CN107744786A - 防止连续反应通道系统堵塞的方法及执行该方法的微反应器 - Google Patents

防止连续反应通道系统堵塞的方法及执行该方法的微反应器 Download PDF

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Publication number
CN107744786A
CN107744786A CN201711012708.9A CN201711012708A CN107744786A CN 107744786 A CN107744786 A CN 107744786A CN 201711012708 A CN201711012708 A CN 201711012708A CN 107744786 A CN107744786 A CN 107744786A
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CN
China
Prior art keywords
channel system
microreactor
ultrasonic wave
process fluid
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711012708.9A
Other languages
English (en)
Chinese (zh)
Inventor
多米尼克·罗贝热
法比奥·拉伊诺内
威廉·奎特曼
迈克尔·高特斯邦那
马库斯·埃雅尔泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2009/061143 external-priority patent/WO2011023236A1/en
Application filed by Lonza AG filed Critical Lonza AG
Publication of CN107744786A publication Critical patent/CN107744786A/zh
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B17/00—Methods preventing fouling
    • B08B17/02—Preventing deposition of fouling or of dust
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0099—Cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B2209/00—Details of machines or methods for cleaning hollow articles
    • B08B2209/005—Use of ultrasonics or cavitation, e.g. as primary or secondary action

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201711012708.9A 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器 Pending CN107744786A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/EP2009/061143 WO2011023236A1 (en) 2009-08-28 2009-08-28 Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method
EPPCT/EP2009/061143 2009-08-28
EP09011726.8 2009-09-14
EP09011726 2009-09-14
EP10157285.7 2010-03-23
EP10157285 2010-03-23
CN2010800216839A CN102427876A (zh) 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2010800216839A Division CN102427876A (zh) 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器

Publications (1)

Publication Number Publication Date
CN107744786A true CN107744786A (zh) 2018-03-02

Family

ID=42829408

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201711012708.9A Pending CN107744786A (zh) 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器
CN2010800216839A Pending CN102427876A (zh) 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2010800216839A Pending CN102427876A (zh) 2009-08-28 2010-08-26 防止连续反应通道系统堵塞的方法及执行该方法的微反应器

Country Status (13)

Country Link
US (1) US10058840B2 (https=)
EP (1) EP2470296A1 (https=)
JP (1) JP5718335B2 (https=)
CN (2) CN107744786A (https=)
BR (1) BR112012004437A2 (https=)
CA (1) CA2757436C (https=)
EA (1) EA026338B1 (https=)
IL (1) IL215568A0 (https=)
IN (1) IN2012DN01781A (https=)
MX (1) MX2012001571A (https=)
SG (1) SG178233A1 (https=)
TW (1) TW201127484A (https=)
WO (1) WO2011023761A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020811A (zh) * 2018-09-19 2018-12-18 张家港瀚康化工有限公司 利用微型反应器制备丙酸酯的方法

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Publication number Priority date Publication date Assignee Title
CN104162395B (zh) * 2014-03-21 2017-01-25 中国科学院大连化学物理研究所 一种强化微反应器内气液过程的方法
EP3031518B1 (en) * 2014-12-08 2021-01-20 Lonza Ltd Fluid mixing structure, continuous reaction unit, continuous reaction reactor and method of using the same
FR3050943B1 (fr) * 2016-05-03 2019-12-20 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Procede de nettoyage d'un canal millimetrique d'un echangeur-reacteur
CN106824909B (zh) * 2017-02-21 2022-11-08 华中农业大学 管道式超声波清洗机
CN108568264A (zh) * 2017-03-13 2018-09-25 许昌义 超声波s形管混合器
US10527843B2 (en) * 2017-05-12 2020-01-07 International Business Machines Corporation Ultra-sonic self-cleaning system
FR3146815A1 (fr) 2023-03-21 2024-09-27 Khimod microréacteur pour la mise en œuvre de procédés de chimie continue impliquant des solides

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JP2007252979A (ja) * 2006-03-20 2007-10-04 National Institute Of Advanced Industrial & Technology マイクロリアクタによる化合物の製造方法、そのマイクロリアクタ、及びマイクロリアクタ用の分流器

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US20050129580A1 (en) * 2003-02-26 2005-06-16 Swinehart Philip R. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
JP2004337649A (ja) 2003-05-13 2004-12-02 Hitachi Ltd 有機塩素化合物処理装置
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JP5061632B2 (ja) * 2007-02-09 2012-10-31 和光純薬工業株式会社 ｏ−二置換芳香族化合物の製造方法
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JP2007252979A (ja) * 2006-03-20 2007-10-04 National Institute Of Advanced Industrial & Technology マイクロリアクタによる化合物の製造方法、そのマイクロリアクタ、及びマイクロリアクタ用の分流器

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* Cited by examiner, † Cited by third party
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CN109020811A (zh) * 2018-09-19 2018-12-18 张家港瀚康化工有限公司 利用微型反应器制备丙酸酯的方法

Also Published As

Publication number Publication date
IN2012DN01781A (https=) 2015-06-05
WO2011023761A1 (en) 2011-03-03
CN102427876A (zh) 2012-04-25
MX2012001571A (es) 2012-04-11
EP2470296A1 (en) 2012-07-04
SG178233A1 (en) 2012-03-29
TW201127484A (en) 2011-08-16
EA201270233A1 (ru) 2012-09-28
BR112012004437A2 (pt) 2016-03-22
IL215568A0 (en) 2011-12-29
EA026338B1 (ru) 2017-03-31
US10058840B2 (en) 2018-08-28
JP2013503030A (ja) 2013-01-31
CA2757436A1 (en) 2011-03-03
CA2757436C (en) 2018-01-02
US20150158007A1 (en) 2015-06-11
JP5718335B2 (ja) 2015-05-13

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Application publication date: 20180302

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