CA2971224C - Formulations of calcium and phosphate for oral inflammation - Google Patents
Formulations of calcium and phosphate for oral inflammation Download PDFInfo
- Publication number
- CA2971224C CA2971224C CA2971224A CA2971224A CA2971224C CA 2971224 C CA2971224 C CA 2971224C CA 2971224 A CA2971224 A CA 2971224A CA 2971224 A CA2971224 A CA 2971224A CA 2971224 C CA2971224 C CA 2971224C
- Authority
- CA
- Canada
- Prior art keywords
- powder
- oral
- alternatively
- calcium
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 77
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims abstract description 42
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 24
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 23
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 24
- 239000011575 calcium Substances 0.000 title claims description 23
- 229910052791 calcium Inorganic materials 0.000 title claims description 23
- 229910019142 PO4 Inorganic materials 0.000 title claims description 22
- 239000010452 phosphate Substances 0.000 title claims description 21
- 238000009472 formulation Methods 0.000 title description 10
- 239000000843 powder Substances 0.000 claims abstract description 93
- 239000007788 liquid Substances 0.000 claims abstract description 51
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 210000000214 mouth Anatomy 0.000 claims abstract description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 26
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims abstract description 23
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims abstract description 22
- 229940095618 calcium glycerophosphate Drugs 0.000 claims abstract description 22
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims abstract description 22
- 239000011780 sodium chloride Substances 0.000 claims abstract description 19
- 239000002244 precipitate Substances 0.000 claims abstract description 18
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 13
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 12
- 239000012905 visible particle Substances 0.000 claims abstract description 12
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims abstract description 10
- 208000005946 Xerostomia Diseases 0.000 claims description 42
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 26
- 206010013781 dry mouth Diseases 0.000 claims description 25
- 208000027418 Wounds and injury Diseases 0.000 claims description 19
- 208000014674 injury Diseases 0.000 claims description 19
- 230000006378 damage Effects 0.000 claims description 18
- 230000001684 chronic effect Effects 0.000 claims description 17
- 206010031009 Oral pain Diseases 0.000 claims description 15
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 13
- 239000000047 product Substances 0.000 claims description 10
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 9
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims description 8
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000006179 pH buffering agent Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
- 239000000739 antihistaminic agent Substances 0.000 claims description 5
- 239000001488 sodium phosphate Substances 0.000 claims description 5
- 235000011008 sodium phosphates Nutrition 0.000 claims description 5
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 239000003429 antifungal agent Substances 0.000 claims description 3
- 229940121375 antifungal agent Drugs 0.000 claims description 3
- 239000004599 antimicrobial Substances 0.000 claims description 3
- 239000003246 corticosteroid Substances 0.000 claims description 3
- 150000004673 fluoride salts Chemical class 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract description 36
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract description 18
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 17
- 239000004615 ingredient Substances 0.000 description 24
- 229960005069 calcium Drugs 0.000 description 22
- 235000021317 phosphate Nutrition 0.000 description 20
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 16
- 238000012360 testing method Methods 0.000 description 13
- 239000008399 tap water Substances 0.000 description 12
- 235000020679 tap water Nutrition 0.000 description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- 210000003296 saliva Anatomy 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 9
- 229960002713 calcium chloride Drugs 0.000 description 9
- 239000001110 calcium chloride Substances 0.000 description 9
- 229910001628 calcium chloride Inorganic materials 0.000 description 9
- PWKNEBQRTUXXLT-ZBHRUSISSA-L calcium lactate gluconate Chemical compound [Ca+2].CC(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PWKNEBQRTUXXLT-ZBHRUSISSA-L 0.000 description 9
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 8
- 229940052299 calcium chloride dihydrate Drugs 0.000 description 8
- 229940041131 calcium lactate gluconate Drugs 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 230000000007 visual effect Effects 0.000 description 8
- 239000006185 dispersion Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 7
- 241000194019 Streptococcus mutans Species 0.000 description 6
- -1 flavoring Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 229940089687 anhydrous monobasic sodium phosphate Drugs 0.000 description 5
- 229940051866 mouthwash Drugs 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 229940125715 antihistaminic agent Drugs 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 4
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 4
- 150000004683 dihydrates Chemical class 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 229940085991 phosphate ion Drugs 0.000 description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- 229940035676 analgesics Drugs 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 208000003265 stomatitis Diseases 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010007134 Candida infections Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- BYMMIQCVDHHYGG-UHFFFAOYSA-N Cl.OP(O)(O)=O Chemical compound Cl.OP(O)(O)=O BYMMIQCVDHHYGG-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 201000003984 candidiasis Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 229960000520 diphenhydramine Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960002409 mepivacaine Drugs 0.000 description 2
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
- 229960004618 prednisone Drugs 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
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- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 1
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
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- YLOZVEBTKJNEIS-UHFFFAOYSA-L calcium;dihydrogen phosphate;chloride Chemical compound Cl.[Ca+2].OP([O-])([O-])=O YLOZVEBTKJNEIS-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093026P | 2014-12-17 | 2014-12-17 | |
| US62/093,026 | 2014-12-17 | ||
| PCT/CA2015/051327 WO2016095036A1 (en) | 2014-12-17 | 2015-12-15 | Formulations of calcium and phosphate for oral inflammation |
Publications (2)
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| CA2971224A1 CA2971224A1 (en) | 2016-06-23 |
| CA2971224C true CA2971224C (en) | 2020-09-22 |
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|---|---|---|---|
| CA2971224A Active CA2971224C (en) | 2014-12-17 | 2015-12-15 | Formulations of calcium and phosphate for oral inflammation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11590165B2 (enExample) |
| EP (1) | EP3233092B1 (enExample) |
| JP (1) | JP6781701B2 (enExample) |
| KR (1) | KR102397070B1 (enExample) |
| CN (1) | CN107530374B (enExample) |
| AU (1) | AU2015367208B2 (enExample) |
| BR (1) | BR112017013158B1 (enExample) |
| CA (1) | CA2971224C (enExample) |
| MX (1) | MX372952B (enExample) |
| WO (1) | WO2016095036A1 (enExample) |
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| US10765650B2 (en) * | 2016-02-03 | 2020-09-08 | Forward Science Technologies, LLC | Artificial saliva |
| US10143635B2 (en) * | 2016-02-03 | 2018-12-04 | Forward Science Technologies, LLC | Artificial saliva |
| GR1009399B (el) * | 2017-06-23 | 2018-11-15 | Χρηστος Γεωργιου Φυτας | Στοματικο διαλυμα κατα της ξηροστομιας και στοματοφαρυγγικης βλεννογονιτιδας |
| WO2023183556A2 (en) * | 2022-03-24 | 2023-09-28 | Amcyte Pharma, Inc. | Treatment for retinal disorders |
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| GB572352A (en) * | 1944-02-26 | 1945-10-03 | Charles Somerville Dillon | Improved tooth powder or preparation |
| US4716035A (en) | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| US5540913A (en) | 1987-03-17 | 1996-07-30 | Turner; Robert E. | Formulations and uses thereof in the prevention and treatment of oral lesions |
| US5268267A (en) | 1987-08-21 | 1993-12-07 | The General Hospital Corporation | Method for diagnosing small cell carcinoma |
| US5427768A (en) | 1993-06-23 | 1995-06-27 | American Dental Association Health Foundation | Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use |
| EP0871427A1 (en) * | 1995-02-24 | 1998-10-21 | American Dental Association Health Foundation | Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use |
| CN1150880C (zh) | 1995-08-08 | 2004-05-26 | 埃纳梅隆公司 | 用于使牙齿再矿化的产品和方法 |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US5993785A (en) * | 1996-09-18 | 1999-11-30 | Erling Johansen | Mouthwash compositions |
| US6159448A (en) * | 1996-09-27 | 2000-12-12 | Enamelon, Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
| US7838046B2 (en) * | 2001-09-26 | 2010-11-23 | Tampa Bay Research Institute | Plant extracts and uses thereof |
| CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| JP4669960B2 (ja) | 2003-06-03 | 2011-04-13 | 株式会社 メドレックス | 局所麻酔薬を含有する口中用または咽頭部用製剤 |
| WO2005002592A2 (en) * | 2003-07-01 | 2005-01-13 | Ranbaxy Laboratories Limited | Stable oral compositions of azithromycin monohydrate |
| AR045068A1 (es) * | 2003-07-23 | 2005-10-12 | Univ Missouri | Formulacion de liberacion inmediata de composiciones farmaceuticas |
| WO2005076987A2 (en) * | 2004-02-10 | 2005-08-25 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent |
| US8518383B2 (en) * | 2006-02-03 | 2013-08-27 | Wm. Wrigley Jr. Company | Oral care products comprising buffer systems for improved mineralization/remineralization benefits |
| RU2421207C2 (ru) * | 2006-04-05 | 2011-06-20 | КЭДБЕРИ АДАМС ЮЭсЭй ЛЛС | Оральная композиция для улучшения подповерхностной реминерализации эмали в зубах млекопитающего |
| TWI445540B (zh) * | 2007-04-20 | 2014-07-21 | Ajinomoto Kk | 抗低體溫組成物 |
| JP5166780B2 (ja) * | 2007-06-20 | 2013-03-21 | 花王株式会社 | 液体口腔用組成物 |
| WO2009012393A1 (en) * | 2007-07-18 | 2009-01-22 | The Curators Of The University Of Missouri | Pharmaceutical composition comprising a proton pump inhibitor and protein component |
| US9358242B2 (en) * | 2007-08-30 | 2016-06-07 | Prelief Inc. | Calcium glycerophosphate for treating and preventing respiratory diseases or conditions |
| US20090130232A1 (en) | 2007-11-20 | 2009-05-21 | Mohammed Zahra | Composition and method for treatment of oral inflammation an ulceration |
| TW200934385A (en) * | 2007-12-21 | 2009-08-16 | Alcon Res Ltd | Stabilized glycerophosphate-containing surgical irrigating solution |
| WO2009105568A1 (en) * | 2008-02-20 | 2009-08-27 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
| JP2009235012A (ja) | 2008-03-28 | 2009-10-15 | Gc Corp | 口腔湿潤用組成物 |
| WO2010054494A2 (en) | 2008-11-14 | 2010-05-20 | Profimed S.R.O. | Biomimetic oral care composition |
| CN101584889B (zh) | 2009-07-10 | 2012-12-12 | 山东大学威海分校 | 一种用于治疗牙周病的外用原位成型基质 |
| US20110086108A1 (en) | 2009-10-12 | 2011-04-14 | Bartholomew Weldon | Dissolving powders that can be mixed with water and used as an oral rinse |
| JP5485677B2 (ja) | 2009-12-16 | 2014-05-07 | 花王株式会社 | 口腔用組成物 |
| WO2012021415A2 (en) * | 2010-08-07 | 2012-02-16 | Research Foundation Of State University Of New York | Oral compositions comprising a zinc compound and an anti-microbial agent |
| EP2919744B1 (en) * | 2012-11-16 | 2020-09-02 | EUSA Pharma (UK) Ltd | Effervescent tablet |
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| BR112017013158B1 (pt) | 2023-05-02 |
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| KR102397070B1 (ko) | 2022-05-16 |
| US20230241102A1 (en) | 2023-08-03 |
| JP6781701B2 (ja) | 2020-11-04 |
| EP3233092A4 (en) | 2018-08-01 |
| MX372952B (es) | 2020-04-03 |
| EP3233092B1 (en) | 2019-09-04 |
| US11590165B2 (en) | 2023-02-28 |
| CN107530374B (zh) | 2021-07-27 |
| US20160175356A1 (en) | 2016-06-23 |
| WO2016095036A1 (en) | 2016-06-23 |
| JP2018505862A (ja) | 2018-03-01 |
| EP3233092A1 (en) | 2017-10-25 |
| AU2015367208A1 (en) | 2017-08-03 |
| CA2971224A1 (en) | 2016-06-23 |
| AU2015367208B2 (en) | 2021-04-01 |
| CN107530374A (zh) | 2018-01-02 |
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