CN105456933A - 一种活血化瘀、通经活络的中药及其制备方法 - Google Patents

一种活血化瘀、通经活络的中药及其制备方法 Download PDF

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CN105456933A
CN105456933A CN201510975652.1A CN201510975652A CN105456933A CN 105456933 A CN105456933 A CN 105456933A CN 201510975652 A CN201510975652 A CN 201510975652A CN 105456933 A CN105456933 A CN 105456933A
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radix
blood
chinese medicine
rhizoma
medicine
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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Abstract

本发明涉及中医药领域,尤其涉及一种活血化瘀、通经活络的中药。由太子参、五味子、黄芪、益母草、三七、牛黄、薄荷、蛇蜕、血竭、枸杞、甘草、金银花、灵芝、鸡血藤、苦参、艾叶、桂枝、莪术、牡丹皮、橘叶、王不留行、地龙、皂角刺、川穹、麦冬、瓜蒌、杜仲、胆南星等组成。本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。本发明中药组合物生产工艺简单,用药安全,稳定可靠,疗效好,在活血化瘀、通经活络方面具有很好的功效。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。

Description

一种活血化瘀、通经活络的中药及其制备方法
技术领域
[0001] 本发明属于中药学技术领域,具体涉及一种活血化瘀、通经活络的中药及其制备 方法。
背景技术
[0002] 中医统称脑血管病为中风,其中肝肾阴虚,经血亏损至肝阳上亢,肝风内动挟痰上 扰与瘀结,气血痰瘀皆奔涌而上络破血溢致脑卒中,元气亏损,气虚无力推动血液运行而瘀 滞,气虚血瘀肝阳上亢、化痰生风、痰瘀交结阻抑气血运行致脑梗塞。现代医学认为本病多 发生在高血压动脉硬化基础上,动脉管壁粥样硬化而粗糙,血液粘稠度增高血流缓慢而易 形成血栓。血压急骤升高,使原微小动脉瘤破裂形成脑出血。无论是梗塞还是出血均存在着 血瘀证侯群和微循环障碍,在治疗上都应以活血化瘀为基础。
[0003] 中医认为心主血脉是血行通畅之主导,心的气血阴阳平衡则心血畅流。由于气血 同源,气为血之帅,血为气之母,气行则血行,气滞则血瘀,气血失调多由于心气不足阳气生 失斡旋,心阳虚弱,阴寒凝滞,血脉不通。心血瘀滞则使心脉痹阻不通,心血瘀阻则心主血脉 功能减弱或血液循环流速减慢,血粘度增高,呈现凝、浓、粘、聚状态。血行不畅,血液瘀阻导 致血瘀证的临床表现。
[0004] 活血化瘀、消肿止痛、祛风散寒、通经活络是传统中药的疗效优势所在,而根据中 医药理论指导的中药复方药物在上述疾病的治疗中取得了较好疗效;然而原有中药复方药 物剂型落后、疗效片面或毒副作用较强,已经成阻碍其广泛应用的重要因素。因而,结合现 代制药技术,在传统中医药理论指导下,筛选优化中药复方组成、优化提取工艺、富集药物 有效成分、结合现代剂型,开发疗效确切、剂型合理、使用便捷的安全、有效、使用方便的现 代中药制剂已势在必行。
发明内容
[0005] 为了克服现有技术中的不足,本发明提供一种活血化瘀、通经活络的中药。
[0006] 为了解决上述技术问题,本发明采用的技术方案如下:一种活血化瘀、通经活络的 中药,由以下重量份数的各组分组成:
[0007] 太子参1-30份、五味子1-30份、黄芪1-30份、益母草1-30份、三七1-30份、牛黄1-30 份、薄荷1-30份、蛇蜕1-30份、血竭1-30份、枸杞1-30份、甘草1-30份、金银花1-30份、灵芝1-30份、鸡血藤1-30份、苦参1-30份、艾叶1-30份、桂枝1-30份、莪术1-30份、牡丹皮1-30份、橘 叶1-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌Ι-ΒΟ份、杜仲 1-30 份、胆南星 1-30 份、决明子 1-30 份、维生素C1-30 份、茜草 1-30 份、葛根 1-30 份、泽泻1 -30份、滴水珠1 -30份、元胡1 -30份、三棱1 -30份、没药1-30份、赤芍1-30份、银杏叶 1-30份、蒲公英1-30份、红花1-30份、牛膝1-30份、紫河车1-30份。
[0008] 所述活血化瘀、通经活络的中药,其所述中药制剂中各种原料药的重量份数可以 优选为:
[0009] 太子参5-30份、五味子5-30份、黄芪5-30份、益母草5-30份、三七5-30份、牛黄5-30 份、薄荷5-30份、蛇蜕5-30份、血竭5-30份、枸杞5-30份、甘草5-30份、金银花5-30份、灵芝5-30份、鸡血藤5-30份、苦参5-30份、艾叶5-30份、桂枝5-30份、莪术5-30份、牡丹皮5-30份、橘 叶5-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌Ι-ΒΟ份、杜仲 1-30 份、胆南星 1-30 份、决明子 1-30 份、维生素C1-30 份、茜草 1-30 份、葛根 1-30 份、泽泻1 -30份、滴水珠1 -30份、元胡1 -30份、三棱1 -30份、没药1-30份、赤芍1-30份、银杏叶 1-30份、蒲公英1-30份、红花1-30份、牛膝1-30份、紫河车1-30份。
[0010] 所述活血化瘀、通经活络的中药,其所述中药制剂中各种原料药的重量份数还可 以优选为:
[0011] 太子参5-30份、五味子5-30份、黄芪5-30份、益母草5-30份、三七5-30份、牛黄5-30 份、薄荷5-30份、蛇蜕5-30份、血竭5-30份、枸杞5-30份、甘草5-30份、金银花5-30份、灵芝5-30份、鸡血藤5-30份、苦参5-30份、艾叶5-30份、桂枝5-30份、莪术5-30份、牡丹皮5-30份、橘 叶5-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌10-30份、杜仲10-30份、胆南星1-30份、决明子1-30份、维生素C10-30份、茜草1-30份、葛根10-30份、泽泻10-30份、滴水珠10-30份、元胡1-30份、三棱10-30份、没药10-30份、赤芍10-30 份、银杏叶1-30份、蒲公英10-30份、红花10-30份、牛膝10-30份、紫河车10-30份。
[0012] 所述活血化瘀、通经活络的中药,所述中药制剂的剂型为:片剂、糖衣片剂、薄膜衣 片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、 溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。
[0013] 为解决上述技术问题,本发明还提供活血化瘀、通经活络的中药的制备方法,所述 胶囊制备包括以下步骤:
[0014]a.将所述原料药放入粉碎机粉碎后过筛,
[0015]b.将过筛后剩下的颗粒物放入乙醇中加热回流提取2次;
[0016]c.再取上述乙醇提取后的药渣,加水加热回流提取2次;
[0017] d.将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;将过筛后得到的原 料细粉与乙醇提炼药粉混合装入胶囊。
[0018] 所述步骤a中,将所述原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的 细粉量在达到50%,收集通过100目筛的原料细粉备用。
[0019] 所述步骤b中,将过筛后剩下的颗粒物放入乙醇中加热回流提取2次,每次1~3小 时,将2次提取液合并静置;所述步骤c中,将上述乙醇提取过的药渣加10倍量水加热回流提 取2次,每次1~3小时,将2次提取液合并静置。
[0020] 所述步骤d中将上述两种提取液合并,减压浓缩相对密度为70°C时1.08的滤液,回 收乙醇,将所得滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的 压缩空气压力为4kg/m2,干燥室热气流温度是60°C,得原料药粉;将过筛后得到的原料细粉 与乙醇提炼药粉混合装入胶囊。
[0021] 为解决上述技术问题,本发明还提供活血化瘀、通经活络的中药的制备方法,所述 中药制剂的剂型为口服液剂,其制备步骤包括:
[0022] a、取原料药放入水中浸泡,热提取2次,成浸膏状,为组分1;
[0023]b、药渣乙醇提取1次,浓缩过滤为浸膏状,为组分2;
[0024] c、将上述两种浸膏浓缩成糊状,浓缩液用⑶60灭菌,辐照剂量8k,加入糊精,然后 真空冷冻密封即得。
[0025] 为解决上述技术问题,本发明还提供活血化瘀、通经活络的中药的制备方法,所述 内服药物的剂型为丸剂,其制备步骤包括:
[0026]a.将所述原料药混合,切碎,过120目筛,得细药粉备用;
[0027]b.将未过筛的粗粉浸泡乙醇中提取2次;
[0028] c.再取上述步骤提取后的药渣,加水加热回流提取2次;
[0029] d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂 蜜搓成丸剂。
[0030] 本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。本发 明中药组合物生产工艺简单,用药安全,稳定可靠,疗效好,在活血化瘀、通经活络方面具有 很好的功效。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于 在临床上大面积推广应用。
具体实施方式
[0031] 本发明采用纯中药制剂,安全无污染,符合临床应用。
[0032]本发明中:太子参:性味:甘苦,微温。①《本草再新》:〃味甘,性温,无毒。〃②《饮片 新参》:〃甘润,微苦平。〃③《中药志》:〃甘苦,微寒。〃归经:《本草再新》:〃入心、脾、肺三经。〃 功能主治:补肺,健牌。治肺虚咳嗽,脾虚食少,心悸自汗,精神疲乏。益气健脾,生津润肺。用 于脾虚体弱、病后虚弱、气阴不足、自汗口渴、肺噪干咳。①《本草从新》:"大补元气。"②《本 草再新》:〃治气虚肺燥,补脾土,消水肿,化痰止渴。〃③《饮片新参》:〃补脾肺元气,止汗生 津,定虚悸。〃④《江苏植药志》:〃治胃弱消化不良,神经衰弱。〃⑤《中药志》:〃治肺虚咳嗽,脾 虚泄泻。〃⑥《陕西中草药》:〃补气益血,健脾生津。治病后体虚,肺虚咳嗽,脾虚腹泻,小儿虚 汗,心悸,口干,不思饮食。〃
[0033]五味子:性味:酸、甘,温。归经:归肺,心、肾经。功能主治:收敛固涩,益气生津,补 肾宁心。用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内 热消渴,心悸失眠。
[0034]黄苗:性味:甘,温。归经:归肺、脾经。功能主治:补气固表,利尿托毒,排脓,敛疮生 肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难 溃,久溃不敛,血虚痿黄,内热消渴;慢性肾炎蛋白尿,糖尿病。
[0035] 益母草:性味:辛苦,凉。①《本草拾遗》:〃寒。〃②《本草蒙筌》:〃味辛甘,气微温,无 毒。〃③《纲目》:〃味辛微苦,无毒。〃④《本草正》:〃味微苦、微辛。微寒,性滑。〃归经:入心包、 肝经。①《本草汇言》:〃手、足厥阴经。〃②《药品化义》:〃入肝、脾、包络三经。〃③《本草再 新》:〃入心、脾、肾三经。〃功能主治:活血,祛瘀,调经,消水。治月经不调,胎漏难产,胞衣不 下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。
[0036]三七:性味:甘微苦,温。①《纲目》:〃甘微苦,温,无毒。〃②《本草汇言》:〃味甘微苦, 性平,无毒。〃归经:入肝、胃、大肠经。①《本草汇言》:〃入阳明、厥阴经。〃②《本草求真》:〃入 肝、胃,兼入心、大肠。〃③《本草再新》:〃入肺、肾二经。〃功能主治:止血,散瘀,消肿,定痛。治 吐血,咳血,衄血,便血,血痢,崩漏,症瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼 痛。①《纲目》:〃止血,散血,定痛。金刃箭伤,跌扑杖疮,血出不止者,嚼烂涂,或为末掺之,其 血即止。亦主吐血,衄血,下血,血痢,崩中,经水不止,产后恶血不下,血运,血痛,赤目,痈 月中,虎咬,蛇伤诸病。〃②《玉揪药解》:〃和营止血,通脉行瘀,行瘀血而敛新血。凡产后、经期、 跌打、痈肿,一切瘀血皆破;凡吐衄、崩漏、刀伤、箭射,一切新血皆止。〃
[0037]牛黄:性味:苦甘,凉。①《本经》:〃味苦,平。〃②《吴普本草》:〃无毒。〃③《别录》:〃有 小毒。〃④《药性论》:〃味甘。〃⑤《日华子本草》:〃凉。〃归经:入心、肝经。①《本草蒙筌》:〃入肝 经。"②《雷公炮制药性解》:〃入心经。〃功能主治:清心,化痰,利胆,镇惊。治热病神昏、谵语, 癫痫发狂,小儿惊风抽搐,牙疳,喉肿,口舌生疮,痈疽,疔毒。
[0038]薄荷:性味:辛,凉。①《医学启源》:〃《主治秘要》云,性凉,辛。〃②《医林纂要》:〃辛, 寒。〃归经:入肺、肝经。①《汤液本草》:〃手大阴、厥阴经药。〃②《纲目》:〃入手少、太阴,足厥 阴。〃③《本草新编》:〃入肺与包络二经,亦能入肝、胆。〃功能主治:疏风,散热,辟秽,解毒。治 外感风热,头痛,目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮疥,瘾疹。
[0039] 蛇銳:性味:甘咸,平,有毒。①《本经》:〃味威,平。〃②《别录》:〃甘,无毒。〃③《药性 论》:〃有毒。〃归经:①《本草经疏》:〃入肝。〃②《本草再新》:〃入肝、脾二经。〃功能主治:祛风, 定惊,退翳,消肿,杀虫。治小儿惊痫,喉风□疮,木舌重舌,目翳内障,疔疮,痈肿,瘰疬,聰腺 炎,痔漏,挤癣。
[0040] 血竭:性味:甘咸,平。①《雷公炮炙论》:〃味微咸甘。〃②《唐本草》:〃味甘咸,平,有 小毒。〃③《本草蒙筌》:〃味辛咸,气平,有小毒。〃归经:入心、肝经。①《纲目》:〃手足厥阴。〃② 《本草经疏》:〃入足厥阴,手少阴经。〃③《本草新编》:〃入肾。〃功能主治:散瘀定痛,止血生 肌。治跌打折损,内伤瘀痛;外伤出血不止,瘰疬,臁疮溃久不合。①《唐本草》:〃主五脏邪气, 带下,止痛,破积血,金创生肉。〃②《海药本草》:〃主打伤折损,一切疼痛,补虚及血气搅刺, 内伤血聚,并宜酒服。〃③《日华子本草》:〃治一切恶疮疥癣久不合者,敷。此药性急,亦不可 多使,却引脓。〃④王好古:〃补心包络,肝血不足。〃
[0041] 枸杞:性味:甘,平。归经:归肝、肾经。功能主治:滋补肝肾,益精明目。用于虚劳精 亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。
[0042] 甘草:性味:甘,平。归经:归心、肺、脾、胃经。功能主治:补脾益气,清热解毒,祛痰 止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急 疼痛,痈肿疮毒,缓解药物毒性、烈性。
[0043] 金银花:性味:甘,寒。①《滇南本草》:〃性寒,味苦。〃②《本草正》:〃味甘,气平,其性 微寒。〃归经:入肺、胃经。①《雷公炮制药性解》:〃入肺经。"②《得配本草》:〃入足阳明、太阴 经。〃功能主治:清热,解毒。治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。①《滇南本草》:〃 清热,解诸疮,痈疽发背,丹流瘰疬。〃②《生草药性备要》;〃能消痈疽疔毒,止痢疾,洗疳疮, 去皮肤血热。"③《本草备要》:〃养血止渴。治疥癣。"④《重庆堂随笔》:〃清络中风火湿热,解 温疫秽恶浊邪,息肝胆浮越风阳,治痉厥癫痫诸症。"⑤广州部队《常用中草药手册》:"清热 解毒。治外感发热咳嗽,肠炎,菌痢,麻疹,腮腺炎,败血症,疮疖肿毒,阑尾炎,外伤感染,小 儿痱毒。制成凉茶,可预防中暑、感冒及肠道传染病。"
[0044]灵芝:性味:甘;平;无毒。归经:肺;心;脾;肾经。功能主治:益气血;安心、神;健脾 胃。主虚劳;心悸;失眠;头晕;神疲乏力;久咳气喘;冠心病;硅肺;肿瘤。
[0045]鸡血藤:性味:苦甘,温。①《饮片新参》:〃苦涩香微甘。〃②《本草正义》:〃温。〃③江 西《中草药学》:〃苦温微甘。〃归经:《本草再新》:〃入心、脾二经。〃功能主治:活血、舒筋。治腰 膝酸痛,麻木瘫痪,月经不调①《纲目拾遗》:〃活血,暖腰膝,已风瘫。〃②《本草再新》:〃补中 燥胃。〃③《饮片新参》:〃去瘀血,生新血,流利经脉。治暑痧,风血痹症。〃④《现代实用中 药》:〃为强壮性之补血药,适用于贫血性之神经麻痹症,如肢体及腰膝酸痛,麻木不仁等。又 用于妇女月经不调,月经闭止等,有活血镇痛之效。〃
[0046] 苦参:性味:苦,寒。归经:归心、肝、胃、大肠、膀胱经。功能主治:清热燥湿,杀虫,利 尿。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治 滴虫性阴道炎。
[0047] 艾叶:性味:苦,寒。归经:归心、肝、胃、大肠、膀胱经。功能主治:清热燥湿,杀虫,利 尿。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治 滴虫性阴道炎。
[0048]桂枝:发汗解肌,温经通脉。治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。①成 无己:〃泄奔豚,和肌表,散下焦蓄血。〃〃利肺气。〃②《医学启源》:〃《主治秘诀》:去伤风头痛, 开腠理,解表,去皮风湿(末二字据《本草发挥》补)。〃③《本草经疏》:〃实表祛邪。主利肝肺 气,头痛,风痹骨节挛痛。〃④《药品化义》:〃专行上部肩臂,能领药至痛处,以除肢节间痰凝 血滞。〃⑤《本草备要》:〃温经通脉,发汗解肌。〃⑥《本草再新》:〃温中行血,健脾燥胃,消肿利 湿。治手足发冷作麻、筋抽疼痛,并外感寒凉等症。"
[0049] 莪术:性味:归经,辛、苦,温。归肝、脾经。功效主治:(1)破血行气,消积止痛。用于 血瘀腹痛、肝脾肿大、心腹胀痛,积聚,妇女血瘀经闭,跌打损伤作痛饮食积滞。(2)行气止 痛,破血消积:用于气滞血瘀之经闭、胸胁痛、腹痛及症瘕肿块等。常配三棱。(3)消食化积: 用于饮食积滞之胃腹胀痛,常配焦麦芽、焦槟榔。
[0050] 牡丹皮:功能主治:清热,凉血,和血,消瘀。治热入血分,发斑,惊痫,吐、衄、便血, 骨蒸劳热,经闭,癥瘕,痈疡,扑损。①《本经》:〃主寒热,中风瘈疯、痉、惊痫邪气,除癥坚瘀血 留舍肠胃,安五脏,疗痈疮。〃②《别录》:〃除时气头痛,客热五劳,劳气头腰痛,风噤,癫疾。〃 ③《药性论》:〃治冷气,散诸痛,治女子经脉不通,血沥腰疼。〃④《日华子本草》:〃除邪气,悦 色,通关腠血脉,排脓,通月经,消扑损瘀血,续筋骨,除风痹,落胎下胞,产后一切冷热血 气。〃⑤《珍珠囊》:〃治肠胃积血、衄血、吐血,无汗骨蒸。〃⑥《滇南本草》:〃破血,行(血),消癥 瘕之疾,除血分之热。〃⑦《医学入门》:〃泻伏火,养真血气,破结蓄。〃⑧《纲目》:〃和血,生血, 凉血。治血中伏火,除烦热。〃
[0051] 橘叶:为芸香科植物橘的叶或朱橘等多种橘类的叶,随时可采,晒干或鲜用。⑥治 气痛、气胀:橘叶捣烂,炒热外包,或煎服。它不是保健茶,要是美白保健的话喝柠檬糖水,可 以美白和防晒。凡病血结气结,痰涎火逆,病为胁痛,为乳痈,为脚气,为肿毒,为胸膈逆气等 疾,或捣汁饮,或取渣敷贴,无不应手获效。
[0052] 王不留行:性味:苦,平。归经:归肝、胃经。功效:活血通经,下乳消肿,利尿通淋。主 治:用于经闭,痛经,乳汁不下,乳痈肿痛,淋证涩痛。
[0053]地龙:热病惊狂、小儿惊风、咳喘、头痛目赤、咽喉肿痛、小便不通、风湿关节疼痛, 半身不遂等症。外用涂丹毒、漆疮等症。
[0054] 皂角刺:性味:辛,温。《纲目》:〃辛,温,无毒。〃《医林纂要》:〃辛咸,温。〃《四川中药 志》:〃性温,味辛,有小毒。〃功能主治:皂角刺有消肿排脓、消毒透脓、搜风、杀虫的功效,皂 角刺别名:皂荚刺、皂刺、天丁、皂角针、皂针,皂角。
[0055] 川穹:性味:辛,温。①《本经》:味辛,温。②《吴普本草》:黄帝、岐伯、雷公:辛,无毒, 香。扁鹊:酸,无毒。李氏:生温,熟寒。③《唐本草》:味苦辛。④《本草正》:味辛微甘,气温。归 经:入肝、胆经。①《汤液本草》:入手足厥阴经、少阳经。②《药品化义》:入肝、脾、三焦三经。 功能主治:行气开郁,法风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难 产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛, 风湿痹痛。
[0056] 麦冬:入胃以养胃液,开胃进食,更能入脾以助脾散精于肺,定喘宁嗽。"中医认为, 麦冬味甘、微苦,性微寒,归胃、肺、心经,有养阴润肺、益胃生津、清心除烦的功效,用于肺燥 干咳、阴虚痨嗽、喉痹咽痛、津伤口渴、内热消渴、心烦失眠、肠燥便秘等症。
[0057] 瓜蒌:性味:甘、微苦、寒。归经:归肺、胃、大肠经。功能主治:清热涤痰,宽胸散结, 润燥滑肠。用于肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肺痈,肠痈肿痛,大便秘结。 [0058] 杜仲:性味:《本经》:"味辛,平。"《别录》:"甘,温,无毒。"《药性论》:"味苦。"《中华 人民共和国药典》2010年版一部:"甘,温。归肝、肾经。"归经:王好古:"肝经气分。"《雷公炮 制药性解》:"入肾经。"《本草经解》:"入手太阴肺经。"功效主治:杜仲具有补肝肾,治腰脊酸 疼,足膝痿弱,小便余沥,阴下湿痒,高血压、安胎的功效。杜仲对免疫系统、内分泌系统、中 枢神经系统、循环系统和泌尿系统都有不同程度的调节作用,杜仲能兴奋垂体-肾上腺皮质 系统,增强肾上腺皮质功能。
[0059] 胆南星:性味归经:性味:苦,凉。归经:入心、肝、胆三经。功效主治:清热化痰,胆南 星苦凉,苦能燥湿化痰,寒能清热。故有清热化痰之功效。为治热痰所常用,可用治痰火咳 嗽,头风眩晕,中风痰壅等证。清心安神胆南星苦凉,入心经,则能清心火,安心神。可用治老 年神困,产后怔忡,痰火失眠等证。
[0060] 决明子:味苦、甘、咸,性微寒,入肝、肾、大肠经;润肠通便,降脂明目,治疗便秘及 高血脂,高血压。清肝明目,利水通便,有缓泻作用,降血压降血脂。
[0061] 维生素C:促进骨胶原的生物合成。利于组织创伤口的更快愈合;促进氨基酸中酪 氨酸和色氨酸的代谢,延长肌体寿命。改善铁、钙和叶酸的利用。改善脂肪和类脂特别是胆 固醇的代谢,预防心血管病。促进牙齿和骨骼的生长,防止牙床出血。增强肌体对外界环境 的抗应激能力和免疫力。
[0062] 茜草:功效主治:凉血活血,祛瘀,通经。用于吐血、衄血、崩漏下血、外伤出血、经闭 瘀阻、关节痹痛、跌扑肿痛。凉血止血,活血祛瘀:本品止血而不留瘀,用于热证出血、经闭腹 痛、跌打损伤。配乌贼骨止血力更强。
[0063] 葛根:清风寒,净表邪,解肌热,止烦渴。泻胃火之药也。尝观发表散邪之药,其品亦 多,如麻黄拔太阳营分之寒,桂枝解太阳卫分之风,防风、紫苏散太阳在表之风寒,藁本、羌 活散太阳在表之寒湿,均称发散药也,而葛根之发散,亦入太阳,亦散风寒,又不同矣,非若 麻、桂、苏、防,辛香温燥,发散而又有损中气之误也;非若藁本、羌活,发散而又有耗营血之 虞也。"
[0064] 泽泻:性味:甘,寒。①《本经》:〃味甘,寒。〃②《别录》:〃咸,无毒。〃⑨《药性论》:〃味 苦。〃④《医学启源》:〃气平,味甘。〃⑤《本草蒙筌》:〃甘酸,气寒。〃归经:入肾、膀胱经。①《汤 液本草》:〃入手太阳、少阴经。〃②《本草衍义补L遗》:〃入足太阳、少阴经。〃③《雷公炮制药性 解》:〃入膀胱、肾、三焦、小肠四经。〃④《本草经巯》:〃入肾、脾。〃功能主治:利水,渗湿,泄热。 治小便不利,水肿胀满,呕吐,泻痢,痰饮,脚气,淋病,尿血。
[0065] 滴水珠:性味:味辛;性温;小毒。归经:肝经。功能主治:解毒消肿;散瘀止痛。主毒 蛇咬伤;乳痈;肿毒;深部脓肿;瘰疬;头痛;胃痛;腰痛;跌打损伤。
[0066] 元胡:性味:辛苦,温。①《海药本草》:〃味苦甘,无毒。〃②《开宝本草》:〃味辛,温,无 毒。〃归经:入肝、胃经。①《汤液本草》:〃入手足太阴经。〃②《本草蒙筌》:〃入太阴脾、肺,一云 又走肝经。〃③《雷公炮制药性解》:〃入心、肺、脾、胃四经。〃功能主治:活血,散瘀,理气,止 痛。治心腹腰膝诸痛,月经不调,症瘕,崩中,产后血晕,恶露不尽,跌打损伤。
[0067]三棱:性味:苦辛,平。①《本草拾遗》:〃甘平,温。〃②《日华子本草》:〃味甘涩,凉。〃 ③《开宝本草》:〃味苦,平,无毒。〃④《本草衍义补遗》:〃辛苦。〃归经:入肝。脾经。①《雷公炮 制药性解〃〉雷公炮制药性解》:〃入肺、脾二经。〃②《本草经疏》:〃入足厥阴、太阴。〃功能主 治:破血,行气,消积,止痛。治症瘕积聚,气血凝滞,心腹疼痛,胁下胀疼,经闭,产后瘀血腹 痛,跌打损伤。疮肿坚硬。
[0068] 没药:性味:苦,平。①《药性论》:〃味苦辛。〃②《海药本草》:〃味苦辛,温,无毒。〃③ 《开宝本草》:〃味苦,平,无毒。〃归经:入肝经。①《本草经疏》:〃入足厥阴经。〃②《本草新 编》:〃入脾、肾二经。〃③《本草求真》:〃入心、肝。〃功能主治:散血去瘀,消肿定痛。治跌损,金 疮,筋骨,心腹诸痛,症瘕,经闭,痈疽肿痛,痔漏,目障,①《药性论》:〃主打榼损,心腹血瘀, 伤折蹂跌,筋骨瘀痛,金刃所损,痛不可忍,皆以酒投饮之。"②《海药本草》:"主折伤马坠,推 陈置新,能生好血,研烂,以热酒调服。堕胎.心腹倶痛及野鸡漏痔、产后血气痛,并宜丸、散 中服。"
[0069] 赤芍::性味:苦;微寒。归经:肝;脾经。功能主治:清热凉血;活血祛瘀。主温毒发 斑;吐血衄血;肠风下血;目赤肿痛;痈肿疮疡;闭经;痛经;崩带淋浊;瘀滞胁痛;疝瘕积聚; 跌扑损伤。
[0070] 银杏叶:性味:甘、苦、涩,平。归经:归心、肺经。功能主治:敛肺,平喘,活血化瘀,止 痛。用于肺虚咳喘;冠心病,心绞痛,高血脂。
[0071] 蒲公英:性味:苦甘,寒。①《唐本草》:〃味甘,平,无毒。〃②李杲:〃微苦,寒。〃③《本 草述》:〃甘,平微寒。〃④广州部队《常用中草药手册》:〃苦甘,寒。〃归经:入肝、胃经。①李 杲:〃足少阴经。〃②《本草衍义补遗》:〃入阳明、太阴经。〃功能主治:清热解毒,利尿散结。治 急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管 炎,胃炎,肝炎,胆囊炎,尿路感染。
[0072] 红花:性味:辛,温。①《开宝本草》:〃辛,温,无毒。〃②《汤液本草》:〃辛而甘温苦。〃 归经:入心、肝经。①《雷公炮制药性解》:〃入心、肝二经。〃②《本草经解》:〃入足厥阴肝经,手 太阴肺经。〃③《本草再新》:〃入肝、肾二经。〃功能主治:活血通经,去瘀止痛。治经闭,症瘕, 难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤。①《唐本草》:〃治口噤不语,血结,产 后诸疾。〃②《开宝本草》:〃主产后血运口噤,腹内恶血不尽、绞痛,胎死腹中,并酒煮服。亦主 蛊毒下血。〃③《本草蒙筌》:〃喉痹噎塞不通,捣汁咽。〃④《纲目》:〃活血,润燥,止痛,散肿,通 经。〃⑤《本草正》:〃达痘疮血热难出,散斑疹血滞不消。〃⑥《本草再新》:〃利水消肿,安生胎, 堕死胎。〃
[0073] 牛膝:性味:甘苦酸,平。①《本经》:〃味苦酸。〃②《别录》:〃酸,平,无毒。〃③《本草 正》:〃味苦甘,气微凉。〃归经:入肝、肾经。①《纲目》:〃足厥阴,少阴。〃②《本草汇言》:〃入足 三阴经。〃功能主治:生用散瘀血,消痈肿。治淋病,尿血,经闭,症瘕,难产,胞衣不下,产后瘀 血腹痛,喉痹,痈肿,跌打损伤。熟用补肝肾,强筋骨。治腰膝骨痛,四肢拘挛,痿痹。
[0074] 紫河车:性味:甘咸,温。①《本草蒙筌》:〃味甘,气大温,无毒。〃②《纲目》:〃味甘咸, 温,无毒。〃③《医林纂要》:〃甘苦咸,温。〃归经:入肺、肝、肾经。①《雷公炮制药性解》:〃入心、 脾、肾三经。〃②《本草经解》:〃入足厥阴肝经、足太阴脾经、足少阴肾经。〃③《本草再新》:〃入 肝、肺、肾三经。〃功能主治:补气,养血,益精。治虚损,羸瘦,劳热骨蒸,咳喘,略血,盗汗,遗 精,阳痿,妇女血气不足,不孕或乳少。①《本草拾遗》:〃主血气羸瘦,妇人劳损,面鼾皮黑,腹 内诸病渐瘦悴者。〃②吴球:〃治虚损劳极,癫痫,失志恍惚,安心养血,益气补精。〃③《本草蒙 筌》:〃疗诸虚白损,劳瘵传尸,治五劳七伤,骨蒸潮热,喉咳音哑,体瘦发枯,吐衄来红。〃④ 《会约医镜》:〃凡骨蒸盗汗,腰痛膝软,体瘦精枯,倶能补益。〃⑤《本草再新》:〃大补元气,理 血分,治神伤梦遗。〃
[0075] 下面结合具体实施例对本发明做进一步阐述。
[0076] 实施例1
[0077]a、将太子参1份、五味子1份、黄芪3份、益母草5份、三七3份、牛黄5份、薄荷5份、蛇 蜕1份、血竭2份、枸杞5份、甘草5份、金银花5份、灵芝1份、鸡血藤2份、苦参1份、艾叶3份、桂 枝5-30份、莪术1份、牡丹皮1份、橘叶1份、王不留行1份、地龙1份、皂角刺1份、川穹1份、麦冬 1份、瓜蒌1份、杜仲1份、胆南星1份、决明子3份、维生素C3份、茜草3份、葛根3份、泽泻3份、 滴水珠3份、元胡2份、三棱3份、没药3份、赤芍3份、银杏叶3份、蒲公英3份、红花3份、牛膝3 份、紫河车3份原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的细粉量在达到 50%,收集通过100目筛的原料细粉备用。
[0078]b.将过筛后剩下的颗粒物放入乙醇中加热回流提取2次,每次1~3小时,将2次提 取液合并静置;
[0079]c.将上述乙醇提取过的药渣加10倍量水加热回流提取2次,每次1~3小时,将2次 提取液合并静置;
[0080]d.将上述两种提取液合并,减压浓缩相对密度为70°C时1.08的滤液,回收乙醇,将 所得滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的压缩空气 压力为4kg/m2,干燥室热气流温度是60°C,得原料药粉;将过筛后得到的原料细粉与乙醇提 炼药粉混合装入胶囊。
[0081 ] 实施例2
[0082]a、将太子参1份、五味子1份、黄芪3份、益母草5份、三七3份、牛黄5份、薄荷5份、蛇 蜕1份、血竭2份、枸杞5份、甘草5份、金银花5份、灵芝1份、鸡血藤2份、苦参1份、艾叶3份、桂 枝5-30份、莪术1份、牡丹皮1份、橘叶1份、王不留行1份、地龙1份、皂角刺1份、川穹1份、麦冬 1份、瓜蒌1份、杜仲1份、胆南星1份、决明子3份、维生素C3份、茜草3份、葛根3份、泽泻3份、 滴水珠3份、元胡2份、三棱3份、没药3份、赤芍3份、银杏叶3份、蒲公英3份、红花3份、牛膝3 份、紫河车3份原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的细粉量在达到 50%,收集通过100目筛的原料细粉备用。
[0083]b.将上述未过筛的粗粉加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次 1-2小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱 超滤,超滤液减压浓缩相对密度为80°C时1.10的浸膏,加热浓缩,静置备用。
[0084]c.将乙醇提取过的药渣放入10倍量水中,加热回流提取2次,每次提取时间为1~2 小时,100-120目滤过,再用孔径在lOOOum,截留分子量在300KDalton的耐高温高截留率卷 式纳滤膜,分离出滤液中的大颗粒物质和上清液,上清液浓缩,浓缩为60°C下相对密度为 1.14的稠膏,加热浓缩,静置备用。
[0085] d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂 蜜搓成丸剂。
[0086] 实施例3
[0087]a、将太子参1份、五味子1份、黄芪3份、益母草5份、三七3份、牛黄5份、薄荷5份、蛇 蜕1份、血竭2份、枸杞5份、甘草5份、金银花5份、灵芝1份、鸡血藤2份、苦参1份、艾叶3份、桂 枝5-30份、莪术1份、牡丹皮1份、橘叶1份、王不留行1份、地龙1份、皂角刺1份、川穹1份、麦冬 1份、瓜蒌1份、杜仲1份、胆南星1份、决明子3份、维生素C3份、茜草3份、葛根3份、泽泻3份、 滴水珠3份、元胡2份、三棱3份、没药3份、赤芍3份、银杏叶3份、蒲公英3份、红花3份、牛膝3 份、紫河车3份原料药放放入乙醇中浸泡,热提取2次,成膏状,为组分1;
[0088]b、药渣水提取2次,浓缩过滤为膏状,为组分2;
[0089]c、将上述两种组分膏状浓缩成糊状,浓缩液用C0 60灭菌,辐照剂量8k,加入糊精, 然后真空罐装密封即得,使用时直接饮用。
[0090] 本发明药物组合物的动物毒性试验
[0091] 1、应用小鼠进行急性毒性实验表明:小鼠口服灌胃本发明的中药制剂口服液,在 488.8g生药/kg剂量下,给药后小鼠出现轻微活动减少,1小时左右恢复正常,给药后连续观 察7天,无一动物死亡,其全身状况、饮食、摄水、小便和体重增长均正常,实验结果表明:小 鼠口服灌胃本发明的中药制剂口服液的最大给药量为488.8g生药/kg/d(LD50>488.8g生 药/kg)。本发明的中药制剂每日临床用药总量为O.lg生药/kg/d;按体重计,小鼠灌胃本发 明的中药制剂的耐受量为临床病人的4888倍。提示该药急性毒性低,临床用药安全。
[0092] 2、选用SD大鼠,给予不同浓度(18.0、6.0、2.0g生药/kg)的本发明的中药制剂丸 剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动 物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90 天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、 八1^、6111、81^、(^^、了?、1'.811^^1^、010〇、尿液生化、脏器系数、病理组织学等指标检查。试 验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活 动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液 生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上 述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据 试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.0g生药/kg)连续90天给药 对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应, 提示本发明的中药制剂临床应用的剂量安全性较高。
[0093] 3、选用SD大鼠,给予不同浓度(18.0、6.0、2.0g生药/kg)的本发明的中药制剂胶囊 剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动 物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90 天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、 八1^、6111、81^、(^^、了?、1'.811^^1^、010〇、尿液生化、脏器系数、病理组织学等指标检查。试 验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活 动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液 生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上 述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据 试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.Og生药/kg)连续90天给药 对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应, 提示本发明的中药制剂临床应用的剂量安全性较高。
[0094] 药理学实验说明:
[0095] 本发明中药组合物于2010年至2015年临床观察所选病例共110例,随机分为两组, 治疗组60例,对照组50例。两组年龄、性别及病程等资料经统计学处理,差异无统计学意义 (P>〇.〇5),具有可比性。
[0096] 2、诊断标准
[0097] (1)患者发病年龄多在50岁以上的有高血压、动脉硬化、高血脂、心脏病、外伤等病 史。(2)急性起病,多在情绪激动或活动时发病,发病前期多有先兆症状。(3)起病急,病情进 展迅速,症状多于数秒钟或数分钟达高峰。(4)头晕、剧烈头痛、恶心、呕吐,半身不遂,神经 系统表现异常,意识障碍甚至昏迷、死亡等为主要特征。(5)眼底检查可见动脉变细,周围血 管出血或乳头水肿。(6)头颅CT/MRI可以确诊。(7)脑脊液压力增高,颜色透明或血性。 [0098] 3、治疗方法
[0099]实验组服用发明中药制剂丸剂,一日三次,5天为一个疗程,实验组针对病情给予 胞二磷胆碱,两组均连续治疗4个疗程。
[0100] 4、疗效标准:
[0101]参照《中医病证诊断疗效标准》判定疗效。显效:意识障碍由昏迷转为清醒,智能、 记忆力明显好转,肌力改善3个级差以上;有效:意识障碍由深昏迷转为中度昏迷或由中度 昏迷转为浅昏迷,智能、记忆力好转,肌力改善2个级差;无效:意识障碍无好转,神经症状和 体征无改善。
[0102] 5、治疗结果。
Figure CN105456933AD00131
[0104] 临床结果也表明了本发明的中药制剂对脑中风恢复有显著疗效,副作用小,费用 低。
[0105] 以上所述,仅是本发明的最佳实施例而已,并非对本发明作任何形式上的限制,任 何熟悉本领域的技术人员,在不脱离本发明技术方案范围情况下,利用上述揭示的方法内 容对本发明技术方案做出许多可能的变动和修饰,均属于权利要求书保护的范围。

Claims (10)

1. 一种活血化瘀、通经活络的中药,其特征在于:由以下重量份数的各组分组成: 太子参1-30份、五味子1-30份、黄芪1-30份、益母草1-30份、三七1-30份、牛黄1-30份、 薄荷1-30份、蛇蜕1-30份、血竭1-30份、枸杞1-30份、甘草1-30份、金银花1-30份、灵芝1-30 份、鸡血藤1-30份、苦参1-30份、艾叶1-30份、桂枝1-30份、莪术1-30份、牡丹皮1-30份、橘叶 1-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌1-30 份、杜仲1-30份、胆南星1-30份、决明子1-30份、维生素C1-30份、茜草1-30份、葛根1-30份、 泽泻1-30份、滴水珠1-30份、元胡1-30份、三棱1-30份、没药1-30份、赤芍1-30份、银杏叶Ι-ΒΟ份、蒲公英 1-30 份、红花 1-30 份、牛膝 1-30 份、紫河车 1-30 份。
2. 根据权利要求1所述的一种活血化瘀、通经活络的中药,其特征在于:由以下重量份 数的各组分组成: 太子参5-30份、五味子5-30份、黄芪5-30份、益母草5-30份、三七5-30份、牛黄5-30份、 薄荷5-30份、蛇蜕5-30份、血竭5-30份、枸杞5-30份、甘草5-30份、金银花5-30份、灵芝5-30 份、鸡血藤5-30份、苦参5-30份、艾叶5-30份、桂枝5-30份、莪术5-30份、牡丹皮5-30份、橘叶 5-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌1-30 份、杜仲1-30份、胆南星1-30份、决明子1-30份、维生素C1-30份、茜草1-30份、葛根1-30份、 泽泻1-30份、滴水珠1-30份、元胡1-30份、三棱1-30份、没药1-30份、赤芍1-30份、银杏叶Ι-ΒΟ份、蒲公英 1-30 份、红花 1-30 份、牛膝 1-30 份、紫河车 1-30 份。
3. 根据权利要求1至2所述的一种活血化瘀、通经活络的中药,其特征在于:由以下重量 份数的各组分组成: 太子参5-30份、五味子5-30份、黄芪5-30份、益母草5-30份、三七5-30份、牛黄5-30份、 薄荷5-30份、蛇蜕5-30份、血竭5-30份、枸杞5-30份、甘草5-30份、金银花5-30份、灵芝5-30 份、鸡血藤5-30份、苦参5-30份、艾叶5-30份、桂枝5-30份、莪术5-30份、牡丹皮5-30份、橘叶 5-30份、王不留行1-30份、地龙1-30份、皂角刺1-30份、川穹1-30份、麦冬1-30份、瓜蒌10-30 份、杜仲10-30份、胆南星1-30份、决明子1-30份、维生素C10-30份、茜草1-30份、葛根10-30 份、泽泻10-30份、滴水珠10-30份、元胡1-30份、三棱10-30份、没药10-30份、赤芍10-30份、 银杏叶1-30份、蒲公英10-30份、红花10-30份、牛膝10-30份、紫河车10-30份。
4. 根据权利要求1至3所述的一种活血化瘀、通经活络的中药,其特征在于:所述中药制 剂的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含 剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。
5. 根据权利要求1至4所述的一种活血化瘀、通经活络的中药的制备方法,其特征在于: 所述胶囊制备的包括以下步骤: a. 将所述原料药放入粉碎机粉碎后过筛, b. 将过筛后剩下的颗粒物放入乙醇中加热回流提取2次; c. 再取上述乙醇提取后的药渣,加水加热回流提取2次; d. 将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;将过筛后得到的原料细 粉与乙醇提炼药粉混合装入胶囊。
6. 根据权利要求5所述的一种活血化瘀、通经活络的中药的制备方法,其特征在于:所 述步骤的a中,将所述原料药放入粉碎机粉碎后过100目细筛,使能通过100目筛的细粉量在 达到50%,收集通过100目筛的原料细粉备用。
7. 根据权利要求5所述的一种预防和治疗乳腺增生的中药组合物的制备方法,其特征 在于:所述步骤b中,将过筛后剩下的颗粒物放入乙醇中加热回流提取2次,每次1~3小时, 将2次提取液合并静置;所述步骤c中,将上述乙醇提取过的药渣加10倍量水加热回流提取2 次,每次1~3小时,将2次提取液合并静置。
8. 根据权利要求5所述的活血化瘀、通经活络的中药的制备方法,其特征在于:所述步 骤d中将上述两种提取液合并,减压浓缩相对密度为70°C时1.08的滤液,回收乙醇,将所得 滤液调整比重到1.06,通入喷雾干燥机进行喷雾干燥,过喷雾干燥机喷头的压缩空气压力 为4kg/m2,干燥室热气流温度是60°C,得原料药粉;将过筛后得到的原料细粉与乙醇提炼药 粉混合装入胶囊。
9. 一种如权利要求1至4所述的活血化瘀、通经活络的中药的制备方法,其特征在于,所 述中药制剂的剂型为口服液剂,其制备步骤包括: a、 取原料药放入水中浸泡,热提取2次,成浸膏状,为组分1; b、 药渣乙醇提取1次,浓缩过滤为浸膏状,为组分2; c、 将上述两种浸膏浓缩成糊状,浓缩液用C060灭菌,辐照剂量8k,加入糊精,然后真空 冷冻密封即得。
10. -种如权利要求1至9所述的活血化瘀、通经活络的中药的制备方法,其特征在于, 所述内服药物的剂型为丸剂,其制备步骤包括: a. 将所述原料药混合,切碎,过120目筛,得细药粉备用; b. 将未过筛的粗粉浸泡乙醇中提取2次; c. 再取上述步骤提取后的药渣,加水加热回流提取2次; d. 将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂蜜搓 成丸剂。
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