CN107530374B - 用于口腔炎症的钙和磷酸盐的制剂 - Google Patents

用于口腔炎症的钙和磷酸盐的制剂 Download PDF

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Publication number
CN107530374B
CN107530374B CN201580075768.8A CN201580075768A CN107530374B CN 107530374 B CN107530374 B CN 107530374B CN 201580075768 A CN201580075768 A CN 201580075768A CN 107530374 B CN107530374 B CN 107530374B
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powder
alternatively
phosphate
calcium
oral
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Chinese (zh)
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CN107530374A (zh
Inventor
B·韦尔登
E·科布斯
S·迪穆兰
A·贝当古
P·戈瑟兰
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VALEANT PHARMACEUTICALS INTERNATIONAL
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VALEANT PHARMACEUTICALS INTERNATIONAL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580075768.8A 2014-12-17 2015-12-15 用于口腔炎症的钙和磷酸盐的制剂 Active CN107530374B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462093026P 2014-12-17 2014-12-17
US62/093,026 2014-12-17
PCT/CA2015/051327 WO2016095036A1 (en) 2014-12-17 2015-12-15 Formulations of calcium and phosphate for oral inflammation

Publications (2)

Publication Number Publication Date
CN107530374A CN107530374A (zh) 2018-01-02
CN107530374B true CN107530374B (zh) 2021-07-27

Family

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Family Applications (1)

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CN201580075768.8A Active CN107530374B (zh) 2014-12-17 2015-12-15 用于口腔炎症的钙和磷酸盐的制剂

Country Status (10)

Country Link
US (2) US11590165B2 (enExample)
EP (1) EP3233092B1 (enExample)
JP (1) JP6781701B2 (enExample)
KR (1) KR102397070B1 (enExample)
CN (1) CN107530374B (enExample)
AU (1) AU2015367208B2 (enExample)
BR (1) BR112017013158B1 (enExample)
CA (1) CA2971224C (enExample)
MX (1) MX372952B (enExample)
WO (1) WO2016095036A1 (enExample)

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US10765650B2 (en) * 2016-02-03 2020-09-08 Forward Science Technologies, LLC Artificial saliva
US10143635B2 (en) 2016-02-03 2018-12-04 Forward Science Technologies, LLC Artificial saliva
GR1009399B (el) * 2017-06-23 2018-11-15 Χρηστος Γεωργιου Φυτας Στοματικο διαλυμα κατα της ξηροστομιας και στοματοφαρυγγικης βλεννογονιτιδας
WO2023183556A2 (en) * 2022-03-24 2023-09-28 Amcyte Pharma, Inc. Treatment for retinal disorders

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US4716035A (en) 1985-05-24 1987-12-29 The Procter & Gamble Company Oral compositions and methods for treating gingivitis
US5540913A (en) 1987-03-17 1996-07-30 Turner; Robert E. Formulations and uses thereof in the prevention and treatment of oral lesions
US5268267A (en) 1987-08-21 1993-12-07 The General Hospital Corporation Method for diagnosing small cell carcinoma
US5427768A (en) 1993-06-23 1995-06-27 American Dental Association Health Foundation Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use
JPH11500724A (ja) * 1995-02-24 1999-01-19 アメリカン デンタル アソシエイション ヘルス ファウンデーション 石灰化組織の処置、鉱化及びフッ化物化用の炭酸塩化した溶液及びその使用方法
CA2224274C (en) 1995-08-08 2001-07-31 Enamelon, Inc. Remineralizing products and methods for teeth
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
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US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
ES2197364T3 (es) 1996-09-18 2004-01-01 Erling Johansen Baño bucal comprendiendo iones de calcio y fosfato en solucion sobresaturada.
US6159448A (en) * 1996-09-27 2000-12-12 Enamelon, Inc. Products and methods for the remineralization and prevention of demineralization of teeth
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TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
JP4669960B2 (ja) 2003-06-03 2011-04-13 株式会社 メドレックス 局所麻酔薬を含有する口中用または咽頭部用製剤
US20070185194A1 (en) * 2003-07-01 2007-08-09 Kamal Mehta Stable oral compositions of azithromycin monohydrate
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CA2648460C (en) * 2006-04-05 2014-09-23 Cadbury Adams Usa Llc Calcium phosphate complex and salts in oral delivery systems
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JP5166780B2 (ja) * 2007-06-20 2013-03-21 花王株式会社 液体口腔用組成物
WO2009012393A1 (en) * 2007-07-18 2009-01-22 The Curators Of The University Of Missouri Pharmaceutical composition comprising a proton pump inhibitor and protein component
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TW200934385A (en) * 2007-12-21 2009-08-16 Alcon Res Ltd Stabilized glycerophosphate-containing surgical irrigating solution
JP2011512416A (ja) * 2008-02-20 2011-04-21 ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法
JP2009235012A (ja) 2008-03-28 2009-10-15 Gc Corp 口腔湿潤用組成物
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JP5485677B2 (ja) 2009-12-16 2014-05-07 花王株式会社 口腔用組成物
KR101953076B1 (ko) * 2010-08-07 2019-05-22 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 구강 건조를 완화시키거나 또는 감소시키는 방법
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Also Published As

Publication number Publication date
CN107530374A (zh) 2018-01-02
MX372952B (es) 2020-04-03
AU2015367208A1 (en) 2017-08-03
MX2017007741A (es) 2018-05-02
JP2018505862A (ja) 2018-03-01
AU2015367208B2 (en) 2021-04-01
BR112017013158A2 (pt) 2018-04-10
US20230241102A1 (en) 2023-08-03
KR102397070B1 (ko) 2022-05-16
CA2971224C (en) 2020-09-22
EP3233092A4 (en) 2018-08-01
US20160175356A1 (en) 2016-06-23
BR112017013158B1 (pt) 2023-05-02
EP3233092B1 (en) 2019-09-04
US11590165B2 (en) 2023-02-28
CA2971224A1 (en) 2016-06-23
WO2016095036A1 (en) 2016-06-23
EP3233092A1 (en) 2017-10-25
KR20170105517A (ko) 2017-09-19
JP6781701B2 (ja) 2020-11-04

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