CN107663384A - 一种荧光染料及其制备方法和用途 - Google Patents
一种荧光染料及其制备方法和用途 Download PDFInfo
- Publication number
- CN107663384A CN107663384A CN201610573970.XA CN201610573970A CN107663384A CN 107663384 A CN107663384 A CN 107663384A CN 201610573970 A CN201610573970 A CN 201610573970A CN 107663384 A CN107663384 A CN 107663384A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- group
- synthesis
- compound
- 400mhz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(C#N)=C(C(*)(*)[Rh])S=*)I Chemical compound *C(C(C#N)=C(C(*)(*)[Rh])S=*)I 0.000 description 13
- JSLGQBRQZHBCET-UHFFFAOYSA-N CC(C)(C(C1)=C2SC1(C)N(C)CCO)c1c2[s]c(C=O)c1 Chemical compound CC(C)(C(C1)=C2SC1(C)N(C)CCO)c1c2[s]c(C=O)c1 JSLGQBRQZHBCET-UHFFFAOYSA-N 0.000 description 1
- SDCNUPYTVIODRM-OQLLNIDSSA-N Cc1ccc2c([s]c(/C=C(/c3cc4ccccc4[s]3)\C#N)c3)c3[s]c2c1 Chemical compound Cc1ccc2c([s]c(/C=C(/c3cc4ccccc4[s]3)\C#N)c3)c3[s]c2c1 SDCNUPYTVIODRM-OQLLNIDSSA-N 0.000 description 1
- NQERGRLDRLWFKN-UHFFFAOYSA-N [Ar]c1cc(Cc2c-3[s]cc2)c-3[s]1 Chemical compound [Ar]c1cc(Cc2c-3[s]cc2)c-3[s]1 NQERGRLDRLWFKN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/005—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a COOH and/or a functional derivative thereof
- C09B23/0058—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a COOH and/or a functional derivative thereof the substituent being CN
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0091—Methine or polymethine dyes, e.g. cyanine dyes having only one heterocyclic ring at one end of the methine chain, e.g. hemicyamines, hemioxonol
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
- C09K2211/1033—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom with oxygen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
- C09K2211/1037—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom with sulfur
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1044—Heterocyclic compounds characterised by ligands containing two nitrogen atoms as heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1092—Heterocyclic compounds characterised by ligands containing sulfur as the only heteroatom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1096—Heterocyclic compounds characterised by ligands containing other heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (10)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610573970.XA CN107663384B (zh) | 2016-07-20 | 2016-07-20 | 一种荧光染料及其制备方法和用途 |
US16/318,762 US11365203B2 (en) | 2016-07-20 | 2017-07-18 | Fluorescent dye and preparation method and use thereof |
PCT/CN2017/093270 WO2018014820A1 (zh) | 2016-07-20 | 2017-07-18 | 一种荧光染料及其制备方法和用途 |
EP17830454.9A EP3489323A4 (en) | 2016-07-20 | 2017-07-18 | FLUORESCENT DYE AND PRODUCTION METHOD AND USE THEREOF |
JP2019502739A JP7186448B2 (ja) | 2016-07-20 | 2017-07-18 | 蛍光染料及びその製造方法と使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610573970.XA CN107663384B (zh) | 2016-07-20 | 2016-07-20 | 一种荧光染料及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107663384A true CN107663384A (zh) | 2018-02-06 |
CN107663384B CN107663384B (zh) | 2020-05-12 |
Family
ID=60991947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610573970.XA Active CN107663384B (zh) | 2016-07-20 | 2016-07-20 | 一种荧光染料及其制备方法和用途 |
Country Status (5)
Country | Link |
---|---|
US (1) | US11365203B2 (zh) |
EP (1) | EP3489323A4 (zh) |
JP (1) | JP7186448B2 (zh) |
CN (1) | CN107663384B (zh) |
WO (1) | WO2018014820A1 (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108300456A (zh) * | 2018-01-26 | 2018-07-20 | 华南理工大学 | 一类具有聚集诱导发光性质的荧光化合物在有机胺检测中的应用 |
CN110437219A (zh) * | 2019-07-09 | 2019-11-12 | 济南大学 | 一种检测粘度和二氧化硫双功能的荧光探针 |
CN110702653A (zh) * | 2019-10-16 | 2020-01-17 | 华中科技大学 | 一种聚集诱导荧光探针在指纹荧光成像中的应用 |
CN111592472A (zh) * | 2019-04-28 | 2020-08-28 | 上海高驰资产管理有限公司 | 一种荧光染料及其制备方法和用途 |
CN111593052A (zh) * | 2019-04-28 | 2020-08-28 | 华东理工大学 | 一种rna检测与定量的方法 |
WO2021057816A1 (zh) * | 2019-09-23 | 2021-04-01 | 华东理工大学 | 核酸适配体分子 |
CN112876496A (zh) * | 2021-03-16 | 2021-06-01 | 南京邮电大学 | 一种新型有机小分子光学诊疗探针及其制备方法与应用 |
WO2021190346A1 (zh) * | 2020-03-23 | 2021-09-30 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
CN113754603A (zh) * | 2021-08-12 | 2021-12-07 | 浙江工业大学 | 一种异恶唑类化合物作为粘度荧光探针的应用 |
CN114605376A (zh) * | 2022-04-21 | 2022-06-10 | 济南大学 | 一种检测半胱氨酸和粘度的双功能荧光探针及其制备 |
CN115703771A (zh) * | 2021-08-06 | 2023-02-17 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110498799B (zh) * | 2018-05-18 | 2022-07-05 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0251114A2 (de) * | 1986-07-02 | 1988-01-07 | BASF Aktiengesellschaft | Thienothiophenfarbstoffe |
ES2307462A1 (es) * | 2008-06-30 | 2008-11-16 | Fundacion Universitaria San Pablo Ceu (70%) | Derivados de naftofurano y naftotiofeno como agentes antiproliferativos del cancer de pancreas y colon. |
WO2012102544A2 (ko) * | 2011-01-28 | 2012-08-02 | 주식회사 동진쎄미켐 | 신규한 유기염료 및 이의 제조방법 |
CN102803924A (zh) * | 2009-06-05 | 2012-11-28 | 丹尼斯科美国公司 | 高流通量分子转子黏度测定法测定 |
WO2014103831A1 (ja) * | 2012-12-28 | 2014-07-03 | 株式会社Adeka | 担持体及び光電変換素子 |
CN105566942A (zh) * | 2015-10-13 | 2016-05-11 | 华东理工大学 | 一种长发射波长荧光染料的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0219896D0 (en) | 2002-08-27 | 2002-10-02 | Bayer Ag | Dihydropyridine derivatives |
US8153446B2 (en) | 2008-05-23 | 2012-04-10 | Kent State University | Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems |
US8906520B2 (en) | 2008-06-09 | 2014-12-09 | Solvay Usa, Inc. | Sulfonated polythiophenes comprising fused ring repeat units |
US20110243850A1 (en) * | 2008-12-25 | 2011-10-06 | Canon Kabushiki Kaisha | Probe for a biological specimen and labelling method and screening method using the probe |
US8846955B2 (en) | 2009-08-24 | 2014-09-30 | National Institute Of Information And Communications Technology | Second-order nonlinear optical compound and nonlinear optical element comprising the same |
WO2012103678A1 (zh) * | 2011-01-31 | 2012-08-09 | 大连理工大学 | 一类五甲川菁荧光染料、制备方法及其应用 |
CN102146215B (zh) * | 2011-01-31 | 2014-04-02 | 大连理工大学 | 一类五甲川菁荧光染料、制备方法及其应用 |
US8841409B2 (en) | 2012-03-22 | 2014-09-23 | Polyera Corporation | Conjugated polymers and their use in optoelectronic devices |
JP2013194039A (ja) | 2012-03-22 | 2013-09-30 | Nippon Shokubai Co Ltd | ホウ素含有化合物及びその製造方法 |
CN102757659B (zh) | 2012-07-24 | 2014-05-21 | 大连理工大学 | 一类咔唑类半菁荧光染料及其应用 |
SG11201502289RA (en) * | 2012-09-26 | 2015-04-29 | Agency Science Tech & Res | Fluorescent molecular rotors |
KR101718867B1 (ko) * | 2014-06-02 | 2017-03-22 | 한국과학기술연구원 | 생체적합성 형광 나노입자 및 이의 용도 |
CN105062465B (zh) | 2015-07-31 | 2018-06-15 | 山东大学 | 一类环境敏感型的α1-肾上腺素能受体近红外荧光配体及其应用 |
CN113444047B (zh) * | 2016-07-20 | 2023-06-16 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
-
2016
- 2016-07-20 CN CN201610573970.XA patent/CN107663384B/zh active Active
-
2017
- 2017-07-18 US US16/318,762 patent/US11365203B2/en active Active
- 2017-07-18 EP EP17830454.9A patent/EP3489323A4/en active Pending
- 2017-07-18 JP JP2019502739A patent/JP7186448B2/ja active Active
- 2017-07-18 WO PCT/CN2017/093270 patent/WO2018014820A1/zh unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0251114A2 (de) * | 1986-07-02 | 1988-01-07 | BASF Aktiengesellschaft | Thienothiophenfarbstoffe |
ES2307462A1 (es) * | 2008-06-30 | 2008-11-16 | Fundacion Universitaria San Pablo Ceu (70%) | Derivados de naftofurano y naftotiofeno como agentes antiproliferativos del cancer de pancreas y colon. |
CN102803924A (zh) * | 2009-06-05 | 2012-11-28 | 丹尼斯科美国公司 | 高流通量分子转子黏度测定法测定 |
WO2012102544A2 (ko) * | 2011-01-28 | 2012-08-02 | 주식회사 동진쎄미켐 | 신규한 유기염료 및 이의 제조방법 |
WO2014103831A1 (ja) * | 2012-12-28 | 2014-07-03 | 株式会社Adeka | 担持体及び光電変換素子 |
CN105566942A (zh) * | 2015-10-13 | 2016-05-11 | 华东理工大学 | 一种长发射波长荧光染料的制备方法 |
Non-Patent Citations (7)
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108300456B (zh) * | 2018-01-26 | 2020-08-18 | 华南理工大学 | 一类具有聚集诱导发光性质的荧光化合物在有机胺检测中的应用 |
CN108300456A (zh) * | 2018-01-26 | 2018-07-20 | 华南理工大学 | 一类具有聚集诱导发光性质的荧光化合物在有机胺检测中的应用 |
CN111592472B (zh) * | 2019-04-28 | 2022-10-21 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
CN111592472A (zh) * | 2019-04-28 | 2020-08-28 | 上海高驰资产管理有限公司 | 一种荧光染料及其制备方法和用途 |
CN111593052A (zh) * | 2019-04-28 | 2020-08-28 | 华东理工大学 | 一种rna检测与定量的方法 |
WO2020221217A1 (zh) * | 2019-04-28 | 2020-11-05 | 上海高驰资产管理有限公司 | 一种荧光染料及其制备方法和用途 |
CN110437219A (zh) * | 2019-07-09 | 2019-11-12 | 济南大学 | 一种检测粘度和二氧化硫双功能的荧光探针 |
WO2021057816A1 (zh) * | 2019-09-23 | 2021-04-01 | 华东理工大学 | 核酸适配体分子 |
CN110702653A (zh) * | 2019-10-16 | 2020-01-17 | 华中科技大学 | 一种聚集诱导荧光探针在指纹荧光成像中的应用 |
WO2021190346A1 (zh) * | 2020-03-23 | 2021-09-30 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
CN113501790A (zh) * | 2020-03-23 | 2021-10-15 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
CN112876496A (zh) * | 2021-03-16 | 2021-06-01 | 南京邮电大学 | 一种新型有机小分子光学诊疗探针及其制备方法与应用 |
CN112876496B (zh) * | 2021-03-16 | 2022-01-28 | 南京邮电大学 | 一种有机小分子光学诊疗探针及其制备方法与应用 |
CN115703771A (zh) * | 2021-08-06 | 2023-02-17 | 纳莹(上海)生物科技有限公司 | 一种荧光染料及其制备方法和用途 |
CN113754603B (zh) * | 2021-08-12 | 2022-04-19 | 浙江工业大学 | 一种异恶唑类化合物作为粘度荧光探针的应用 |
CN113754603A (zh) * | 2021-08-12 | 2021-12-07 | 浙江工业大学 | 一种异恶唑类化合物作为粘度荧光探针的应用 |
CN114605376A (zh) * | 2022-04-21 | 2022-06-10 | 济南大学 | 一种检测半胱氨酸和粘度的双功能荧光探针及其制备 |
Also Published As
Publication number | Publication date |
---|---|
WO2018014820A1 (zh) | 2018-01-25 |
EP3489323A4 (en) | 2020-05-06 |
EP3489323A1 (en) | 2019-05-29 |
US11365203B2 (en) | 2022-06-21 |
JP2019527279A (ja) | 2019-09-26 |
US20190241584A1 (en) | 2019-08-08 |
CN107663384B (zh) | 2020-05-12 |
JP7186448B2 (ja) | 2022-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107663384A (zh) | 一种荧光染料及其制备方法和用途 | |
JP7227741B2 (ja) | カルボキシxローダミン類似体 | |
JP7383283B2 (ja) | 蛍光プローブ及びその製造方法と使用 | |
EP1866387B1 (en) | Polar dyes | |
CA3025880C (en) | Coumarin compounds and their uses as fluorescent labels | |
KR20180129896A (ko) | 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료 | |
CN109574880A (zh) | 一种荧光探针及其制备方法和用途 | |
JP2020537630A (ja) | 第二級アミン置換クマリン化合物、および蛍光標識としてのそれらの使用 | |
CN102061103A (zh) | 一类氟化硼络合二吡咯甲川染料、制备方法及其应用 | |
CN108864058A (zh) | 一类氧杂蒽酮类荧光染料及应用 | |
CN104276936B (zh) | 一种双芘类化合物及其荧光纳米聚集体和应用 | |
CN105670608B (zh) | 一种可检测活细胞线粒体中镍离子的高选择性荧光探针及其制备方法 | |
CN106749366B (zh) | 一种含三芳基硼骨架的化合物及其制备方法和应用 | |
CN102590494B (zh) | 检测单链和/或双链dna的分子探针及其应用 | |
JP5319130B2 (ja) | ケイ光ソルバトクロミック色素及びその使用法 | |
EP4261209A1 (en) | Nucleic acid detection method, compound and fluorescent probe | |
CN104387790A (zh) | 一种含噻吩基团的苯并吲哚盐染料及其制备方法和用途 | |
Gupta et al. | Design and development of fluorescence-capable novel pyrazine-based polycyclic heteroaromatics for cellular bioimaging | |
CN112724701B (zh) | 一类红光香豆素类聚集诱导发光荧光染料 | |
He et al. | Design and chiroptical properties of a water-soluble and violet-blue emissive alkyne template | |
CN116535378A (zh) | 罗丹明类荧光染料及其应用 | |
JP6491486B2 (ja) | 8−アザ−3,7−ジデアザアデニンヌクレオシド誘導体、8−アザ−3,7−ジデアザアデニンヌクレオチド誘導体及びポリヌクレオチド誘導体ならびにプローブ | |
Clima | Application of a new Fluorescence Resonance Energy Transfer (FRET) system in synthetic DNA | |
CN102627635A (zh) | 罗丹明6g噁二唑化合物及其制备方法与应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200407 Address after: Room 306-6, building 1, No. 116, zhongjinqiao Road, Chongming District, Shanghai (Chongming Forest Tourism Park) (Chengqiao Town, Chongming District) Applicant after: Shanghai gaochi Asset Management Co., Ltd Address before: 200237 East China University of Science and Technology, 130 Meilong Road, Shanghai, Xuhui District Applicant before: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210203 Address after: 200231 room 412, 2A / F, phase I, 2715 Longwu Road, Xuhui District, Shanghai Patentee after: Naying (Shanghai) Biotechnology Co.,Ltd. Address before: Room 306-6, building 1, 116 zhongjinqiao Road, Chongming District, Shanghai (Chongming Forest Tourism Park) (Chengqiao Town, Chongming District) Patentee before: Shanghai gaochi Asset Management Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20180206 Assignee: Changzhou fuluosen Medical Technology Co.,Ltd. Assignor: Naying (Shanghai) Biotechnology Co.,Ltd. Contract record no.: X2022980001579 Denomination of invention: The invention relates to a fluorescent dye and a preparation method and application thereof Granted publication date: 20200512 License type: Exclusive License Record date: 20220216 |
|
EE01 | Entry into force of recordation of patent licensing contract |