CN109030097B - Liquid taking test method and device - Google Patents
Liquid taking test method and device Download PDFInfo
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- CN109030097B CN109030097B CN201810574689.7A CN201810574689A CN109030097B CN 109030097 B CN109030097 B CN 109030097B CN 201810574689 A CN201810574689 A CN 201810574689A CN 109030097 B CN109030097 B CN 109030097B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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Abstract
The application provides a liquid taking testing method and device, and relates to the technical field of biological medical treatment. The liquid extraction testing method comprises the following steps: acquiring measurement parameters of the probe in the primary liquid taking process, wherein the measurement parameters are parameters causing signal change of the probe; and determining whether the liquid taking in the primary liquid taking process is successful or not according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter at the default liquid taking end moment and the variation of the measurement parameter at the moment after the default liquid taking end moment. By using the technical scheme of the application, the misjudgment rate for judging whether the probe is successful in liquid taking can be reduced.
Description
Technical Field
The invention relates to the field of biomedical treatment, in particular to a liquid taking testing method and device.
Background
In the biomedical field, various types of experiments are often required. During the course of the experiment, it was necessary to suck up the liquid from the liquid-holding container. Specifically, a probe for sucking liquid in the liquid sucking device is driven by a motor to move downwards or upwards in the liquid containing container. To prevent the probe from hitting the bottom of the liquid container and sucking unnecessary liquid, the probe sucks the liquid when the probe touches the liquid level of the liquid in the liquid container. After the liquid is sucked up by the probe, the liquid is transferred to other containers and discharged.
In the actual operation of liquid suction, factors such as bubbles, static electricity, electromagnetic interference, distributed capacitance and the like often exist, so that the probe is judged to be contacted with the liquid level by mistake when not contacted with the liquid level, the liquid taking failure is judged to be successful by mistake, and the misjudgment rate of the liquid taking success is higher. At the present stage, in order to reduce the misjudgment rate of successful liquid taking, the liquid suction device can record the position of the liquid level contacted by the probe each time. And judging whether the current probe is in contact with the liquid level or not by comparing the current probe position with the recorded last probe contact position on the liquid level. If the difference distance between the two positions exceeds a reasonable threshold value, the current probe is determined not to contact the liquid level, the liquid taking is not successful, and the misjudgment is generated. However, in a case where only one liquid extraction is required and a case where the liquid extraction is performed for the first time, since the probe does not come into contact with the liquid surface in the previous time, it is impossible to determine whether or not the current probe has succeeded in extracting the liquid, and the erroneous determination rate is still high.
Disclosure of Invention
The embodiment of the invention provides a liquid taking test method and device, which can reduce the misjudgment rate of judging whether the probe successfully takes liquid or not.
In a first aspect, the present invention provides a liquid extraction testing method, comprising: acquiring measurement parameters of the probe in a primary liquid taking process, wherein the measurement parameters are parameters causing signal change of the probe; and determining whether the liquid taking in the primary liquid taking process is successful or not according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter at the default liquid taking end moment and the variation of the measurement parameter at the moment after the default liquid taking end moment.
In a second aspect, the present invention provides a liquid taking test apparatus, comprising a probe and a liquid taking test circuit; the probe is used for taking liquid; the liquid taking test circuit is used for obtaining a measurement parameter of the probe in a liquid taking process at one time, and the measurement parameter is a parameter causing the signal change of the probe; and the device is used for determining whether the liquid taking is successful in the primary liquid taking process according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the measurement parameter at the default liquid taking end time and the variation of the measurement parameter at the time after the default liquid taking end time.
The invention provides a liquid taking test method and a liquid taking test device, which are used for determining whether liquid taking is successful in the liquid taking process by utilizing the variable quantity and the judgment threshold value in the liquid taking process at one time. The variation in the liquid extraction process includes a measurement parameter at a default liquid extraction end time and a variation in a measurement parameter at a time after the default liquid extraction end time. In the scene that the situation that the probe does not contact the liquid level is judged to be the situation that the probe contacts the liquid level or the situation that the liquid is not taken by the probe is insufficient, the measurement parameter at the liquid taking end time is close to the measurement parameter at the time after the liquid taking end time, and judgment can be carried out by utilizing the judgment threshold value, so that misjudgment is avoided, and the misjudgment rate of judging whether the liquid is taken by the probe successfully is reduced. Moreover, the liquid taking test method is suitable for both a scene only requiring single liquid taking and a scene requiring initial liquid taking, and can reduce the misjudgment rate of judging whether the probe is successful in liquid taking.
Drawings
The present invention will be better understood from the following description of specific embodiments thereof taken in conjunction with the accompanying drawings, in which like or similar reference characters designate like or similar features.
FIG. 1 is a schematic diagram of an application scenario according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing a relationship between oscillation frequency and time of a probe signal during a liquid extraction process according to an embodiment of the present invention;
FIG. 3 is a diagram illustrating a variation of oscillation frequency of a probe signal with respect to time during a liquid extraction process according to an embodiment of the present invention;
FIG. 4 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention;
FIG. 5 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention;
FIG. 6 is a flow chart of a fluid extraction testing method according to an embodiment of the present disclosure;
FIG. 7 is a schematic structural diagram of a liquid sampling testing apparatus according to an embodiment of the present disclosure;
fig. 8 is a schematic hardware structure diagram of a liquid extraction device in an embodiment of the present invention.
Detailed Description
Features and exemplary embodiments of various aspects of the present invention will be described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the present invention by illustrating examples of the present invention. The present invention is in no way limited to any specific configuration and algorithm set forth below, but rather covers any modification, replacement or improvement of elements, components or algorithms without departing from the spirit of the invention. In the drawings and the following description, well-known structures and techniques are not shown in order to avoid unnecessarily obscuring the present invention.
References in the present application to "one embodiment," "an embodiment," "various embodiments," "an example," etc., indicate that the embodiment(s) or example(s) described may include a particular feature, structure, or characteristic, but every embodiment or example need not necessarily include the particular feature, structure, or characteristic. Moreover, repeated usage of the phrase "in one example" does not necessarily refer to the same example, although it may.
The liquid taking test method, the liquid taking test device, the liquid taking equipment and the storage medium provided by the embodiment of the invention can be applied to scenes in which liquid is required to be taken for experiments or experiments in the fields of biology, medicine, chemistry, physics and the like. Fig. 1 is a schematic view of an application scenario in an embodiment of the present invention. As shown in fig. 1, the probe of the liquid taking test device moves up and down under the control of the liquid taking test circuit, and sucks the liquid (i.e., the liquid taking) in the liquid container. In the process of one-time liquid taking, the probe gradually descends from the upper part of the liquid until a part of the probe is immersed into the liquid, and the probe stops moving to take the liquid. When the preset liquid taking time is reached or the quantity of the obtained liquid reaches a preset quantity, the probe finishes liquid taking and gradually rises until the position of the probe is reset to the position when the liquid taking process is started.
In the liquid taking process, the liquid taking testing device can judge whether the probe contacts the liquid level according to the change of the probe signal. In the process that the probe does not contact the liquid level, the probe always moves in a certain medium (air in the embodiment of the invention), and the signal of the probe has no change or has small change. After the probe contacts the liquid surface and before the probe leaves the liquid surface, the head of the probe stays or moves in a certain medium (which can be liquid in the embodiment of the invention), and the signal of the probe has no change or has small change.
During the process from the probe never contacting the liquid surface to the probe contacting the liquid surface, the probe signal suddenly changes greatly (i.e. changes suddenly) to generate large fluctuation due to the head of the probe entering from one medium (air in the embodiment of the present invention) to another medium (liquid in the embodiment of the present invention). However, due to the influence of external factors, such as air bubbles, static electricity, electromagnetic interference, distributed capacitance, etc., the probe signal may suddenly change greatly (i.e., suddenly change), resulting in large fluctuation. Under the influence of external factors, the probe is not contacted with the liquid level, and the probe is possibly mistakenly judged to be contacted with the liquid level. After the misjudgment occurs, the probe starts to take liquid under the condition that the probe does not contact the liquid level, so that the liquid taking fails. Or, the distance of the probe entering the liquid level is not matched with the preset liquid taking amount, so that the probe is separated from the liquid level in the liquid taking process, and the liquid taking is insufficient. Insufficient liquid extraction is an embodiment of liquid extraction failure.
In one example, the mutation in the probe signal can be embodied as a mutation in the oscillation frequency of the probe signal. For example, fig. 2 is a schematic diagram illustrating a relationship between oscillation frequency of a probe signal and time in a liquid extraction process according to an embodiment of the present invention. As shown in fig. 2, noise is taken as an external factor. Noise can cause the oscillation frequency to suddenly change. The probe enters the liquid from the air and the probe enters the air from the liquid, both of which cause the oscillation frequency to change abruptly. Therefore, noise and probe pipetting success during pipetting are difficult to distinguish.
Fig. 3 is a schematic diagram illustrating a relationship curve between a variation of an oscillation frequency of a probe signal and time in a liquid extraction process according to an embodiment of the present invention. As shown in fig. 3, in the course of one successful liquid extraction, when the probe contacts the liquid surface, the change amount of the oscillation frequency of the probe signal changes abruptly. And in the process that the probe enters the liquid level and takes the liquid, the variation of the oscillation frequency of the probe signal is gradually reduced until the oscillation frequency returns to zero. When the probe leaves the liquid surface, the amount of change in the oscillation frequency of the probe signal changes abruptly again. And in the process of rising and resetting the probe away from the liquid level, the variation of the oscillation frequency of the probe signal is gradually reduced until the oscillation frequency returns to zero.
Fig. 4 is a schematic diagram illustrating a variation of oscillation frequency of a probe signal in a liquid extraction process according to another embodiment of the present disclosure. As shown in fig. 4, if the probe successfully takes the liquid, the EG section is the stage of the probe base liquid level; the GH section is a stage of taking liquid by a probe; the HI section is the stage where probe draw successfully exits the liquid. However, if the probe draw does not reach the standard amount, it is removed from the liquid level, and as can be seen from FIG. 4, a sudden change in the amount of change in the oscillation frequency occurs in the GH section (i.e., before the HI section) where the amount of change in the oscillation frequency does not suddenly change.
FIG. 5 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention. As shown in fig. 5, if the probe successfully takes the liquid, the EG section is the stage of the probe base liquid level; the GH section is a stage of taking liquid by a probe; the HI section is the stage where probe draw successfully exits the liquid. However, if the oscillation frequency of the probe signal is affected by external factors such as noise, the amount of change in the oscillation frequency of the probe signal changes abruptly even when the probe does not contact the liquid surface. Or, if the time for taking the liquid by the probe is too short, the oscillation frequency of the probe signal is not recovered in the process from the end of taking the liquid by the probe to the separation of the probe from the liquid surface, so that the variation of the oscillation frequency of the probe signal in the process from the end of taking the liquid by the probe to the separation of the probe from the liquid surface is small. As can be seen from fig. 5, however, in the HI section, the amount of change in the oscillation frequency does not change abruptly.
According to the liquid taking test method, the device, the equipment and the storage medium provided by the embodiment of the invention, whether liquid taking is successful in the liquid taking process is determined according to the variable quantity and the judgment threshold value of the measurement parameter in the one-time liquid taking process. Whether the liquid extraction is successful or not in the liquid extraction process can be judged more accurately, so that the misjudgment of the successful liquid extraction is avoided, and the misjudgment rate of the successful liquid extraction judgment is reduced. It should be noted that "mutation" in the following examples refers to an increase or decrease in a measured parameter over a period of time exceeding a threshold value.
Fig. 6 is a flowchart of a liquid extraction testing method according to an embodiment of the present invention. As shown in fig. 6, the liquid extraction testing method includes steps S101 to S102.
In step S101, measurement parameters of the probe in one liquid extraction process are acquired.
Wherein the measured parameter is a parameter that causes a change in the signal of the probe. Such as one or more of capacitance, resistance, inductance, pressure, oscillation frequency of the probe signal. In the process that the probe enters liquid from air, the capacitance, the resistance, the inductance and the pressure of the probe all generate mutation, and the mutation of the capacitance, the resistance, the inductance and the pressure of the probe can be embodied as the mutation of the oscillation frequency of a probe signal. To facilitate the recording of observations and determinations, the oscillation frequency of the probe signal can be monitored and acquired. For example, the change of the capacitance value of the probe with respect to ground can be converted into the oscillation frequency of the probe signal or the charge-discharge time in the oscillation cycle of the probe signal, which is easier to monitor, according to the RC oscillator principle, and the capacitance is inversely proportional to the oscillation frequency. For another example, the change in the capacitance value of the probe with respect to ground can be converted into an oscillation frequency of the probe signal or a charge/discharge time in an oscillation cycle of the probe signal, which is easier to monitor, according to the LC oscillator principle.
The probe obtains measurement parameters for many times in the process of one-time liquid taking. In one example, the period for acquiring the measurement parameter may be set, for example, the period for acquiring the measurement parameter is set to 10 milliseconds, and the liquid taking test device acquires the measurement parameter every 10 milliseconds in the liquid taking process.
In step S102, it is determined whether the liquid extraction in the primary liquid extraction process is successful according to the variation of the measurement parameter in the primary liquid extraction process and the determination threshold.
In the process of one-time liquid taking, the difference value of the measurement parameters at any two moments is the variation of the measurement parameters at the two moments. The variation in the one-time liquid extraction process includes a variation in the measurement parameter at the default liquid extraction end time and a variation in the measurement parameter at a time subsequent to the default liquid extraction end time. The default tapping end time will be specifically described in the following example. The decision threshold is used to assist in determining whether the fluid draw was successful during the fluid draw process. The determination threshold may be set according to a work scenario and a work requirement, and is not limited herein.
In one example, a tapping process includes a default non-contact level time, a default contact level time, and a default tapping end time. Wherein the default liquid extraction end time is the default time of the probe liquid extraction end. During one liquid taking process, when the measurement parameter changes suddenly for the first time, the default probe contacts the liquid level, but actually, whether the probe contacts the liquid level cannot be determined at this time. The probe is controlled to draw fluid at or after the default probe contacts the fluid level. And recording the moment when the liquid taking time length reaches the preset liquid taking time length as the default liquid taking finishing moment. The default non-contact time is the time when the probe has not contacted the liquid surface. The default contact time is the default contact time of the probe with the liquid surface. In the process of taking liquid once, when the measurement parameters are mutated for the first time, the default probe contacts the liquid level. The time before the first sudden change in the measured parameter can be recorded as the default non-contact level time. The moment when the measurement parameter changes suddenly for the first time in the liquid taking process can be recorded as the default liquid level contact moment.
In this example, the variation in the liquid extraction process includes a first variation and a second variation. The first variation and the second variation are positive values. The first variable quantity is the variable quantity of the measurement parameter at the first judgment moment and the measurement parameter at the default liquid taking ending moment. The first judgment time is a certain time after the default liquid taking finishing time in the primary liquid taking process. After the default liquid taking end time, the measurement parameters can be acquired periodically. And the time of acquiring the measurement parameters every time after the default liquid taking finishing time can be used as the first judgment time. At each first judgment moment, whether the liquid extraction is successful can be judged. The first variation may specifically be an absolute value of a difference between the measurement parameter at the first determination time and the measurement parameter at the default liquid extraction end time. The second variation is the variation of the measurement parameter at the time of not contacting the liquid level by default and the variation of the measurement parameter at the time of contacting the liquid level by default. The second variation may specifically be an absolute value of a difference between the measured parameter at the time of the default non-contact with the liquid level and the measured parameter at the time of the default contact with the liquid level. The default non-liquid-level-contact time and the default liquid-level-contact time are both times in the process of detecting the liquid level by descending the probe. That is, the second variation is a variation obtained in the process of the probe descending to detect the liquid level.
The decision threshold comprises an error adjustment threshold. And considering the influence factors such as the distributed capacitance and the like in the liquid taking testing device, and setting an error adjusting threshold value, thereby further improving the accuracy of the judgment of whether the liquid taking is successful or not on the premise of not influencing the successful judgment of the liquid taking. The error adjusting threshold is an error value which can be received whether the liquid is taken successfully or not. The error adjustment threshold may be specifically set according to a working scenario and a working requirement, and is not limited herein. For example, the error adjustment threshold may be a maximum fluctuation value of background noise, i.e., background noise, of the liquid taking test device.
And if the difference value between the first variable quantity and the error adjusting threshold is smaller than or equal to the second variable quantity, and the sum of the first variable quantity and the error adjusting threshold is larger than or equal to the second variable quantity, determining that the liquid taking is successful. And if the difference value between the first variable quantity and the error adjusting threshold is larger than the second variable quantity, or the sum of the first variable quantity and the error adjusting threshold is smaller than the second variable quantity, determining that the liquid extraction fails.
For example, the measurement parameter at the first determination time is F1, the measurement parameter at the default liquid extraction end time is F2, the second variation amount is F3, and the error adjustment threshold value is F4. Then, if F1, F2, F3 and F4 satisfy the following relational expression (1), it is determined that the liquid extraction is successful. If F1, F2, F3 and F4 do not satisfy the following relation (1), it is determined that the liquid extraction has failed.
F1-F2-F4≤F3≤F1-F2+F4(1)
For example, the measured parameter is the oscillation frequency of the probe signal. The error adjustment threshold F4 is 0.002MHz. The oscillation frequency F1 of the acquired probe signal at the first determination time is 3.976MHz, the oscillation frequency F2 of the probe signal at the default liquid-taking completion time is 3.956MHz, and the second variation F3 is 0.019MHz. The success of liquid taking is determined because 3.976MHz-3.956MHz-0.002MHz < 0.019MHz < 3.976MHz-3.956MHz + 0.002MHz. The oscillation frequency F1 of the probe signal at the first determination time obtained is 3.976MHz. The oscillation frequency F2 of the probe signal at the liquid extraction completion time is 3.974MHz. The second variation F3 is 0.019MHz. . Since 3.976MHz-3.974MHz +0.002MHz < 0.019MHz, it is determined that the liquid extraction failed.
The difference value between the first variable quantity and the error adjusting threshold is smaller than or equal to the second variable quantity, which indicates that the variable quantity of the measurement parameter at the first judgment moment and the measurement parameter at the default liquid taking ending moment is similar to the variable quantity of the measurement parameter at the default liquid level non-contact moment and the measurement parameter at the default liquid level contact moment. The difference value between the first variable quantity and the error adjusting threshold is larger than the second variable quantity, which indicates that the difference between the variable quantity of the measurement parameter at the first judgment moment and the variable quantity of the measurement parameter at the default liquid taking ending moment is larger than the difference between the variable quantity of the measurement parameter at the default liquid level non-contact moment and the variable quantity of the measurement parameter at the default liquid level contact moment.
If the liquid is successfully taken in the liquid taking process, the head part of the probe is in the air at the moment of not contacting the liquid level by default, and the head part of the probe is in the liquid at the moment of contacting the liquid level by default. The head of the probe is still in the liquid at the default liquid taking end time, and the head of the probe is in the air at the first judgment time. The measurement parameters are subject to sudden changes at the moment the probe head enters and leaves the liquid. I.e. the first variation should be similar to the second variation.
Conversely, if the liquid extraction fails due to misjudgment that the probe contacts the liquid level when the probe does not contact the liquid level in the liquid extraction process, the head of the probe is in the air at the moment of default non-contact with the liquid level, and the head of the probe is not in the liquid at the moment of default contact with the liquid level, but the measurement parameters are suddenly changed due to the influence of external factors. The head of the probe is not in the liquid but in the air at the default liquid taking end time, the head of the probe is also in the air at the first judgment time, and the measurement parameter does not change suddenly. Namely, the first variation and the second variation are different greatly.
Or if the liquid taking process fails due to the fact that the probe is separated from the liquid level and liquid is not sufficiently taken in the liquid taking process, the head of the probe is in the air at the moment when the probe is not in contact with the liquid level by default, the head of the probe is in the liquid at the moment when the probe is in contact with the liquid level by default, and the measurement parameters are suddenly changed. The head of the probe is not in the liquid but in the air at the default liquid taking end time, the head of the probe is also in the air at the first judgment time, and the measurement parameter does not change suddenly. Namely, the first variation and the second variation are different greatly.
Therefore, considering the error of the liquid taking test system, whether the probe contacts the liquid level in the liquid taking process is judged by mistake can be determined through the relation among the first variable quantity, the second variable quantity and the error adjusting threshold value. Therefore, whether the liquid extraction is successful or not can be accurately judged, the misjudgment is avoided, and the misjudgment rate of successful judgment of the liquid extraction is reduced.
In another example, a tapping process includes a default non-contact level time, a default contact level time, and a default end-of-tapping time. The description of the default liquid level non-contact time, the default liquid level contact time and the default liquid-taking end time may refer to the related description in the foregoing, and will not be described herein again.
In this example, the variation in the liquid extraction process includes a second variation and a third variation. The second variation and the third variation are positive values. The third variation is the sum of the variations of the measurement parameter at every two adjacent second determination times up to the current second determination time. The second judgment time is the default liquid taking ending time in the primary liquid taking process or a certain time after the default liquid taking ending time. The second variation is the variation of the measurement parameter at the time of not contacting the liquid level by default and the variation of the measurement parameter at the time of contacting the liquid level by default.
For example, the measurement parameter is acquired every 10 milliseconds after the default liquid withdrawal end time in the liquid withdrawal process, and the current second determination time is assumed to be 30 milliseconds after the default liquid withdrawal end time. The variation of the measurement parameter at the default liquid taking ending time and the measurement parameter at the 10 th millisecond after the default liquid taking ending time is delta f1; the variation of the measurement parameter of 10 milliseconds after the default liquid taking end time and the measurement parameter of 20 milliseconds after the default liquid taking end time is delta f2; the variation of the measurement parameter at 20 milliseconds after the default liquid extraction end time and the measurement parameter at 30 milliseconds after the default liquid extraction end time is delta f3; the third variation F5= Δ F1+ Δ F2+ Δ F3.
The decision threshold comprises an error adjustment threshold. And considering the influence factors such as the distributed capacitance and the like in the liquid taking testing device, and setting an error adjusting threshold value, thereby further improving the accuracy of the judgment of whether the liquid taking is successful or not on the premise of not influencing the successful judgment of the liquid taking. The error adjusting threshold is an error value which can be received whether the liquid is taken successfully or not. The error adjustment threshold may be specifically set according to a working scenario and a working requirement, and the error adjustment threshold in this example may be the same as or different from the error adjustment threshold in the previous example, which is not limited herein. For example, the error adjustment threshold may be a maximum fluctuation value of background noise, i.e., background noise, of the liquid taking test device.
And if the difference value between the third variation and the error adjusting threshold is smaller than or equal to the second variation, and the sum of the third variation and the error adjusting threshold is larger than or equal to the second variation, determining that the liquid is successfully taken. And if the difference value between the third variation and the error adjusting threshold is larger than the second variation, or the sum of the third variation and the error adjusting threshold is smaller than the second variation, determining that the liquid extraction fails.
For example, the second variation is F3, the third variation is F5, and the error adjustment threshold is F4. Then if F3, F5 and F4 satisfy the following relational expression (2), it is determined that the liquid extraction is successful.
F5-F4≤F3≤F5+F4(2)
For example, the measurement parameter is the oscillation frequency of the probe signal. The error adjustment threshold F4 is 0.002MHz. The second variation F3 and the third variation F5 are acquired to be 0.019MHz and 0.02MHz, respectively. The success of liquid taking is determined because 0.02MHz-0.002MHz < 0.019MHz < 0.02MHz + 0.002MHz. The second variation F3 obtained is 0.019MHz, and the third variation F5 is 0.002MHz. The failure of liquid taking is determined because 0.002MHz +0.002MHz < 0.019MHz.
The difference value between the third variation and the error adjustment threshold is smaller than or equal to the second variation, which indicates that the variation of the measurement parameter at the second judgment time and the variation of the measurement parameter at the default liquid taking end time are similar to the variation of the measurement parameter at the default liquid level non-contact time and the variation of the measurement parameter at the default liquid level contact time. The difference value between the third variation and the error adjusting threshold is larger than the second variation, which indicates that the variation between the measurement parameter at the second judgment moment and the measurement parameter at the default liquid taking ending moment is larger than the variation between the measurement parameter at the default liquid level non-contact moment and the measurement parameter at the default liquid level contact moment.
If the liquid is successfully taken in the liquid taking process, the head part of the probe is in the air at the moment of not contacting the liquid level by default, and the head part of the probe is in the liquid at the moment of contacting the liquid level by default. The head of the probe is still in the liquid at the default liquid-taking-off end time, and the head of the probe is in the air at the second judgment time. The measurement parameters are subject to sudden changes at the moment the probe head enters and leaves the liquid. I.e. the third variation should be similar to the second variation.
Conversely, if the liquid extraction fails due to misjudgment that the probe contacts the liquid level when the probe does not contact the liquid level in the liquid extraction process, the head of the probe is in the air at the moment of default non-contact with the liquid level, and the head of the probe is not in the liquid at the moment of default contact with the liquid level, but the measurement parameters are suddenly changed due to the influence of external factors. The head of the probe is not in the liquid but in the air at the default liquid taking end time, the head of the probe is also in the air at the second judgment time, and the measurement parameter does not change suddenly. That is, the third variation is different from the second variation by a relatively large amount.
Or if the liquid taking process fails due to the fact that the probe is separated from the liquid level and liquid is not sufficiently taken in the liquid taking process, the head of the probe is in the air at the moment when the probe is not in contact with the liquid level by default, the head of the probe is in the liquid at the moment when the probe is in contact with the liquid level by default, and the measurement parameters are suddenly changed. The head of the probe is not in the liquid but in the air at the default liquid taking end time, the head of the probe is also in the air at the second judgment time, and the measurement parameter does not change suddenly. That is, the third variation is different from the second variation by a relatively large amount.
Therefore, considering the error of the liquid taking test system, whether the liquid level is contacted by the probe in the liquid taking process is judged by mistake can be determined through the relation among the third variable quantity, the second variable quantity and the error adjusting threshold value. Therefore, whether the liquid extraction is successful or not can be accurately judged, the misjudgment is avoided, and the misjudgment rate of successful judgment of the liquid extraction is reduced.
In the embodiment of the invention, whether the liquid extraction is successful in the liquid extraction process is determined by using the variable quantity and the judgment threshold value in the liquid extraction process at one time. The variation in the liquid extraction process includes a measurement parameter at a default liquid extraction end time and a variation in a measurement parameter at a time after the default liquid extraction end time. The main reasons for misjudging the liquid taking failure as the liquid taking success include that the probe does not contact the liquid level and is misjudged as the probe contacts the liquid level, or the probe does not take the liquid enough, so that the head of the probe is separated from the liquid when the liquid taking of the probe is finished. In the scene that the situation that the probe does not contact the liquid level is judged to be the situation that the probe contacts the liquid level or the situation that the liquid is not taken by the probe is insufficient, the measurement parameter at the liquid taking end time is close to the measurement parameter at the time after the liquid taking end time, and judgment can be carried out by utilizing the judgment threshold value, so that misjudgment is avoided, and the misjudgment rate of judging whether the liquid is taken by the probe successfully is reduced. The liquid taking test method in the embodiment of the invention is suitable for scenes only needing single liquid taking, scenes only needing initial liquid taking and other scenes, and can reduce the misjudgment rate of judging whether the probe successfully takes the liquid. Moreover, on the basis of reducing the misjudgment rate of judging whether the probe successfully takes the liquid, the embodiment of the invention does not influence the time occupied by the liquid taking process, and does not add a device in the liquid taking test device, namely does not increase the complexity of the liquid taking test device.
Fig. 7 is a schematic structural diagram of a liquid extraction testing device according to an embodiment of the present invention. As shown in fig. 7, the liquid sampling test apparatus includes a probe 21 and a liquid sampling test circuit 22.
Wherein the probe 21 is used for taking the liquid.
The liquid taking test circuit 22 is used for obtaining a measurement parameter of the probe in a liquid taking process at one time, wherein the measurement parameter is a parameter causing the signal change of the probe; and the device is used for determining whether the liquid extraction is successful in the primary liquid extraction process according to the variation and the judgment threshold of the measurement parameter in the primary liquid extraction process, wherein the variation in the primary liquid extraction process comprises the measurement parameter at the default liquid extraction end time and the variation of the measurement parameter at the time after the default liquid extraction end time.
Specifically, the one-time liquid taking process comprises the default liquid level non-contact time, the default liquid level contact time and the default liquid taking finishing time. The decision threshold comprises an error adjustment threshold. In another example, the detection module 221 may also be configured to determine that the liquid extraction is successful if the difference between the first variation and the error adjustment threshold is smaller than or equal to the second variation, and the sum of the first variation and the error adjustment threshold is greater than or equal to the second variation. The detection module 221 may be further configured to determine that the liquid extraction fails when a difference between the first variation and the error adjustment threshold is greater than a second variation, or a sum of the first variation and the error adjustment threshold is less than the second variation. The liquid level measuring method comprises the steps of obtaining a liquid level, and obtaining a liquid level, wherein the liquid level is a liquid level, and the liquid level is a liquid level.
Specifically, the one-time liquid taking process comprises the default liquid level non-contact time, the default liquid level contact time and the default liquid taking finishing time. The decision threshold comprises an error adjustment threshold. The detecting module 221 may also be configured to determine that the liquid is successfully extracted when a difference between the third variation and the error adjustment threshold is smaller than or equal to the second variation, and a sum of the third variation and the error adjustment threshold is larger than or equal to the second variation. The detection module 221 may be further configured to determine that the liquid extraction fails when a difference between the third variation and the error adjustment threshold is greater than the second variation, or a sum of the third variation and the error adjustment threshold is less than the second variation. And the third variable quantity is the sum of the variable quantities of the measurement parameters at every two adjacent second judgment moments by the current second judgment moment. The second judgment time is the default liquid taking ending time in the primary liquid taking process or a certain time after the default liquid taking ending time. The second variation is the variation of the measurement parameter at the time of not contacting the liquid level by default and the variation of the measurement parameter at the time of contacting the liquid level by default.
The error adjustment threshold may be selected to be the maximum fluctuation of the background noise.
The measurement parameter may include one or more of capacitance, resistance, inductance, pressure, and oscillation frequency of the probe signal, and is not limited herein.
It should be noted that the liquid taking test circuit may further include a signal processing module 222, a conversion module 223, a conditioning module 224, and a control module 225.
Wherein, an external power supply 23 can be arranged to supply power for the liquid taking testing device. The conditioning module 224 can convert the basic measurement parameters of the probe relative to the ground, such as capacitance, resistance, inductance, pressure, etc., into the oscillation frequency of the probe signal or the charge-discharge time in the oscillation cycle of the probe signal, which is easy to measure, and input the oscillation frequency or the charge-discharge time to the conversion module 223 in the form of an analog signal. The conversion module 223 converts the analog signal into a digital signal. The digital signal is further filtered by the signal processing module 222. The detection module 221 may determine whether the liquid extraction is successful according to the filtered digital signal. The detection module 221 may be further configured to generate and send a success notification message or a failure notification message when it is determined that the liquid extraction is successful or failed. The control module 225 may control the movement, stopping, and extraction of the probe. The above modules may also be implemented by more modules or fewer modules through functional integration or functional division, and are not limited herein.
In one example, the probe 21 may be a double-layer probe. The inner layer of the double-layer probe 21 is connected with the liquid taking test circuit 22, and specifically, the inner layer of the double-layer probe 21 can be connected with the conditioning module 224 in the liquid taking test circuit 22. The outer layer of the bi-layer probe is connected to a reference ground. The reference ground is an internal ground isolated from the power supply. That is, the reference ground is isolated from the power ground. The core in the liquid taking test device 20, namely the liquid taking test circuit 22, is isolated from other equipment or components, and the adverse effect of interference signals brought by other equipment or components on the liquid taking test process is prevented. Therefore, the accuracy of judging whether the liquid extraction is successful is further improved, and the misjudgment rate of whether the liquid extraction is successful is reduced.
The embodiment of the invention also provides a liquid taking system, which comprises the liquid taking test device and a tray 31 for placing a liquid container. Wherein the tray 31 is connected to a reference ground. Specifically, the tray 31 may be a metal tray.
In one example, the insulating layer 32 and the instrument rack 33 may be further stacked in order downward below the tray 31. The instrument rack is connected to a power ground. In particular, the instrument rack may be a metal rack. The insulating layer 32 serves to isolate the tray 31 from the instrument housing 33.
The tray 31 is connected to a reference ground with both outer layers of the bi-layer probe. The instrument frame is connected with a power ground. The reference ground is isolated from the power ground. Therefore, the core of the liquid taking test device 20, namely the liquid taking test circuit 22, is further isolated from peripheral equipment, such as an instrument frame and the like, in the liquid taking system, and the adverse effect of interference signals brought by the peripheral equipment on the liquid taking test process is prevented. Therefore, the accuracy of judging whether the liquid extraction is successful is further improved, and the misjudgment rate of whether the liquid extraction is successful is reduced.
For the specific functions and benefits of the liquid extraction testing device, reference may be made to the relevant details of the liquid extraction testing method in the above embodiments, which are not described herein again.
The liquid extraction testing method and apparatus according to various embodiments of the present invention described in connection with fig. 1 to 7 may be implemented by a liquid extraction device 400. Fig. 8 is a schematic hardware structure diagram of a liquid extraction apparatus 400 according to an embodiment of the present invention.
The tapping device 400 comprises a probe (not shown in fig. 8), a memory 401 and a processor 402. The memory 401 has stored thereon a program that is executable on the processor 402. The program runs on the processor 402 to implement the fluid extraction test method in the above-described embodiment.
In one example, the processor 402 may include a Central Processing Unit (CPU), or an Application Specific Integrated Circuit (ASIC), or may be configured to implement one or more integrated circuits of embodiments of the present application.
Memory 401 may include mass storage for data or instructions. By way of example, and not limitation, memory 401 may include an HDD, floppy disk drive, flash memory, optical disk, magneto-optical disk, magnetic tape, or a Universal Serial Bus (USB) drive or a combination of two or more of these. Memory 401 may include removable or non-removable (or fixed) media, where appropriate. The reservoir 401 may be internal or external to the tapping device 400, where appropriate. In a particular embodiment, the memory 401 is a non-volatile solid-state memory. In a particular embodiment, the memory 401 includes Read Only Memory (ROM). Where appropriate, the ROM may be mask-programmed ROM, programmable ROM (PROM), erasable PROM (EPROM), electrically Erasable PROM (EEPROM), electrically Alterable ROM (EAROM), or flash memory, or a combination of two or more of these.
The processor 402 runs a program corresponding to the executable program code by reading the executable program code stored in the memory 401, for executing the liquid taking test method in each of the above embodiments.
In one example, the fluid extraction device 400 can also include a communication interface 403 and a bus 404. As shown in fig. 8, the memory 401, the processor 402, and the communication interface 403 are connected by a bus 404 to complete communication therebetween.
The communication interface 403 is mainly used for implementing communication between modules, apparatuses, units and/or devices in this embodiment. The communication interface 403 may also access input devices and/or output devices.
Bus 404 comprises hardware, software, or both that couple the components of fluid-withdrawal device 400 to one another. By way of example, and not limitation, bus 404 may include Accelerated Graphics Port (AGP) or other graphics bus, enhanced Industrial Standard Architecture (EISA) bus, front Side Bus (FSB), hyper Transport (HT) interconnect, industrial Standard Architecture (ISA) bus, infiniband interconnect, low Pin Count (LPC) bus, memory bus, micro Channel Architecture (MCA) bus, peripheral Component Interconnect (PCI) bus, PCI-Express (PCI-X) bus, serial Advanced Technology Attachment (SATA) bus, video electronics standards association local (VLB) bus, or other suitable bus or a combination of two or more of these. Bus 404 may include one or more buses, where appropriate. Although specific buses are described and shown in the embodiments of the application, any suitable buses or interconnects are contemplated by the application.
An embodiment of the present invention further provides a storage medium, where the storage medium stores a program, and the program, when executed by a processor, can implement the liquid taking test method in each of the above embodiments.
All parts of the specification are described in a progressive mode, the same and similar parts of all embodiments can be referred to each other, and each embodiment is mainly introduced to be different from other embodiments. In particular, apparatus embodiments, device embodiments, and storage medium embodiments are substantially similar to method embodiments and therefore are described in relatively simple relation with reference to the description of the method embodiments.
The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily think of the changes or substitutions within the technical scope of the present disclosure, and shall cover the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (4)
1. A liquid extraction testing method is characterized by comprising the following steps:
acquiring measurement parameters of a probe in a primary liquid taking process, wherein the measurement parameters are parameters causing probe signal change, and the measurement parameters comprise one or more of capacitance, resistance, inductance, pressure and oscillation frequency of a probe signal;
determining whether the liquid taking in the primary liquid taking process is successful or not according to the variation and a judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter at a default liquid taking ending moment and the variation of the measurement parameter at a moment after the default liquid taking ending moment, and the default liquid taking ending moment is the moment when the liquid taking duration reaches a preset liquid taking duration;
the primary liquid taking process comprises a default liquid level non-contact moment, a default liquid level contact moment and a default liquid taking finishing moment; the decision threshold comprises an error adjustment threshold;
the determining whether the liquid extraction in the primary liquid extraction process is successful according to the variation and the judgment threshold of the measurement parameter in the primary liquid extraction process includes:
determining that the liquid extraction is successful if the difference between a first variation and the error adjustment threshold is smaller than or equal to a second variation, and the sum of the first variation and the error adjustment threshold is greater than or equal to the second variation, wherein the first variation is the variation of the measurement parameter at a first judgment time and the measurement parameter at the default liquid extraction end time, the first judgment time is a certain time after the default liquid extraction end time in the one-time liquid extraction process, and the second variation is the variation of the measurement parameter at the default liquid level non-contact time and the measurement parameter at the default liquid level contact time;
if the difference value between the first variable quantity and the error adjusting threshold is larger than a second variable quantity, or the sum of the first variable quantity and the error adjusting threshold is smaller than the second variable quantity, determining that the liquid extraction fails;
alternatively, the first and second electrodes may be,
the primary liquid taking process comprises a default liquid level non-contact moment, a default liquid level contact moment and a default liquid taking finishing moment; the decision threshold comprises an error adjustment threshold;
the determining whether the liquid extraction in the primary liquid extraction process is successful according to the variation and the judgment threshold of the measurement parameter in the primary liquid extraction process comprises:
determining that the liquid extraction is successful if a difference between a third variation and the error adjustment threshold is smaller than or equal to a second variation, and a sum of the third variation and the error adjustment threshold is greater than or equal to the second variation, where the third variation is a sum of variations of the measurement parameter at every two adjacent second determination times by a current second determination time, the second determination time is the default liquid extraction end time or a time after the default liquid extraction end time in the one-time liquid extraction process, and the second variation is a variation of the measurement parameter at the default liquid level non-contact time and the measurement parameter at the default liquid level contact time;
and if the difference value between the third variable quantity and the error adjusting threshold is larger than a second variable quantity, or the sum of the third variable quantity and the error adjusting threshold is smaller than the second variable quantity, determining that the liquid extraction fails.
2. The method of claim 1, wherein the error adjustment threshold is a maximum fluctuation value of background noise.
3. A liquid taking test device is characterized by comprising a probe and a liquid taking test circuit;
the probe is used for taking liquid;
the liquid taking test circuit is used for obtaining a measurement parameter of the probe in a liquid taking process at one time, the measurement parameter is a parameter causing the change of a probe signal, and the measurement parameter comprises one or more of capacitance, resistance, inductance, pressure and oscillation frequency of the probe signal; and determining whether the liquid extraction is successful in the primary liquid extraction process according to the variation and the judgment threshold of the measurement parameter in the primary liquid extraction process, wherein the variation in the primary liquid extraction process comprises the variation of the measurement parameter at the default liquid extraction end time and the variation of the measurement parameter at the time after the default liquid extraction end time, and the default liquid extraction end time is the time when the liquid extraction duration reaches the preset liquid extraction duration;
the liquid taking process comprises a default liquid level non-contact time, a default liquid level contact time and a default liquid taking finishing time; the decision threshold comprises an error adjustment threshold;
the liquid taking test circuit comprises a detection module, and the detection module is used for:
determining that the liquid extraction is successful if a difference between a first variation and the error adjustment threshold is smaller than or equal to a second variation, and a sum of the first variation and the error adjustment threshold is greater than or equal to the second variation, wherein the first variation is a variation between the measurement parameter at a first determination time and the measurement parameter at the default liquid extraction end time, the first determination time is a time after the default liquid extraction end time in the one-time liquid extraction process, and the second variation is a variation between the measurement parameter at the default liquid level non-contact time and the measurement parameter at the default liquid level contact time;
determining that liquid extraction fails when the difference between the first variation and the error adjustment threshold is greater than a second variation, or the sum of the first variation and the error adjustment threshold is less than the second variation;
alternatively, the first and second electrodes may be,
the liquid taking process comprises a default liquid level non-contact moment, a default liquid level contact moment and a default liquid taking finishing moment; the decision threshold comprises an error adjustment threshold;
the liquid taking test circuit comprises a detection module, and the detection module is used for:
determining that the liquid extraction is successful if a difference between a third variation and the error adjustment threshold is smaller than or equal to a second variation, and a sum of the third variation and the error adjustment threshold is greater than or equal to the second variation, where the third variation is a sum of variations of the measured parameter at every two adjacent second determination times by a current second determination time, the second determination time is the default liquid extraction end time or a time after the default liquid extraction end time in the one-time liquid extraction process, and the second variation is a variation of the measured parameter at the default liquid level non-contact time and the measured parameter at the default liquid level contact time;
and determining that the liquid extraction fails under the condition that the difference value between the third variation and the error adjusting threshold is larger than a second variation, or the sum of the third variation and the error adjusting threshold is smaller than the second variation.
4. The apparatus of claim 3, wherein the probe is a bi-layer probe, wherein an inner layer of the bi-layer probe is connected to the fluid extraction test circuit, an outer layer of the bi-layer probe is connected to a reference ground, and the reference ground is isolated from a power ground.
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