CN107510044B - 一种肝病临床营养配方及其制备方法 - Google Patents
一种肝病临床营养配方及其制备方法 Download PDFInfo
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Abstract
本发明公开了属于肝病营养品技术领域的一种肝病临床营养配方及其制备方法。由如下重量份数的组分组成：蛋白质300‑500份，脂肪100‑200份，糖类120‑230份，淀粉300‑600份，维生素0.05‑1份，矿物质3‑8份，天然植物干粉末10‑30份，增稠剂15‑80份，抗氧化剂0.1‑2份。本发明制备的肝病临床营养食品，具有护肝养肝的功效，选取天然植物干粉末作为护肝养肝的活性组分，配合蛋白质，脂肪，糖类，淀粉等营养物质，以及维生素，矿物质，抗氧化剂等有益因子，最大化恢复肝病病人的肝脏功能。
Description
技术领域
本发明属于肝病营养品技术领域，具体涉及一种肝病临床营养配方及其制备方法。
背景技术
肝病是指发生在肝脏的病变，包括乙肝、甲肝、丙肝、肝硬化、脂肪化、肝癌、酒精肝等等多种肝病。肝病的主要表现有：恶心、厌油腻、食欲差等，可出现呕吐，腹泻，脾肿大等症状，此类症状也可能与慢性肝病引起的肝原性溃疡病，门静脉高压性肠病等有关；肝区不适和肝区疼痛较具有特异性，往往与肝肿大压迫肝包膜有关，随着病情的转归，肝肿大的加重或减轻，肝区疼痛的性质和程度也不相同；身体乏力、容易疲劳是最常见的全身表现，部分肝病患者可伴有不同程度黄疸，表现为尿黄、眼睛黄和皮肤黄，是最具有特异性的肝病症状；很多慢性肝病会出现肝掌、蜘蛛痣、肝病面容，尤其肝硬化病人比较多见，肝病出血现象体现在肝功能减退，使凝血因子合成减少所致，容易引起肝病患者牙龈出血、痔疮出血、胃肠道出血等，且出血时难以止住。
肝脏对于糖类，脂类，蛋白质的代谢起着关键的作用，对于肝病患者，合理的膳食和营养对于肝病的治疗和肝脏的恢复起着重要的作用。专利201410260526.3公开了一种适合肝病病人的营养膳，由以下重量百分比原料组成：膨化粉10％～30％、麦芽糊精12％～32％、奶粉8％～25％、全脂大豆粉2％～10％、水解乳清蛋白2％～8％、乳清蛋白3％～10％、牛磺酸0.2％～0.8％、精氨酸0.3％～0.9％、谷胱甘肽0.1％～0.5％、粉末油脂2％～8％、粉末中链油2％～8％、菊粉2％～10％、白砂糖粉3％～9％、三聚磷酸钠0.2％～1％、氯化钾0.1％～0.8％、乳酸钙0.2％～0.8％、葡萄糖酸镁0.2％～0.8％、维生素A0.0001％～0.0003％、维生素B10.0001％～0.0003％、维生素B20.0001％～0.0003％、维生素B60.0001％～0.0003％、维生素C0.01％～0.03％、L-肉碱0.1％～0.3％、肌醇0.06％～0.15％。该膳食配方对于对 CCl4 亚急性肝损伤小鼠具有肝损伤保护作用，但是对于其他原因引起的肝脏损伤没有作用，专一性强，应用范围窄。
发明内容
本发明的目的在于提供一种肝病临床营养食品及其制备方法。
一种肝病临床营养配方，由如下重量份数的组分组成：蛋白质300-500份，脂肪100-200份，糖类120-230份，淀粉300-600份，维生素0.05-1份，矿物质3-8份，天然植物干粉末10-30份，增稠剂15-80份，抗氧化剂0.1-2份。
所述蛋白质为鱼粉，肉粉，蛋白胨，酵母提取物中的一种或一种以上。
所述蛋白质为三虫粉。
所述脂肪为猪油，花生油，大豆油，芝麻油，玉米胚芽油，油菜籽油，棉子油中的一种或一种以上。
所述糖类为麦芽糖，蔗糖，果糖，葡萄糖，甘露糖，饴糖，红糖中的一种或一种以上。
所述维生素为维生素A，维生素B1，维生素B2，维生素B6，维生素C，维生素D，维生素E，维生素K，维生素PP中的一种或一种以上。
所述矿物质为麦饭石粉，碳酸钙，碳酸钠，硫酸镁，硫酸锌，碳酸铁中的一种或一种以上。
所述天然植物干粉末为树灰藓干粉末，肿足蕨干粉末，泽泻蕨干粉末中的一种或一种以上。
所述增稠剂为卡拉胶，瓜尔胶，黄原胶，阿拉伯胶，明胶，桃胶中的一种或一种以上。
所述抗氧化剂为胡萝卜素，谷胱甘肽，硫代巴比士酸，虾青素，角黄素，叶黄素中的一种或一种以上。
本发明的有益效果：本发明制备的肝病临床营养食品，具有护肝养肝的功效，选取天然植物干粉末作为护肝养肝的活性组分，配合蛋白质，脂肪，糖类，淀粉等营养物质，以及维生素，矿物质，抗氧化剂等有益因子，最大化恢复肝病病人的肝脏功能。
具体实施方式
下面结合具体实施例对本发明做进一步说明。
实施例1
一种肝病临床营养配方，由如下重量份数的组分组成：鱼粉400份，猪油150份，麦芽糖160份，淀粉450份，维生素A 0.02份，维生素C 0.02份，维生素D 0.02份，维生素E 0.02份，维生素B6 0.02份，麦饭石粉5份，树灰藓干粉末20份，黄原胶60份，胡萝卜素0.5份。
实施例2
一种肝病临床营养配方，由如下重量份数的组分组成：肉粉300份，花生油100份，蔗糖120份，淀粉300份，维生素A 0.01份，维生素B1 0.01份，维生素B2 0.01份，维生素B60.01份，维生素C 0.01份，碳酸钙1份，硫酸镁1份，硫酸锌1份，肿足蕨干粉末10份，瓜尔胶15份，谷胱甘肽0.1份。
实施例3
一种肝病临床营养配方，由如下重量份数的组分组成：蛋白胨500份，大豆油200份，果糖230份，淀粉600份，维生素C 0.2份，维生素D 0.2份，维生素E 0.2份，维生素K 0.2份，维生素PP 0.2份，碳酸钙2份，碳酸钠2份，硫酸镁2份，硫酸锌2份，泽泻蕨干粉末30份，明胶80份，虾青素2份。
实施例4
一种肝病临床营养配方，由如下重量份数的组分组成：三虫粉400份，猪油150份，麦芽糖160份，淀粉450份，维生素A 0.02份，维生素C 0.02份，维生素D 0.02份，维生素E0.02份，维生素B6 0.02份，麦饭石粉5份，树灰藓干粉末20份，黄原胶60份，胡萝卜素0.5份。
实施例5
一种肝病临床营养配方，由如下重量份数的组分组成：鱼粉400份，猪油150份，麦芽糖160份，淀粉450份，维生素A 0.02份，维生素C 0.02份，维生素D 0.02份，维生素E 0.02份，维生素B6 0.02份，麦饭石粉5份，树灰藓干粉末20份，二药藻5份，黄原胶60份，胡萝卜素0.5份。
实施例6
一种肝病临床营养配方，由如下重量份数的组分组成：鱼粉400份，猪油150份，麦芽糖160份，淀粉450份，维生素A 0.02份，维生素C 0.02份，维生素D 0.02份，维生素E 0.02份，维生素B6 0.02份，麦饭石粉5份，树灰藓干粉末20份，黄原胶60份，胡萝卜素0.5份，1-癸烯-3-醇0.1份。
对比例1
一种肝病临床营养配方，由如下重量份数的组分组成：鱼粉400份，猪油150份，麦芽糖160份，淀粉450份，维生素A 0.02份，维生素C 0.02份，维生素D 0.02份，维生素E 0.02份，维生素B6 0.02份，麦饭石粉5份，黄原胶60份，胡萝卜素0.5份。
实验例：
取清洁级雄性 NIH 小鼠900 只，体重 18 ～ 22g，分为7组；喂养 1 周适应环境后，自由摄食饮水、基础饲料正常供给 ； 每组每天分别给予营养配方 80g/kg bw，进食营养配方结束后给予基础饲料，连续 7 周，自由摄食饮水。
亚急性肝损伤模型的诱导 ：小鼠从实验第 1 天起腹腔注射0.3％的 CCl4 玉米油溶液，剂量为 10ml/kg bw，每周注射 2 次，共注射 3 周，以诱导化学性亚急性肝损伤动物模型。末次注射 CCl4 后禁食 8 小时，眼眶后静脉丛采血测定血清谷 丙转氨酶 (ALT)和谷草转氨酶 (AST) 水平，评价肝损伤模型是否诱导成功。肝损伤模型诱导成功后继续按原方案予以喂食。7 周后，各组小鼠禁食 12 小时，摘除眼球采血制备血清， 测定 ALT 和AST。营养配方对 CCl4 亚急性肝损伤小鼠血清肝酶活性的影响如表1所示：
表1营养膳对 CCl4 亚急性肝损伤小鼠 3w、 7w 时血清肝酶活性的影响
表中同列不同字母表示有显著差异 (p<0.05)。
由表1可以看出，小鼠造模 3 周后，与正常对照组比，肝损伤模型组血清 ALT、AST 活性显著升高 (P<0.05)，实施例1-6与模型组相比，血清中的肝酶活有降低趋势，继续给小鼠喂食至7周末，模型组血清ALT、 AST活性仍显著高于正常对照组(P<0.05) ； 与模型组相比，实施例1-6可显著地抑制CCl4 引起的血清ALT和AST的升高， 表明本发明营养膳对CCl4 亚急性肝损伤小鼠具有肝损伤保护作用。小鼠造模 3 周和7周，对比例1的ALT、 AST活性与模型组相当，显著高于实施例1，与实施例1相比，其他实验条件完全相同，仅仅是对比例1少加入了树灰藓干粉末，可见树灰藓干粉末具有肝损伤保护作用；实施例4-6的血清ALT、 AST活性降低效果优于实施例1，与实施例1相比，其他实验条件完全相同，仅仅是实施例4将三虫粉替代为实施例1鱼粉，实施例5和6中分别多加入了二药藻和1-癸烯-3-醇；可见二药藻和1-癸烯-3-醇具有肝损伤保护作用。
Claims (8)
1.一种肝病临床营养组合物，其特征在于，由如下重量份数的组分组成：蛋白质300-500份，脂肪100-200份，糖类120-230份，淀粉300-600份，维生素0.05-1份，矿物质3-8份，树灰藓干粉末10-30份，增稠剂15-80份，抗氧化剂0.1-2份；
所述糖类为麦芽糖，蔗糖，果糖，葡萄糖，甘露糖，饴糖，红糖中的一种或一种以上。
2.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述蛋白质为鱼粉，肉粉，蛋白胨，酵母提取物中的一种或一种以上。
3.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述蛋白质为三虫粉。
4.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述脂肪为猪油，花生油，大豆油，芝麻油，玉米胚芽油，油菜籽油，棉子油中的一种或一种以上。
5.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述维生素为维生素A，维生素B1，维生素B2，维生素B6，维生素C，维生素D，维生素E，维生素K，维生素PP中的一种或一种以上。
6.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述矿物质为麦饭石粉，碳酸钙，碳酸钠，硫酸镁，硫酸锌，碳酸铁中的一种或一种以上。
7.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述增稠剂为卡拉胶，瓜尔胶，黄原胶，阿拉伯胶，明胶，桃胶中的一种或一种以上。
8.根据权利要求1所述一种肝病临床营养组合物，其特征在于，所述抗氧化剂为胡萝卜素，谷胱甘肽，虾青素，角黄素，叶黄素中的一种或一种以上。
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Effective date of registration: 20210608 Address after: 272000 Jining public health medical center, jiumigudui, Rencheng District, Jining City, Shandong Province Patentee after: Jining public health medical center Address before: 272031 Jiudui Infectious Diseases Hospital, Rencheng District, Jining City, Shandong Province Patentee before: Li Shaobo |