CN107708727A - 一种用于治疗肝癌的肿瘤疫苗及其制备方法 - Google Patents
一种用于治疗肝癌的肿瘤疫苗及其制备方法 Download PDFInfo
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Abstract
一种用于治疗肝癌的肿瘤疫苗及其制备方法，该治疗效果改进的肝癌疫苗包括肝癌细胞分泌的exosomes小体，所述的肝癌细胞是经过Cephaloziellins J和SAHA联合加药处理的，Cephaloziellins J和SAHA的摩尔浓度之比为0.8～1.2∶1。通过使用Cephaloziellins J和SAHA加药处理肝癌细胞，结果表明，处理后的肝癌细胞分泌的exosomes及其可溶性免疫分子则能显著改善前述的抑制作用，显著提高了exosomes肿瘤疫苗治疗效果，具有重要的临床应用价值。
Description
PCT国内申请，说明书已公开。
Claims (7)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2015107139344 | 2015-10-28 | ||
| CN201510713934.4A CN105288603A (zh) | 2015-10-28 | 2015-10-28 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
| PCT/CN2016/096036 WO2017071380A1 (zh) | 2015-10-28 | 2016-08-19 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107708727A true CN107708727A (zh) | 2018-02-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510713934.4A Withdrawn CN105288603A (zh) | 2015-10-28 | 2015-10-28 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
| CN201680035580.5A Pending CN107708727A (zh) | 2015-10-28 | 2016-08-19 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510713934.4A Withdrawn CN105288603A (zh) | 2015-10-28 | 2015-10-28 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
Country Status (2)
| Country | Link |
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| CN (2) | CN105288603A (zh) |
| WO (1) | WO2017071380A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288603A (zh) * | 2015-10-28 | 2016-02-03 | 杨廷稳 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
| CN110604813A (zh) * | 2018-06-14 | 2019-12-24 | 深圳市人民医院 | 一种肿瘤细胞来源外泌体抗原在dc疫苗中的应用方法 |
| CN117547600B (zh) * | 2023-11-15 | 2024-04-30 | 华中科技大学同济医学院附属协和医院 | 一种靶向hdac的脂质体疫苗的制备及应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101948453A (zh) * | 2006-05-23 | 2011-01-19 | 山东绿叶制药有限公司 | 新的neo-克罗烷型二萜化合物及其应用 |
| CN103816535A (zh) * | 2014-03-04 | 2014-05-28 | 肖文华 | 一种肿瘤疫苗及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078966A (zh) * | 2015-08-28 | 2015-11-25 | 林天样 | Cephaloziellin A在制备治疗胃癌药物中的应用 |
| CN105288603A (zh) * | 2015-10-28 | 2016-02-03 | 杨廷稳 | 一种用于治疗肝癌的肿瘤疫苗及其制备方法 |
-
2015
- 2015-10-28 CN CN201510713934.4A patent/CN105288603A/zh not_active Withdrawn
-
2016
- 2016-08-19 WO PCT/CN2016/096036 patent/WO2017071380A1/zh active Application Filing
- 2016-08-19 CN CN201680035580.5A patent/CN107708727A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101948453A (zh) * | 2006-05-23 | 2011-01-19 | 山东绿叶制药有限公司 | 新的neo-克罗烷型二萜化合物及其应用 |
| CN103816535A (zh) * | 2014-03-04 | 2014-05-28 | 肖文华 | 一种肿瘤疫苗及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| RUI-IUAN LI等: "Secondary Metabolites from the Chinese Liverwort Cephaloziella kiaeri", 《JOURNAL OF NATURAL PRODUCTS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105288603A (zh) | 2016-02-03 |
| WO2017071380A1 (zh) | 2017-05-04 |
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