CN107496752A - A kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof Download PDF

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CN107496752A
CN107496752A CN201710935073.3A CN201710935073A CN107496752A CN 107496752 A CN107496752 A CN 107496752A CN 201710935073 A CN201710935073 A CN 201710935073A CN 107496752 A CN107496752 A CN 107496752A
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chinese medicine
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medicine composition
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谷训想
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Abstract

The present invention discloses a kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof.The 18 taste Chinese medicines compositions such as said composition rhododendron mariae, Folium Apocyni Veneti, agaric, fore-telling mustard, screwtree root, birthwort, Tabasheer, Lasiosphaera fenzlii, rhizoma nardostachyos, Chinese gall, Chinese knotweed, treebine stem, elephants-foot, caulis bambusae in taenian, Gorgon fruit, Buddha's hand, myrobalan and spina gleditsiae.Tablet, capsule, granule, pill, oral liquid, emplastrum, ointment, spray, liniment, drops or the tincture that clinical receiving is made according to customary adjuvant are made according to common process addition customary adjuvant for Chinese medicine composition of the present invention.Topical composition of the present invention, which has, to strengthen muscles and bones, relaxing tendons and activating collaterals, qi and activate blood circulation, dissipates stasis of blood analgesia, dispelling wind and eliminating dampness and other effects, for treating the rheumatism bone disease significant effects such as weak aching pain in waist and back, ostalgia knee, quadriplegia, arthritis, osteoproliferation, and it is quick, short treating period, have no toxic side effect.

Description

A kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of Chinese medicine composition and its system for treating rheumatism bone disease Preparation Method.
Background technology
Rheumatism bone disease is obstructed mainly due to blood circulation caused by chill, causes to include flesh, ligament, synovial bursa, manadesma Nutrition supply it is bad caused by disease.Arthropathy, still with swelling and moving obstacle, in breaking-out and is alleviated in addition to having pain The alternate chronic course of disease, some patientss and may occur in which that joint is disabled and viscera function exhaustion.Rheumatism bone disease is touching refractory slow Property systemic disease, especially higher (80% patient age was at 20 years old -- 45 years old) with the between twenty and fifty incidence of disease, onset is slow when initial, To forerunner's disease such as lassitude and weak, weight loss, anorexia, low-heat and numb in every limb shouting pain of some months in patient's several weeks before this Shape.Arthralgia, stiff, enlargement surrounding skin warm then occurs, flush is automatic and passive movement all causes pain.Start First, two joint involvements, it is often migrans.Develop into symmetry panarthritis since the Minor articulus of distal limbs again later Involve other joints.Secondly it is metacarpophalangeal, toe, wrist, knee, elbow, ankle, shoulder and hip joint etc., daystart anchylosis, DOMS.With The development of rheumatism, rheumatoid arthritis lesion, patient irregularly generates heat, and pulse is accelerated, notable anaemia, and joint is into stiff and abnormal Shape, cause deformity.Knee, elbow, finger, wrist lose energy of taking care of oneself into subluxation, patient laterally into fixed position in the wrong, finger Power, all day not from bedding, it is impossible to move and angor.Western medicine does not have specific medicament for this kind of disease at present, in more uses The wind-damp dispelling of medicine, easing joint movement, active pain relieving, strengthening the bones and muscles and other effects can mitigate illness.It is this kind of for treating in the market The Chinese medicine preparation of disease is a lot, but generally existing curative effect is slow, the course for the treatment of length, it is costly the shortcomings that.
The content of the invention
Present invention aims at provide a kind of Chinese medicine composition for treating rheumatism bone disease.
Another object of the present invention is to provide a kind of preparation method for the Chinese medicine composition for treating rheumatism bone disease.
The present invention is achieved through the following technical solutions：
The bulk drug of the present composition forms：
The bulk drug of the present composition forms：
The bulk drug of the present composition forms：
The bulk drug of the present composition forms：
The bulk drug of the present composition forms：
The preparation method of the present composition is：By rhododendron mariae, Folium Apocyni Veneti, screwtree root, birthwort and myrobalan's ultra micro Crush to obtain fine powder；Rhizoma nardostachyos, Tabasheer, Chinese knotweed, elephants-foot, Gorgon fruit and Buddha's hand are put in extractor, 4-12 times is added and measures 65- 85% ethanol is heated to 65 DEG C of refluxing extractions 1-3 times, extracts 1-3 hours every time, filtering, merges 2 filtrates, recovery ethanol is simultaneously Relative density 1.10-1.30 thick pastes A is concentrated into 50-70 DEG C；Remaining 7 taste bulk drugs are added into the 4-12 times of water measured immersion 15-45 Minute, decocted, decoct 1-3 hours for the first time, filter to get filtrate；The dregs of a decoction boil 1-2 hours, mistake with the 3-9 times of decocting measured again Filter, filtrate being obtained, merge filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifuges 2-6 minutes, separates supernatant, Water bath method is concentrated into relative density 1.25-1.30 thick paste B；The beeswax of 50-150 parts by weight is taken, puts in boiling water and dissolves；Will Thick paste A and thick paste B is stirred to put in boiling water with homogenizer to be heated, and is then added the natural rubber of 20-40 parts by weight, is stirred The beeswax after uniformly, adding dissolving is mixed, after quickly stirring, above-mentioned fine powder is added, stirs, emplastrum is made after tabletting Agent.
The preparation method of the present composition is preferably：By rhododendron mariae, Folium Apocyni Veneti, screwtree root, birthwort and myrobalan Ultramicro grinding obtains fine powder；Rhizoma nardostachyos, Tabasheer, Chinese knotweed, elephants-foot, Gorgon fruit and Buddha's hand are put in extractor, add 8 times of amounts 75% ethanol is heated to 65 DEG C of refluxing extractions 2 times, and extraction 2 hours, filtering, merges 2 filtrates every time, reclaims ethanol and in 60 DEG C it is concentrated into relative density 1.10-1.30 thick pastes A；The water that remaining 7 taste bulk drugs add 8 times of amounts is soaked 30 minutes, decocted, Decoct 2 hours, filter to get filtrate for the first time；The dregs of a decoction are boiled 1.5 hours with the decocting of 6 times of amounts again, are filtered, and obtain filtrate, are merged twice Filtrate, filtering, filtrate centrifuge, and 3000rpm centrifugations, centrifuge 4 minutes, separate supernatant, water bath method is concentrated into relatively close Spend 1.25-1.30 thick paste B；The beeswax of 100 parts by weight is taken, puts in boiling water and dissolves；By thick paste A and thick paste B homogenizers Stir to put in boiling water and heat, then add the natural rubber of 30 parts by weight, stir, the beeswax added after dissolving, After quickly stirring, above-mentioned fine powder is added, is stirred, emplastrum is made after tabletting.
The present composition according to common process add customary adjuvant be made the tablet of clinical receiving, capsule, granule, Pill, oral liquid, emplastrum, ointment, spray, liniment, drops or tincture.
The present composition, which has, to strengthen muscles and bones, relaxing tendons and activating collaterals, qi and activate blood circulation, dissipates stasis of blood analgesia, dispelling wind and eliminating dampness and other effects, right In rheumatism bone disease significant effects such as treatment aching pain in waist and back, ostalgia knee be weak, quadriplegia, arthritis, osteoproliferations, and it is quick, Short treating period, have no toxic side effect.
Bulk drug in the present composition carries out compatibility, wherein rhododendron mariae, Folium Apocyni Veneti, horse pocket by monarch Bell, Tabasheer, rhizoma nardostachyos, Chinese gall, treebine stem, caulis bambusae in taenian and the taste bulk drug of Gorgon fruit 9 are monarch drug in a prescription, in the present invention treats rheumatism bone disease Main therapeutic action is played, another agaric, fore-telling mustard, Lasiosphaera fenzlii, elephants-foot and the taste bulk drug of Buddha's hand 5 are ministerial drug, are aided in the present invention Monarch drug in a prescription strengthens the adjuvant for the treatment of rheumatism bone disease, and other screwtree roots, Chinese knotweed, myrobalan and the taste bulk drug of spina gleditsiae 4 are adjutant and made Medicine, play a part of accompanying symptoms in the compositions of the present invention.
Experimental example is used to further illustrate the present invention below, but is not limited to the present invention.
Experimental example one：Clinical test
1st, clinical observation
Treating rheumatic ostealgia, aching pain in waist and back, ostalgia knee be weak, four limbs to controlling for emplastrum of the present invention (being prepared according to the method for embodiment 1) The treating rheumatic ostealgia Patients with 300 Cases such as paralysis, arthritis, osteoproliferation, wherein male 150, women 150.Age 30-80 year.
2nd, medicament selection emplastrum of the present invention (being prepared according to the method for embodiment 1), two courses for the treatment of (5 days courses for the treatment of), daily One patch, is affixed on affected part.
3rd, diagnostic criteria
(1) treating rheumatic ostealgia
1) arthroncus, pain, the pain increased when passively stretching in the wrong, arthrochalasis and unstable, limitation of activity.
2) just fallen ill when the slightly more lost articles found of even bending over of activity, sneezing, in great pain, function limitation.
3) rainy days or wind-engaging, which are caught a cold, can cause the recurrence or exacerbation of pain.
4th, criterion of therapeutical effect
Implement within 1994 with reference to State Administration of Traditional Chinese Medicine《In cure the desease Standardization of diagnosis and curative effect》Draft as follows：
Clinical recovery：Tcm clinical practice symptom, sign disappear or basic disappearance；
It is effective：Tcm clinical practice symptom, sign substantially change；
Effectively：Tcm clinical practice symptom, sign take a favorable turn；
It is invalid：Tcm clinical practice symptom, sign are not improved；
5th, treatment results
Group Treatment number Cure Effectively It is invalid Total effective rate
Treating rheumatic ostealgia 300 258 40 2 99%
6th, conclusion
300 patients use two courses for the treatment of of emplastrum (each course for the treatment of 5 days) of the present invention, and treatment results show that total effective rate is 99%.
7th, discuss
Rhododendron mariae (scientific name in pharmaceutical composition of the present invention:Rhododendron amesiae Rehd.et Wils.): Shrub, high 2-4 rice.Sprout is close by body of gland shape scale, with or without bristle, major function：Cough-relieving, timid phlegm, for tracheitis；Spread out Sesame slices, alias:Bluish dogbane, wartwort be numb, wild tealeaves, sage, wild flax；Latin literary fame:Dogbane leaf. Angiospermaes, Dicotyledoneae, function is with curing mainly：Soothing the liver is calmed the nerves, clearing away heat and promoting diuresis, for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria；High blood Pressure disease, neurasthenia, ephritis edema；Agaric (English:Agaric), mainly it is grown in China and Japan.Most of China is east Northern agaric and Qinling Mountains agaric.Agaric not only can be wild but also can cultivateeed, and it is not hungry to cure mainly QI invigorating, strong will of making light of one's life by commiting suicide, moreover it is possible to which disconnected paddy is treated Hemorrhoid；Foretell the rhizome that mustard source is aroid Rhizoma Alocasiae Cucullatae, brought down a fever with removing toxic substances, Repercusion analgesia controls hyperpyrexia, and poisonous snake stings Wound, pulmonary tuberculosis, influenza, ileotyphus, cellulitis, nameless sores or boils, poisonous wasp sting；Screwtree root is Sterculiaceae screwtree root platymiscium mountain Sesame Helictercs angustifolia L., are used as medicine with root or complete stool.Summer, autumn excavation, clean section are dried, function master Control：It is clearing heat and detoxicating, cough-relieving, for cold and high fever, tonsillitis, sphagitis, parotitis, measles, cough, malaria；Poison is controlled in external application Snake bite, traumatism and bleeding, hemorrhoid, carbuncle swells furunculosis；Birthwort (scientific name:Aristolochia debilis Sieb.et Zucc), Alias water Ma Xiangguo, snake ginseng fruit, smallflower bracketplant herb, autumn banksia rose tank, Chinese name obtain because of the jingle bell that its ripening fruits is such as hung under Horse Neck, Birthwort is perennial prehensile herbaceous plant, and its root, stem, fruit all claim birthwort, and birthwort has clearing lung-heat sending down abnormally ascending, cough-relieving to put down Asthma, gut purge disappear hemorrhoid the effect of；Tabasheer be grass bambusa texlitis etc. because stinging hole by the India wasp of parasitism after, and in ring Between the bleeding sap stored up, the cake mass formed through dry condensation, there is dispelling wind and eliminating dampness, promoting blood circulation, which is relaxed, to pass through, the effect of cough-relieving.For Arthralgia pain due to rheumatism, numb limb, infantile pertussis, leukorrhea；Lasiosphaera fenzlii, stropharia coronilla or horseshoe bag some places are commonly called as pack Son, Ma Pipao, belong to basidiomycetes Lycoperdaceae, color is white when tender, and ball is but larger shaped like mushroom, delicious edible, tender such as bean curd, always Then brown and it is empty soft, the dust that has of bullet flies out, internal such as sponge, and dry fructification is medicinal in can doing, neutral in nature and sweet in taste, main to use Make local hemostatic；Rhizoma nardostachyos, (Latin literary fame:Nardostachys chinensis Batal.) perennial herb, complete stool has by force Strong rosin sample fragrance, the effect of rhizoma nardostachyos contributes to regulating qi-flowing for relieving pain, activating spleen and strengthening stomach, help to treat abdominal distention, do not feel like eating, tooth Bitterly, the effect of tinea pedis；Chinese gall scientific name (Rhus chinensis Mill.), also known as hundred worm storehouses, fermented Chinese gall herb and tea leaves, gall, it is same wing The horned gall aphid or melaphis peitan Tsai et Tang female adult of mesh aphid section parasitize Anacardiaceae plant " Chinese sumac " and its tender leaf for belonging to other plant together or Petiole, stab and generate a kind of cryptomere consor thing insect gall, the gained after drying and times drying, Chinese gall effect to astringe the lung, it is hidroschesis, puckery Intestines, controlling nocturnal emission with astringent drugs, hemostasis, removing toxic substances, are cured mainly：Chronic cough of deficiency lung, spontaneous sweating, protracted dysentery chronic diarrhea, prolapse of the anus, seminal emission, gonorrhoea, various bleedings, carbuncle Swollen boil etc.；Chinese knotweed (Polygonum chinense L.), alias wing land productivity, live charcoal star, live charcoal rattan, plain rice rattan, letter meal Rattan, live charcoal dish, polygonaceae plant Chinese knotweed are perennial herb, and complete stool can be used as medicine, and Chinese knotweed has clearing heat and detoxicating, and dampness removing disappears It is stagnant, blood-cooling itch-relieving, bright retaining screen；The red treebine stem of treebine stem alias, wing branch Cissus repens, for arthralgia pain due to rheumatism, joint distending pain, psoas Strain, grain arrested anxious；Elephants-foot (scientific name:Elephantopus scaber L.) composite family, Elephantopus, upright draft, is born in On meadow, the discrimination branch of stem 2, sometimes complete stool have white coarse wool, basal leaf is grown thickly, and blade cochlear or long round shape fall lanceolar, edge Slightly crenation, stem leaf is few, minimum, major function：It is clearing heat and detoxicating, inducing diuresis to remove edema, for catching a cold, acute tonsillitis, pharynx Laryngitis, eye conjunctivitis, Japanese Type-B encephalitis, pertussis, acute icteric hepatitis, cirrhotic ascites, acute and chronic ephritis, furuncle It is swollen, eczema；Caulis bambusae in taenian, Chinese medicine name.For grass bambusa breviflora Munro Bambusa tuldoides Munro, major part allusion quotation bamboo Sinocalamus beecheyanus (Munro) McClure var. pubescens P.F.Li or henon bamboo The drying of PhyILostachys nigra (Lodd.) Munrovar.henonis (Mitf.) Stapf ex Rendle stalk Intermediate layer, has a clearing heat and eliminating phlegm, relieving restlessness, and the effect of preventing or arresting vomiting, caulis bambusae in taenian is used for phlegm-heat cough, and courage fire holds phlegm under the arm, not peaceful, vexed mistake of palpitating with fear Sleep, middle wind phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, fetal irritability；Astringent medicinal in Gorgon fruit category Chinese medicine, it is Nymphaeceae The dry mature kernal of plant Gorgon euryale, originates in the ground such as Hubei, Hunan, Jiangxi, Anhui, function tonifying middle-Jiao and Qi, supplementing the kidney to control the nocturnal, and dehumidifying stops Band, for emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, gonorrhoea, with；Buddha's hand (scientific name:Citrus medica L. var.sarcodactylis Swingle):Fruit each carpel separation in maturation, form the fruit lobe of elongate curved, shape such as hand Refer to, therefore named Buddha's hand, Buddha's hand there are a variety of medicinal functions such as regulating qi-flowing for eliminating phlegm, preventing or arresting vomiting dissipate-swelling, liver soothing and speen fortifying and stomach；Myrobalan is the fruit of Rangoon creeper Section plant myrobalan Terminalia chebula Retz. or fine hair myrobalan Terminalia chebula Retz.var.tomentella Kurt. dry mature fruit, the ground such as Yunnan are distributed in, there is relieving diarrhea with astringents, astringe the lung to stop cough, The effect of fall fire relieving sore-throat, it is usually used in protracted dysentery and diarrhea, prolapse of the anus of having blood in stool, the deficiency syndrome of the lung is breathed with cough, and is coughed long more than, pharyngalgia sound is mute；Spina gleditsiae is beans Section plant Chinese honey locust Gleditsia sinensis Lam. drying quil；With detumescence eliminating toxic, apocenosis, the effect of desinsection, commonly use In ulcer from the beginning of or purulence into not bursting, control mange leprosy outside.The all medicine of the present invention merge have strengthen muscles and bones, relaxing tendons and activating collaterals, QI invigorating are lived Blood, stasis of blood analgesia, dispelling wind and eliminating dampness and other effects are dissipated, for treating weak aching pain in waist and back, ostalgia knee, quadriplegia, arthritis, osteoproliferation Deng rheumatism bone disease significant effect, and quick, short treating period, have no toxic side effect.
Experimental example two：Model case
Case 1：Zhao so-and-so, man, 55 years old.Main suit：Right elbow joint pain, joint stuffiness more than 3 years.Patient is engaged in builds at an early age Building site work is built, arthralgia often occurs in weight muscle power, but do not paid attention to.Front right elbow joint pain companion's swelling in 1 year, Symptom gradually aggravates, and dysarthrasis occurs, and right elbow stretching, extension is limited.Through using emplastrum of the present invention (according to the method system of embodiment 1 Standby, be affixed on affected part, 1 day/patch) pain and swelling substantially mitigates after 5 days, and dysarthrasis also slowly recovers, after being continuing with 5 days, pain Pain swelling symptom is completely without dysarthrasis also recovers, and has been fully recovered through looking into.Follow-up 1 year is without recurrence.
Case 2：Jiang, female, 68 years old.Symptom：Protrusion of lumber intervertebral disc, spinal canal stenosis.Protrusion of lumber intervertebral disc L5-4 L6-S2, Spinal canal stenosis, because of left lower extremity pain, numb several months, it is impossible to walk, pain, powerless and cause to walk, interruption rest occur Symptom mitigation afterwards, occur this clinical symptoms repeatedly again after walking on.Carry out our hospital's diagnosis and treatment upon somebody's introduction, look into waist L5,6 during examining Pressure pain is obvious on the left of vertebra spine and lower limb radiate to the left.30 degree of leg raising straight, lumbar vertebrae limitation of activity, left foot muscular strength weaken, and patellar tendon is anti- Penetrate good.One treatment for the treatment of (is prepared, three times a day, 2 tablets once) according to the method for embodiment 2 by using Tablets are taken After journey (each course for the treatment of 5 days), pain relief, after one course for the treatment of of continual cure, above-mentioned symptom is wholly absent, recovery from illness.1 year nothing of follow-up Recurrence.
Case 3：Guo, man, 71 years old.Symptom：The right leg ankle-joint of patient, pain and swelling, inconvenient walking, because the activity state of an illness adds Weight, rheumatic arthritis is diagnosed as in local hospital, hospital is to Chinese medicine and plaster partner treatment has been issued, and symptom does not obtain after January To alleviation.(prepared according to the method for embodiment 3 using ointment of the present invention upon somebody's introduction, ointment is applied at tender joint, gone forward side by side Row massage to absorb, twice a day) treatment one course for the treatment of (course for the treatment of 5 days) after, painful swelling of joints is clearly better, left ankle-joint work( It can be obviously improved, patient can normally walk, and be continuing with one course for the treatment of of ointment of the present invention, painful swelling of joints is without function of joint is Recover normal.Follow-up is without recurrence after 1 year.
Test example three, animal pharmacodynamics test compare
1. materials and methods
1.1 sample preparation
Experimental group tablet of the present invention (being prepared according to the method for embodiment 2) plus distilled water is taken to be configured to the molten of 1g/10ml respectively Liquid.
2. the influence that pair mouse carrageenan swells enough
30 male mices, male and female half and half, body weight (21 ± 3) g are selected in this experiment.It is randomly divided into 2 groups, blank group and Ben Fa Bright group, every group 15.Blank group gives physiological saline, the of the present invention group of solution for giving the invention described above preparation, as shown in table 1 The daily gastric infusion of dosage 1 time, successive administration 5 days.30 minutes after last dose, foot pad portion is subcutaneously injected behind the mouse right side 1% lrish moss mucilage 0.05ml causes scorching.Respectively 1,2,3,4 and 6 hour after causing scorching preceding and cause scorching, with projecting apparatus (8 times of amplification) Diameter at every mouse right hind ankle-joint lower section 0.5cm is measured, with the swelling difference for causing inflammation preceding with cause different time points after scorching As swelling.As a result find of the present invention group to mouse carrageenan enough the swollen inhibitory action for having highly significant and action time compared with Long, its anti-inflammatory intensity is most strong.It is substantially better than blank group.There were significant differences compared with blank group for present invention group.
The influence that table 1 swells enough to mouse carrageenan
3. the influence pair the reaction of mouse acetic acid twisting
30 mouse, male and female half and half, body weight (23 ± 2) g are selected in experiment.It is randomly divided into 2 groups, blank group and of the present invention group, Every group 15.Blank group gives physiological saline, and of the present invention group is given the solution that the invention described above is prepared, and the dosage as shown in table 2 is every Day gastric infusion once, successive administration 7 days.0.67% glacial acetic acid solution is injected intraperitoneally 40 minutes after last dose in each group 0.2ml/ only, then with the writhing number of every mouse in counter records second 10 minutes.The average writhing of each group is administered As a result number shows that of the present invention group can significantly decrease acetic acid induced mice writhing number compared with the average writhing number of blank group, and The analgesic effect that the present invention organizes is most strong.It is substantially better than blank group.There were significant differences compared with blank group for present invention group.
The influence that table 2 is reacted mouse acetic acid twisting
Packet Dosage (ml) Number of animals (only) Average writhing number (X ± SD times)
Blank group 10 15 48±12
Of the present invention group 10 15 10±2
4. the swollen influence experiment of pair mouse knoting oil ear
30 mouse, male and female half and half, body weight (21 ± 2) g are selected in experiment.It is randomly divided into 2 groups, control group and of the present invention group, Every group 15.Blank group gives physiological saline, the of the present invention group of solution for giving the invention described above preparation, the daily agent as shown in table 3 Measure gastric infusion once, successive administration 5 days.After last dose, by 2% croton oil proinflammatory agent 0.05ml drops in every mouse Auris dextra shell causes scorching.Cause inflammation to take off neck after 2 hours and put to death mouse, cut left and right ear, same position ear is laid with diameter 9mm card punch Piece, weigh, mouse dropsy of ear degree is used as using the difference of two ear weight.As a result show, of the present invention group has highly significant to mouse ear swelling Inhibitory action, hence it is evident that better than blank group.There were significant differences compared with blank group for present invention group.
The influence that table 3 swells to mouse knoting oil ear
Packet Dosage (ml) Number of animals (only) Ear swells degree (X ± SD mg)
Blank group 10 15 16.1±3.1
Of the present invention group 10 15 6.2±2.2
5. the influence pair mouse granuloma induced by implantation of cotton pellets
30 mouse, male and female half and half, body weight (23 ± 2) g are selected in experiment.It is randomly divided into 2 groups, control group and of the present invention group, Every group 15.Blank group gives physiological saline, the of the present invention group of solution for giving the invention described above preparation, daily gastric infusion 1 time, Successive administration 7 days.After the 3rd administration, by mouse back shaving, sterilization, incision skin under ether light anaesthesia, 30mg is gone out Bacterium cotton balls embedment both sides armpit is subcutaneous, sews up the incision, continues to be administered.Put to death mouse within 24 hours after last dose, strip out cotton balls Granuloma thing, the materials such as fat, the connective tissue of outside attachment are removed, claim weight in wet base with electronic balance, then in 60-70 DEG C of baking It is dry, dry weight is claimed after constant weight, subtracts the weight of cotton balls, as granuloma weight (mg).Take each administration group granuloma weight in wet base and dry weight Average compares.As a result show, of the present invention group has the inhibitory action of highly significant to mouse granuloma induced by implantation of cotton pellets, while shows this hair Bright group of medicine has good antiinflammatory action to chronic inflammation.It is substantially better than blank group.Present invention group relatively has significantly with blank group Difference.
Influence of the table 4 to mouse granuloma induced by implantation of cotton pellets weight
6. mouse water-bath whipping, which is reacted, influences experiment
30 mouse, male and female half and half, body weight (21 ± 2) g are selected in experiment.It is randomly divided into 2 groups, control group and of the present invention group, Every group 15.Blank group gives physiological saline, the of the present invention group of solution for giving the invention described above preparation, daily gastric infusion 1 time, Successive administration 5 days.Mouse Tail-tip 1.5cm is immersed water bath with thermostatic control by 0.5h, 1h, 2h, 3h respectively before experiment and after last dose In (55 ± 0.5 DEG C), with Casio stopwatches record rat-tail from be immersed in the water occur whipping act time, hidden as whipping Phase.The average flick latency that each group is administered is compared.As a result showing of the present invention group, can significantly to extend the reaction of mouse whipping latent Phase.Show that this hair group medicine has significant analgesic activity to pain caused by warm stimulation, hence it is evident that better than blank group.Of the present invention group There were significant differences compared with blank group.
The influence n=10 that table 5 is reacted mouse whipping
Following embodiments can realize the effect of above-mentioned experimental example.
Embodiment
The emplastrum of embodiment 1
Rhododendron mariae, Folium Apocyni Veneti, screwtree root, birthwort and myrobalan's ultramicro grinding are obtained into fine powder；By rhizoma nardostachyos, Tabasheer, Chinese knotweed, elephants-foot, Gorgon fruit and Buddha's hand are put in extractor, and the ethanol for adding 8 times of amounts 75% is heated to 65 DEG C of refluxing extractions 2 times, Extraction 2 hours every time, filtering, merge 2 filtrates, reclaim ethanol and relative density 1.10-1.30 thick pastes A is concentrated into 60 DEG C； The water that remaining 7 taste bulk drugs add 8 times of amounts is soaked 30 minutes, is decocted, is decocted 2 hours, filter to get filtrate for the first time；The dregs of a decoction Boiled 1.5 hours with the decoctings of 6 times of amounts again, filter, obtain filtrate, merge filtrate twice, filtering, filtrate centrifuges, 3000rpm from The heart, centrifuge 4 minutes, separate supernatant, water bath method is concentrated into relative density 1.25-1.30 thick paste B；Take 100 parts by weight Beeswax, put in boiling water and dissolve；Thick paste A and thick paste B are stirred to put in boiling water with homogenizer and heated, then adds 30 The natural rubber of parts by weight, stirs, and the beeswax added after dissolving, after quickly stirring, adds above-mentioned fine powder, stirs Uniformly, emplastrum is made after tabletting.A daily patch, is affixed on and suffers from piece.
The tablet of embodiment 2
The water that said medicine plus 8 times are measured is soaked 30 minutes, decocted, decocts 2 hours, filters to get filtrate for the first time； The dregs of a decoction are boiled 1.5 hours with the decocting of 6 times of amounts again, are filtered, and obtain filtrate, merge filtrate twice, filtering, and filtrate centrifuges, 3000rpm is centrifuged, and is centrifuged 4 minutes, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract；Medicinal extract is added into 10g PVPP is mixed evenly, and particle is made, tabletted, film coating piece.0.25g/ pieces, twice a day, often Secondary 2.
The ointment of embodiment 3
Said medicine adds customary adjuvant according to common process and ointment is made, and every 15ml, twice daily applies and gives affected part, And massaged.
The capsule of embodiment 4
The water that said medicine plus 8 times are measured is soaked 30 minutes, decocted, decocts 2 hours, filters to get filtrate for the first time； The dregs of a decoction are boiled 1.5 hours with the decocting of 6 times of amounts again, are filtered, and obtain filtrate, merge filtrate twice, filtering, and filtrate centrifuges, 3000rpm is centrifuged, and is centrifuged 4 minutes, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract；Medicinal extract is added into 10g PVPP is mixed evenly, and particle is made, encapsulated.0.25g/ grains, twice a day, 2 tablets each time.
The spray of embodiment 5
Said medicine adds customary adjuvant according to common process and spray, every 30ml is made, and affected part is given in twice daily spray, And massaged.
The pill of embodiment 6
Said medicine according to common process add customary adjuvant water-honeyed pill, 4g/ grains, twice a day, 1 tablet each time.
The ointment of embodiment 7
Said medicine adds customary adjuvant according to common process and ointment is made, and twice daily wipes in affected part, and rubbed Rub with the hands.
The tincture of embodiment 8
Said medicine adds customary adjuvant according to common process and tincture is made, and twice daily drips in affected part, and rubbed.
The oral liquid of embodiment 9
Said medicine adds customary adjuvant according to common process and is made oral liquid, every 10ml, twice daily, 1 every time.

Claims (10)

1. a kind of Chinese medicine composition for treating rheumatism bone disease, it is characterised in that the bulk drug of said composition, which forms, is：
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of said composition, which forms, is：
3. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of said composition, which forms, is：
4. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of said composition, which forms, is：
5. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of said composition, which forms, is：
6. the Chinese medicine composition as described in one of claim 1-5, it is characterised in that the preparation method of said composition is：Will be pale reddish brown Cuckoo, Folium Apocyni Veneti, screwtree root, birthwort and myrobalan's ultramicro grinding obtain fine powder；By rhizoma nardostachyos, Tabasheer, Chinese knotweed, elephants-foot, Gorgon fruit and Buddha's hand are put in extractor, are added the 4-12 times of ethanol for measuring 65-85% and are heated to 65 DEG C of refluxing extractions 1-3 times, carry every time 1-3 hours are taken, are filtered, merge 2 filtrates, ethanol is reclaimed and relative density 1.10-1.30 thick pastes A is concentrated into 50-70 DEG C；Will Remaining 7 taste bulk drugs add the 4-12 times of water measured immersion 15-45 minute, are decocted, decoct 1-3 hours for the first time, filtering to filter Liquid；The dregs of a decoction are boiled 1-2 hours with the 3-9 times of decocting measured again, filtering, obtain filtrate, merge filtrate twice, filtering, and filtrate centrifuges, 3000rpm is centrifuged, and centrifuges 2-6 minutes, separates supernatant, and water bath method is concentrated into relative density 1.25-1.30 thick paste B；Take The beeswax of 50-150 parts by weight, puts in boiling water and dissolves；Thick paste A and thick paste B are stirred to put in boiling water with homogenizer and added Heat, the natural rubber of 20-40 parts by weight is then added, is stirred, the beeswax added after dissolving, after quickly stirring, Above-mentioned fine powder is added, is stirred, emplastrum is made after tabletting.
7. Chinese medicine composition as claimed in claim 6, it is characterised in that the preparation method of said composition is：By rhododendron mariae, Folium Apocyni Veneti, screwtree root, birthwort and myrobalan's ultramicro grinding obtain fine powder；By rhizoma nardostachyos, Tabasheer, Chinese knotweed, elephants-foot, Gorgon fruit To be put with Buddha's hand in extractor, the ethanol for adding 8 times of amounts 75% is heated to 65 DEG C of refluxing extractions 2 times, every time extraction 2 hours, filtering, Merge 2 filtrates, reclaim ethanol and relative density 1.10-1.30 thick pastes A is concentrated into 60 DEG C；Remaining 7 taste bulk drugs are added 8 times The water of amount soaks 30 minutes, is decocted, and decocts 2 hours, filters to get filtrate for the first time；The dregs of a decoction boil 1.5 with the decocting of 6 times of amounts again Hour, filtering, filtrate is obtained, merge filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifuges 4 minutes, in separation Clear liquid, water bath method are concentrated into relative density 1.25-1.30 thick paste B；The beeswax of 100 parts by weight is taken, puts in boiling water and dissolves；Will Thick paste A and thick paste B is stirred to put in boiling water with homogenizer to be heated, and then adds the natural rubber of 30 parts by weight, stirring Uniformly, the beeswax added after dissolving, after quickly stirring, adds above-mentioned fine powder, stirs, emplastrum is made after tabletting Agent.
8. the Chinese medicine composition as described in one of claim 1-5, it is characterised in that said composition adds normal according to common process Rule auxiliary material be made the tablet of clinical receiving, capsule, granule, pill, oral liquid, emplastrum, ointment, spray, liniment, Drops or tincture.
9. application of the Chinese medicine composition in the medicine for preparing treatment rheumatism bone disease as described in one of claim 1-5.
10. application of the Chinese medicine composition in the medicine for preparing treatment rheumatism bone disease, its feature exist in as claimed in claim 9 Refer to weak treating rheumatic ostealgia, aching pain in waist and back, ostalgia knee, quadriplegia, arthritis or osteoproliferation in the rheumatism bone disease.
CN201710935073.3A 2017-10-10 2017-10-10 A kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof Pending CN107496752A (en)

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Publication number Priority date Publication date Assignee Title
CN101310756A (en) * 2007-05-21 2008-11-26 曹翔量 Infused medicine for treating winddampness, neck, shoulder, waist, leg, itai-itai disease
CN105435053A (en) * 2015-12-25 2016-03-30 青岛昌安达药业有限公司 Traditional Chinese medicine for treating rheumatism
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101310756A (en) * 2007-05-21 2008-11-26 曹翔量 Infused medicine for treating winddampness, neck, shoulder, waist, leg, itai-itai disease
CN106806780A (en) * 2015-11-27 2017-06-09 黑龙江众生生物工程有限公司 A kind of treebine stem dispelling wind and eliminating dampness piece and preparation method thereof
CN105435053A (en) * 2015-12-25 2016-03-30 青岛昌安达药业有限公司 Traditional Chinese medicine for treating rheumatism

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