auxiliary material；
(c) mixed oil phase auxiliary material is pumped under vacuum in emulsification pot, it is auxiliary then adds mixed aqueous phase
Material；
(d) cool, add dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extraction
Thing, and plant whitening element；
(e) continue to cool, add preservative and essence；
(f) continue to cool, recover to atmospheric pressure, stop stirring, discharging, produce beautiful containing dendrobium candidum extract and plant
Bai Su skin care item.
Preferably, in preparation method step (a) of the present invention, the temperature of heating is 70~80 DEG C；And/or step
(b) in, the temperature of heating is 70~80 DEG C.And/or in step (d), the cooling is 50 DEG C or so；And/or step (e)
In, it is described to continue cooling as 40 DEG C or so；And/or in step (f), it is described to continue cooling as less than 40 DEG C.
Further, present invention provides the skin care item containing dendrobium candidum extract and plant whitening element to exist
Application in anti-acne, whitening；And/or the skin care item containing dendrobium candidum extract and plant whitening element disappear in antibacterial
Application in scorching, light spot and reduction wrinkle.
Compared with prior art, beneficial effects of the present invention are：
(1) in skin care item of the present invention, primary efficacy material is natural plant extracts, skin tape will not be come any
Excitant；
Meanwhile by dendrobium candidum extract, oat kernel extract, dried tremella extract, turn round thorn Cactus Pedicel extract with
And the compound action of the raw material such as plant whitening element, the effect of also enabling skin care item of the present invention to play nature whitening, anti-acne；
(2) preparation method process step of the present invention is easy, simple to operate, suitable for scale, industrialized production.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
It is more single in view of current whitening, product for resolving poxes performance, and synthetic ingredient can produce not on the contrary for skin
The problems such as good influence, spy of the present invention provide a kind of new skin care item, and are functional component by using natural plant composition
Method, so as to reach the functional effects such as whitening, anti-acne.
Specifically, the skin care item containing dendrobium candidum extract and plant whitening element are preferably a kind of skin care milk,
Its raw material be dendrobium candidum extract, oat kernel extract, dried tremella extract, turn round thorn Cactus Pedicel extract, plant whitening element,
Water, aqueous phase auxiliary material, oil phase auxiliary material, preservative, and spices；
Wherein, the compositions such as alkaloid, polysaccharide, trace element and amino acid, its extract are contained in dendrobium candidum extract
There is outstanding water holding effect, the CBF of capillary can be increased；And superoxide dismutase (SOD) level can be significantly improved,
So as to play a part of reducing lipid peroxide (LPO)；Also from the horizontal regulation angle of brain monoaminergic transmitters, as similar
The inhibitor of monoamine oxidase (MAO) and play anti-aging effects；
And dendrobium candidum extract and oat kernel extract, dried tremella extract, torsion are pierced into Cactus Pedicel extract, Yi Jizhi
The multiple efficacies materials such as thing whitening element are used in combination, and can not only play the effect of whitening spot-removing, but also dispel with good
Acne effect.
Preferably, the plant whitening element is ophiopogon japonicus extract, oriental cherry extract, and hyperici,herba extract, and this three
Plant Extracts are used cooperatively the effect that can not only play antibacterial sterilization, while can also play good whitening effect,
So as to further improve the white-skinned face function of skin care item of the present invention.
Preferably, the aqueous phase auxiliary material is glycerine, propane diols, Sodium Hyaluronate, and carbomer.
Preferably, the oil phase auxiliary material be saualane, cyclomethicone, stereth -2, stereth -
21st, cetostearyl alcohol, Butyrospermum parkii fruit fatty oil, glycerine polymethacrylates, Gantrez AN-119, PAA/acryloyl
Dimethyltaurine sodium copolymer, isohexadecane, the smooth oleate of sorb, and triethanolamine.
Preferably, the preservative is Butylated Hydroxytoluene, methylisothiazolinone, and iodine propilolic alcohol butyl mephenesin Carbamate.
Preferably, the spices is essence.
Still more preferably, calculated according to mass fraction, in skin care item of the present invention, each raw material dosage is as follows：Iron
20~30 parts of skin Herba Dendrobii extract, 5~10 parts of oat kernel extract, 2~5 parts of dried tremella extract, turn round thorn Cactus Pedicel extract 2
~5 parts, 20~30 parts of plant whitening element, 30~60 parts of water, 1~20 part of aqueous phase auxiliary material, 1~20 part of oil phase auxiliary material, preservative 0.1
~1 part, and 0.5~2 part of spices；
And by the adjustment for raw material dosage, the use that also further can improve and optimize skin care item of the present invention is imitated
Fruit.
Meanwhile the preparation flow of skin care item of the present invention is also relatively simple, specific steps refer to as follows：
The preparation method comprises the following steps：
(a) by water and the heating mixing of aqueous phase auxiliary material, it is completely dissolved to Aqueous Phase Raw Material；
Preferably, it is to add water, glycerine, propane diols, Sodium Hyaluronate, and carbomer in water pot in this step, and
Preferably it is heated to 70~80 DEG C so that Aqueous Phase Raw Material is completely dissolved, and is well mixed；
(b) oil phase auxiliary material is heated and mixed, it is well mixed to the dissolving of oil phase auxiliary material；
Preferably, in this step, be by saualane, cyclomethicone, stereth -2, stereth -
21st, cetostearyl alcohol, Butyrospermum parkii fruit fatty oil, glycerine polymethacrylates, Gantrez AN-119, PAA/acryloyl
Dimethyltaurine sodium copolymer, isohexadecane, the smooth oleate of sorb, and triethanolamine are added in oil tank, then preferably
70~80 DEG C are heated to, and make it that the dissolving of oil phase auxiliary material is well mixed；
(c) mixed oil phase auxiliary material is pumped under vacuum in emulsification pot, it is auxiliary then adds mixed aqueous phase
Material；
(d) cool, add dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extraction
Thing, and plant whitening element；
Preferably, in this step, it is when the temperature for emulsifying pot is down to 50 DEG C or so, then adds iron sheet under vacuum conditions
Herba Dendrobii extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extract, ophiopogon japonicus extract, oriental cherry extract,
And hyperici,herba extract；
(e) continue to cool, add preservative and essence；
Preferably, in this step, be emulsify pot be cooled to 40 DEG C or so when, then under vacuum conditions add fourth hydroxyl first
Benzene, methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate, and essence；
(f) continue to cool, recover to atmospheric pressure, stop stirring, discharging, produce beautiful containing dendrobium candidum extract and plant
Bai Su skin care item.
Preferably, in this step, it is after emulsification pot is cooled to below 40 DEG C, bleeds off vacuum so that emulsification system is in
Under atmospheric pressure state, and stop stirring, discharge；
It is preferred that after discharging, still further comprise and stand resulting material, the step of then testing, it is qualified to examine
Product be the skin care item containing dendrobium candidum and plant whitening element of the invention, is then carried out canned, packing, encapsulate and
Packaging, is then sold.
Embodiment 1
According to mass fraction：25 parts of dendrobium candidum extract, 8 parts of oat kernel extract, 3 parts of dried tremella extract, it is celestial to turn round thorn
People's 4 parts of stem extraction of the palm, 10 parts of ophiopogon japonicus extract, 10 parts of oriental cherry extract, 5 parts of hyperici,herba extract, 50 parts of water, 2 parts of glycerine,
1 part of propane diols, 0.5 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.5 part of saualane, 1 part of cyclomethicone, stearyl alcohol
0.5 part of polyethers -2,0.5 part of stereth -21,0.3 part of cetostearyl alcohol, 0.5 part of Butyrospermum parkii fruit fatty oil, the poly- first of glycerine
0.2 part of base acrylate, 0.3 part of Gantrez AN-119,0.5 part of PAA/sodium acryloyldimethyl taurate copolymers are different
0.5 part of hexadecane, 1 part of the smooth oleate of sorb, 0.2 part of triethanolamine, 0.1 part of Butylated Hydroxytoluene, 0.05 part of methylisothiazolinone,
0.05 part of iodine propilolic alcohol butyl mephenesin Carbamate, and 2 parts of spices, appropriate each raw material is weighed respectively；
Then, the skin care milk containing dendrobium candidum and plant whitening element of embodiment 1 is made as follows；
(a) water, glycerine, propane diols, Sodium Hyaluronate, and carbomer are added in water pot, is heated to 70~80 DEG C, makes
Obtain Aqueous Phase Raw Material to be completely dissolved, and be well mixed；
(b) by saualane, cyclomethicone, stereth -2, stereth -21, cetostearyl alcohol, ox
Oily fruit tree fruit fatty oil, glycerine polymethacrylates, Gantrez AN-119, PAA/sodium acryloyldimethyl taurate are common
The smooth oleate of polymers, isohexadecane, sorb, and triethanolamine are added in oil tank, are heated to 70~80 DEG C, and make it that oil phase is auxiliary
Material dissolving is well mixed；
(c) mixed oil phase auxiliary material is pumped under vacuum in emulsification pot, it is auxiliary then adds mixed aqueous phase
Material；
(d) when the temperature of emulsification pot is down to 50 DEG C, dendrobium candidum extract, oat kernel extraction are added under vacuum conditions
Thing, dried tremella extract, turn round thorn Cactus Pedicel extract, ophiopogon japonicus extract, oriental cherry extract, and hyperici,herba extract；
(e) emulsification pot is cooled to 40 DEG C, adds Butylated Hydroxytoluene, methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate,
And essence；
(f) continue to be cooled to less than 40 DEG C, recover to atmospheric pressure, stop stirring, discharging, then stand, it is qualified to examine, i.e.,
For the skin care milk containing dendrobium candidum and plant whitening element of embodiment 1.
Embodiment 2
According to mass fraction：30 parts of dendrobium candidum extract, 5 parts of oat kernel extract, 2 parts of dried tremella extract, it is celestial to turn round thorn
People's 2 parts of stem extraction of the palm, 5 parts of ophiopogon japonicus extract, 10 parts of oriental cherry extract, 5 parts of hyperici,herba extract, 50 parts of water, 2 parts of glycerine,
1 part of propane diols, 0.5 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.5 part of saualane, 1 part of cyclomethicone, stearyl alcohol
0.5 part of polyethers -2,0.5 part of stereth -21,0.3 part of cetostearyl alcohol, 0.5 part of Butyrospermum parkii fruit fatty oil, the poly- first of glycerine
0.2 part of base acrylate, 0.3 part of Gantrez AN-119,0.5 part of PAA/sodium acryloyldimethyl taurate copolymers are different
0.5 part of hexadecane, 1 part of the smooth oleate of sorb, 0.2 part of triethanolamine, 0.1 part of Butylated Hydroxytoluene, 0.05 part of methylisothiazolinone,
0.05 part of iodine propilolic alcohol butyl mephenesin Carbamate, and 2 parts of spices, appropriate each raw material is weighed respectively；
Then, according to the method for embodiment 1, the skin care milk containing dendrobium candidum and plant whitening element of embodiment 2 is obtained.
Embodiment 3
According to mass fraction：20 parts of dendrobium candidum extract, 10 parts of oat kernel extract, 5 parts of dried tremella extract, it is celestial to turn round thorn
People slaps 5 parts of stem extraction, 10 parts of ophiopogon japonicus extract, 10 parts of oriental cherry extract, 10 parts of hyperici,herba extract, 50 parts of water, glycerine 2
Part, 1 part of propane diols, 0.5 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.5 part of saualane, 1 part of cyclomethicone, tristearin
- 2 0.5 parts of alcohol polyethers, 0.5 part of stereth -21,0.3 part of cetostearyl alcohol, 0.5 part of Butyrospermum parkii fruit fatty oil, glycerine gathers
0.2 part of methacrylate, 0.3 part of Gantrez AN-119,0.5 part of PAA/sodium acryloyldimethyl taurate copolymers,
0.5 part of isohexadecane, 1 part of the smooth oleate of sorb, 0.2 part of triethanolamine, 0.1 part of Butylated Hydroxytoluene, methylisothiazolinone 0.05
Part, 0.05 part of iodine propilolic alcohol butyl mephenesin Carbamate, and 2 parts of spices, appropriate each raw material is weighed respectively；
Then, according to the method for embodiment 1, the skin care milk containing dendrobium candidum and plant whitening element of embodiment 3 is obtained.
Comparative example 1
According to mass fraction：15 parts of oat kernel extract, 5 parts of dried tremella extract, turn round 5 parts of thorn Cactus Pedicel extract, wheat
10 parts of winter extract, 15 parts of oriental cherry extract, 15 parts of hyperici,herba extract, 50 parts of water, 2 parts of glycerine, 1 part of propane diols, hyalomitome
Sour 0.5 part of sodium, 0.5 part of carbomer, 0.5 part of saualane, 1 part of cyclomethicone, 0.5 part of stereth -2 are stearic
- 21 0.5 parts of alcohol polyethers, 0.3 part of cetostearyl alcohol, 0.5 part of Butyrospermum parkii fruit fatty oil, 0.2 part of glycerine polymethacrylates,
0.3 part of Gantrez AN-119,0.5 part of PAA/sodium acryloyldimethyl taurate copolymers, 0.5 part of isohexadecane, sorb
Smooth 1 part of oleate, 0.2 part of triethanolamine, 0.1 part of Butylated Hydroxytoluene, 0.05 part of methylisothiazolinone, iodine propilolic alcohol butyl ammonia first
0.05 part of acid esters, and 2 parts of spices, appropriate each raw material is weighed respectively；
Then, with reference to the method for embodiment 1, the skin care milk of comparative example 1 is obtained.
Comparative example 2
According to mass fraction：40 parts of dendrobium candidum extract, 10 parts of oat kernel extract, 5 parts of dried tremella extract, it is celestial to turn round thorn
People slaps 10 parts of stem extraction, 50 parts of water, 2 parts of glycerine, 1 part of propane diols, 0.5 part of Sodium Hyaluronate, 0.5 part of carbomer, saualane
0.5 part, 1 part of cyclomethicone, 0.5 part of stereth -2,0.5 part of stereth -21, cetostearyl alcohol
0.3 part, 0.5 part of Butyrospermum parkii fruit fatty oil, 0.2 part of glycerine polymethacrylates, 0.3 part of Gantrez AN-119, PAA/
0.5 part of sodium acryloyldimethyl taurate copolymers, 0.5 part of isohexadecane, 1 part of the smooth oleate of sorb, 0.2 part of triethanolamine,
0.1 part of Butylated Hydroxytoluene, 0.05 part of methylisothiazolinone, 0.05 part of iodine propilolic alcohol butyl mephenesin Carbamate, and 2 parts of spices, point
Also known as take appropriate each raw material；
Then, with reference to the method for embodiment 1, the skin care milk of comparative example 2 is obtained.
Comparative example 3
According to mass fraction：35 parts of dendrobium candidum extract, 30 parts of plant whitening element, 50 parts of water, 2 parts of glycerine, propane diols 1
Part, 0.5 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.5 part of saualane, 1 part of cyclomethicone, stereth -2
0.5 part, 0.5 part of stereth -21,0.3 part of cetostearyl alcohol, 0.5 part of Butyrospermum parkii fruit fatty oil, glycerine polymethyl
0.2 part of acid esters, 0.3 part of Gantrez AN-119,0.5 part of PAA/sodium acryloyldimethyl taurate copolymers, isohexadecane
0.5 part, 1 part of the smooth oleate of sorb, 0.2 part of triethanolamine, 0.1 part of Butylated Hydroxytoluene, 0.05 part of methylisothiazolinone, iodine propine
0.05 part of alcohol butyl mephenesin Carbamate, and 2 parts of spices, appropriate each raw material is weighed respectively；
Then, with reference to the method for embodiment 1, the skin care milk of comparative example 3 is obtained.
The safety testing of experimental example 1
1st, tested material：Skin care milk of the embodiment 1 containing dendrobium candidum and plant whitening element；
2nd, negative control：Blank；
3rd, subject：Totally 30 people, male 12 people, the people of female 18, at 37.5 ± 13.5 years old age, meet the selected mark of tested volunteer
It is accurate；
4th, spot method for testing：From suitable spot try device, with closed patch experiment violate the law, by tested material 0.020~
0.025ml is applied in spot examination device, and external application special adhesive tape is pasted on subject back, and 24h removes tested material, try 0.5 respectively at spot,
24th, 48h observes dermoreaction, according to《Cosmetics health specification》Dermoreaction grade scale records its knot in (version in 2007)
Fruit；
5th, result criterion：Occur the number of 1 grade of skin adverse reaction in 30 subjects more than 5, or 2 grades bad
The number of reaction is more than 2, or when 13 grades of appearance or more than 3 grades skin adverse reactions, judges tested material human body skin patch
Experimental result is unqualified.
Experimental result is as follows：
The skin care milk for containing dendrobium candidum and plant whitening element by results showed that as above meets national standard, and
Any skin irritation will not be brought to user.
The acne-removing of experimental example 2 is verified
Light, moderate face acnes are chosen (with reference to PillSburv and international improvement acne pulvis method diagnosis mild or moderate acne
Person) volunteer totally 190, wherein man 99, the people of female 91；Age between 17~35 years old, average age 28.3 years old；The course of disease 4 weeks
It is~7 years, average 3.5 years；
2 weeks before experiment, glucocorticosteroid hormone, tretinoin and antibiotics, no high fat of blood and liver kidney function is not used
Can be abnormal, excessive drinking of compacting, avoid sunburst or ultraviolet excessive radiation.
Volunteer is randomly divided into 7 groups, every group of 30 volunteers of 1-6 groups, are experimental group, respectively using embodiment 1-3
And comparative example 1-3 skin care milk；7th group is blank control group, does not apply any cosmetics；
After experimental group volunteer is opened with warm water cleaning pars affecta skin disease wiping, daily to smear counter sample sooner or later 1 time, validity period
Between disable other drugs or skin care item, 2 weeks by a definite date.It is total to subject's face inflammatory damage respectively before the treatment and after treatment
Number (inflamed papules and useless fellow summation), non-inflammatory lesions summation (summation of Whiteheads and blackhead) count, while in detail
Record the adverse reaction after use.
Evaluation criterion：
Recovery from illness：Therapeutic index >=90%；It is effective：60%≤therapeutic index ＜ 90%；Effectively：20%≤therapeutic index ＜
60%；It is invalid：Therapeutic index ＜ 20%.
Total skin lesion number × 100% before therapeutic index=(total skin lesion number after total skin lesion number-treatment before treatment)/treatment；
Effective percentage=(base is cured number+effective number)/total number of persons × 100%.
As a result it is as shown in the table：
| Experimental group | Recovery from illness | It is effective | Effectively | It is invalid | Efficient (× 100%) |
| Embodiment 1 | 11 | 14 | 5 | 0 | 100 |
| Embodiment 2 | 5 | 11 | 12 | 2 | 93.3 |
| Embodiment 3 | 6 | 13 | 10 | 1 | 96.6 |
| Comparative example 1 | 0 | 5 | 13 | 12 | 60 |
| Comparative example 2 | 2 | 13 | 8 | 7 | 76.7 |
| Comparative example 3 | 3 | 11 | 10 | 6 | 80 |
| Control | 0 | 0 | 0 | 10 | 0 |
From comparative test result as above, face cream of the present invention has good therapeutic action for acne；Meanwhile
Experimental group volunteer is fed back, and after using face cream 3 days, facial whelk is just significantly reduced/calmed down；
And by embodiment and comparative example face cream Contrast on effect it is recognized that while the compounding use of partial efficacy material equally
Certain acne treatment effect can be played, but various effect materials, which are used in combination, can obtain preferably treatment effect
Fruit.
The whitening of experimental example 3 is tested
Suppress TYR enzyme active testing
B16 melanocytes are inoculated in 96 orifice plates, per hole 100uL, puts after 24h is educated in culture in incubator and adds implementation
(each group skin care milk solution is appropriate each group skin care milk is soluble in water, constant volume, then mixes system for example and comparative example skin care milk solution
)；It is blank control by positive control, sterile deionized water of ursin；
Wherein, the addition of embodiment and comparative example skin care milk solution is identical with ursin solution usage；
Abandoning supernatant after 3d is acted on, is rinsed twice with pH6.8 PBS, adds 90uL containing volume fraction to be 1% per hole
Ultrasonication in Tritonx-100 PBS ice baths, 10uL10mmoL/L L-Dopa, 37 DEG C of incubation 60min are added per hole, in
Colorimetric at 475nm, each hole absorbance is surveyed after blank well is returned to zero.
Inhibiting rate=(1- medicine groups mean absorbance values/control group mean absorbance values) × 100%.
As a result it is as shown in the table：
From as above check experiment result, skin care milk of the present invention can effectively suppress TYR enzyme activity, meanwhile, compare
In partial efficacy material it is compound for, the powerful material of institute be used in conjunction with can substantially obtaining more preferable TYR enzyme suppressed
Performance, and this also illustrates that embodiment skin care milk can play more preferable whitening spot-removing effect.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of skin care item containing dendrobium candidum extract and plant whitening element, it is characterised in that described to contain dendrobium candidum
The raw material of skin care articles of extract and plant whitening element includes：
Dendrobium candidum extract, oat kernel extract, dried tremella extract, turn round thorn Cactus Pedicel extract, plant whitening element, water,
Aqueous phase auxiliary material, oil phase auxiliary material, preservative, and spices；
Preferably, the skin care item are skin care milk.
2. the skin care item according to claim 1 containing dendrobium candidum extract and plant whitening element, it is characterised in that institute
Stating plant whitening element includes：One or more in ophiopogon japonicus extract, oriental cherry extract, and hyperici,herba extract.
3. the skin care item according to claim 1 containing dendrobium candidum extract and plant whitening element, it is characterised in that institute
Stating aqueous phase auxiliary material includes：One or more in glycerine, propane diols, Sodium Hyaluronate, and carbomer.
4. the skin care item according to claim 1 containing dendrobium candidum extract and plant whitening element, it is characterised in that institute
Stating oil phase auxiliary material includes：Saualane, cyclomethicone, stereth -2, stereth -21, cetostearyl alcohol,
Butyrospermum parkii fruit fatty oil, glycerine polymethacrylates, Gantrez AN-119, PAA/sodium acryloyldimethyl taurate
The smooth oleate of copolymer, isohexadecane, sorb, and the one or more in triethanolamine.
5. the skin care item according to claim 1 containing dendrobium candidum extract and plant whitening element, it is characterised in that institute
Stating preservative includes：One or more in Butylated Hydroxytoluene, methylisothiazolinone, and iodine propilolic alcohol butyl mephenesin Carbamate.
6. the skin care item according to claim 1 containing dendrobium candidum extract and plant whitening element, it is characterised in that institute
Stating spices includes essence.
7. the skin care item containing dendrobium candidum extract and plant whitening element according to any one of claim 1-6, its
It is characterised by, in parts by weight, the raw material of skin care articles containing dendrobium candidum extract and plant whitening element includes：
20~30 parts of dendrobium candidum extract, 5~10 parts of oat kernel extract, 2~5 parts of dried tremella extract, turn round thorn Cactus Pedicel
2~5 parts of extract, 20~30 parts of plant whitening element, 30~60 parts of water, 1~20 part of aqueous phase auxiliary material, 1~20 part of oil phase auxiliary material, prevent
Rotten 0.1~1 part of agent, and 0.5~2 part of spices.
8. the preparation side of the skin care item containing dendrobium candidum extract and plant whitening element any one of claim 1-7
Method, it is characterised in that the preparation method comprises the following steps：
(a) by water and the heating mixing of aqueous phase auxiliary material, it is completely dissolved to Aqueous Phase Raw Material；
(b) oil phase auxiliary material is heated and mixed, it is well mixed to the dissolving of oil phase auxiliary material；
(c) mixed oil phase auxiliary material is pumped under vacuum in emulsification pot, then adds mixed aqueous phase auxiliary material；
(d) cool, add dendrobium candidum extract, oat kernel extract, dried tremella extract, torsion thorn Cactus Pedicel extract, with
And plant whitening element；
(e) continue to cool, add preservative and essence；
(f) continue to cool, recover to atmospheric pressure, stop stirring, discharging, produce containing dendrobium candidum extract and plant whitening element
Skin care item.
9. preparation method according to claim 8, it is characterised in that the temperature of heating is 70~80 DEG C in step (a)；
And/or in step (b), the temperature of heating is 70~80 DEG C.
And/or in step (d), the cooling is 50 DEG C or so；
And/or in step (e), it is described to continue cooling as 40 DEG C or so；
And/or in step (f), it is described to continue cooling as less than 40 DEG C.
10. skin care item containing dendrobium candidum extract and plant whitening element any one of claim 1-7 anti-acne,
Application in whitening；
And/or the skin care item containing dendrobium candidum extract and plant whitening element are in anti-inflammation, light spot and reduction
Application in wrinkle.
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