CN107709357B - Alk4:actriib异多聚体和其用途 - Google Patents

Alk4:actriib异多聚体和其用途 Download PDF

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Publication number
CN107709357B
CN107709357B CN201680033053.0A CN201680033053A CN107709357B CN 107709357 B CN107709357 B CN 107709357B CN 201680033053 A CN201680033053 A CN 201680033053A CN 107709357 B CN107709357 B CN 107709357B
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alk4
actriib
seq
activin
polypeptide
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CN107709357A (zh
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R.库马
A.格林伯格
D.S.萨科
R.S.皮尔萨尔
R.卡斯通瓜伊
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Acceleron Pharma Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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CN201680033053.0A 2015-04-06 2016-04-06 Alk4:actriib异多聚体和其用途 Expired - Fee Related CN107709357B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562143579P 2015-04-06 2015-04-06
US62/143579 2015-04-06
US201562220836P 2015-09-18 2015-09-18
US62/220836 2015-09-18
PCT/US2016/026269 WO2016164497A1 (en) 2015-04-06 2016-04-06 Alk4:actriib heteromultimers and uses thereof

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CN107709357A CN107709357A (zh) 2018-02-16
CN107709357B true CN107709357B (zh) 2022-12-06

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US (6) US10196434B2 (cg-RX-API-DMAC7.html)
EP (2) EP3929211A1 (cg-RX-API-DMAC7.html)
JP (2) JP7055637B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180002660A (cg-RX-API-DMAC7.html)
CN (1) CN107709357B (cg-RX-API-DMAC7.html)
AU (2) AU2016246703B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017021525A2 (cg-RX-API-DMAC7.html)
CA (1) CA2981831A1 (cg-RX-API-DMAC7.html)
EA (1) EA201792217A1 (cg-RX-API-DMAC7.html)
ES (1) ES2882105T3 (cg-RX-API-DMAC7.html)
HK (1) HK1250374A1 (cg-RX-API-DMAC7.html)
MA (2) MA41919A (cg-RX-API-DMAC7.html)
MX (2) MX395238B (cg-RX-API-DMAC7.html)
SG (1) SG11201708176UA (cg-RX-API-DMAC7.html)
WO (1) WO2016164497A1 (cg-RX-API-DMAC7.html)

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JP6810702B2 (ja) 2015-04-06 2021-01-06 アクセルロン ファーマ インコーポレイテッド シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用
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CN116650622A (zh) * 2016-10-05 2023-08-29 艾科赛扬制药股份有限公司 用于治疗肾脏疾病的组合物和方法
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JP7219705B2 (ja) * 2016-10-05 2023-02-08 アクセルロン ファーマ インコーポレイテッド ＡＬＫ４：ＡｃｔＲＩＩＢヘテロ多量体およびその使用
KR102761094B1 (ko) 2016-10-05 2025-02-03 악셀레론 파마 인코포레이티드 변이체 actriib 단백질 및 이의 용도
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US11857599B2 (en) * 2017-04-03 2024-01-02 Acceleron Pharma Inc. Compositions and methods for treating spinal muscular atrophy
KR20220148189A (ko) * 2020-02-03 2022-11-04 악셀레론 파마 인코포레이티드 변이체 actriib 단백질 및 이의 용도
KR20230002391A (ko) * 2020-03-13 2023-01-05 악셀레론 파마 인코포레이티드 신장 질환 또는 병태를 치료하기 위한 단일-가지 actriia 및 actriib 이종다량체 및 치료 방법
JP2023534127A (ja) * 2020-06-17 2023-08-08 アクセルロン ファーマ インコーポレイテッド ＡｃｔＲＩＩ－ＡＬＫ４アンタゴニストおよび心不全を処置する方法
EP4243933A4 (en) * 2020-11-13 2024-09-25 The Jackson Laboratory THERAPEUTIC AGENTS TARGETING TRANSFORMING GROWTH FACTOR BETA FAMILY SIGNALING
BR112023018283A2 (pt) * 2021-03-10 2023-10-31 Acceleron Pharma Inc Antagonistas de actrii-alk4 e métodos para tratar insuficiência cardíaca
KR20230169123A (ko) * 2021-03-10 2023-12-15 악셀레론 파마 인코포레이티드 Actrii-alk4 길항제 및 심부전을 치료하는 방법

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