CN107501426A - A kind of Phellinus polysaccharide with moisturizing reparation and its preparation method and application - Google Patents
A kind of Phellinus polysaccharide with moisturizing reparation and its preparation method and application Download PDFInfo
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- CN107501426A CN107501426A CN201710705750.2A CN201710705750A CN107501426A CN 107501426 A CN107501426 A CN 107501426A CN 201710705750 A CN201710705750 A CN 201710705750A CN 107501426 A CN107501426 A CN 107501426A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
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Abstract
The invention discloses a kind of Phellinus polysaccharide with moisturizing reparation and its preparation method and application, comprise the following steps：(1) Phellinus residue is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts pH to 5 to add 0.1~1% complex enzyme, and 90 DEG C of water-baths extract 3h, filter, take filtrate；(3) make Phellinus polysaccharide that alcohol precipitation occur toward addition absolute ethyl alcohol in filtrate and separate out, precipitation therein is subsequently isolated out；(4) wash precipitation 3~4 times with organic detergent, in 60 DEG C of drying, produce Phellinus polysaccharide.The present invention improves the oxidation resistance of cell by improving the activity of antioxidase, effectively reduces the oxidative damage of cell, anti-aging；It can promote the structure repair of damaged cell, promote the healing at cell damage position, the effect of playing reparation.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of Phellinus polysaccharide with moisturizing reparation and preparation method thereof and
Using.
Background technology
Phellinus is a kind of conventional Chinese herbal medicine, is the fructification of On Polyporaceae phelliuns igniarius.Phellinus polysaccharide is Phellinus
In one of main active, there is multi-efficiency, can effectively improve skin quality.Phellinus polysaccharide mainly by galactolipin,
Glucose and mannose are with about 4:3.7:What 1 ratio was combined into, cell growth can be effectively controlled, improves damaging cells
Restoring force, remove free radical and then antioxidation, finally can also further protection cell not by all kinds of factor shadows
Pilot causes damage, prevents from further producing inflammatory reaction.Macromolecular polysaccharide is because it has a large amount of hydrophilic radicals simultaneously, these
Hydrophilic radical with water by combining to form hydrogen bond so as to the stable glue for being retained in around itself, forming stabilization of large quantity of moisture
Shape structure, cause it that there is good water imbibition and suitable tackifying.
Alcohol extracting method is commonly used in production and extracts flavonoids from phellinus therein, for the other compositions that also contain in Phellinus due to by it
In macromolecular structure protection, and dissolve in alcohol, therefore remain in residue, not utilized is to be thrown aside.
The research to Phellinus is concentrated mainly on component and effect at present, equal to the extracting method or patent application of Phellinus residue
Corresponding record is not retrieved.
The content of the invention
Based on this, it is an object of the invention to provide a kind of Phellinus polysaccharide with moisturizing reparation and preparation method thereof and answer
With.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts answering for the additions of pH to 5 0.1~1%
Synthase, 90 DEG C of water-baths extract 3h, filter, take filtrate；
(3) make Phellinus polysaccharide that alcohol precipitation occur toward addition absolute ethyl alcohol in filtrate and separate out, precipitation therein is subsequently isolated out；
(4) wash precipitation 3~4 times with organic detergent, in 60 DEG C of drying, produce Phellinus polysaccharide.
In wherein some embodiments, the Phellinus residue is the residue that Phellinus obtains after alcohol extracting.
In wherein some embodiments, the complex enzyme used during the water-bath in the step (2) is 2~3 parts of fibre
Tie up the glucose oxidase that plain enzyme mixes 1 part.
In wherein some embodiments, the precipitation process in the step (3) concretely comprises the following steps：Add alpha-amylase and
60 DEG C digest 0.5~1.5 hour, then concentration of alcohol is adjusted to 50~70% with adding absolute ethyl alcohol by concentration, and with
4000~6000r/min carries out 20~40min of centrifugation with precipitation and separation.
In wherein some embodiments, organic detergent in the step (4) is 70~90% ethanol solution.
Present invention also offers the Phellinus polysaccharide that effect is repaired with moisturizing according to obtained by above-mentioned preparation method.
Present invention also offers above-mentioned there is moisturizing to repair application of the Phellinus polysaccharide of effect in cosmetics are prepared.
In wherein some embodiments, the State of cosmetics includes cream, emulsion, aqua.
Present invention also offers a kind of cosmetics, and it is more that it includes the foregoing Phellinus that effect is repaired with moisturizing
Sugar.
Present invention also offers a kind of moisturizing essence, includes following mass percent composition：It is foregoing that there is guarantor
It is wet repair the Phellinus polysaccharide 0.3~3% of effect, glycerine polymethacrylates 1~3%, ring five dimethyl silicone polymer 1~
2%th, propane diols 1~3%, dimethyl silicone polymer 1~2%, sodium citrate 0.01~0.05%, carbohydrate isomer 0.5
~1.5%, citric acid 0.01~0.05%, dimethiconol 1~2%, glycerin polyether -261~3%, xanthans 0.5
~1%, pectin 2~6%, butanediol 1~3%, urea 1~3%, Sodium Hyaluronate 0.01~0.03%, Anjidew NL50 1~3%,
Trehalose 1~3%, glycerine 1~3%, tocopherol acetate 0.3~0.9%, panthenol 1~2%, polysorbate -200.1~
0.5%th, beta glucan 0.05~0.1%, allantoin 0.1~0.2%, carbomer 0.1~0.3%, sodium hydroxide 0.1~
0.2%th, Sensiva SC50 0.01~0.1%, Phenoxyethanol 0.3~0.8%, deionized water surplus.
The present invention has the advantages that：The present invention is largely tested by inventor and the preferred preparation side of experience
The various conditions of method, the preparation method optimized, with the addition of a variety of enzymes, can effectively dissociate originally stably protected into
Point, the recovery rate of raising Phellinus polysaccharide.The present invention improves the anti-oxidant energy of cell by improving the activity of antioxidase
Power, effectively reduce the oxidative damage of cell, anti-aging；The structure repair of damaged cell can be promoted, promote cell damage portion
The healing of position, the effect of playing reparation.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated：
All the components appeared in text are INCI (International Nomenclature Cosmetic
Ingredient), i.e., international cosmetic raw material is obviously said to its defined title.
Embodiment 1
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts the compound of the additions of pH to 5 0.5%
Enzyme, and complex enzyme is made up of the glucose oxidase of 2.5 parts of 1 part of cellulase mixing, is extracted 3h in 90 DEG C of water-baths, is filtered,
Take filtrate；
(3) add alpha-amylase and digested at 60 DEG C 1 hour, concentration of alcohol is then made with adding absolute ethyl alcohol by concentration
Regulation centrifuge 30min with precipitation and separation to 60%, and with 5000r/min.
(4) wash precipitation 3 times with 80% ethanol, in 60 DEG C of drying, produce Phellinus polysaccharide.
Embodiment 2
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts the compound of the additions of pH to 5 0.1%
Enzyme, and complex enzyme is made up of the glucose oxidase of 2 parts of 1 part of cellulase mixing, is extracted 3h in 90 DEG C of water-baths, is filtered, take
Filtrate；
(3) add alpha-amylase and digested at 60 DEG C 0.5 hour, then make ethanol dense with adding absolute ethyl alcohol by concentration
Degree regulation centrifuge 200min with precipitation and separation to 60%, and with 4000r/min.
(4) wash precipitation 3 times with 70% ethanol, in 60 DEG C of drying, produce Phellinus polysaccharide.
Embodiment 3
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts pH to 5 to add 1% complex enzyme,
And complex enzyme is made up of the glucose oxidase of 3 parts of 1 part of cellulase mixing, is extracted 3h in 90 DEG C of water-baths, is filtered, take filter
Liquid；
(3) add alpha-amylase and digested at 60 DEG C 1.5 hours, then make ethanol dense with adding absolute ethyl alcohol by concentration
Degree regulation centrifuge 40min with precipitation and separation to 70%, and with 6000r/min.
(4) wash precipitation 3 times with 90% ethanol, in 60 DEG C of drying, produce Phellinus polysaccharide.
Comparative example 1
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 50 DEG C of dryings, crosses 60 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：50 material-water ratio adds deionized water, adjusts pH to 5 to add 2% complex enzyme,
And complex enzyme is made up of the glucose oxidase of 2 parts of 1 part of cellulase mixing, is extracted 2h in 90 DEG C of water-baths, is filtered, take filter
Liquid；
(3) add alpha-amylase and digested at 65 DEG C 3 hours, concentration of alcohol is then made with adding absolute ethyl alcohol by concentration
Regulation centrifuge 40min with precipitation and separation to 70%, and with 6000r/min.
(4) wash precipitation 3 times with 95% ethanol, in 65 DEG C of drying, produce Phellinus polysaccharide.
Comparative example 2
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 80 DEG C of dryings, crosses 30 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：20 material-water ratio adds deionized water, adjusts the compound of the additions of pH to 5 0.5%
Enzyme, and complex enzyme is made up of the glucose oxidase of 3 parts of 1 part of cellulase mixing, is extracted 3h in 90 DEG C of water-baths, is filtered, take
Filtrate；
(3) add alpha-amylase and digested at 60 DEG C 2 hours, concentration of alcohol is then made with adding absolute ethyl alcohol by concentration
Regulation centrifuge 40min with precipitation and separation to 70%, and with 6000r/min.
(4) wash precipitation 3 times with 90% ethanol, in 60 DEG C of drying, produce Phellinus polysaccharide.
Comparative example 3
A kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, comprises the following steps：
(1) Phellinus residue after alcohol extracting is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts pH to 5, is extracted in 90 DEG C of water-baths
3h, filter, take filtrate；
(3) concentration of alcohol is adjusted to 70% with adding absolute ethyl alcohol by concentration, and centrifuged with 6000r/min
40min is with precipitation and separation.
(4) wash precipitation 3 times with 90% ethanol, in 60 DEG C of drying, produce Phellinus polysaccharide.
Interpretation of result：Embodiment 1-3 and comparative example 1-3 preparation condition have moisturizing repair effect Phellinus polysaccharide it is as follows
Table 1.
Table 1
From the data analysis of table 1：The content of the Phellinus polysaccharide obtained under embodiment 1-3 preparation condition substantially compares ratio
The content of the Phellinus polysaccharide obtained under example 1-3 preparation condition is substantially higher；Comparative example 1 and comparative example 2 change preparation technology
All parameters, the content that Comparative result example 1 obtains Phellinus polysaccharide is significantly lower than embodiment 1；Comparative example 3 compared with Example 1,
Any enzyme is not added in technique, but the content of Phellinus polysaccharide is obvious lower than embodiment, illustrates that enzyme is preparing Phellinus
Have the function that to improve recovery rate in polysaccharide；And pass through multiple change technological parameter, step etc. and test, obtaining the present invention will protect
The preparation method of shield.
The Phellinus polysaccharide that effect is repaired with moisturizing that embodiment 1-3 is prepared is applied in preparation moisturizing essence
In, table 2 specific as follows.
Table 2
Efficacy validation
Determination oxidative：
Instrument：Remove the electronic paramagnetic resonance spectrometer experiment of hydroxyl radical free radical
At room temperature, 5mL test tubes are taken, sequentially add phosphate buffer (pH 7.4) 0.5ml, 5 μ L 5,5- dimethyl -1-
Pyrrolin-N oxides (DMP0), 250 μ L 0.1M H202, 1.5ml 0.1mM Phellinus polysaccharide solutions, the essence medicinal extract aqueous solution,
Simultaneously using it is a it is commercially available declare to have good anti-oxidant serum as control group, 250 μ L3mM FeS04Solution, in 5 minutes left sides
ESR detections are carried out in right injection quartz capillary.As a result such as table 3 below.
Table 3
| Composition | Phellinus polysaccharide | Essence | Control group |
| Clearance rate % | 91.2 | 89.7 | 76.4 |
From the data analysis of table 3, Phellinus polysaccharide has significant effect of scavenging radical, is applied in cosmetics essence
Hua Suzhong, it can assign cosmetics good antioxidant effect.
Moistening effect is verified
Instrument：SK-III numeral moisture tellers
Principle：Utilize circuit change in resistance reaction keratoderma moisture content caused by the height of the water content of cuticula
Change.Therefore the moisture retention of essence can be represented with the moisture content of cuticula, moisture content is higher, illustrates keratoderma water
Point content is higher, and the moistening effect of essence is better.
Experiment material：Phellinus polysaccharide prepared by embodiment 1, the essence in, the Sodium Hyaluronate of cosmetics-stage are done
Control group.
Test crowd：Totally 30 people, it is divided into 3 groups, age 20-45 year, without other disease of skin.
Method of testing：(1) the Phellinus polysaccharide of debita spissitudo is smeared in first group of experimenter face, is surveyed after smearing 2 weeks, 4 weeks
Determine the water content and record of skin；(2) essence of above-mentioned preparation is smeared in second group of experimenter face, at the 2nd week, the 4th week
The water content and record of skin are determined afterwards；(3) Sodium Hyaluronate of debita spissitudo is smeared in the 3rd group of experimenter face, smears 2
Week.The water content and record of skin are determined after 4 weeks.Three groups of experimenters should survey the water content of skin before use.
Test result is taken the mean, as a result such as table 4 below.
Table 4
From the data analysis of table 4, the Phellinus polysaccharide with moisturizing effects is applied to and prepared in moisturizing essence, assigned
Give the moisturizing water supplement function that essence is good.
Above example only shows several embodiments of the present invention, therefore its description is more specific and detailed, but can not be
And it is interpreted as the limitation scope to patent of the present invention.It should be noted that：It is any to be engaged in professional and technical personnel, all have the ability
Using the technology contents having revealed that, some are made to it and changes or modifies, turns into the equivalent embodiment of equivalent variations.According to this hair
Bright technical spirit, simple modification, equivalent change and modification is carried out to the present invention, belonged in the range of technical solution of the present invention.
Claims (10)
1. a kind of preparation method for the Phellinus polysaccharide that effect is repaired with moisturizing, it is characterised in that comprise the following steps：
(1) Phellinus residue is passed through into 45 DEG C of dryings, crosses 70 mesh sieves, obtain Phellinus residue powder；
(2) by Phellinus residue powder, with 1：70 material-water ratio adds deionized water, adjusts pH to 5 to add 0.1~1% complex enzyme,
90 DEG C of water-baths extract 3h, filter, take filtrate；
(3) make Phellinus polysaccharide that alcohol precipitation occur toward addition absolute ethyl alcohol in filtrate and separate out, precipitation therein is subsequently isolated out；
(4) wash precipitation 3~4 times with organic detergent, in 60 DEG C of drying, produce Phellinus polysaccharide.
2. preparation method according to claim 1, it is characterised in that the Phellinus residue is that Phellinus obtains after alcohol extracting
The residue arrived.
3. preparation method according to claim 1, it is characterised in that in step (2), the complex enzyme that is used during water-bath
1 part of glucose oxidase is mixed for 2~3 parts of cellulases.
4. preparation method according to claim 1, it is characterised in that in step (3), the precipitation process specific steps
For：Add alpha-amylase and digested at 60 DEG C 0.5~1.5 hour, concentration of alcohol is then made with adding absolute ethyl alcohol by concentration
Regulation carries out 20~40min of centrifugation with precipitation and separation to 50~70%, and with 4000~6000r/min.
5. preparation method according to claim 1, it is characterised in that in step (4), the organic detergent be 70~
90% ethanol solution.
6. there is the Phellinus polysaccharide that effect is repaired in moisturizing according to obtained by any one of Claims 1 to 5 preparation method.
7. the Phellinus polysaccharide according to claim 6 that effect is repaired with moisturizing.
8. according to claim 7 there is moisturizing to repair application of the Phellinus polysaccharide of effect in cosmetics are prepared, it is special
Sign is that the State of cosmetics includes cream, emulsion, aqua.
9. a kind of cosmetics, it is characterised in that include the Phellinus polysaccharide that there is moisturizing to repair effect described in claim 6.
10. a kind of moisturizing essence, it is characterised in that the moisturizing essence includes following mass percent composition：Right will
Seek the Phellinus polysaccharide 0.3~3%, glycerine polymethacrylates 1~3%, ring five poly- two that there is moisturizing to repair effect described in 6
Methylsiloxane 1~2%, propane diols 1~3%, dimethyl silicone polymer 1~2%, sodium citrate 0.01~0.05%, carbohydrate
Isomer 0.5~1.5%, citric acid 0.01~0.05%, dimethiconol 1~2%, glycerin polyether -261~
3%th, xanthans 0.5~1%, pectin 2~6%, butanediol 1~3%, urea 1~3%, Sodium Hyaluronate 0.01~0.03%,
Anjidew NL50 1~3%, trehalose 1~3%, glycerine 1~3%, tocopherol acetate 0.3~0.9%, panthenol 1~2%, poly- sorb
Alcohol ester -200.1~0.5%, beta glucan 0.05~0.1%, allantoin 0.1~0.2%, carbomer 0.1~0.3%, hydrogen-oxygen
Change sodium 0.1~0.2%, Sensiva SC50 0.01~0.1%, Phenoxyethanol 0.3~0.8%, deionized water surplus.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324618A (en) * | 2018-04-18 | 2018-07-27 | 淮北市儒伽医疗科技有限公司 | A kind of facial mask for men only |
| CN108567643A (en) * | 2018-07-12 | 2018-09-25 | 哈尔滨伟平科技开发有限公司 | A kind of preparation method of anti-bacterial hand lotion |
| CN108852912A (en) * | 2018-08-31 | 2018-11-23 | 青岛银色世纪健康产业集团有限公司 | A kind of skin-moisturizing, skin lotion and preparation method thereof |
| CN115154363A (en) * | 2022-09-01 | 2022-10-11 | 广东省农业科学院蚕业与农产品加工研究所 | Mulberry resource oligosaccharide moisturizing composition and preparation method and application thereof |
-
2017
- 2017-08-16 CN CN201710705750.2A patent/CN107501426A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324618A (en) * | 2018-04-18 | 2018-07-27 | 淮北市儒伽医疗科技有限公司 | A kind of facial mask for men only |
| CN108567643A (en) * | 2018-07-12 | 2018-09-25 | 哈尔滨伟平科技开发有限公司 | A kind of preparation method of anti-bacterial hand lotion |
| CN108852912A (en) * | 2018-08-31 | 2018-11-23 | 青岛银色世纪健康产业集团有限公司 | A kind of skin-moisturizing, skin lotion and preparation method thereof |
| CN115154363A (en) * | 2022-09-01 | 2022-10-11 | 广东省农业科学院蚕业与农产品加工研究所 | Mulberry resource oligosaccharide moisturizing composition and preparation method and application thereof |
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