CN105535682A - External-application traditional Chinese medicine for treating traumatic synovitis of knee joint and preparation method - Google Patents
External-application traditional Chinese medicine for treating traumatic synovitis of knee joint and preparation method Download PDFInfo
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- CN105535682A CN105535682A CN201610022937.8A CN201610022937A CN105535682A CN 105535682 A CN105535682 A CN 105535682A CN 201610022937 A CN201610022937 A CN 201610022937A CN 105535682 A CN105535682 A CN 105535682A
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Abstract
The invention discloses an external-application traditional Chinese medicine for treating traumatic synovitis of the knee joint. The external-application traditional Chinese medicine is prepared from, by weight, 7-12 parts of semen brassicae, 5-9 parts of valeriana jatamansi, 8-13 parts of begonia roots, 6-12 parts of cynanchum amplexicaule, 10-15 parts of semen coicis, 5-12 parts of sweet gourd rind, 3-8 parts of rohdea japonica flowers, 6-10 parts of marsdenia tenacissima, 9-12 parts of caulis spatholobi, 4-9 parts of tongking pepper, 6-11 parts of sarcopyramis nepalensis, 4-12 parts of phaseolus calcaratus, 2-8 parts of cinnamomum burmanni peel and 5-10 parts of dillseed. The external-application traditional Chinese medicine further has the advantages that the external-application traditional Chinese medicine is attached to the body surface, expands blood vessels by stimulating nerve endings of the affected part, promotes local blood circulation, improves nutrition of surrounding tissues, promotes smoothness of blocked microcirculation, eliminates heavy malabsorption of synovial fluid and achieves the healing purpose of complete recovery.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Traditional Chinese Medicine for external application and method for making for the treatment of traumatic synovitis of knee joint.
Background technology
After knee wound or many reasons stimulate, cause synovial membrane to damage, make articular cavity inner accumulated volume transudate person be called traumatic synovitis of knee joint.Knee joint is human body the most complicated maximum joint, and its major part is covered by synovial membrane.When after knee joint is injured or when excessively straining for a long time, the reaction of knee joint synovial membrane is the most obvious.Modern medicine thinks that SCID Mice is weight-bearing joints, and direct or indirect violence all can cause articular sprain; Long-term heavy burden forms chronic old damage; Or the change of the biomechanics of limbs own, operation technique waits roughly and synovial membrane also may be caused to damage.Main pathology shows as synovial membrane telangiectasis, hyperemia, edema, oozes out or Rupture haemorrhag, produce hydrarthrosis or hematocele, thus there is symptom, the signs such as knee joint swelling, pain, limitation of activity, as treated not in time, synovial membrane irriate of a specified duration then hypertrophy, plumpness, fiber is calm, and machine adhesion, causes serious joint function disturbance.
The clinical manifestation of traumatic synovitis of knee joint: acute injury, there is hematoma in knee joint.Hemarthrosis is generally that have blood stasis, ecchymosis widely around knee, during palpation, there is tension at skin turgor place, and floating patella test is positive, and local is hotter, and primary disease is often the complication that other damage in wound instant or generation in 1-2 hour after hindering afterwards.Chronic injury, the heavy discomfort of common trouble knee joint, knee joint bends and stretches difficulty, and passive activity is all normal, and pain is inviolent, and local is not red not hot, and general hydrarthrosis is less, and floating patella test is negative.If hydrops is more than 10 milliliters, then floating patella test is positive.Be more common in old fat person clinically, have other illness of knee joint more.If acute synovitis is dealt with improperly, also chronic synovitis can be converted into.
Traumatic synovitis of knee joint belongs to categories such as motherland's medical science " arthromyodynia " " arthroncus of knee ", caused by wound or old damage, has " knee joint is house of tendons " to say, and points out: " spleen governing muscles, extremity, main transporting in " The Yellow Emperor's Canon of Internal Medicine "; Liver governing tendons, store blood; Kidney governing bones, raw marrow "." Prescriptions for Succouring the Sick numbness " cloud: " all because body is empty, space between skin and muscles is empty, and dampness of having a cold forms numbness also ".Motherland's medical science thinks that traumatic synovitis is stagnation of blood stasis after the internal injury of joint, disorder of meridian-QI, and stasis of blood heat-transformation of a specified duration causes synovial membrane hyperemia, inflammatory seep, hydrops, swelling pain, belongs to motherland's medical science " blood stasis symptom " category.
Application publication number CN105012643A(application number 201510398370.X) Chinese invention patent document disclose a kind of external traditional Chinese medicinal application and care method for the treatment of traumatic synovitis of knee joint, be made up of the Chinese medicine of following weight portion: Flos Woodfordiae Fruticosae 10-20 part, Folium et Ramulus Callicarpae nudiflorae 10-20 part, Radix rubi coreani 4-6 part, Radix ardisiae villosae 6-10 part, Radix Pterospermi Heterophylli 8-12 part, Radix Desmodii Caudati 15-25 part, Herba Begoniae Cavalerei 7-10 part, Herba Geranii eriostemonis 10-20 part, Herba Lysimachiae Circaeoidis 4-8 part, Bulbus scillae scilloidis 3-6 part.Application publication number CN104840691A(application number 201510228189.4) Chinese invention patent document disclose a kind of Chinese medicine preparation and care method for the treatment of traumatic synovitis of knee joint, be made up of the Chinese medicine of following weight portion: Radix Pedicularis Henryi 10-20 part, Rhizoma Dispori Calcarati 8-12 part, Herba Crotalariae Ferrugineae 10-20 part, Herba Vaccinii Bracteati 3-5 part, Herba Pachysandrae Terminalis 6-9 part, Radix Acanthopanacis Trifoliati 10-20 part, Radix Zanthoxyli Spinifolii 3-9 part, Radix Campylotropis Cavaleriei 20-40 part, Coniogramme japonica (Thunb.) Diels 8-12 part.Application publication number CN104352642A(application number 201410637139.7) Chinese invention patent document disclose a kind of external use traditional Chinese medicine tincture for the treatment of knee joint Causes of Acute Traumatic synovitis, be prepared from by the raw material of following weight portion: Herba sambuci chinensis 10 parts, pubescent angelica root 8 parts, 2 parts, the Radix Euphorbiae Pekinensis, Fructus Forsythiae 5 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 5 parts, Radix Psammosilenes 3 parts, Cortex schizophragmatis integrifolii radicis 2 parts, white Calyx Solani melongenae 2 parts, Camphora 2 parts.
Clinical treatment synovitis is comparatively thorny, and general treatment is oral anti-inflammatory analgetic class medicine, cures the symptoms, not the disease, does not reach the object for the treatment of.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, effect rapidly, the Traditional Chinese Medicine for external application of the treatment traumatic synovitis of knee joint for the treatment of both the principal and secondary aspects of a disease.This Chinese Herbs is remarkable, without any side effects.
Technical scheme of the present invention is:
The Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint, is prepared from (being weight portion) by following bulk drugs: Semen Sinapis Albae 7-12; Rhizoma valerianae latifoliae 5-9; Radix Bischofiae Javanicae 8-13; Radix Cynanchi Amplexicaulis 6-12; Semen Coicis 10-15; Pericarpium Lagenariae hispidae 5-12; Flos Rohdeae Japonicae 3-8; Caulis Marsdeniae Tenacissimae 6-10; Caulis Spatholobi 9-12; Herba Piperris Tonkinensis 4-9; Herba Sarcopyramis nepalensis 6-11; Semen Phaseoli 4-12; Cortex Cinnamomi Burmannii 2-8; Fructus anethi 5-10.
Preferred scheme is: Semen Sinapis Albae 8-11; Rhizoma valerianae latifoliae 6-8; Radix Bischofiae Javanicae 9-12; Radix Cynanchi Amplexicaulis 8-10; Semen Coicis 11-14; Pericarpium Lagenariae hispidae 7-10; Flos Rohdeae Japonicae 4-7; Caulis Marsdeniae Tenacissimae 7-9; Caulis Spatholobi 10-11; Herba Piperris Tonkinensis 5.5-7.5; Herba Sarcopyramis nepalensis 7-10; Semen Phaseoli 6-10; Cortex Cinnamomi Burmannii 4-6; Fructus anethi 6.5-8.5.
More preferably: Semen Sinapis Albae 9.5; Rhizoma valerianae latifoliae 7; Radix Bischofiae Javanicae 10.5; Radix Cynanchi Amplexicaulis 9; Semen Coicis 12.5; Pericarpium Lagenariae hispidae 8.5; Flos Rohdeae Japonicae 5.5; Caulis Marsdeniae Tenacissimae 8; Caulis Spatholobi 10.5; Herba Piperris Tonkinensis 6.5; Herba Sarcopyramis nepalensis 8.5; Semen Phaseoli 8; Cortex Cinnamomi Burmannii 5; Fructus anethi 7.5.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint, step is as follows:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae to be placed in ginger decoction and to soak 5-8 hour (be preferably placed in ginger decoction and soak 6-7 hour), take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, takes out, for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami (Oleum Sesami into 0.22-0.28 times amount is drenched on stir-fry limit, preferred limit) into 0.18-0.32 times amount is drenched on stir-fry limit, limit, fry to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, add ethanol sealing lixiviate, collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice clear water slow fire boiling of 5-7 times of medicinal residues amount (preferably add twice) of 4-8 times of medicinal residues amount, each respectively decoction 25-35 minute (preferably each each decoction 28-32 minute), merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, sterilizing, encapsulation, to obtain final product.
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, the middle 90-130 mesh sieve excessively of step (3) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, in step (4), the amount of ethanol is the 3.8-5.4 of described raw material dose doubly (amount of preferred ethanol is 4.2-5.0 times of described raw material dose, and the amount of the ethanol be more preferably is 4.6 times of described raw material dose).
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, in step (4), the concentration of ethanol is the concentration of the preferred ethanol of 50%-90%(is 60%-80%, and the concentration of the ethanol be more preferably is 70%).
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, in step (4), the time of lixiviate is 2-6 days (time of preferred lixiviate is 3-5 days, and the time of the lixiviate be more preferably is 4 days).
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, in step (5), the temperature of sterilizing is 80-102 DEG C (temperature of preferred sterilizing is 84-88 DEG C, and the temperature of the sterilizing be more preferably is 86 DEG C).
The preparation method of the Traditional Chinese Medicine for external application of above-mentioned treatment traumatic synovitis of knee joint, preferred scheme is, in step (5), the time of sterilizing is 27-47 minute (time of preferred sterilizing is 32-42 minute, and the time of the sterilizing be more preferably is 37 minutes).
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1, the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component, strengthens effect of its damp eliminating, dredging collateral, pain relieving;
2, Traditional Chinese Medicine for external application of the present invention, is affixed on body surface, by stimulating affected part teleneuron, blood vessel dilating, promoting local blood circulation, improving surrounding tissue nutrition, impel the microcirculation be obstructed unimpeded, eliminate the heavy malabsorption of joint fluid, reach the healing object of thorough rehabilitation;
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 treats the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, is prepared from by following bulk drugs, is weight portion (45g/ part): Semen Sinapis Albae 7 parts; Rhizoma valerianae latifoliae 5 parts; Radix Bischofiae Javanicae 8 parts; Radix Cynanchi Amplexicaulis 6 parts; Semen Coicis 10 parts; Pericarpium Lagenariae hispidae 5 parts; Flos Rohdeae Japonicae 3 parts; Caulis Marsdeniae Tenacissimae 6 parts; Caulis Spatholobi 9 parts; Herba Piperris Tonkinensis 4 parts; Herba Sarcopyramis nepalensis 6 parts; Semen Phaseoli 4 parts; Cortex Cinnamomi Burmannii 2 parts; Fructus anethi 5 parts.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint is:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae and be placed in ginger decoction immersion 5 hours, take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, and taking-up is for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami into 0.18 times amount is drenched on stir-fry limit, limit, fries to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, crosses 90 mesh sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, the concentration adding 3.8 times of described raw material doses is the ethanol sealing lixiviate 2 days of 50%, and collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice of 4 times of medicinal residues amounts, each each decoction 25 minutes, and merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, 80 DEG C of sterilizings 27 minutes, encapsulation, to obtain final product.
The using method of gained Traditional Chinese Medicine for external application of the present invention is: by affected part warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.
Model case: old XX, man, 21 years old, people from Dezhou.Patient is to our hospital on November 4th, 2013.Patient is students, and a physical education surprisingly causes left knee joint injured, and after school infirmary uses reducing swelling and alleviating pain spraying treatment, pain relief, the swelling of second day affected part, joint stuffiness, treats in my institute's inspection of accompanying of classmate.Check: the left knee joint swelling of patient, pain, incapable of flexing and extending, illing skin flushing.Floating kneecap experiment (+), left lower limb of walking is spasticity; Red tip of the tongue, tongue is white, deep-thready pulse.Traumatic synovitis of knee joint is diagnosed as through x-ray auxiliary examination.
Use the Traditional Chinese Medicine for external application of the present embodiment gained treatment traumatic synovitis of knee joint, using method: affected part is used warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.After treating a course for the treatment of, swell and ache and obviously alleviate in affected part, left knee joint can bend and stretch by a small margin; After treating three courses for the treatment of, affected part arthroncus, pain disappear, and bend and stretch the limbs freely, and lab testing affected part recovers normal, and patient fully recovers.
Embodiment 2 treats the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, is prepared from by following bulk drugs, is weight portion (25g/ part): Semen Sinapis Albae 12 parts; Rhizoma valerianae latifoliae 9 parts; Radix Bischofiae Javanicae 13 parts; Radix Cynanchi Amplexicaulis 12 parts; Semen Coicis 15 parts; Pericarpium Lagenariae hispidae 12 parts; Flos Rohdeae Japonicae 8 parts; Caulis Marsdeniae Tenacissimae 10 parts; Caulis Spatholobi 12 parts; Herba Piperris Tonkinensis 9 parts; Herba Sarcopyramis nepalensis 11 parts; Semen Phaseoli 12 parts; Cortex Cinnamomi Burmannii 8 parts; Fructus anethi 10 parts.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint is:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae and be placed in ginger decoction immersion 8 hours, take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, and taking-up is for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami into 0.32 times amount is drenched on stir-fry limit, limit, fries to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, crosses 130 mesh sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, the concentration adding 5.4 times of described raw material doses is the ethanol sealing lixiviate 6 days of 90%, and collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice of 8 times of medicinal residues amounts, each each decoction 35 minutes, and merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, 102 DEG C of sterilizings 47 minutes, encapsulation, to obtain final product.
The using method of gained Traditional Chinese Medicine for external application of the present invention is: by affected part warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.
Embodiment 3 treats the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, is prepared from by following bulk drugs, is weight portion (40g/ part): Semen Sinapis Albae 8 parts; Rhizoma valerianae latifoliae 6 parts; Radix Bischofiae Javanicae 9 parts; Radix Cynanchi Amplexicaulis 8 parts; Semen Coicis 11 parts; Pericarpium Lagenariae hispidae 7 parts; Flos Rohdeae Japonicae 4 parts; Caulis Marsdeniae Tenacissimae 7 parts; Caulis Spatholobi 10 parts; Herba Piperris Tonkinensis 5.5 parts; Herba Sarcopyramis nepalensis 7 parts; Semen Phaseoli 6 parts; Cortex Cinnamomi Burmannii 4 parts; Fructus anethi 6.5 parts.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint is:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae and be placed in ginger decoction immersion 6 hours, take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, and taking-up is for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami into 0.22 times amount is drenched on stir-fry limit, limit, fries to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, crosses 100 mesh sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, the concentration adding 4.2 times of described raw material doses is the ethanol sealing lixiviate 3 days of 60%, and collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice of 5 times of medicinal residues amounts, each each decoction 28 minutes, and merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, 84 DEG C of sterilizings 32 minutes, encapsulation, to obtain final product.
The using method of gained Traditional Chinese Medicine for external application of the present invention is: by affected part warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.
Model case: Zhao XX, female, 51 years old, people from Jining.Patient is to our hospital in JIUYUE in 2014 11 days.Patient, when working in farmland, slips on ridge because of carelessness, at that time conscious pair of knee joint pain, inconvenient activity, and check in clinic and give external application of ointment and oral medicinal herb treatment, treat after three days, affected part pain symptom has no obvious improvement, double knee joint enlargement, difficulty in walking.Introduce through neighbours, come my institute and check treatment.Check: the swelling of patient's double knee joint, to harden, Leatherwear color is normal; Both legs can not bend and stretch, and x-ray shows: left knee space narrows; Sharp ache, purplish tongue, thick fur, stringy and tense pulse.Be diagnosed as traumatic synovitis of knee joint.
Use the Traditional Chinese Medicine for external application of the present embodiment gained treatment traumatic synovitis of knee joint, using method: affected part is used warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.After treating a course for the treatment of, two knee joint swelling pain symptom obviously alleviates, and two knee joint can bend and stretch by a small margin; After treating three courses for the treatment of, affected part arthroncus, pain disappear, and bend and stretch the limbs freely, and lab testing affected part recovers normal, and patient fully recovers.
Embodiment 4 treats the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, is prepared from by following bulk drugs, is weight portion (30g/ part): Semen Sinapis Albae 11 parts; Rhizoma valerianae latifoliae 8 parts; Radix Bischofiae Javanicae 12 parts; Radix Cynanchi Amplexicaulis 10 parts; Semen Coicis 14 parts; Pericarpium Lagenariae hispidae 10 parts; Flos Rohdeae Japonicae 7 parts; Caulis Marsdeniae Tenacissimae 9 parts; Caulis Spatholobi 11 parts; Herba Piperris Tonkinensis 7.5 parts; Herba Sarcopyramis nepalensis 10 parts; Semen Phaseoli 10 parts; Cortex Cinnamomi Burmannii 6 parts; Fructus anethi 8.5 parts.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint is:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae and be placed in ginger decoction immersion 7 hours, take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, and taking-up is for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami into 0.28 times amount is drenched on stir-fry limit, limit, fries to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, crosses 120 mesh sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, the concentration adding 5.0 times of described raw material doses is the ethanol sealing lixiviate 5 days of 80%, and collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice of 7 times of medicinal residues amounts, each each decoction 32 minutes, and merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, 88 DEG C of sterilizings 42 minutes, encapsulation, to obtain final product.
The using method of gained Traditional Chinese Medicine for external application of the present invention is: by affected part warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.
Embodiment 5 treats the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, is prepared from by following bulk drugs, is weight portion (35g/ part): Semen Sinapis Albae 9.5 parts; Rhizoma valerianae latifoliae 7 parts; Radix Bischofiae Javanicae 10.5 parts; Radix Cynanchi Amplexicaulis 9 parts; Semen Coicis 12.5 parts; Pericarpium Lagenariae hispidae 8.5 parts; Flos Rohdeae Japonicae 5.5 parts; Caulis Marsdeniae Tenacissimae 8 parts; Caulis Spatholobi 10.5 parts; Herba Piperris Tonkinensis 6.5 parts; Herba Sarcopyramis nepalensis 8.5 parts; Semen Phaseoli 8 parts; Cortex Cinnamomi Burmannii 5 parts; Fructus anethi 7.5 parts.
The preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint is:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae and be placed in ginger decoction immersion 6.5 hours, take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, and taking-up is for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami into 0.25 times amount is drenched on stir-fry limit, limit, fries to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, crosses 110 mesh sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, the concentration adding 4.6 times of described raw material doses is the ethanol sealing lixiviate 4 days of 70%, and collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice of 6 times of medicinal residues amounts, each each decoction 30 minutes, and merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, 86 DEG C of sterilizings 37 minutes, encapsulation, to obtain final product.
The using method of gained Traditional Chinese Medicine for external application of the present invention is: by affected part warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Sinapis Albae: base is former: be the seed of crucifer Caulis et Folium Sinapis albee.Chemical analysis: Semen Sinapis Albae is containing Sinapine glucosinalbate., sinapic acid choline ester., myrosase, fat, protein and phlegmatic temperament.Sinapine glucosinalbate. is hydrolyzed through myrosase, produces P-hydroxybonzyl isothiocyanale (white mustard oil), sinapine bisulfate and glucose.Sinapine bisulfate can generate sinapic acid and choline through basic hydrolysis.Nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach warp.Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Rhizoma valerianae latifoliae: be the rhizome of Valerianaceae platymiscium Rhizoma valerianae latifoliae.Composition: root welding technology, mainly containing volatile ingredient, also contains caffeic acid.Pharmacology: inhibited to nervus centralis, has antineoplastic action.The property of medicine: pungent, micro-hardship, temperature.Function cures mainly: regulating the flow of Qi and the middle Jiao, dispelling cold and removing dampness, promoting blood circulation and detumescence.
Radix Bischofiae Javanicae: base is former: be the root of Begoniaceae plant Flos Begoniae Evansianae.Chemical analysis: tuber is containing Flos Begoniae Evansianae Saponin.Nature and flavor: sour in the mouth; Puckery.Function cures mainly: blood stasis dispelling; Hemostasis; Clearing away heat-damp and promoting diuresis.Main traumatic injury; Spit blood, spit blood; Epistaxis; Knife injury is hemorrhage; Metrorrhagia; Blood stasis amenorrhea; Menoxenia; Leukorrhagia; Stranguria with turbid discharge; Dysentery; Stomachache; Laryngopharynx swelling and pain.
Radix Cynanchi Amplexicaulis: base is former: be root or the herb of asclepiadaceae plant Radix Cynanchi Amplexicaulis.Chemical analysis: containing steroidal glycoside composition in yellowish green colored Radix Cynanchi Amplexicaulis root.Be separated to Rhizoma Cynanchi Stauntonii glycoside unit B and Rhizoma Cynanchi Stauntonii glycoside unit-C-single-D-Semen Thevetiae glucoside.Nature and flavor: bitter in the mouth; Pungent; Property is put down.Gui Jing: lung; Spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Wind-damp dispelling; Promoting blood circulation and detumescence.Main air pain of dampness syndrome; Migraine; Lumbago; Menoxenia; Acute mastitis; Carbuncle furunculosis.
Semen Coicis: base is former: be the kernel of grass Semen Coicis.Nature and flavor: sweet light, cool.Gui Jing: enter spleen, lung, kidney channel.Function cures mainly: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Pericarpium Lagenariae hispidae: base is former: be the aging peel of cucurbitaceous plant Pericarpium Lagenariae hispidae.Character: dry peel, many in broken strip of sheet, thick about 5-7mm.Appearance yellow-white or lark, smoothly, inwall canescence, as silk floss is cotton-shaped.Matter is crisp easily broken, and section is uneven.With drying, appearance yellow skin, inwall white, be good without chip person.Nature and flavor: bitter in the mouth; Light; Cold in nature.Function cures mainly: inducing diuresis to remove edema.Interarea order extremity edema; Expand; Urinary obstruction.
Flos Rohdeae Japonicae: base is former: the alabastrum of liliaceous plant Rohdea japonica Roth.Original shape state: Rohdea japonica Roth: perennial evergreen draft.The thick 1.5-2.5cm of rhizome, has most crude fibre root.Scape is shorter than leaf; The long 3-4cm of spike, wide 1.2-1.7cm, the flower that tool tens is intensive; Bract is avette, film quality, is shorter than flower, long 2.5-6mm, wide 2-4mm; Perianth symphysis, spherical bell, long 4-5mm, wide 6mm, sliver 6, not fairly obvious, introversive, thick meat, faint yellow or brown; Stamen 6, flower pesticide is avette, long 1.4-1.5mm; Ovary is spherical, and style is not obvious, and stigma 3 splits.Berry diameter is about 8mm, red time ripe.The florescence 5-6 month, the fruit phase 9-11 month.Habitats distribution: ecological environment: be born in the sylvan life of height above sea level 750-1700m, dark and damp meadow, mountain valley.Function cures mainly: stasis-dispelling and pain-killing; The kidney invigorating.Main traumatic injury; Lumbago due to renal deficiency.
Caulis Marsdeniae Tenacissimae: base is former: be the rattan of asclepiadaceae plant Caulis Marsdeniae Tenacissimae, root or leaf.Nature and flavor: 1. " choosing of Yunnan Chinese herbal medicine ": " bitter, be slightly cold." 2. " Red River Chinese herbal medicine ": " bitter micro-sweet, cool." function cures mainly: heat-clearing and toxic substances removing, relieving cough and asthma.Control pneumonia, bronchitis, bronchial asthma, pharyngolaryngitis, tonsillitis, cystitis, treat pyogenic infections from tumour or sore.
Caulis Spatholobi: base is former: this product is the dry rattan of leguminous plant spatholobus suberectus.Character: this product is oval, long square circle or irregular sheet of cutting sth. askew, thick 0.3-1cm.Cork taupe brown, the visible greyish white mottle had, cork comes off and locates aobvious rufous.Nature and flavor: bitter, sweet, temperature.Gui Jing: return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.Cure mainly: for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Herba Piperris Tonkinensis: base is former: be the Herb of Piperaceae plant optical axis ramie leaf Betel.Nature and flavor: pungent; Temperature.Gui Jing: Liver Channel.Function cures mainly: expelling wind and cold; Promoting blood flow to regulate menstruation; Reducing swelling and alleviating pain.Main anemofrigid cold, rheumatic arthralgia, coldness and pain in the epigastrium, toothache, menoxenia, pain is exhausted, treating swelling and pain by traumatic injury, snake bite and insect sting.
Herba Sarcopyramis nepalensis: base is former: be the herb of Melastomateae plants Herba Sarcopyramis nepalensis.Nature and flavor: bitter in the mouth; Sweet; Cold nature.Gui Jing: return lung; Liver Channel.Function cures mainly: heat clearing away suppressing the hyperactive liver; Eliminating damp, detoxifying.Main cough due to lung-heat; The vertigo; Tinnitus; Deaf; Day red photophobia; Hepatitis; Rheumatic arthralgia; Traumatic injury wound is swollen; Snake head-like infection; Innominate toxic swelling.
Semen Phaseoli: base is former: be the seed of leguminous plant Semen Phaseoli or Semen Phaseoli.Chemical analysis: every hectogram is containing 20.7 grams, protein, 0.5 gram, fat, carbohydrate 58 grams, crude fibre 4.9 grams, ash 3.3 grams, calcium 67 milligrams, 305 milligrams, phosphorus, ferrum 5.2 milligrams, thiamine 0.31 milligram, 0.11 milligram, riboflavin, nicotinic acid 2.7 milligrams.Nature and flavor: sweet acid are flat.Gui Jing: enter the heart, small intestine meridian.Function cures mainly: diuretic dehumidifies, and blood evacuation of pus, subduing swelling and detoxicating.Harness the river swollen, beriberi, jaundice, dysentery, has blood in stool, carbuncle.
Cortex Cinnamomi Burmannii: base is former: be the cloudy fragrant bark of canella.Chemical analysis: bark is containing volatile oil 0.2%-0.4%.Main component in oil is cinnamic aldehyde, accounts for 77%.In addition, also containing eugenol, the compositions such as safrole.Nature and flavor: pungent; Micro-sweet; Warm in nature.Gui Jing: spleen channel.Function cures mainly: warming middle-JIAO to relieve pain; Expelling wind and cold; Removing toxic substances and promoting subsidence of swelling; Hemostasis.Cure mainly cold stomachache; Stomachache is had loose bowels; Inappetence; Anemofrigid-damp arthralgia; Lumbago and skelalgia; Traumatic injury; Wound hemorrhage; Furuncle toxic swelling.
Fructus anethi: base is former: be the fruit of samphire Fructus anethi.Chemical analysis: fruit is containing Eucarvone, limonene, dill-apiol, bergapton, umbelliprenin and 7-hydroxycoumarin Acacia farnesiana Willd. alcohol ether, wax, wax and clionasterol etc.Seed, stem, leaf contain 6,7-dihydro-8,8-diformazan-2H, 8H-benzo [1,2-b:5,4-b] two pyrans-2,6-diketone, scopoletin, 7-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-acrylic acid .delta.-lactone.In addition, also containing 16 kinds of volatile oil components in seed, α-Eucarvone is mainly, limonene, phellandrene, dihydro Eucarvone.Pharmacological action: non-terpenoid oil contained in seed has antifungic action.Nature and flavor: acrid in the mouth; Warm in nature.Gui Jing: return spleen; Stomach; Liver; Kidney channel.Function cures mainly: warming the spleen whets the appetite; Cold expelling warms up liver; Regulating QI to relieve pain.Cold type of pain in main abdomen; Side of body rib distension; Vomiting lack of appetite; Colic of cold type.
The clinical practice of the Traditional Chinese Medicine for external application (embodiment 5) of test example gained treatment of the present invention traumatic synovitis of knee joint:
1, data and method
1.1 physical data
Choose the patient being diagnosed as traumatic synovitis of knee joint totally 355 examples that in JIUYUE, 2011 in JIUYUE ,-2013 carrys out my institute's treatment, the age 22-60 year, the mean age was at 36.5 ± 3.5 years old.Wherein male patient's totally 193 examples, female patient is totally 162 examples, and the course of disease is the longest 4 years, the shortest three months.
1.2 diagnostic criteria
With reference to the diagnostic criteria of State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect " traumatic synovitis of knee joint.(1) there is trauma history or always damage history; (2) old, fat person is mainly in; (3) knee joint swelling, bulge, distending pain, difficulty of going down on one's knees; (4) floating patella test (+); (5) arthrocentesiS is rose pink liquid, fat-free of surface.(6) make a definite diagnosis through x-ray, MRI auxiliary examination.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random.Two groups of patients have comparability (P > 0.05) in sex, age, the state of an illness etc.Experimental group takes product of the present invention, using method: affected part is used warm water wiped clean, gets appropriate medicine of the present invention, with the furnishing such as Chinese liquor, vinegar pasty state, spreads on affected part, five days courses for the treatment of.Matched group uses other medicines (as conventional medication such as Votalin Ointment, synovitis sheet, the subsides of synovial membrane health).Observe three courses for the treatment of of treatment altogether.
1.4 efficacy assessment standard
With the gonalgia, edema, the large primary symptom of dysfunction three for treatment standard.
Cure: treatment patella pain and edema disappear completely, functional activity is normal, without recurrence in 1 year;
Take a turn for the better: after treatment, local edema disappears, pain relief, and functional activity is normal;
Invalid: the symptoms such as treatment rear local pain, edema, dysfunction are without significant change.
Total effective rate=(cure number of cases+improvement number of cases) ∕ total inspection case load × 100%.
1.4 therapeutic outcome
The therapeutic outcome of two groups of patients, as shown in table 1
Table 1: the therapeutic outcome of experimental group and matched group patient compares
Therapeutic effect: experimental group cures 137 examples (70.3%), 54 examples that take a turn for the better (27.7%), invalid 4 examples (2%), total effective rate 98%, and matched group is only 79.4%.Show that the Traditional Chinese Medicine for external application therapeutic effect of gained of the present invention treatment traumatic synovitis of knee joint is obviously better than other conventional medicine.
The present invention select Semen Sinapis Albae, Rhizoma valerianae latifoliae, Radix Bischofiae Javanicae, Radix Cynanchi Amplexicaulis, Semen Coicis, Pericarpium Lagenariae hispidae, Flos Rohdeae Japonicae, Caulis Marsdeniae Tenacissimae etc. totally ten four taste primary raw material medicines be prepared from.Fang Zhong, Semen Sinapis Albae warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain; Rhizoma valerianae latifoliae regulating the flow of Qi and the middle Jiao, dispelling cold and removing dampness, promoting blood circulation and detumescence; Radix Cynanchi Amplexicaulis heat-clearing and toxic substances removing, promoting blood circulation and detumescence; Semen Coicis spleen invigorating, tonifying the lung, heat clearing away, dampness removing; Pericarpium Lagenariae hispidae inducing diuresis to remove edema; Flos Rohdeae Japonicae stasis-dispelling and pain-killing; Caulis Spatholobi is invigorated blood circulation, dredging collateral; Herba Piperris Tonkinensis expelling wind and cold, reducing swelling and alleviating pain; Herba Sarcopyramis nepalensis heat clearing away suppressing the hyperactive liver, eliminating damp, detoxifying; Cortex Cinnamomi Burmannii warming middle-JIAO to relieve pain, expelling wind and cold, removing toxic substances and promoting subsidence of swelling; Fructus anethi regulating QI to relieve pain.Full side's compatibility, plays the merit of damp eliminating, dredging collateral, pain relieving altogether.Treat three courses for the treatment of, experimental group effective percentage can reach 98%, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Traditional Chinese Medicine for external application of traumatic synovitis of knee joint, it is characterized in that, be prepared from (being weight portion) by following bulk drugs: Semen Sinapis Albae 7-12; Rhizoma valerianae latifoliae 5-9; Radix Bischofiae Javanicae 8-13; Radix Cynanchi Amplexicaulis 6-12; Semen Coicis 10-15; Pericarpium Lagenariae hispidae 5-12; Flos Rohdeae Japonicae 3-8; Caulis Marsdeniae Tenacissimae 6-10; Caulis Spatholobi 9-12; Herba Piperris Tonkinensis 4-9; Herba Sarcopyramis nepalensis 6-11; Semen Phaseoli 4-12; Cortex Cinnamomi Burmannii 2-8; Fructus anethi 5-10.
2. the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint as claimed in claim 1, is characterized in that, be prepared from (being weight portion) by following bulk drugs: Semen Sinapis Albae 8-11; Rhizoma valerianae latifoliae 6-8; Radix Bischofiae Javanicae 9-12; Radix Cynanchi Amplexicaulis 8-10; Semen Coicis 11-14; Pericarpium Lagenariae hispidae 7-10; Flos Rohdeae Japonicae 4-7; Caulis Marsdeniae Tenacissimae 7-9; Caulis Spatholobi 10-11; Herba Piperris Tonkinensis 5.5-7.5; Herba Sarcopyramis nepalensis 7-10; Semen Phaseoli 6-10; Cortex Cinnamomi Burmannii 4-6; Fructus anethi 6.5-8.5.
3. the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint as claimed in claim 1, is characterized in that, be prepared from (being weight portion) by following bulk drugs: Semen Sinapis Albae 9.5; Rhizoma valerianae latifoliae 7; Radix Bischofiae Javanicae 10.5; Radix Cynanchi Amplexicaulis 9; Semen Coicis 12.5; Pericarpium Lagenariae hispidae 8.5; Flos Rohdeae Japonicae 5.5; Caulis Marsdeniae Tenacissimae 8; Caulis Spatholobi 10.5; Herba Piperris Tonkinensis 6.5; Herba Sarcopyramis nepalensis 8.5; Semen Phaseoli 8; Cortex Cinnamomi Burmannii 5; Fructus anethi 7.5.
4. the preparation method of the Traditional Chinese Medicine for external application of the treatment traumatic synovitis of knee joint as described in claim 1-3, it is characterized in that, step is as follows:
(1) get Radix Bischofiae Javanicae, Cortex Cinnamomi Burmannii, Caulis Spatholobi and Rhizoma valerianae latifoliae to be placed in ginger decoction and to soak 5-8 hour (be preferably placed in ginger decoction and soak 6-7 hour), take out, be placed in medicine cookeding pot, slow fire heating fried dry is degree, takes out, for subsequent use;
(2) Fructus anethi, Semen Sinapis Albae and Pericarpium Lagenariae hispidae are placed in medicine cookeding pot, and slow fire heats, and the Oleum Sesami (Oleum Sesami into 0.22-0.28 times amount is drenched on stir-fry limit, preferred limit) into 0.18-0.32 times amount is drenched on stir-fry limit, limit, fry to glassy yellow, slightly focal spot, take out, suck unnecessary oil content, for subsequent use;
(3) crude drug after step (1) and (2) process is ground into fine powder, sieves, obtain mixing fine powders for subsequent use;
(4) surplus stock medicated powder is broken into coarse powder, is placed in hermetic container, add ethanol sealing lixiviate, collect lixiviating solution, reclaim ethanol, concentrating under reduced pressure becomes thick paste a; Gained medicinal residues are placed in frying pan, add the clear water slow fire boiling twice clear water slow fire boiling of 5-7 times of medicinal residues amount (preferably add twice) of 4-8 times of medicinal residues amount, each respectively decoction 25-35 minute (preferably each each decoction 28-32 minute), merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste b of 1.28-1.30, for subsequent use;
(5) mix in step (3) gained mixing fine powders with step (4) gained thick paste a and thick paste b, mix thoroughly, sterilizing, encapsulation, to obtain final product.
5. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, is characterized in that, the middle 90-130 mesh sieve excessively of step (3) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
6. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, it is characterized in that, in step (4), the amount of ethanol is the 3.8-5.4 of described raw material dose doubly (amount of preferred ethanol is 4.2-5.0 times of described raw material dose, and the amount of the ethanol be more preferably is 4.6 times of described raw material dose).
7. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, it is characterized in that, in step (4), the concentration of ethanol is the concentration of the preferred ethanol of 50%-90%(is 60%-80%, and the concentration of the ethanol be more preferably is 70%).
8. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, is characterized in that, in step (4), the time of lixiviate is 2-6 days (time of preferred lixiviate is 3-5 days, and the time of the lixiviate be more preferably is 4 days).
9. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, it is characterized in that, in step (5), the temperature of sterilizing is 80-102 DEG C (temperature of preferred sterilizing is 84-88 DEG C, and the temperature of the sterilizing be more preferably is 86 DEG C).
10. the preparation method of the Traditional Chinese Medicine for external application for the treatment of traumatic synovitis of knee joint according to claim 4, it is characterized in that, in step (5), the time of sterilizing is 27-47 minute (time of preferred sterilizing is 32-42 minute, and the time of the sterilizing be more preferably is 37 minutes).
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| CN107929495A (en) * | 2018-01-08 | 2018-04-20 | 杨生直 | A kind of Chinese medicine for treating effusion of knee joint |
| CN113797240A (en) * | 2021-10-21 | 2021-12-17 | 河南省纳普生物技术有限公司 | Application of total polyphenol extract of tung tree in preparation of calcium ion channel inhibiting medicine |
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Address after: 741000 Gansu province Tianshui District Huangcheng Road No. 138 Building 2 room 1-301 Applicant after: Tian Junqing Address before: 250000 Ji'nan Province, Lixia District, Shandong by Road No. ten, No. 50 Applicant before: Tian Junqing |
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Application publication date: 20160504 |