CN107551262A - It is a kind of that there is anti-ageing, wrinkle removing effect formulation product - Google Patents
It is a kind of that there is anti-ageing, wrinkle removing effect formulation product Download PDFInfo
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Abstract
There is anti-ageing, wrinkle removing effect formulation product the invention provides a kind of, it is mainly made up of the raw material of following parts by weight：1 50 parts of collagen；0.1 10 parts of aloe vera gel；1 50 parts of Bee Pollen.The present invention realizes metabolism synthesis of the human body itself to collagenous fibres, elastomer, contributes to the reparation, reconstruction and growth of collagenous fibres and elastomer by each raw material components scientific compatibility, makes that the turgor of human body, water be tender, gloss.Good effect, safe and non-toxic evil, does not produce accordance with tolerance, the effect of can reach anti-ageing, smoothing wrinkle.
Description
Technical field
It is more particularly to a kind of that there is anti-ageing, smoothing wrinkle formulation product (composition) the present invention relates to a kind of compound composition,
A kind of more particularly to formulation product prepared using collagen, aloe vera gel and Bee Pollen as raw material.
Background technology
Aging turns into whole one heavy problem of Chinese society, with the development of bioscience, the progress of medical science, people
Also achieve part achievement in terms of anti-aging, and the aging form of face is embodied directly in the performance of wrinkle.Wrinkle is face
The aging sign in portion, a series for the treatment of methods that rhytidectomy is carried out primarily directed to facial tissue's relaxation caused by aging, its
Very long evolution process is experienced, still needs further to be developed perfect.
1 operation rhytidectomy
With the progress to facial anatomical study and the deep understanding to skin senescence, face crinkle-removing operation have passed through many
Change.
1.1 first generation, simple subcutaneous stripping resection and suture operation, correct skin of cheek sagging, and deeper Nasolabial furrow wrinkles effect is poor,
Postoperative effect is held time shorter.
1.2 second generations, SMAS peel off rhytidectomy, and the effect that the art improves Middle face skin aging is unsatisfactory, and
SMAS shaping suspensions also have the danger for forming hemotoncus and damaging facial nerve.
1.3 third generations, subperiosteum rhytidectomy, subperiosteum rhytidectomy technical requirements are higher, complex operation, and damage is relatively
Greatly, periosteum and skull metabolism can be influenceed, has cut off scalp blood confession, it is big to body injury.
1.4 endoscopic face rhytidectomies, be by instrument, and equipment is expensive, complex operation, and the postoperative swelling time is longer.
2 laser class rhytidectomies
Mainly for the collagen tissue and elastomer of skin, it is divided into exfoliative Laser final guidance shell and non-stripping property laser smoothing wrinkle
Art.At present, lossless laser smoothing wrinkle shortcoming is offer limited effectiveness and treatment number of times is more, the cycle is longer.
3 biological rhytidectomies
3.1A type btulinum toxin injections, smoothing wrinkle need it is vigilant be can cause it is of flaccid muscles, what muscle was benumbed
Poison, injection technique requires high, and dosage is difficult that control reaches precision.
3.2 sheep placentas inject smoothing wrinkle sheep placenta, and due to various conditionalities, present this injection system is at home not yet just
Rule use.
3.3 collagen injection smoothing wrinkles, it is maximum the shortcomings that be exactly that can only keep the effect of 3 months or so after injection, need to fill out repeatedly
Fill, while the possibility for thering is foreign body granuloma to occur, it is domestic seldom to carry out.
3.4 hyaluronic acid injection smoothing wrinkles are, it is necessary to ceaselessly inject supplement, the duration is substantially similar with collagen, and price is held high
It is expensive.
3.5 organizational project auto derma cell infusions, its process are to separate a kind of cell in autologous skin,
Injected after in-vitro multiplication, still there are many experts to breed the controllability of this process for laboratory and represent doubt, technology
It is immature.
3.6 autologous fat cell transplantation rhytidectomies, fatty absorptivity are 50%~70%, so needing constantly repeatedly more
Secondary injection, and risk is big, cost is high.
3.7 variant cells transplanting carry out smoothing wrinkle, at present for, still have one section of no small distance apart from clinical practice.
Anti-aging is one of emphasis and difficult point of life science.Now widely used operation method price is held high
It is expensive, and technical problem, safety problem more or less be present, make it difficult to be obtained and be widely applied.
In addition, present whitening goes the product of wrinkle to contain the material such as hormone or some heavy metals mostly, even if a period of time energy
Enough play a part of whitening and go wrinkle, it is permanent to use, some side effects can be produced to skin, while some danger can be also produced to human body
Evil.
The content of the invention
The engineering properties of skin is mainly due to two fibre fractionations of okioplast matter：Collagenous fibres and elastomer.
Collagenous fibres bear degrees of tensions, and complete elastic webs provide elastic force, and two different processes are presented in skin aging, with not
Elastin laminin is worked with mode：Congenital ageing process is presented with the loss crumbling method of elastic fibers of skin, cutis laxa,
Wrinkle and thinning.The day after tomorrow solar exposure, it is thickening to be rendered as skin, nonelastic like grass-like.Although the elastic material of two processes is absolute
It is horizontal different, but in both cases, the loss of function elastic webs has common feature, and therefore, skin elasticity is with complete
Based on elastic webs, with reference to the interaction between other related organizations.In human body cell inner transparent matter acid molecule
The not connection breaking of chain forms hyaluronic acid post, and hyaluronic acid identification, affine, connection collagen form core protein post, sulfuric acid
Chondroitin, keratan sulfate multi-form are connected to the electronegative egg of macromolecular long-chain that grid structure is formed on core protein post
White polysaccharide condensate, the place held and cut is created for hydrone, is formed in " water storage storehouse ", is moisturized so as to play, is lifted skin
Elasticity and gloss.
The present inventor by studying for a long period of time discoverys, anti-ageing, smoothing wrinkle composition of the invention by comprising (preferably II types)
Collagen forms dermal matrix, and proteoglycan aggregate that they are formed participates in intradermal collagenous fibres and elastomer
Synthesis and renewal.(preferably II types) collagen can enable skin give full play to increment, differentiation and growth regeneration function, make
Elastomer and collagenous fibres in corium are repaired in time, and the function that proteoglycan aggregate recovers its " water storage storehouse " pins water
Point, skin elasticity, tension force enhancing, phenomena such as skin metabolism is accelerated, desalinates wrinkle, make loose, dark yellow, greasy, pigmentation, obtain
To being obviously improved.By supplementing appropriate (preferably II types) collagen, strengthen the biosynthesis of elastomer, with skin physiology
Approach prevents elastin degradation from slowing down ageing process.In the cooperation of the nutriments such as aloe vera gel, Bee Pollen
Under synergy, nutrition reparation side more excellent, safe, natural, have no toxic side effect, convenient is provided for target group
Case.
Therefore, the present invention provides the following：
1. a kind of have anti-ageing, wrinkle removing effect formulation product, wherein the formulation product includes by weight：Collagen
Albumen 1-50 parts；Aloe vera gel 0.1-10 parts；Bee Pollen 1-50 parts.It is preferred that above-mentioned parts by weight are dry weight parts by weight.
2. the formulation product described in 1 according to more than, wherein the formulation product includes by weight：Collagen 15-
35 parts；Aloe vera gel 0.3-1 parts；Bee Pollen 15-35 parts.
3. the formulation product described in 1 or 2 according to more than, wherein the collagen is I-type collagen, II Collagen Type VI eggs
In vain, type III collagen or their mixture, and/or from biological cartilage (such as chicken cartilage, fish cartilage, ox cartilage, pig
Cartilage and other biological cartilages), fish scale, animal skin (such as fish-skin, pigskin, ox-hide and other biological skins), biological muscle tendon groups
Knit, bone extraction made from collagen, compound ossein, ossein, bone collagen, bone collagen peptide, I-type collagen or
Combinations thereof/mixture.
4. the formulation product any one of 1 to 3 according to more than, wherein the aloe vera gel can be Curacao
Aloe gel powder, aloe vera gel juice or combinations thereof/mixture.
5. the formulation product according to more than any one of 1 to 4, wherein the Bee Pollen be rape pollen, lotus powder,
Zasiokaurin, pollen pini, sunflower powder, Pollen Astragali Melilotoidis (Pollen Astragali Sinici), pollen of Semen Fagopyri Esculenti, sesame pollen, jowar pollen etc. or their group
Conjunction/mixture.
6. the formulation product any one of 1 to 5 according to more than, wherein the formulation product can also wrap by weight
The isoflavones of part containing 1-50, vitamin C, tomato meal, purple sweet potato powder etc. or combinations thereof.It is preferred that above-mentioned parts by weight are dry weights
Parts by weight.
7. the formulation product according to more than any one of 1 to 6, its also comprising one or more sweeteners, flavor enhancement,
Stabilizer and/or colouring agent.
8. the formulation product any one of 1 to 7 according to more than, it can be configured to powder, particle, solution, suspension
Liquid, tablet, capsule pharmaceutical dosage forms or be formulated into bread, soft or boiled goods, special medicine purposes formula food, biscuit
Or the food form for meal product.
9. a kind of method for preparing the formulation product any one of 1 to 8 according to more than, methods described include：By glue
Former albumen, aloe vera gel, Bee Pollen are mixed and made into the formulation product.
10. formulation product according to more than any one of 1 to 9 prepare anti-ageing, smoothing wrinkle product (for example, cosmetics,
Food, nutriment and medicine) in application.
Embodiment
According to an aspect of the invention, there is provided a kind of be used for anti-ageing, wrinkle removing effect formulation product, wherein described match somebody with somebody
Square product contains collagen, aloe vera gel and Bee Pollen.
Collagen
Collagen is a kind of hmw protein, thread collagen fabric, skin can be made to keep solid and have bullet
Property.Collagen is the main component in skin, accounts for more than 71% of protein content in skin cell.The growth of skin, repair
Multiple and nutrition all be unable to do without collagen.Collagen can promote the growth of collagenous fibres, elastomer, cell is become rich
It is full, so that skin fills, skin elasticity is kept with moistening.Therefore, supplement skin collagen is just particularly important, the traditional Chinese medical science
It has long been recognized that by the use of tortoise-shell glue, deer horn glue, donkey-hide gelatin etc. as invigorant, anti-aging, the effect of beautifying face and moistering lotion can be played.These
All contain substantial amounts of collagen.In addition, also containing substantial amounts of amino acid in collagen, its main component is glycine, hydroxyl
The free amino acid such as proline, alanine, asparatate, serine, amino acid content account for 40% or so, and they are all days
Right moisturizing factor composition.In addition, on the outside of tropocollagen molecule hydrophilic groups and hydroxyl etc. a large amount of presence, make tropocollagen molecule easily
Hydrogen bond is formed with water, therefore collagen and polypeptide have good water conservation moisture-keeping functions.The species of collagen is more, common
Type is I types, II types, type III, V-type and XI types.In the present invention, it is preferred to II collagen types.
Aloe vera gel
Aloe has the reputation of skin care good product according to Historical Data Data About from ancient times, and protrusion, which is embodied in it, has excellent humectant properties.Nearly 10
Year, the composition to aloe and medical value have been carried out widely studied both at home and abroad, it was demonstrated that contain abundant natural bioactivity substance
Such as polysaccharide, aloin, amino acid, protein, organic acid, organized enzyme and various trace elements, there is the good of beautifying
Good effect.
The moisturizing mechanism of active aloe polysaccharide is that it contains a large amount of polar groups such as hydroxyl, carboxyl etc., can be with hydrone
Form hydrogen bond and be bonded water lock, while polysaccharide molecule chain is interweaved and reticulated, so as to there is very strong water lock effect.Other polysaccharide
With good film forming, one layer of uniform film can be formed in skin surface, reduce the moisture evaporation of epidermis, preserve skin
The moisture of itself, reach moisturizing effect.In addition, aloe polysaccharide and the endogenous polysaccharide component and threadiness in skin extracellular matrix
Protein collectively constitutes extracellular gelatinised matrix, and the matrix contains large quantity of moisture, can provide moisture for skin and reach moisturizing effects.
In the present invention, it is preferred to aloe be aloe barbadensis Miller (Aloe barbadensis), originate in the western India in America
The Curacao archipelago in archipelago and Barbados, so also someone is referred to as barbados aloe, U.S.'s aloe barbadensis Miller and luxuriant drawing
Aloe.Aloe vera gel is using aloe barbadensis Miller blade as raw material, and the step such as cleaned, peeling, blanching, sterilization is made.
Aloe vera gel can be the form of aloe vera gel juice.It is alternative, aloe vera gel by drying and/or
Aloe vera gel powder can be made in crushing.
Bee Pollen
Bee Pollen refers to the pollen load taken back during honeybee producting honey, the pollen formed in honeycomb after storage and fermentation.
Bee Pollen anti-aging effects mechanism Bee Pollen anti-aging effects be based primarily upon Bee Pollen can remove cause human senility it is excessive from
By base, the disease caused by free radical is excessive is prevented and treated, the aging rate of delaying human body, extends the life-span.It is in particular in following several
Aspect.
1st, for Bee Pollen to the facilitation of humoral immunity and cellular immunity according to animal experiment, the mouse for eating pollen can be bright
ATP content in the aobvious old Mice red cell of increase, myocardial freedom base is reduced after person in middle and old age mouse eats pollen, and in liver, lung tissue
Superoxide dismutase (SOD) substantially doubles, and lung is especially notable, muscle and corticocerebral lipofuscin (age pigment)
Also obvious to reduce, pollen also can reduce the free-radical chemistry luminous intensity of housefly in addition, and SOD activity significantly increases, and says
Bright pollen anti-aging is effective.
2nd, the antioxidant content such as the superoxide dismutase contained by Bee Pollen, vitamin E, vitamin C, selenium, zinc can prevent
The formation of lipid peroxide, so as to play a part of building up health and anti-aging, nutrition skin is moistened, improves skin appearance,
Make skin emolliency and increase elasticity, recover the elastic and bright and clean of skin.
It is used for the proportioning of each component in anti-ageing, wrinkle removing effect formulation product for the present invention, is not particularly limited.At this
In one preferred embodiment of invention, the formulation product includes by weight：Collagen 1-50 parts (for example, 10 parts,
25 parts, 40 parts)；Aloe vera gel 0.1-10 parts (for example, 0.1 part, 5 parts, 8 parts)；With Bee Pollen 1-50 parts (for example, 10
Part, 25 parts, 40 parts).In another preferred embodiment of the present invention, the formulation product includes by weight：Collagen
- 35 parts of protein 15；Aloe vera gel 0.3-1 parts；Bee Pollen 15-35 parts.
In another preferred embodiment of the present invention, the present invention is a kind of with the production of anti-ageing, wrinkle removing effect formula
Product, wherein be only to be made up of collagen, aloe vera gel and Bee Pollen for anti-ageing, smoothing wrinkle active component, and
Not comprising other active materials, preferably described formulation product consists of by weight：Collagen 1-50 parts；Ku La
Rope aloe gel 0.1-10 parts；Bee Pollen 1-50 parts.
In another embodiment of the present invention, the formulation product also includes other composition.It is preferred real at one
Apply in scheme, the formulation product also includes the isoflavones, vitamin C, tomato meal, purple sweet potato powder of 1-50 parts by weight
Deng or combinations thereof.
In another embodiment of the present invention, the formulation product is also comprising can on one or more medicines or food
The assistant agent of receiving, such as sweetener, flavor enhancement, stabilizer and/or colouring agent.
The formulation product of the present invention can be configured to the pharmaceutical preparation of powder, particle, solution, suspension, tablet, capsule
Form or be formulated into bread, soft or boiled goods, special medicine purposes formula food (can basis《Special medicine purposes formula is eaten
Product general rule》(GB 29922-2013) prepare), biscuit or for meal product food form.
According to another aspect of the present invention, there is provided the method that one kind prepares above-mentioned formulation product (composition), it is described
Method includes：Collagen, aloe vera gel and Bee Pollen are mixed and made into the formulation product.
The present invention also provides above-mentioned formulation product (composition) in preparing with anti-ageing, wrinkle removing effect formulation product
Using.
Therefore, the present invention provides a kind of with anti-ageing, wrinkle removing effect collagen, aloe vera gel, Bee Pollen
Compound formulation formula, good effect, safe and non-toxic evil, do not produce dependence, internal collagenous fibres and elastomer can be promoted
Tissue regeneration ability, reach anti-ageing, smoothing wrinkle purpose.
Embodiment
The present invention is described in detail hereinafter with reference to embodiment, the embodiment is only intended to illustrate the present invention, without
It is intended to limit the scope of the present invention.The scope of the present invention is specifically limited by appended claims.
Prepare embodiment
Collagen (II collagen types) is purchased from Gongan County regent biochemistry Co., Ltd (lot number：
20160301), aloe vera gel powder is purchased from Yunnan Evergreen Biotechnology Co., Ltd.'s (lot number：20160101), melissa
Powder (broken wall rape pollen) is purchased from Henan Wei Kang apicultures Co., Ltd (lot number：WK2016040301).Weigh according to dry weight meter.
Embodiment 1：
In this embodiment, formulation product of the invention (composition) includes by weight：10 parts of collagen, Curacao
0.1 part of aloe gel, 10 parts of Bee Pollen, the powder made after being mixed, particle, liquid, tablet or capsule.
Embodiment 2：
In this embodiment, formulation product of the invention (composition) includes by weight：25 parts of collagen, Curacao
5 parts of aloe gel, 25 parts of Bee Pollen, the powder made after being mixed, particle, liquid, tablet or capsule.
Embodiment 3：
In this embodiment, formulation product of the invention (composition) includes by weight：40 parts of collagen, Curacao
8 parts of aloe gel, 40 parts of Bee Pollen, the powder made after being mixed, particle, liquid, tablet or capsule.
Embodiment 4：
In this embodiment, formulation product of the invention (composition) includes by weight：10 parts of collagen, Curacao
0.3 part of aloe gel, 5 parts of Bee Pollen, the powder made after being mixed, particle, liquid, tablet or capsule.
Effect example
Embodiment 5：
Population experiment
Dept. of dermatology of Hubei Provincial Hospital of TCM in 2016 is carried out to 200 dry skins, the women that face wrinkles are more, deeper
Continuous trimestral efficacy validation orally takes experiment by a definite date, and tested population ages are between 35-55 year.
When they are taking anti-ageing, smoothing wrinkle the composition product (collagen of the present invention：Aloe vera gel powder：Honeybee
Pollen (pressing dry weight weight part ratio)=10:0.3:5) while, subject does not change original eating habit during experiment, just
Normal diet, it must not take or inject the article of other holding moisture of skin and influence the cosmetics of result of determination.
The assay method of moisture：The skin test produced using German Courage+Khazaka companies (German CK companies)
Instrument, Corneometer CM825 survey moisture of skin, by the tested skin surface that is pressed in of moisture measurement probe vertical during measurement, visit
Overhead is pushed back a segment distance, and result is shown on main frame in 1 second.Measurement 3 times, averages.
PH assay method：Using the Skin- using German Courage+Khazaka companies (German CK companies) production
PH-Meter PH900 detect skin pH, and first instrument is corrected with pH=7.0 and pH=4.0 standard liquid before measurement.
Test probe is soaked in potassium chloride buffer solution before measurement, cleans in distilled water popping one's head in during test, gently gets rid of
Probe vertical is placed on tester's skin surface after unnecessary distilled water, the switch in test probe is clicked, measures and terminate after 1s
After read result.Measurement 3 times, averages.
By NULL, 40 collagens for taking (each 3g, daily morning and evening 2 times) above example of the present invention,
The subject of aloe vera gel, broken wall rape pollen compound formulation formulation product, uninterruptedly took through 90 days, 37 skins
Texture substantially reduces, and skin is moist than before, elastic increase, total effective rate 92.5%.
40 simple subjects for taking collagen raw material, uninterruptedly took, 18 dermatoglyphs are obvious by 90 days
Reduce, skin is moist than before, elastic increase, total effective rate 45%.
40 simple subjects for taking aloe vera gel raw material, uninterruptedly took, 9 dermatoglyphs by 90 days
It has been reduced that, skin is moist than before, total effective rate 22.5%.
40 simple subjects for taking melissa powder raw material, uninterruptedly took, 5 dermatoglyphs have subtracted by 90 days
Few, skin is moist than before, total effective rate 12.5%.
40 subjects for only taking aloe vera gel and Bee Pollen, during uninterruptedly being taken by 90 days, 11
Dermatoglyph has been reduced, and skin is moist than before, total effective rate 27.5%.
Following table is that subject takes the moisture of skin after different formulations composition and pH value and improves situationIts
InAverage value is represented, S represents standard deviation：
Above experiment results proved, while take collagen, aloe vera gel, the production of Bee Pollen compound formulation formula
The total effective rate of product significantly larger than individually take each raw material efficient plus and, it was demonstrated that collagen egg in formulation product of the invention
In vain, aloe vera gel and the Bee Pollen three in terms of anti-ageing, smoothing wrinkle have synergy.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
1. a kind of have anti-ageing, wrinkle removing effect formulation product, wherein the formulation product includes by weight：Collagen
1-50 parts；Aloe vera gel 0.1-10 parts；Bee Pollen 1-50 parts.
2. formulation product according to claim 1, wherein the formulation product includes by weight：Collagen 15-
35 parts；Aloe vera gel 0.3-1 parts；Bee Pollen 15-35 parts.
3. formulation product according to claim 1 or 2, wherein the collagen is I-type collagen, II Collagen Type VI eggs
In vain, type III collagen or their mixture, and/or from biological cartilage (such as chicken cartilage, fish cartilage, ox cartilage, pig
Cartilage and other biological cartilages), fish scale, animal skin (such as fish-skin, pigskin, ox-hide and other biological skins), biological muscle tendon groups
Knit, bone extraction made from collagen, compound ossein, bone collagen, bone collagen peptide, I-type collagen or they
Combination/mixture.
4. formulation product according to any one of claim 1 to 3, wherein the aloe vera gel can be Curacao
Aloe gel powder, aloe vera gel juice or combinations thereof/mixture.
5. formulation product according to any one of claim 1 to 4, wherein the Bee Pollen be rape pollen, lotus powder,
Zasiokaurin, pollen pini, sunflower powder, Pollen Astragali Melilotoidis (Pollen Astragali Sinici), pollen of Semen Fagopyri Esculenti, sesame pollen, jowar pollen etc. or their group
Conjunction/mixture.
6. formulation product according to any one of claim 1 to 5, wherein the formulation product can also wrap by weight
The isoflavones of part containing 1-50, vitamin C, tomato meal, purple sweet potato powder etc. or combinations thereof/mixture.
7. formulation product according to any one of claim 1 to 6, its also comprising one or more sweeteners, flavor enhancement,
Stabilizer and/or colouring agent.
8. formulation product according to any one of claim 1 to 7, it can be configured to powder, particle, solution, suspension
Liquid, tablet, capsule pharmaceutical dosage forms or be formulated into bread, soft or boiled goods, special medicine purposes formula food, biscuit
Or the food form for meal product.
9. a kind of method for preparing formulation product according to any one of claim 1 to 8, methods described include：By glue
Former albumen, aloe vera gel and Bee Pollen are mixed and made into the formulation product.
10. formulation product according to any one of claim 1 to 9 prepare anti-ageing, smoothing wrinkle product (for example, cosmetics,
Food, nutriment and medicine) in application.
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| CN109106679A (en) * | 2018-11-01 | 2019-01-01 | 独角兽生命科学股份公司 | Anti-ageing Regeneration and Repair liquid of skin and preparation method thereof |
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Application publication date: 20180109 |