CN107613965A - 用于减少胃排空的方法和组合物 - Google Patents
用于减少胃排空的方法和组合物 Download PDFInfo
- Publication number
- CN107613965A CN107613965A CN201680021578.2A CN201680021578A CN107613965A CN 107613965 A CN107613965 A CN 107613965A CN 201680021578 A CN201680021578 A CN 201680021578A CN 107613965 A CN107613965 A CN 107613965A
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- CN
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- Prior art keywords
- alkyl
- group
- amino
- medicament
- compound
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
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- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562118268P | 2015-02-19 | 2015-02-19 | |
| US62/118,268 | 2015-02-19 | ||
| PCT/US2016/018715 WO2016134283A1 (en) | 2015-02-19 | 2016-02-19 | Methods and compositions for decreasing gastric emptying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107613965A true CN107613965A (zh) | 2018-01-19 |
Family
ID=56689101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680021578.2A Pending CN107613965A (zh) | 2015-02-19 | 2016-02-19 | 用于减少胃排空的方法和组合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9763955B2 (enExample) |
| EP (1) | EP3258925B1 (enExample) |
| JP (1) | JP6762308B2 (enExample) |
| KR (1) | KR20170117170A (enExample) |
| CN (1) | CN107613965A (enExample) |
| AU (1) | AU2016219879A1 (enExample) |
| BR (1) | BR112017017619A2 (enExample) |
| CA (1) | CA2977367A1 (enExample) |
| IL (1) | IL253949A0 (enExample) |
| MX (1) | MX2017010682A (enExample) |
| PH (1) | PH12017501393A1 (enExample) |
| WO (1) | WO2016134283A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106397426A (zh) * | 2016-03-29 | 2017-02-15 | 广东环境保护工程职业学院 | 一种1,3,4-噻二唑类化合物及其制备方法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012007836A1 (en) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Pyridine compounds as sodium channel blockers |
| CA2822789A1 (en) | 2010-12-22 | 2012-06-28 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| TW201331186A (zh) | 2011-09-02 | 2013-08-01 | Purdue Pharma Lp | 作為鈉通道阻斷劑之嘧啶類 |
| US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| EP3039019B1 (en) | 2013-08-26 | 2020-04-22 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2015099841A1 (en) | 2013-12-23 | 2015-07-02 | Purdue Pharma L.P. | Indazoles and use thereof |
| EP3087073B1 (en) | 2013-12-26 | 2018-07-04 | Purdue Pharma LP | 10-substituted morphinan hydantoins |
| JP6526023B2 (ja) | 2014-01-24 | 2019-06-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン類及びピリミジン類並びにその使用 |
| AU2016219879A1 (en) * | 2015-02-19 | 2017-08-24 | Purdue Pharma L.P. | Methods and compositions for decreasing gastric emptying |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017490C1 (ru) * | 1990-01-18 | 1994-08-15 | Назаренко Петр Михайлович | Способ лечения демпин-синдрома после резекции желудка по способу бильрот-1 |
| CN1882536A (zh) * | 2003-11-21 | 2006-12-20 | 纽朗制药公司 | 3-氨基吡咯烷酮衍生物 |
| WO2014135955A1 (en) * | 2013-03-04 | 2014-09-12 | Purdue Pharma L.P. | Pyrimidine carboxamides as sodium channel blockers |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| US20040038970A1 (en) * | 1998-06-12 | 2004-02-26 | Societe De Conseils De Recherches Etd' Application Scientifiques, S.A.S. A Paris, France Corp. | Beta-carboline compounds |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| WO2001072714A2 (en) | 2000-03-24 | 2001-10-04 | Euro-Celtique S.A. | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker |
| AU2001249610B2 (en) | 2000-03-31 | 2005-03-24 | Euro-Celtique S.A. | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| MXPA04000411A (es) | 2001-07-16 | 2004-03-18 | Euro Celtique Sa | Tiazolidinonas arilo sustituidas y uso de las mismas. |
| AR036873A1 (es) | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| KR20040099324A (ko) | 2002-03-13 | 2004-11-26 | 유로-셀티큐 에스.에이. | 아릴 치환된 피리미딘 및 이것의 용도 |
| KR20050026031A (ko) | 2002-07-31 | 2005-03-14 | 유로-셀티큐 에스.에이. | 아릴 치환된 벤즈이미다졸 및 나트륨 채널 차단제로서이의 용도 |
| WO2004066987A2 (en) * | 2003-01-30 | 2004-08-12 | Dynogen Pharmaceuticals, Inc. | Use of sodium channel modulators for treating gastrointestinal tract disorders |
| EP1841415A2 (en) * | 2005-01-20 | 2007-10-10 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
| US20070020194A1 (en) | 2005-06-08 | 2007-01-25 | Greenway Frank L Iii | Nasally administered appetite suppressant |
| CA2633329A1 (en) | 2006-01-23 | 2007-07-26 | Pfizer Limited | Pyridine derivatives as sodium channel modulators |
| EP2078523A4 (en) * | 2006-10-13 | 2010-02-10 | Ajinomoto Kk | AGENT COMPRISING 4-HYDROXYISOLEUCINE FOR THE SUPPRESSION OF GASTRIC DRAIN |
| ES2389456T3 (es) | 2006-11-01 | 2012-10-26 | Purdue Pharma Lp | Compuestos de fenilpropionamida y uso de los mismos |
| JP5463285B2 (ja) | 2007-07-13 | 2014-04-09 | アイカジェン, インコーポレイテッド | ナトリウムチャネル阻害物質 |
| WO2009012242A2 (en) | 2007-07-13 | 2009-01-22 | Icagen, Inc. | Sodium channel inhibitors |
| EP2582666B1 (en) | 2010-06-16 | 2014-08-13 | Purdue Pharma L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
| WO2012004664A2 (en) | 2010-07-07 | 2012-01-12 | Purdue Pharma L.P. | Analogs of sodium channel peptide toxin |
| WO2012007836A1 (en) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Pyridine compounds as sodium channel blockers |
| EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| JP2013540130A (ja) | 2010-10-05 | 2013-10-31 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのキナゾリン化合物 |
| CA2822789A1 (en) | 2010-12-22 | 2012-06-28 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| TW201331186A (zh) | 2011-09-02 | 2013-08-01 | Purdue Pharma Lp | 作為鈉通道阻斷劑之嘧啶類 |
| UA109220C2 (uk) | 2011-10-26 | 2015-07-27 | Пфайзер Лімітед | Похідні (4-фенілімідазол-2-іл)етиламіну як модулятори натрієвих каналів |
| WO2013064884A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| JP5938219B2 (ja) * | 2012-01-23 | 2016-06-22 | 株式会社明治 | 胃排出遅延のための食品用の剤または医療用の剤 |
| US9206127B2 (en) | 2012-03-16 | 2015-12-08 | Purdue Pharm, L.P. | Substituted pyridines as sodium channel blockers |
| WO2014016673A1 (en) | 2012-07-27 | 2014-01-30 | Purdue Pharma L.P. | Sodium channel blocking peptides and the use thereof |
| CA3082427A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| AU2016219879A1 (en) * | 2015-02-19 | 2017-08-24 | Purdue Pharma L.P. | Methods and compositions for decreasing gastric emptying |
-
2016
- 2016-02-19 AU AU2016219879A patent/AU2016219879A1/en not_active Abandoned
- 2016-02-19 US US15/048,530 patent/US9763955B2/en active Active
- 2016-02-19 BR BR112017017619A patent/BR112017017619A2/pt not_active Application Discontinuation
- 2016-02-19 JP JP2017543916A patent/JP6762308B2/ja active Active
- 2016-02-19 KR KR1020177025621A patent/KR20170117170A/ko not_active Withdrawn
- 2016-02-19 CN CN201680021578.2A patent/CN107613965A/zh active Pending
- 2016-02-19 MX MX2017010682A patent/MX2017010682A/es unknown
- 2016-02-19 WO PCT/US2016/018715 patent/WO2016134283A1/en not_active Ceased
- 2016-02-19 CA CA2977367A patent/CA2977367A1/en not_active Abandoned
- 2016-02-19 EP EP16753165.6A patent/EP3258925B1/en active Active
-
2017
- 2017-08-03 PH PH12017501393A patent/PH12017501393A1/en unknown
- 2017-08-10 IL IL253949A patent/IL253949A0/en unknown
- 2017-08-18 US US15/680,737 patent/US10143696B2/en active Active
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| RU2017490C1 (ru) * | 1990-01-18 | 1994-08-15 | Назаренко Петр Михайлович | Способ лечения демпин-синдрома после резекции желудка по способу бильрот-1 |
| CN1882536A (zh) * | 2003-11-21 | 2006-12-20 | 纽朗制药公司 | 3-氨基吡咯烷酮衍生物 |
| WO2014135955A1 (en) * | 2013-03-04 | 2014-09-12 | Purdue Pharma L.P. | Pyrimidine carboxamides as sodium channel blockers |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106397426A (zh) * | 2016-03-29 | 2017-02-15 | 广东环境保护工程职业学院 | 一种1,3,4-噻二唑类化合物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016134283A1 (en) | 2016-08-25 |
| EP3258925A4 (en) | 2019-01-09 |
| BR112017017619A2 (pt) | 2018-05-08 |
| KR20170117170A (ko) | 2017-10-20 |
| JP2018509397A (ja) | 2018-04-05 |
| MX2017010682A (es) | 2018-04-24 |
| US20170340646A1 (en) | 2017-11-30 |
| IL253949A0 (en) | 2017-10-31 |
| AU2016219879A1 (en) | 2017-08-24 |
| US9763955B2 (en) | 2017-09-19 |
| US10143696B2 (en) | 2018-12-04 |
| CA2977367A1 (en) | 2016-08-25 |
| JP6762308B2 (ja) | 2020-09-30 |
| PH12017501393A1 (en) | 2018-01-08 |
| US20160243129A1 (en) | 2016-08-25 |
| EP3258925B1 (en) | 2023-03-29 |
| EP3258925A1 (en) | 2017-12-27 |
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