CN2588334Y - Liquid level detector for biochemical analysis - Google Patents
Liquid level detector for biochemical analysis Download PDFInfo
- Publication number
- CN2588334Y CN2588334Y CN 02250812 CN02250812U CN2588334Y CN 2588334 Y CN2588334 Y CN 2588334Y CN 02250812 CN02250812 CN 02250812 CN 02250812 U CN02250812 U CN 02250812U CN 2588334 Y CN2588334 Y CN 2588334Y
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- Prior art keywords
- needle tube
- needle tubing
- liquid level
- locked loop
- conduction
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Abstract
The utility model relates to a liquid level detector for biochemical analysis, which comprises a sampling needle tube, a needle tube moving mechanism, and a detecting control circuit, wherein, the sampling needle tube is a double-layer sampling needle tube (10) which comprises an electric conduction outer needle tube (12), an electric conduction inner needle tube (14), and the intermediate insulating layer (13), and the detecting control circuit comprises a phase locked loop integrated circuit; a conducting wire led out from the electric conduction outer needle tube (12) is grounded, and a conducting wire led out from the electric conduction inner needle tube (14) is connected with a pin in the phase locked loop integrated circuit that a voltage control oscillator is connected with an oscillating capacitor; when a needle head of the sampling needle tube is contacted with liquid surface, a motor (20) stops the rotation, and the sampling needle tube stops the motion and returns after the sample is sucked. The utility model has the advantages of stably and reliability, accuracy and convenience, and low cost.
Description
Technical field the utility model relates to liquid surface sensing device, detects the sensing device of sample liquid level in sampling process especially for Biochemical Analyzer.
The main mode of biochemical analysis level detection of background technology prior art has, and the one,, use two electrodes, one another is as receiving end as transmitting terminal, and transmitting terminal is the sample disk base, sends the sine wave signal that frequency is several KHz.During work, needle tubing moves downward from sample cup top, inserts in the sample cup, and when in the syringe needle contact cup during liquid, receiving circuit detects a signal level, after receiving end is received signal, promptly controls the pin stop motion, the absorption sample.Another kind of circuit is to reach the purpose of level detection by single tube at the capacitance variations between the earth, and this kind detection method very easily is subjected to external interference, and is higher to the sample disk grounding requirement.Preceding a kind of device, physical construction and circuit structure are all complicated, a kind of ground connection situation that depends on sample disk in back, and work is extremely unstable.Though the machine that uses two-tube pin to detect liquid level is abroad arranged, and its circuit structure is very complicated, and cost is very high.
Summary of the invention problem to be solved in the utility model is to avoid above-mentioned the deficiencies in the prior art part and the liquid level sensor that proposes a kind of low cost, high sensitivity, simple in structure, reliable operation.Comprise: double-deck sampling needle tubing, needle tubing motion and level detection control circuit.Double-deck sampling needle tubing is equivalent to a capacitor, inserts by lead and detects control circuit, determines the oscillation frequency of VCO with the oscillating capacitance of the VCO (voltage controlled oscillator) in the phase-locked loop intergrated circuit wherein.When the syringe needle of bilayer sampling needle tubing touches liquid level, the variation of capacitance causes the variation of oscillation frequency, the variation that the output of phaselocked loop has a current potential to increase, this current potential that increases is amplified by operational amplifier, compare with reference voltage then, if surpass threshold value, the comparer upset is exported a high level signal and is removed the control step motor.
The utility model solves the problems of the technologies described above the technical scheme of taking and comprises: liquid level sensor of processing and manufacturing, comprise the sampling needle tubing, the needle tubing motion, detect control circuit, particularly described sampling needle tubing is processed into double-deck sampling needle tubing, and double-deck sampling needle tubing comprises the outer needle tubing of conduction and conduction inner needle tube and intermediate insulating layer; Insulation course is one deck at least, and the best is two-layer, and promptly the outside surface of needle tubing is provided with an external insulation layer again outside conduction.Comprise a phase-locked loop intergrated circuit in the described detection control circuit; By the outer needle tubing of the conduction lead ground connection of drawing, connect that pin that voltage controlled oscillator in the phase-locked loop intergrated circuit should connect oscillating capacitance by conducting electricity lead that inner needle tube draws.
The model of phase-locked loop intergrated circuit adopts CD4046 in the utility model, and two pins that its inner VCO (voltage controlled oscillator) connects oscillating capacitance are the 6th pin and the 7th pin.It is the 7th pin of CD4046 that the conduction inner needle tube lead of drawing connects that pin that voltage controlled oscillator among the phase-locked loop intergrated circuit U1 connects oscillating capacitance.Can certainly adopt the phase-locked loop intergrated circuit of other models.The outer needle tubing that conducts electricity is made of conductive material with the conduction inner needle tube, and what use in the utility model is medical stainless steel.
The pin arm that can conveniently fix the sampling needle tubing is set again, and the pin arm is linked to the needle tubing motion, and the needle tubing motion is by step motor drive.A liquid level detection circuit also is set, the lead-in wire that inside and outside needle tubing picks out inserts the phase-locked loop intergrated circuit in the liquid level detection circuit, the outer needle tubing that conducts electricity is equivalent to the vibration that an electric capacity participates in VCO (voltage controlled oscillator) with the conduction inner needle tube, phaselocked loop is also imported the signal of another oscillator, when the frequency of these two oscillators is identical, phase-locked loop intergrated circuit is output as one than electronegative potential, and the needle tubing of taking a sample this moment does not touch liquid level.When the sampling needle tubing moves downward when touching liquid level, its capacitance changes, the frequency of A oscillation circuit also changes thereupon, because the frequency of A and B is different, the phase-locked loop intergrated circuit output potential also raises, and makes the comparer upset after operational amplifier amplifies, and the control motor stops operating, the sampling needle tubing is stop motion, returns behind the suction sample.
Compared with prior art, the utility model is reliable and stable, and is accurately convenient, with low cost.
Description of drawings Fig. 1 is the structural representation of the double-deck sampling of the utility model needle tubing;
Fig. 2 is a sampling synoptic diagram of the present utility model;
Fig. 3 is the functional-block diagram that the utility model detects control circuit;
Fig. 4 is the electrical schematic diagram that the utility model detects control circuit.
Embodiment is described in further detail below in conjunction with most preferred embodiment shown in the accompanying drawing: as shown in Figure 1: double-deck sampling needle tubing 10 comprises the outer needle tubing 12 of conduction and conduction inner needle tube 14 and intermediate insulating layer 13; Insulation course is one deck at least, and the best is two-layer, and promptly the outside surface of needle tubing is provided with an external insulation layer 11 again outside conduction.
The bottom skin of double-deck sampling needle tubing 10 is external insulation layers 11, and its inside is the outer needle tubing 12 of conduction, is inner insulating layer 13 again toward in, and penetralia is a conduction inner needle tube 14, and the part that foot is given prominence to is a syringe needle, and it is used for immersed in liquid level, the absorption sample.
As shown in Figure 2: need the sample 30 of biochemical analysis to be contained in 90 li of sample tube, test tube 90 is fixed on the sample disk 40, double-deck sampling needle tubing 10 is fixed on the pin arm 60, pin arm 60 can be driven by stepper motor 20 and move up and down, test tube 90 can be plastics or glass test tube, the double-deck sampling of stepper motor 20 controls needle tubing 10 moves to above the liquid level of sample 30 when work, open detection control circuit then, the outer needle tubing 12 of the conduction of double-deck sampling needle tubing 10 is by lead-in wire ground connection, conduction inner needle tube 14 70 is connected on the pin 7 of phase-locked loop intergrated circuit by going between, double-deck sampling needle tubing 10 detects control circuit and inquires about syringe needle always and whether touch liquid level in moving downward process, when syringe needle touches liquid level, because the electric capacity between the inside and outside needle tubing changes, the centre frequency that detects control circuit is offset, detects control circuit this change transitions is become a high level, control motor 20 is stopped operating, the also stop motion of double-deck sampling needle tubing 10 is returned behind the suction sample.
Fig. 3 detects the control circuit block diagram, detects control circuit and is made of vibration and frequency dividing circuit (B road), phase-locked loop (A road), low-pass filter circuit, high-pass filtering circuit, voltage amplifier circuit, reference voltage and voltage comparator circuit.Sampling needle tubing 10 is as the part of the external capacitor of the oscillation circuit A of phase-locked loop, and when the capacitance of bilayer sampling needle tubing 10 formations changed, the frequency of the VCO of phase-locked loop (voltage controlled oscillator) changed, the inevitable phase change that correspondingly produce.This phase change is compared with the stable phase angle of oscillator B in phase detector (within phase-locked loop intergrated circuit), make one of phase detector output and the proportional error voltage of phase error, after low-pass filter filtering, take out the DC voltage component that wherein slowly changes.Be used for controlling the voltage-controlled component values among the VCO (voltage controlled oscillator), and the ingredient that this voltage-controlled element is the VCO oscillation circuit, the variation of the voltage-controlled element electric capacity of result is withdrawn into the output frequency of VCO on the stationary value again.In capacitance variations moment, this DC quantity again by high-pass filtering, is amplified by amplifier after low-pass filtering, and the signal after the amplification outputs to the control step motor through comparator circuit after relatively.
Fig. 4 is the electrical schematic diagram that the utility model detects control circuit, U1 is phase-locked loop intergrated circuit CD4046, the oscillation frequency of its inner VCO (voltage controlled oscillator) is mainly determined by the electric capacity of R1 and the double-deck sampling of C1+ needle tubing, R2, R14, R15, R16, R17 and VR1 are used for the fine tuning frequency, and this constitutes oscillator A.The square wave of a 6MHZ of crystal oscillator X1 output is input to the 14th pin of U1 by the U4 frequency division, and this is oscillator B.When the frequency of A and B was identical, output terminal the 13rd pin of U1 was a low level; When syringe needle 18 touches liquid level, the frequency change of oscillator A, the level of the 13rd pin raises, this variation is exaggerated device U2A behind filter filtering amplifies, and comparer U2B is 6 pin high level when flat, 5 pin low levels, this moment, 5 pin level were higher than 6 pin, the comparer upset, it is exported the 7th pin and becomes high level, stops operating through U3A, U3B shaping output control step motor 20.
R10, R4 constitute reference voltage with 5V voltage dividing potential drop and offer U2B.
U5 and U6 are integrated regulators, and U5 is output as+5V, and U6 is output as+9V.
The following table of the main former device of the utility model:
| Symbol | Title | Parameter |
| ?U1 | Phaselocked loop | CD4046 |
| ?U2 | Operational amplifier | LM358 |
| ?U3 | Schmidt trigger | 74HC14 |
| ?C1 | Electric capacity | 1000P |
| ?R1 | Resistance | 100K |
| ?R2 | Resistance | 15K |
| ?R4 | Resistance | 22K |
| ?R10 | Resistance | 22K |
| ?VR1 | Potentiometer | 50K |
| ?R14、R15 ?R16 | Resistance | 10K |
| ?X1 | 4 pin crystal oscillators | 6MHZ |
| ?U4 | Counter | CD4024 |
Facts have proved that the utility model is reliable and stable, accurately convenient.
Claims (5)
1. biochemical analysis liquid level sensor, comprise the sampling needle tubing, the needle tubing motion detects control circuit, it is characterized in that: described sampling needle tubing comprises conduction outer needle tubing (12) and conduction inner needle tube (14) and intermediate insulating layer (13) for double-deck sampling needle tubing (10); Described detection control circuit comprises a phase-locked loop intergrated circuit; By the outer needle tubing of conduction (12) the lead ground connection of drawing, connect that pin that voltage controlled oscillator in the phase-locked loop intergrated circuit should connect oscillating capacitance by conducting electricity lead that inner needle tube (14) draws.
2. biochemical analysis liquid level sensor according to claim 1 is characterized in that: the outside surface of the outer needle tubing (12) of described conduction has an external insulation layer (11).
3. biochemical analysis liquid level sensor according to claim 1 is characterized in that: the employing CD4046 of described phase-locked loop intergrated circuit.
4. according to the described biochemical analysis liquid level sensor of claim 1 claim 3, it is characterized in that: it is the 7th pin of CD4046 that the lead that described conduction inner needle tube (14) is drawn connects that pin that voltage controlled oscillator in the phase-locked loop intergrated circuit should connect oscillating capacitance.
5. biochemical analysis liquid level sensor according to claim 1 is characterized in that: outer needle tubing (12) of described conduction and conduction inner needle tube (14) adopt medical stainless steel to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02250812 CN2588334Y (en) | 2002-12-27 | 2002-12-27 | Liquid level detector for biochemical analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02250812 CN2588334Y (en) | 2002-12-27 | 2002-12-27 | Liquid level detector for biochemical analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2588334Y true CN2588334Y (en) | 2003-11-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02250812 Expired - Lifetime CN2588334Y (en) | 2002-12-27 | 2002-12-27 | Liquid level detector for biochemical analysis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2588334Y (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7603899B2 (en) | 2006-08-31 | 2009-10-20 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Apparatus and method for detecting liquid level with a probe |
| CN101900596A (en) * | 2010-06-04 | 2010-12-01 | 深圳市新产业生物医学工程有限公司 | Reagent warning device for chemiluminescent immunoassay |
| US8358216B2 (en) | 2009-04-09 | 2013-01-22 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Liquid level detecting device and sample applying system |
| CN104111102A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, liquid level detection device and immunity analyzer |
| CN104359529A (en) * | 2014-11-11 | 2015-02-18 | 常熟理工学院 | Sensing detecting device for liquid level of biochemical analyzer and method |
| CN104764508A (en) * | 2015-03-28 | 2015-07-08 | 苏州长光华医生物医学工程有限公司 | Liquid level detection circuit suitable for in-vitro diagnostic device |
| CN105758497A (en) * | 2014-12-18 | 2016-07-13 | 苏州长光华医生物医学工程有限公司 | Liquid level detection device for excitation liquid |
| CN106092259A (en) * | 2015-04-27 | 2016-11-09 | 西门子医学诊断产品有限责任公司 | For the method monitoring the function of the rinsing table of liquid-transfering needle |
| WO2017008249A1 (en) * | 2015-07-14 | 2017-01-19 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling mechanism, skipped-vacuum testing method therefor, and sample analyzer |
| CN107290027A (en) * | 2016-03-31 | 2017-10-24 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level sensor and detection method and Full-automatic picking sampling device |
| US11231309B2 (en) * | 2016-05-11 | 2022-01-25 | Siemens Healthcare Diagnostics Inc. | Quick connection for liquid level sense-enabled metering probe |
-
2002
- 2002-12-27 CN CN 02250812 patent/CN2588334Y/en not_active Expired - Lifetime
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7603899B2 (en) | 2006-08-31 | 2009-10-20 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Apparatus and method for detecting liquid level with a probe |
| US8358216B2 (en) | 2009-04-09 | 2013-01-22 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Liquid level detecting device and sample applying system |
| CN101900596A (en) * | 2010-06-04 | 2010-12-01 | 深圳市新产业生物医学工程有限公司 | Reagent warning device for chemiluminescent immunoassay |
| CN101900596B (en) * | 2010-06-04 | 2012-02-01 | 深圳市新产业生物医学工程有限公司 | Reagent warning device for chemiluminescent immunoassay |
| US9702749B2 (en) | 2013-04-16 | 2017-07-11 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Liquid surface detection method and device, and immunoassay analyzer |
| CN104111102A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, liquid level detection device and immunity analyzer |
| WO2014169575A1 (en) * | 2013-04-16 | 2014-10-23 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method and device, and immunoassay analyzer |
| CN104111102B (en) * | 2013-04-16 | 2018-10-26 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level checking method, device and immunity analysis instrument |
| CN104359529A (en) * | 2014-11-11 | 2015-02-18 | 常熟理工学院 | Sensing detecting device for liquid level of biochemical analyzer and method |
| CN104359529B (en) * | 2014-11-11 | 2017-12-29 | 常熟理工学院 | A kind of biochemical instruments liquid level sensing detection device and method |
| CN105758497A (en) * | 2014-12-18 | 2016-07-13 | 苏州长光华医生物医学工程有限公司 | Liquid level detection device for excitation liquid |
| CN104764508A (en) * | 2015-03-28 | 2015-07-08 | 苏州长光华医生物医学工程有限公司 | Liquid level detection circuit suitable for in-vitro diagnostic device |
| CN106092259A (en) * | 2015-04-27 | 2016-11-09 | 西门子医学诊断产品有限责任公司 | For the method monitoring the function of the rinsing table of liquid-transfering needle |
| US10514387B2 (en) | 2015-04-27 | 2019-12-24 | Siemens Healthcare Diagnostics Products Gmbh | Method for monitoring the functionality of a wash station for pipetting needles |
| WO2017008249A1 (en) * | 2015-07-14 | 2017-01-19 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling mechanism, skipped-vacuum testing method therefor, and sample analyzer |
| CN107709958A (en) * | 2015-07-14 | 2018-02-16 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling mechanism and its suction detection method, sample analyser |
| CN107709958B (en) * | 2015-07-14 | 2020-04-14 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling mechanism, air suction detection method thereof and sample analyzer |
| CN107290027A (en) * | 2016-03-31 | 2017-10-24 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level sensor and detection method and Full-automatic picking sampling device |
| US11231309B2 (en) * | 2016-05-11 | 2022-01-25 | Siemens Healthcare Diagnostics Inc. | Quick connection for liquid level sense-enabled metering probe |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20121227 Granted publication date: 20031126 |