JP5718335B2 - 連続反応流路システムの閉塞防止方法及びこの方法を実施するための超小型反応装置 - Google Patents

連続反応流路システムの閉塞防止方法及びこの方法を実施するための超小型反応装置 Download PDF

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JP5718335B2
JP5718335B2 JP2012526059A JP2012526059A JP5718335B2 JP 5718335 B2 JP5718335 B2 JP 5718335B2 JP 2012526059 A JP2012526059 A JP 2012526059A JP 2012526059 A JP2012526059 A JP 2012526059A JP 5718335 B2 JP5718335 B2 JP 5718335B2
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flow path
process fluid
flow
ultrasonic wave
path system
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JP2013503030A (ja
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ロベルジュ、ドミニク
ライノネ、ファビオ
クイットマン、ビルヘルム
ゴットスポナー、ミハエル
アイホルツァー、マルクス
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ロンザ アーゲー
ロンザ アーゲー
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Priority claimed from PCT/EP2009/061143 external-priority patent/WO2011023236A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B17/00—Methods preventing fouling
    • B08B17/02—Preventing deposition of fouling or of dust
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0099—Cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B2209/00—Details of machines or methods for cleaning hollow articles
    • B08B2209/005—Use of ultrasonics or cavitation, e.g. as primary or secondary action

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2012526059A 2009-08-28 2010-08-26 連続反応流路システムの閉塞防止方法及びこの方法を実施するための超小型反応装置 Active JP5718335B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/EP2009/061143 WO2011023236A1 (en) 2009-08-28 2009-08-28 Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method
EPPCT/EP2009/061143 2009-08-28
EP09011726.8 2009-09-14
EP09011726 2009-09-14
EP10157285.7 2010-03-23
EP10157285 2010-03-23
PCT/EP2010/062476 WO2011023761A1 (en) 2009-08-28 2010-08-26 Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method

Publications (2)

Publication Number Publication Date
JP2013503030A JP2013503030A (ja) 2013-01-31
JP5718335B2 true JP5718335B2 (ja) 2015-05-13

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JP2012526059A Active JP5718335B2 (ja) 2009-08-28 2010-08-26 連続反応流路システムの閉塞防止方法及びこの方法を実施するための超小型反応装置

Country Status (13)

Country Link
US (1) US10058840B2 (https=)
EP (1) EP2470296A1 (https=)
JP (1) JP5718335B2 (https=)
CN (2) CN107744786A (https=)
BR (1) BR112012004437A2 (https=)
CA (1) CA2757436C (https=)
EA (1) EA026338B1 (https=)
IL (1) IL215568A0 (https=)
IN (1) IN2012DN01781A (https=)
MX (1) MX2012001571A (https=)
SG (1) SG178233A1 (https=)
TW (1) TW201127484A (https=)
WO (1) WO2011023761A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104162395B (zh) * 2014-03-21 2017-01-25 中国科学院大连化学物理研究所 一种强化微反应器内气液过程的方法
EP3031518B1 (en) * 2014-12-08 2021-01-20 Lonza Ltd Fluid mixing structure, continuous reaction unit, continuous reaction reactor and method of using the same
FR3050943B1 (fr) * 2016-05-03 2019-12-20 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Procede de nettoyage d'un canal millimetrique d'un echangeur-reacteur
CN106824909B (zh) * 2017-02-21 2022-11-08 华中农业大学 管道式超声波清洗机
CN108568264A (zh) * 2017-03-13 2018-09-25 许昌义 超声波s形管混合器
US10527843B2 (en) * 2017-05-12 2020-01-07 International Business Machines Corporation Ultra-sonic self-cleaning system
CN109020811A (zh) * 2018-09-19 2018-12-18 张家港瀚康化工有限公司 利用微型反应器制备丙酸酯的方法
FR3146815A1 (fr) 2023-03-21 2024-09-27 Khimod microréacteur pour la mise en œuvre de procédés de chimie continue impliquant des solides

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JPS4734027Y1 (https=) 1970-09-03 1972-10-14
US5830127A (en) 1996-08-05 1998-11-03 Cybersonics, Inc. Method and apparatus for cleaning endoscopes and the like
DE10143189A1 (de) 2001-09-04 2003-03-20 Clariant Gmbh Verfahren und Vorrichtung zur prozeßbegleitenden Reinigung von Mikro-und Minireaktoren
MXPA05008842A (es) 2003-02-21 2005-10-05 Novartis Ag Proceso quimico.
US20050129580A1 (en) * 2003-02-26 2005-06-16 Swinehart Philip R. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
JP2004337649A (ja) 2003-05-13 2004-12-02 Hitachi Ltd 有機塩素化合物処理装置
US20050016851A1 (en) * 2003-07-24 2005-01-27 Jensen Klavs F. Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles
JP2005060281A (ja) 2003-07-29 2005-03-10 Idemitsu Kosan Co Ltd ビニル化合物又はビニリデン化合物の二量化方法
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JP4734027B2 (ja) 2005-05-17 2011-07-27 株式会社ブリヂストン 空気入りタイヤ
DE102005025248B4 (de) 2005-06-02 2009-07-30 Forschungszentrum Karlsruhe Gmbh Fluidführungssystem
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TW200738328A (en) 2006-03-31 2007-10-16 Lonza Ag Micro-reactor system assembly
JP5061632B2 (ja) * 2007-02-09 2012-10-31 和光純薬工業株式会社 ｏ−二置換芳香族化合物の製造方法
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Also Published As

Publication number Publication date
IN2012DN01781A (https=) 2015-06-05
WO2011023761A1 (en) 2011-03-03
CN102427876A (zh) 2012-04-25
MX2012001571A (es) 2012-04-11
EP2470296A1 (en) 2012-07-04
SG178233A1 (en) 2012-03-29
TW201127484A (en) 2011-08-16
EA201270233A1 (ru) 2012-09-28
BR112012004437A2 (pt) 2016-03-22
IL215568A0 (en) 2011-12-29
EA026338B1 (ru) 2017-03-31
US10058840B2 (en) 2018-08-28
CN107744786A (zh) 2018-03-02
JP2013503030A (ja) 2013-01-31
CA2757436A1 (en) 2011-03-03
CA2757436C (en) 2018-01-02
US20150158007A1 (en) 2015-06-11

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