CN107709958A - Sampling mechanism and its suction detection method, sample analyser - Google Patents
Sampling mechanism and its suction detection method, sample analyser Download PDFInfo
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- CN107709958A CN107709958A CN201580081158.9A CN201580081158A CN107709958A CN 107709958 A CN107709958 A CN 107709958A CN 201580081158 A CN201580081158 A CN 201580081158A CN 107709958 A CN107709958 A CN 107709958A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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Abstract
A kind of sampling mechanism and its suction detection method, sample analyser, the sampling mechanism includes moving assembly (20), sampling component (10), driver element (30) and control unit (40), collection characterizes the electric signal of sampling needle physical quantity to the sampling mechanism respectively before and after stock layout and/or before and after suction sample, for judging whether suction amount reaches scheduled volume.Electric signal is gathered also before and after stock layout to judge whether suction amount reaches scheduled volume, solves the situation that suction sample is failed to report in conventional art.
Description
Sampling mechanism and its suction detection method, sample analyser technical field
[0001] the present invention relates to sample analysis technologies, and in particular to the sampling mechanism and its suction detection method [0002] of sample analyser
[0003] background technique
[0004] sample analyser is carrying out the sample that analysis inch needs to acquire predetermined amount from sample container by sampling needle to sample, the reagent of predetermined amount is acquired from reagent container, sample is all referred to as inhaled to the acquisition of sample and reagent, then incubation reaction will be carried out in the sample of acquisition and reagent injection reaction vessel, finally the sample after reaction is detected.Inch is being acquired to sample or reagent, (such as sample or reagent are finished) sample or reagent that do not collect predetermined amount may be led to for some reason, cause suction, suction includes not collecting sample/reagent of sample/reagent and acquisition to be not up to predetermined amount, and suction finally results in testing result inaccuracy.Therefore sample analyser is generally configured with suction detection function, to detect whether suction amount reaches predetermined amount.
[0005] the suction detection scheme generallyd use are as follows: sampling needle progress liquid level voltage measurement obtains a voltage value before inhaling sample
V., sampling needle carries out liquid level voltage measurement again and obtains a voltage value v after the completion of inhaling sample1 ;Since sampling needle in air, requires sampling needle under remaining liquid level after inhaling sample before inhaling sample, there is some difference for the voltage of both of these case, utilizes, with.Difference may determine that after sampling needle inhales sample whether under liquid level, if sampling needle is inhaled after sample still under liquid level, i.e., known to sampling needle collected the sample or reagent of predetermined amount.But during inhaling sample, if sampling needle has encountered the unexpected interior object inch such as test tube tube wall, or there are bubbles in sampling needle or in test tube, even if sampling needle suction has occurred, voltage difference obtained in voltage difference that sampling needle obtains before and after inhaling sample and the smooth sampling process of sampling needle is close, the case where suction sample being caused to fail to report in this way.
[0006]
[0007] summary of the invention
[0008] according in a first aspect, providing a kind of sampling mechanism in a kind of embodiment, comprising:
[0009] moving assembly；
[0010] sampling component, the sampling component include sampling needle and detection module, and the sampling needle is fixed on moving assembly
On, detection module and sampling needle electrical connection, the variation of the physical quantity of real inch detection sampling needle, and be converted to electric signal；
[0011] driving unit is coupled to moving assembly, and driving moving assembly is mobile, to drive sampling needle mobile；
[0012] control unit, it is electrically connected with driving unit, driving control signal is sent to driving unit, described control unit is also electrically connected with detection module, electric signal is acquired from detection module, described control unit judges whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal, first electric signal be sampling needle execute stock layout before detection module export electric signal, second electric signal be sampling needle stock layout after detection module export electric signal.
[0013] another embodiment also provides another sampling mechanism, comprising:
[0014] moving assembly；
[0015] sampling component, the sampling component include sampling needle and detection module, and the sampling needle is fixed on moving assembly, detection module and sampling needle electrical connection, the variation of the physical quantity of real inch detection sampling needle, and are converted to electric signal；
[0016] driving unit is coupled to moving assembly, and driving moving assembly is mobile, to drive sampling needle mobile；[0017] control unit, it is electrically connected with driving unit, driving control signal is sent to driving unit, described control unit is also electrically connected with detection module, electric signal is acquired from detection module, on the one hand its control unit tentatively judges whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal, on the other hand tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of third electric signal and the 4th electric signal, and go out whether suction amount reaches predetermined amount according to the result comprehensive descision tentatively judged twice, first electric signal is the electric signal that detection module exports before sampling needle executes stock layout, second electric signal be sampling needle stock layout after detection module export electric signal, the third electric signal is that sampling needle executes inspection before inhaling sample Survey module output electric signal, the 4th electric signal be sampling needle inhale sample after detection module export electric signal.
[0018] according to second aspect, a kind of sampling mechanism suction detection method is provided in a kind of embodiment, the method includes
[0019] before sampling needle executes stock layout, detection module detects the physical quantity of sampling needle, exports the first electric signal；
[0020] after sampling needle stock layout, detection module detects the physical quantity of sampling needle, exports the second electric signal；
[0021] judge whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal.
[0022] in another embodiment, which comprises
[0023] before sampling needle executes and inhales sample, detection module detects the physical quantity of sampling needle, exports third electric signal；[0024] after sampling needle inhales sample, detection module detects the physical quantity of sampling needle, exports the 4th electric signal；[0025] tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of third electric signal and the 4th electric signal；[0026] before sampling needle executes stock layout, detection module detects the physical quantity of sampling needle, exports the first electric signal；[0027] after sampling needle stock layout, detection module detects the physical quantity of sampling needle, exports the second electric signal；[0028] tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal；[0029] go out whether suction amount reaches predetermined amount according to the result comprehensive descision tentatively judged twice.
[0030] according to the third aspect, a kind of sample analyser is provided in a kind of embodiment, including above-mentioned sampling mechanism.
[0031]
[0032] according to the sampling mechanism and its suction detection method, sample analyser of above-described embodiment, since the two inch carve two electric signals of acquisition to detection module before and after sampling needle stock layout, control unit judges whether suction amount reaches predetermined amount further according to the two electric signals so that the suction sample of the application judge it is more relatively reliable than traditional.In other embodiment, also two electric signals of acquisition can also be carved by the two inch before and after sampling needle inhales sample, control unit judges whether suction amount reaches predetermined amount according to the two electric signals, the finally comprehensive combination of judgement twice of control unit provides one and reliably judges, to greatly avoid the case where suction sample is failed to report to program.
[0033]
[0034] Detailed description of the invention
[0035] Fig. 1 is the structural representation of sampling mechanism in the embodiment of the present application one；
[0036] Fig. 2 is the structural schematic diagram of sampling mechanism part in the embodiment of the present application one；
[0037] figure3For the flow chart of suction detection method in the embodiment of the present application one；
[0038] Fig. 4 is the schematic diagram of sampling mechanism work inch in the embodiment of the present application one；
[0039] Fig. 5 is the flow chart of suction detection method in the embodiment of the present application two.
[0040]
[0041] specific embodiment
[0042] sample analyser is carrying out analysis inch to sample, and one of operation is sampling: acquiring sample, the reagent of predetermined amount from sample container, reagent container respectively by sampling mechanism.When sampling mechanism leads to the sample for not collecting predetermined amount or reagent inch for some reason (such as sample or reagent are finished), suction will cause, so as to cause the testing result inaccuracy to sample.
[0043] the application proposes a kind of sample analyser comprising sampling mechanism.Relative to traditional sampling mechanism, the sampling mechanism of the application takes a judgment mechanism to determine whether suction, to improve the accuracy of testing result in stock layout inch.It is further illustrated below by embodiment combination attached drawing.
[0044]
[0045] embodiment one
[0046] Fig. 1 and Fig. 2 are please referred to, the sampling mechanism of this implementation public affairs Jian includes sampling component 10, moving assembly 20, driving unit 30 and control unit 40.
[0047] sampling component 10 includes sampling needle 11 and detection module 12, sampling needle 11 is fixed on moving assembly 20, detection module 12 and sampling needle 11 are electrically connected, the variation of the physical quantity of real inch detection sampling needle 11, and it is converted into electric signal, more preferably, electric signal can be voltage signal.
[0048] there are many implementations for sampling needle 11, in the present embodiment, sampling needle 11 includes the double-level-metal syringe of inside and outside nesting: inner layer metal syringe 111 and outer layer metal syringe 112, wherein for drawing, facing inch storage and discharge sample or reagent (below might as well be all by taking sample as an example), outer layer metal syringe 112 is fixed on moving assembly 20 inner layer metal syringe 111.Inner layer metal syringe 111 and outer layer metal syringe 112 can be coaxially disposed and insulate between each other, therefore sampling needle 11 can be considered a capacitor, the difference and sampling needle 11 of the sample size that the capacitance of this capacitor can be stored by sampling needle 11 change due to whether contacting liquid level, therefore the variation that 11 physical quantity of sampling needle can be characterized with the capacitance of sampling needle 11 judges sampling needle by this variation and whether contacts liquid level and whether collect enough sample sizes.In order to detect the capacitance of sampling needle 11, the inner layer metal syringe 111 of sampling needle 11 and outer layer metal syringe 112 are electrically connected by a conducting wire with detection module 12 respectively.
[0049] also there are many implementations for detection module 12, in the present embodiment, detection module 12 is fixed on moving assembly 20 comprising oscillator 121, phase discriminator 122, reference signal device 123, filter 124 and analog-digital converter 1 25.Oscillator 121 is connected with the inner layer metal syringe 111 of sampling needle 11, outer layer metal syringe 112 with conducting wire, to the parametric device by sampling needle 11 as the resonance circuit of oscillator 121, that is the frequency of the pulse signal of the output of oscillator 121 can change with the variation of the physical quantity (such as capacitance) of sampling needle 11, when the capacitance of sampling needle 11 changes inch, oscillator 121 will generate the pulse signal of a corresponding frequencies, and be input in phase discriminator 122.Above-mentioned pulse signal and reference signal in reference signal device 123 are carried out after phase bit comparison output phase error signal to filter 124 by phase discriminator 122, output carries out modulus through filtered phase error signal to analog-digital converter 125,125 pairs of analog-digital converter after filter 124 is filtered phase error signal
An electric signal is exported after conversion for the acquisition of control unit 40, when oscillator 121 is voltage controlled oscillator inch, the electric signal that analog-digital converter 125 exports is voltage signal.
[0050] in order to successfully carry out inhaling sample and stock layout, sampling component 11 can also include syringe 13, the output end of syringe 13 is connected to by pipeline with the inner layer metal syringe 111 of sampling needle 11, driving unit 30 is coupled to the promote-side of syringe 13, to drive promote-side mobile.When promote-side is driven to outer drawing inch, sampling needle 11 carries out suction sample
, inch is pushed away in promote-side is driven to, sampling needle 11 carries out stock layout.
[0051] moving assembly 20 is three-dimensional or two-dimensional mobile mechanism, and the sampling needle being fixed thereon 11 can be driven to be moved in three-dimensional or two-dimensional directional, to make sampling needle 11 be moved to designated position to complete to inhale sample and stock layout operation.There are many implementations, such as rocker structure and linear slider guide rail structure etc. for moving assembly 20.
[0052] driving unit 30 is coupled to moving assembly 20, and driving moving assembly 20 is mobile, to drive sampling needle 11 mobile
[0053] control unit 40 is electrically connected with driving unit 30, driving control signal is sent to driving unit 30, after driving unit 30 receives driving control signal, drive moving assembly 20 mobile according to driving control signal to which sampling needle to be moved to specified position, or the promote-side of driving syringe 13 inwardly or outwardly moves a certain distance.Control unit 40 is also electrically connected with detection module 12, electric signal is acquired to 12 output circuit parameter of detection module and from detection module 12, control unit 40 judges whether suction amount reaches predetermined amount according to the fiducial value of collected first electric signal and the second electric signal, wherein, first electric signal is the electric signal that detection module 12 exports before sampling needle 11 executes stock layout, specifically, first electric signal can be moved to the electric signal that behind reaction cup position and control unit 40 is acquired from detection module 12 before executing stock layout for sampling needle 11, second electric signal be 11 stock layout of sampling needle after detection module 12 export electric signal, specifically, second electric signal can be the control unit after stock layout of stock layout position of sampling needle 11 40 electric signals acquired from detection module 12, stock layout position is that sampling needle 11 executes stock layout operation inch position into reaction cup, sampling needle executes stock layout and operates inch, the position of a certain height in reaction cup should be located at, the position is known as stock layout position, stock layout position is different according to detection project and the difference of concrete operations so that sampling needle 11 before stock layout in air, after stock layout under the liquid level of reaction cup.The second electric signal collected in this way, more easily judges with the fiducial value of the first electric signal.As described above, control unit 40 judges whether suction amount reaches predetermined amount according to the fiducial value of collected first electric signal and the second electric signal, in this judgment mechanism, control unit 40 can be greater than or equal to a given threshold inch in above-mentioned fiducial value, think that suction amount reaches predetermined amount, otherwise it is assumed that suction amount is not up to the i.e. sampling mechanism suction of predetermined amount.For convenience
Quickly judged, above-mentioned fiducial value can be the difference or ratio of the first electric signal and the second electric signal.
[0054] above content is the sampling mechanism of the present embodiment public affairs Jian, correspondingly, a kind of sampling mechanism suction detection method (hereinafter referred to as suction detection method) of the present embodiment also public affairs Jian, below with reference to Fig. 3,4 detailed descriptions.
[0055] step S100 inhales sample.Referring to figure 4., the sample tube 50 for containing sample is placed in figure on sample rack 51, the reaction cup 52 for containing sample and reagent is placed in reaction tray 53, sample and reagent carry out incubation reaction after being successively injected into reaction cup 52, in the present embodiment, reaction cup 52 uses disposal reaction cup, to avoid reaction cup bottom residual liquid, to influence following detection.Sample operation inch is inhaled executing, driving unit 30 is mobile according to the driving control signal driving moving assembly 20 that control unit 40 issues, driving sampling needle 11 to carry out, horizontal, vertical direction is mobile, the lower end (one end not connecting with syringe 13) of sampling needle 11 is set to be moved to the liquid level in sample tube 50, driving unit 30 pulls out a distance further according to the promote-side for the driving control signal driving syringe 13 that control unit 40 issues, a suction is generated, sampling needle 11 is made to draw the sample of predetermined amount.The driving control signal driving moving assembly 20 that driving unit 30 is issued further according to control unit 40 is mobile, and sampling needle 11 is made to be moved upwards up to 50 top of sample tube, inhales sample operation and is finished.
[0056] step S201: prepare stock layout.After sampling needle 11 inhales sample, from the position inhaled and be moved to where executing the reaction cup 50 that stock layout operates above the sample tube 50 that sample operates is executed, control sampling needle 11 stops above reaction cup after being moved to reaction cup position；
[0057] step S202: control unit 40 acquires current electric signal as the first electric signal from detection module 12.In order to steadily collect the first electric signal, control sampling needle 11 stops such as 200 microseconds between one section of inch above reaction cup 52, and control unit 40 detects current electric signal as the first electric signal from detection module 12 in this 200 microsecond.
[0058] step S203: control sampling needle 11 is moved down into stock layout position above reaction cup, executes stock layout.After sampling needle 11 is moved down into stock layout position above reaction cup 52, driving unit 30 drives the promote-side of syringe 13 inwardly to promote a distance, generates a thrust, and sampling needle 11 is made to inject the sample of predetermined amount to reaction cup 52, completes stock layout.
[0059] step S204: after stock layout between stock layout position stops predetermined inch, such as 200 microseconds, control unit acquires current electric signal as the second electric signal from detection module 12 during this period.
[0060] step S210: the first electric signal and the second electric signal are compared, and judge whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal.In a specific example, control unit 40 calculates the
The difference of one electric signal and the second electric signal, when difference is greater than or equal to given threshold inch, make the judgement that suction amount reaches predetermined amount, illustrate that this operation is normal and inhales sample and/or stock layout success, otherwise the judgement that suction amount is not up to predetermined amount is made, illustrates this operation suction and/or stock layout failure.In the specific example having, control unit 40 can also calculate the ratio of the first electric signal and the second electric signal, according to ratio in judgement whether suction.When judging that suction amount reaches predetermined amount inch, continue to execute step S301, execute next operation (such as inhaling reagent or stirring operation), when judging that suction amount is not up to predetermined amount and causes suction inch, execute step S302, it alarms, the operation of sampling needle can also be suspended in the same inch of alarm.
[0061] sampling mechanism and its suction detection method, sample analyser of this implementation public affairs Jian, the two inch are carved respectively to acquire the first electric signal and the second electric signal before and after sampling needle stock layout, in addition to solving the problem of that easily causing the case where suction sample is failed to report in the prior art can also solve when sample to be that gel inch is not easy to judge whether normally to inhale sample and stock layout.
[0062]
[0063] embodiment two
[0064] on the basis of embodiment one, the sampling mechanism and its suction detection method, sample analyser of the present embodiment public affairs Jian, the two inch, which are carved, before and after inhaling sample also acquires two electric signals for judging it is normally to inhale sample or suction, is specifically described below.
[0065] on the basis of example 1, 40-the aspect of control unit of the present embodiment tentatively judges whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal, on the other hand tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of third electric signal and the 4th electric signal, and go out whether suction amount reaches predetermined amount according to the result comprehensive descision tentatively judged twice, specifically, control unit 40 is once not up to predetermined amount inch in preliminary judging result twice for suction amount, then think that suction amount is not up to predetermined amount (i.e. suction)
, all it is that suction amount reaches predetermined amount inch in preliminary judging result twice, then it is assumed that suction amount has reached predetermined amount；Wherein, first electric signal is the electric signal that detection module 12 exports before sampling needle 11 executes stock layout, second electric signal be 11 stock layout of sampling needle after detection module 12 export electric signal, third electric signal be sampling needle 11 execute inhale sample before detection module 12 export electric signal, the 4th electric signal be sampling needle 11 inhale sample after detection module 12 export electric signal.
[0066] its specific detection process is as shown in figure 5, include the following steps.
[0067] before sampling needle 11 executes and inhales sample, detection module 12 detects the physical quantity of sampling needle 11, exports third telecommunications
Number, specifically comprising step S 101, S102:
[0068] step S101: control sampling needle 11 is moved to sample tube position and stops above sample tube；
[0069] step S102: current electric signal is acquired as third electric signal from detection module 12.
[0070] after sampling needle 11 inhales sample, detection module 12 detects the physical quantity of sampling needle, exports the 4th electric signal, specifically comprising step S 103, S104:
[0071] step S103: control sampling needle 11 is moved down into above sample tube 50 inhales sample position, it executes and inhales sample, it inhales sample position and refers to that sampling needle 11 executes the position for inhaling sample operation in sample tube 50, sample position is inhaled according to the sample size and suction amount determination in sample tube 50, it makes sampling needle 11 after inhaling sample position and executing suction sample, is still under liquid level
[0072] step S104: between stopping predetermined inch after inhaling sample, current electric signal is acquired as the 4th electric signal from detection module 12 during this period.
[0073] step S110: tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of third electric signal and the 4th electric signal.Judgment method can be identical as the step S210 in embodiment one.When judging that suction amount reaches predetermined amount inch, continue to execute step S201, prepare stock layout, and continue to execute step S202-S210, the first electric signal and the second electric signal are acquired from detection module 12 before and after stock layout respectively, and judging whether suction, the particular content of each step is the same as example 1, and details are not described herein；When judging that suction amount is not up to predetermined amount and causes suction inch, step S302 is executed, is alarmed.
[0074] the present embodiment acquires electric signal before and after inhaling sample and carries out the first time judgement whether suction amount reaches predetermined amount, electric signal is acquired before and after stock layout carries out second of the judgement whether suction amount reaches predetermined amount, it is being judged as suction inch for the first time, it just alarms, and stops next stock layout operation and judge for second.In further embodiments, it can also be judged as the first time suction inch, without alarm, and it is to continue with next stock layout and second of judgement, after making second of judgement, then it is comprehensive judge for the first time as a result, if the result once judged is just alarmed as suction, only when judging result twice is all that pipette sample reaches predetermined amount inch, next operation is just continued to execute.
[0075] the present embodiment is before and after inhaling sample and before and after stock layout, all progress suction amount judgements for whether reaching predetermined amount, and the comprehensive result judged twice makes final judgement, compares embodiment one, the result of judgement is relatively reliable
[0076] use above specific case is illustrated the present invention, is merely used to help understand the present invention, not to
The limitation present invention.For those of ordinary skill in the art, according to the thought of the present invention, above-mentioned specific embodiment can be changed.
Technical problem
Solution to the problem
Advantageous effect of the invention
Claims (1)
- ClaimsA kind of [claim 1] sampling mechanism, characterized by comprising:Moving assembly (20)；Sampling component (10), the sampling component (10) includes sampling needle (11) and detection module (12), the sampling needle (11) is fixed on moving assembly (20), detection module (12) and sampling needle (11) electrical connection, the variation of the physical quantity of real inch detection sampling needle (11), and be converted to electric signal；Driving unit (30) is coupled to moving assembly (20), and driving moving assembly (20) is mobile, to drive sampling needle (11) mobile；Control unit (40), it is electrically connected with driving unit (30), driving control signal is sent to driving unit (30), described control unit (40) is also electrically connected with detection module (12), electric signal is acquired from detection module (12), described control unit (40) judges whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal, first electric signal is the electric signal that detection module (12) exports before sampling needle (11) execute stock layout, second electric signal be sampling needle (11) stock layout after detection module (12) export electric signal.[claim 2] sampling mechanism as described in claim 1, it is characterized in that, described control unit (40) is greater than or equal to given threshold inch in the fiducial value, it is believed that suction amount reaches predetermined amount, otherwise it is assumed that suction amount is not up to predetermined amount.[claim 3]-kind of sampling mechanism, characterized by comprising:Moving assembly (20)；Sampling component (10), the sampling component (10) includes sampling needle (11) and detection module (12), the sampling needle (11) is fixed on moving assembly (20), detection module (12) and sampling needle (11) electrical connection, the variation of the physical quantity of real inch detection sampling needle (11), and be converted to electric signal；Driving unit (30) is coupled to moving assembly (20), and driving moving assembly (20) is mobile, to drive sampling needle (11) mobile；Control unit (40) is electrically connected with driving unit (30), sends driving control signal to driving unit (30), and described control unit (40) is also electrically connected with detection module (12), Electric signal is acquired from detection module (12), described control unit (40)-aspect tentatively judges whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal, on the other hand tentatively judge whether suction amount reaches predetermined amount according to the fiducial value of third electric signal and the 4th electric signal, and go out whether suction amount reaches predetermined amount according to the result comprehensive descision tentatively judged twice, first electric signal is the electric signal that detection module (12) exports before sampling needle (11) execute stock layout, second electric signal be sampling needle (11) stock layout after detection module (12) export electric signal, the third electric signal is that sampling needle (11) execute detection module (12) output before inhaling sample Electric signal, the 4th electric signal be sampling needle (11) inhale sample after detection module (12) export electric signal.[claim 4] sampling mechanism as claimed in claim 3, it is characterized in that, described control unit (40) is once not up to predetermined amount inch in preliminary judging result twice for suction amount, then think that suction amount is not up to predetermined amount, it is all that suction amount reaches predetermined amount inch in preliminary judging result twice, then it is assumed that suction amount has reached predetermined amount.[claim 5] such as sampling mechanism of any of claims 1-4, which is characterized in that the variation of the physical quantity of the sampling needle refers to the variation of sampling needle capacitor, and the electric signal is voltage signal.[claim 6] such as sampling mechanism of any of claims 1-4, it is characterized in that, first electric signal is the electric signal that sampling needle (11) are moved to that behind reaction cup position and control unit (40) is acquired from detection module (12) before executing stock layout, and second electric signal is sampling needle (11) electric signal that control unit (40) is acquired from detection module (12) after the stock layout of stock layout position[claim 7] such as sampling mechanism of any of claims 1-4, which is characterized in that sampling needle (11) it include inside and outside nested double-level-metal syringe, the double-level-metal syringe insulate each other and is electrically connected to detection module (12) by conducting wire respectively, and the detection module (12) is fixed on moving assembly (20)；The sampling component (10) further includes syringe (13), the output end of the syringe (13) is connected to by pipeline with the internal layer syringe of sampling needle (11), the driving unit (30) is coupled to the promote-side of syringe (13), and driving promote-side is mobile.[claim 8]-kind of sampling mechanism suction detection method, the sampling mechanism include sampling needle (11) and detection module (12), and detection module (12) and sampling needle (11) are electrically connected, detection module (12 ) real inch detection sampling needle (11) physical quantity variation, and be converted to electric signal, it is characterised in that the described method includes:Before sampling needle (11) execute stock layout, detection module (12) detects the physical quantity of sampling needle (11), exports the first electric signal；After sampling needle (11) stock layout, detection module (12) detects the physical quantity of sampling needle (11), exports the second electric signal；Judge whether suction amount reaches predetermined amount according to the fiducial value of the first electric signal and the second electric signal.A kind of [claim 9] sampling mechanism suction detection method, the sampling mechanism includes sampling needle (11) and detection module (12), detection module (11) and sampling needle (12) electrical connection, the variation of the physical quantity of detection module (12) reality inch detection sampling needle (11), and be converted to electric signal, it is characterised in that the described method includes:Before sampling needle (11) execute and inhale sample, detection module (12) detects the physical quantity of sampling needle (11), exports third electric signal；After sampling needle (11) inhale sample, detection module (12) detects the physical quantity of sampling needle, exports the 4th electric signal；Before tentatively judging whether suction amount reaches pre- settled sampling needle (11) execution stock layout according to the fiducial value of third electric signal and the 4th electric signal, detection module (12) detects the physical quantity of sampling needle (11), exports the first electric signal；After sampling needle (11) stock layout, detection module (12) detects the physical quantity of sampling needle (11), exports the second electric signal；Tentatively judge whether suction amount reaches predetermined and go out whether suction amount reaches predetermined amount according to the result comprehensive descision tentatively judged twice according to the fiducial value of the first electric signal and the second electric signal.[claim 10] method as claimed in claim 8 or 9, which is characterized in that the variation of the physical quantity of the sampling needle refers to the variation of sampling needle capacitor, and the electric signal is voltage signal.[claim 11] method as claimed in claim 8 or 9, which is characterized in thatThe detection process of first electric signal and the second electric signal includes: Control sampling needle (11) is moved to reaction cup position and stops above reaction cup；Current electric signal is acquired as the first electric signal from detection module (12)；Control sampling needle (11) is moved down into stock layout position, executes stock layout；Between stopping predetermined inch after stock layout, current electric signal is acquired as the second electric signal from detection module (12) during this period.[claim 12]-kind of sample analyser, which is characterized in that including the sampling mechanism as described in any one of claims 1 to 7.
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| PCT/CN2015/083976 WO2017008249A1 (en) | 2015-07-14 | 2015-07-14 | Sampling mechanism, skipped-vacuum testing method therefor, and sample analyzer |
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| CN107709958A true CN107709958A (en) | 2018-02-16 |
| CN107709958B CN107709958B (en) | 2020-04-14 |
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| CN114166830A (en) * | 2021-12-08 | 2022-03-11 | 苏州长光华医生物医学工程有限公司 | Sampling needle pipeline and sampling judgment method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109030096A (en) * | 2018-06-06 | 2018-12-18 | 迈克医疗电子有限公司 | Take liquid test method and device |
| CN109030098A (en) * | 2018-06-06 | 2018-12-18 | 迈克医疗电子有限公司 | Take liquid test method and device |
| CN109030097B (en) * | 2018-06-06 | 2023-04-18 | 迈克医疗电子有限公司 | Liquid taking test method and device |
| WO2021223168A1 (en) * | 2020-05-07 | 2021-11-11 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer, sample analysis method, and computer-readable storage medium |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2588334Y (en) * | 2002-12-27 | 2003-11-26 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detector for biochemical analysis |
| JP2005249521A (en) * | 2004-03-03 | 2005-09-15 | Yaskawa Electric Corp | Dispenser and dispensing method |
| CN101135584A (en) * | 2006-08-31 | 2008-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Detecting probe liquid level detector and method |
| CN101858770A (en) * | 2009-04-09 | 2010-10-13 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection device and sample adding system |
| CN101865718A (en) * | 2009-04-17 | 2010-10-20 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection circuit, device and calibration method thereof |
| CN101881706A (en) * | 2010-07-05 | 2010-11-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling device and method |
| CN103900997A (en) * | 2012-12-28 | 2014-07-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser and method and device for detecting liquor drainage of sampling needle |
| CN104111102A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, liquid level detection device and immunity analyzer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7191647B2 (en) * | 2003-10-30 | 2007-03-20 | Perkinelmer Las, Inc. | Method and apparatus to reject electrical interference in a capacitive liquid level sensor system |
| JP5200126B2 (en) * | 2011-02-02 | 2013-05-15 | ベックマン コールター， インコーポレイテッド | Liquid level contact detection method and apparatus |
-
2015
- 2015-07-14 WO PCT/CN2015/083976 patent/WO2017008249A1/en active Application Filing
- 2015-07-14 CN CN201580081158.9A patent/CN107709958B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2588334Y (en) * | 2002-12-27 | 2003-11-26 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detector for biochemical analysis |
| JP2005249521A (en) * | 2004-03-03 | 2005-09-15 | Yaskawa Electric Corp | Dispenser and dispensing method |
| CN101135584A (en) * | 2006-08-31 | 2008-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Detecting probe liquid level detector and method |
| CN101858770A (en) * | 2009-04-09 | 2010-10-13 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection device and sample adding system |
| CN101865718A (en) * | 2009-04-17 | 2010-10-20 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection circuit, device and calibration method thereof |
| CN101881706A (en) * | 2010-07-05 | 2010-11-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling device and method |
| CN103900997A (en) * | 2012-12-28 | 2014-07-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser and method and device for detecting liquor drainage of sampling needle |
| CN104111102A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, liquid level detection device and immunity analyzer |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110221090A (en) * | 2019-06-21 | 2019-09-10 | 苏州长光华医生物医学工程有限公司 | A kind of anti-suction of applied chemistry luminescence analyzer, idle discharge system and method |
| CN111812343A (en) * | 2020-07-02 | 2020-10-23 | 桂林优利特医疗电子有限公司 | Liquid path system based on immunoturbidimetry measurement and control method thereof |
| CN114441279A (en) * | 2020-10-30 | 2022-05-06 | 深圳市瑞图生物技术有限公司 | Sample sampling and mixing device, mixing control method and sperm quality analyzer |
| CN114166830A (en) * | 2021-12-08 | 2022-03-11 | 苏州长光华医生物医学工程有限公司 | Sampling needle pipeline and sampling judgment method |
| CN114166830B (en) * | 2021-12-08 | 2023-07-14 | 苏州长光华医生物医学工程有限公司 | Sampling needle pipeline and sampling judgment method |
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|---|---|
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| CN107709958B (en) | 2020-04-14 |
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