CN107496641A - 一种用于治疗痛经的药物制备方法 - Google Patents

一种用于治疗痛经的药物制备方法 Download PDF

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CN107496641A
CN107496641A CN201710781755.3A CN201710781755A CN107496641A CN 107496641 A CN107496641 A CN 107496641A CN 201710781755 A CN201710781755 A CN 201710781755A CN 107496641 A CN107496641 A CN 107496641A
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夏伟
王旦
张涛
何怀深
贾延凤
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Abstract

本发明涉及医药技术领域,具体地说,涉及一种用于治疗痛经的药物制备方法,是由以下重量份:当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份制成的复方中药。本发明证实,舒尔经片对气滞血瘀型痛经具有显著的治疗作用,具有疗程短,疗效高的特点,且相对于西药抗生素效果更佳,从而为传统中药制剂增加了新的治疗用途,极具推广使用价值,且通过添加一定剂量的辅料,可有效提高舒尔经片硬度达30%左右,并充分改善药物溶出。

Description

一种用于治疗痛经的药物制备方法
技术领域
本发明涉及医药技术领域,具体为一种用于治疗痛经的药物制备方法。
背景技术
痛经是未婚青少年女性多发常见疾病,给患者的生活和工作带来很多的不便和痛苦。
现代医学对痛经的治疗主药采用抑制排卵,如口服避孕片(复方炔诺酮片或复方甲地孕酮片)等,但若除非患者需要同时避孕,一般不受欢迎,而且会对患者的月经生理周期产生不良影响;对不愿避孕的病人,则宜前列腺素合成抑制剂,但对有消化道溃疡及药物过敏者忌用,但此类药物多是在月经来潮前3天左右开始服用,月经结束后体用,需要每个月经周期反复用药,患者容易有依赖性,而且胃肠道反应发生率较高,还可发生头晕、疲乏虚弱感、头痛等症状,以致治疗中途停药者甚多,若用量较大时,偶尔出现较严重副反应。其他的治疗方法,如使用β-受体兴奋剂,但有增快心率、升高血压的副反应。以上治疗均是对症疗法,不能彻底治愈。
中医治疗痛经,则根据患者体质、症状和体征,审其病因,辨其寒、热、虚、实,因人施治。临床多见的情况有气滞血瘀、寒湿凝滞、气血虚弱、肝肾亏损等证型,采取活血化瘀,行气理气,温经散寒,除湿,益气补血,益肾养肝等方法治疗痛经,效果非常明显,往往可以治愈,而且很少会有不良反应。鉴于此,我们提出一种用于治疗痛经的药物制备方法。
发明内容
本发明的目的在于提供一种用于治疗痛经的药物制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种用于治疗痛经的药物制备方法,是由以下重量份:当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份制成的复方中药。
优选的,还包括药物辅料。
优选的,所述药物辅料包括填充剂、粘合剂和润滑剂。
优选的,所述填充剂采用淀粉、糊精、乳糖、可压性淀粉、甘露醇、磷酸氢钙和硫酸钙中的任一种或几种。
优选的,所述粘合剂采用淀粉浆、聚乙稀吡咯烷酮水溶液、聚乙稀吡咯烷酮醇溶液、胶化淀粉、羧甲基纤维素钠水溶液中的任一种或几种。
优选的,所述润滑剂采用硬脂酸镁、滑石粉、微粉硅胶中的任一种或几种。
优选的,一种用于治疗痛经的药物制备方法,包括如下步骤:1)按处方重量配比称取当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份,总计共11味药材;2)将140份的延胡索粉碎成细粉;3)将剩余140份的延胡索与当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份总计十味药材粉碎成粗的颗粒,加水温浸(94±6℃)2.5小时,过滤,滤液浓缩至相对密度为1.20~1.25(45~55℃)的清膏;4)喷雾干燥,得浸膏粉,与上述延胡索细粉混合均匀,作为药物活性成分,经过处理后与药物辅料混合,使用常规制剂技术制成所需的舒尔经片片剂。
与现有技术相比,本发明的有益效果:
本发明证实,使用本发明药物治疗中医辩证属气滞血瘀型痛经患200例,重度痛经50例,中度痛经85例,轻度痛经65例,患者服用舒尔经片,与经前2~6天开始服用舒尔经片至月经来潮2~3天,一次2粒,一日2次,重度痛经患者剂量加倍,经过2~3个月经周期的药物治疗后,治愈110例,占475%;显效50例,占285%;有效20例,占13.8%;无效20例,占12.1%。总有效率为83.4%;因此,舒尔经片对气滞血瘀型痛经具有显著的治疗作用,具有疗程短,疗效高的特点,且相对于西药抗生素效果更佳,从而为传统中药制剂增加了新的治疗用途,极具推广使用价值,且通过添加一定剂量的辅料,可有效提高舒尔经片硬度达30%左右,并充分改善药物溶出。
具体实施方式
为进一步了解本发明的内容,结合实施例对本发明作详细描述。应当理解的是,实施例仅仅是对本发明进行解释而并非限定。
实施例1
一种用于治疗痛经的药物制备方法,是由以下重量份:当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份制成的复方中药。
本实施例中,还包括药物辅料。
本实施例中,所述药物辅料包括填充剂、粘合剂和润滑剂。
本实施例中,所述填充剂采用淀粉、糊精、乳糖、可压性淀粉、甘露醇、磷酸氢钙和硫酸钙中的任一种或几种。
本实施例中,所述粘合剂采用淀粉浆、聚乙稀吡咯烷酮水溶液、聚乙稀吡咯烷酮醇溶液、胶化淀粉、羧甲基纤维素钠水溶液中的任一种或几种。
本实施例中,所述润滑剂采用硬脂酸镁、滑石粉、微粉硅胶中的任一种或几种。
一种用于治疗痛经的药物制备方法,包括如下步骤:1)按处方重量配比称取当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份,总计共11味药材;2)将140份的延胡索粉碎成细粉;3)将剩余140份的延胡索与当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份总计十味药材粉碎成粗的颗粒,加水10倍量温浸(94±6℃)2.5小时,过滤,滤液浓缩至相对密度为1.20~1.25(45~55℃)的清膏;4)喷雾干燥,得浸膏粉,与上述延胡索细粉混合均匀,作为药物活性成分,经过处理后与药物辅料混合,使用常规制剂技术制成所需的舒尔经片片剂。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的仅为本发明的优选例,并不用来限制本发明,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (7)

1.一种用于治疗痛经的药物制备方法,其特征在于:是由以下重量份:当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份制成的复方中药。
2.根据权利要求1所述的用于治疗痛经的药物制备方法,其特征在于:还包括药物辅料。
3.根据权利要求2所述的用于治疗痛经的药物制备方法,其特征在于:所述药物辅料包括填充剂、粘合剂和润滑剂。
4.根据权利要求3所述的用于治疗痛经的药物制备方法,其特征在于:所述填充剂采用淀粉、糊精、乳糖、可压性淀粉、甘露醇、磷酸氢钙和硫酸钙中的任一种或几种。
5.根据权利要求3所述的用于治疗痛经的药物制备方法,其特征在于:所述粘合剂采用淀粉浆、聚乙稀吡咯烷酮水溶液、聚乙稀吡咯烷酮醇溶液、胶化淀粉、羧甲基纤维素钠水溶液中的任一种或几种。
6.根据权利要求3所述的用于治疗痛经的药物制备方法,其特征在于:所述润滑剂采用硬脂酸镁、滑石粉、微粉硅胶中的任一种或几种。
7.一种用于治疗痛经的药物制备方法,包括如下步骤:1)按处方重量配比称取当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份、延胡索280份,总计共11味药材;2)将140份的延胡索粉碎成细粉;3)将剩余140份的延胡索与当归420份、牡丹皮220份、赤芍340份、柴胡280份、桃仁280份、陈皮280份、香附420份、益母草388份、牛膝226份、白芍230份总计十味药材粉碎成粗的颗粒,加水温浸(94±6℃)2.5小时,过滤,滤液浓缩至相对密度为1.20~1.25(45~55℃)的清膏;4)喷雾干燥,得浸膏粉,与上述延胡索细粉混合均匀,作为药物活性成分,经过处理后与药物辅料混合,使用常规制剂技术制成所需的舒尔经片片剂。
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CN1742919A (zh) * 2005-09-23 2006-03-08 北京润德康医药技术有限公司 一种舒尔经中药制剂及其制备方法

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