CN107536802A - 注射剂 - Google Patents
注射剂 Download PDFInfo
- Publication number
- CN107536802A CN107536802A CN201710701596.1A CN201710701596A CN107536802A CN 107536802 A CN107536802 A CN 107536802A CN 201710701596 A CN201710701596 A CN 201710701596A CN 107536802 A CN107536802 A CN 107536802A
- Authority
- CN
- China
- Prior art keywords
- injection
- bases
- salt
- compound
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000002347 injection Methods 0.000 title claims abstract description 199
- 150000003839 salts Chemical class 0.000 claims abstract description 128
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- 229930192474 thiophene Natural products 0.000 claims abstract description 48
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 95
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 41
- 239000011230 binding agent Substances 0.000 claims description 33
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 25
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 11
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- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims description 3
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023036003A1 (zh) | 2021-09-07 | 2023-03-16 | 四川科伦药物研究院有限公司 | 注射用布瑞哌唑长效制剂及其制备方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| JOP20210047A1 (ar) * | 2012-10-25 | 2017-06-16 | Otsuka Pharma Co Ltd | عامل وقائي و/أو علاجي للأعراض السلوكية والنفسية المصحوبة بمرض تنكسي عصبي أو الأعراض الإندفاعية المصحوبة بمرض ذهني، يحتوي على بريكسبيرازول أو ملحه |
| WO2017106641A1 (en) * | 2015-12-17 | 2017-06-22 | Assia Chemical Industries Ltd. | Solid state forms of brexpiprazole |
| US10501450B2 (en) | 2016-02-01 | 2019-12-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole di-hydrate for use in intramuscular injectable sustained release formulations |
| WO2017208251A1 (en) * | 2016-05-31 | 2017-12-07 | Cipla Limited | A new stable polymorph of brexpiprazole and process for preparation thereof |
| WO2018033484A1 (en) | 2016-08-16 | 2018-02-22 | Hexal Aktiengesellschaft | Pharmaceutical compositions of a benzothiophene compound |
| WO2018141886A1 (en) | 2017-02-02 | 2018-08-09 | Hexal Aktiengesellschaft | Crystalline brexpiprazole |
| WO2020196814A1 (en) * | 2019-03-28 | 2020-10-01 | Otsuka Pharmaceutical Co., Ltd. | Benzoazepine compound-containing freeze-dried composition |
| WO2021029020A1 (ja) * | 2019-08-13 | 2021-02-18 | 大塚製薬株式会社 | 経口医薬組成物 |
| CN117214053A (zh) * | 2023-10-17 | 2023-12-12 | 海南卫康制药(潜山)有限公司 | 一种注射用头孢呋辛钠肌注混悬液的粒度测定方法 |
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| ES2284202T3 (es) | 1997-05-14 | 2007-11-01 | Senju Pharmaceutical Co., Ltd. | Preparaciones acuosas en suspension con excelente redispersabilidad. |
| JP3402195B2 (ja) * | 1997-05-14 | 2003-04-28 | 千寿製薬株式会社 | 再分散性の良い水性懸濁液剤 |
| US6656505B2 (en) * | 2000-07-21 | 2003-12-02 | Alpharma Uspd Inc. | Method for forming an aqueous flocculated suspension |
| JP5000835B2 (ja) * | 2000-08-25 | 2012-08-15 | 千寿製薬株式会社 | 水性懸濁液剤 |
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| US20050032811A1 (en) * | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| CA2543242C (en) * | 2003-10-23 | 2015-04-14 | Otsuka Pharmaceutical Co., Ltd. | Controlled release sterile freeze-dried aripiprazole formulation and injectable formulation thereof |
| JP4315393B2 (ja) | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| US20070148100A1 (en) | 2005-09-15 | 2007-06-28 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| CA2717605C (en) * | 2008-03-11 | 2012-05-15 | Alcon Research Ltd. | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection |
| MX2011005217A (es) * | 2008-11-19 | 2011-06-01 | Merial Ltd | Formulaciones que comprenden ceftiofur y cetoprofeno o ceftiofur y alcohol bencilico. |
| EP2629775A4 (en) * | 2010-10-18 | 2014-06-11 | Dainippon Sumitomo Pharma Co | INJECTABLE FORMULATION WITH DELAYED RELEASE |
| PL2685979T3 (pl) * | 2011-03-18 | 2017-02-28 | Alkermes Pharma Ireland Limited | Kompozycje farmaceutyczne do wstrzykiwania zawierające środek nierozpuszczalny w wodzie, środek przeciwpsychotyczny, laurynian sorbitanu i polisorbat 20 |
| JP2012232958A (ja) | 2011-05-09 | 2012-11-29 | Otsuka Pharmaceut Co Ltd | 注射製剤 |
| CA2867137C (en) * | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| JOP20200109A1 (ar) * | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
-
2013
- 2013-04-22 AR ARP130101320A patent/AR090775A1/es not_active Application Discontinuation
- 2013-04-23 UA UAA201412554A patent/UA118084C2/uk unknown
- 2013-04-23 HR HRP20190841TT patent/HRP20190841T4/hr unknown
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- 2013-04-23 MX MX2014012734A patent/MX361722B/es active IP Right Grant
- 2013-04-23 CN CN201710701596.1A patent/CN107536802A/zh active Pending
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- 2013-04-23 IN IN8870DEN2014 patent/IN2014DN08870A/en unknown
- 2013-04-23 JO JOP/2013/0115A patent/JO3524B1/ar active
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- 2013-04-23 US US14/395,681 patent/US20150086632A1/en not_active Abandoned
- 2013-04-23 KR KR1020147032097A patent/KR102168263B1/ko active Active
- 2013-04-23 WO PCT/JP2013/061950 patent/WO2013161830A1/ja not_active Ceased
- 2013-04-23 PT PT13781458T patent/PT2868318T/pt unknown
- 2013-04-23 DK DK13781458.8T patent/DK2868318T4/da active
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- 2013-04-23 MY MYPI2014703102A patent/MY169099A/en unknown
- 2013-04-23 PL PL13781458T patent/PL2868318T5/pl unknown
- 2013-04-23 SI SI201331442T patent/SI2868318T2/sl unknown
- 2013-04-23 EP EP13781458.8A patent/EP2868318B2/en active Active
- 2013-04-23 HU HUE13781458A patent/HUE043686T2/hu unknown
- 2013-04-23 SG SG11201406775UA patent/SG11201406775UA/en unknown
- 2013-04-23 CN CN201911077087.1A patent/CN110638752A/zh active Pending
- 2013-04-23 BR BR112014026398-1A patent/BR112014026398B1/pt active IP Right Grant
- 2013-04-23 CN CN201380021612.2A patent/CN104363912A/zh active Pending
- 2013-04-23 SG SG10201608684QA patent/SG10201608684QA/en unknown
- 2013-04-23 LT LTEP13781458.8T patent/LT2868318T/lt unknown
- 2013-04-23 NZ NZ630255A patent/NZ630255A/en unknown
- 2013-04-23 CN CN202010921162.4A patent/CN111888329A/zh active Pending
- 2013-04-23 AU AU2013253518A patent/AU2013253518B2/en active Active
- 2013-04-23 EA EA201491937A patent/EA026124B1/ru not_active IP Right Cessation
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2014
- 2014-10-20 IL IL235211A patent/IL235211A0/en active IP Right Grant
- 2014-10-22 PH PH12014502366A patent/PH12014502366A1/en unknown
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2017
- 2017-09-12 US US15/702,361 patent/US10624889B2/en active Active
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2019
- 2019-06-06 CY CY20191100602T patent/CY1123195T1/el unknown
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2020
- 2020-01-28 US US16/775,222 patent/US20200163960A1/en not_active Abandoned
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2022
- 2022-02-11 US US17/650,822 patent/US20220305007A1/en not_active Abandoned
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2023
- 2023-12-15 US US18/541,083 patent/US20240277702A1/en not_active Abandoned
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2024
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023036003A1 (zh) | 2021-09-07 | 2023-03-16 | 四川科伦药物研究院有限公司 | 注射用布瑞哌唑长效制剂及其制备方法 |
| EP4400097A4 (en) * | 2021-09-07 | 2025-06-25 | Sichuan Kelun Pharmaceutical Research Institute Co., Ltd. | PREPARATION OF LONG-ACTING BREXPIPRAZOLE FOR INJECTION AND PROCESS FOR ITS PREPARATION |
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