CN107468575A - A kind of composition and its preparation method and application of light spot, nti-freckle - Google Patents
A kind of composition and its preparation method and application of light spot, nti-freckle Download PDFInfo
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- CN107468575A CN107468575A CN201710762920.0A CN201710762920A CN107468575A CN 107468575 A CN107468575 A CN 107468575A CN 201710762920 A CN201710762920 A CN 201710762920A CN 107468575 A CN107468575 A CN 107468575A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Abstract
The invention discloses a kind of light spot, the composition and its preparation method and application of nti-freckle, following raw material is weighed respectively according to parts by weight：0.5 3 parts of radix glycyrrhizae, 0.5 3 parts of Ligusticum wallichii, 0.5 3 parts of radix scutellariae, 0.5 1.5 parts of ginseng, 0.5 3 parts of aloe, 0.5 1.5 parts of kuh-seng, 1 12 parts of papain, 0.08 0.4 parts of capsaicine, 38 parts of ursin, 1 10 parts of Vitamin C, 0.5 2 parts of niacinamide；Radix glycyrrhizae, Ligusticum wallichii, radix scutellariae, ginseng, aloe, kuh-seng co-grinding plus ultra-pure water decoction, concentration, filtering, layering are taken into supernatant, centrifuging and taking supernatant, concentrated, then is mixed with surplus stock, adds deionized water stirring and dissolving to produce.The inventive method technique is simple, easy to operate, is adapted to industrialized production, safe without toxic side effect, and cost is relatively low, whitening, nti-freckle, light spot positive effect, makes skin gloss, exquisiteness, delicate.
Description
Technical field
The present invention relates to cosmetic field, specifically a kind of light spot, the composition and its preparation method and application of nti-freckle.
Background technology
Chloasma is a kind of chromatodermatosis for betiding facial area, belongs to the frequently-occurring disease of dept. of dermatology and intractable
Disease.Have a strong impact on face appearance and confidence.
Melanocyte is formed as the reasons such as qi and blood retardance, stagnation of liver qi, the deficiency of the kidney yin, internal lesion caused by overexertion spleen soil, using with benefit
The Chinese medicine of blood, promoting blood circulation and qi-regulating effect, the formation of melanocyte is reduced by blood-nourishing, promoting blood circulation, liver soothing and depression relief.From Chinese medicine whitening,
During nti-freckle, mostly based on activating blood and removing stasis drug.Activating blood and removing stasis Method can dredge stasis blocking, enable mechanism of qi smoothness, promote local
Blood circulation, improve local skin metabolism, pigment is dribbled.
Cosmetics of existing many remove spots classes on the market at present, but it is ineffective in terms of effective and security and
Price is costly.
Capsaicine is the main matter for causing acid in capsicum, is the capsicum bases separated from pepper fruit
Compound.Have shown that capsaicine has many physiologically actives through substantial amounts of research, have and stimulate circulation, the work(of uniform bright color
Effect, in conjunction with a variety of nti-freckle Chinese medical extracts, is acted synergistically by different approaches, reaches good freckle effect, and to human body
The side effect such as nontoxic, harmless.
Present invention aims at the composition for providing a kind of light spot, nti-freckle, said composition utilizes the reinforcement blood of capsaicine
Liquid circulation, promote the effect of skin metabolism, capsaicine is added in light spot, nti-freckle product first, it is dense in suitable capsaicine
The effect of making capsaicine to play its promoting blood circulation, skin lightening under degree, it is unlikely to stimulate again and arrives skin.
The content of the invention
It is an object of the invention to provide a kind of light spot, the composition and its preparation method and application of nti-freckle, with solution
State the problem of being proposed in background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of light spot, nti-freckle composition preparation method, comprise the following steps：
1）Weigh following raw material respectively according to parts by weight：Radix glycyrrhizae 0.5-3 parts, Ligusticum wallichii 0.5-3 parts, radix scutellariae 0.5-3 parts, ginseng 0.5-
1.5 parts, aloe 0.5-3 parts, kuh-seng 0.5-1.5 parts, papain 1-12 parts, capsaicine 0.08-0.4 parts, ursin 3-8
Part, Vitamin C 1-10 parts, niacinamide 0.5-2 parts；
2）Radix glycyrrhizae, Ligusticum wallichii, radix scutellariae, ginseng, aloe, kuh-seng are mixed, crushed, crosses 20 mesh sieves, adds above-mentioned raw materials gross mass 20-
30 times of ultra-pure water, 30-60min is decocted, above-mentioned steps is repeated after filtering and is decocted, decocted 3-5 times altogether, merged and decoct
Liquid, concentrate, filtering, obtain the preliminary extract solution of vegetable active that relative density is 0.9-1.2mg/ml；
3）The preliminary extract solution of above-mentioned vegetable active is placed on 6-12h in -5 ~ 5 DEG C of environment, is layered, is taken out, Aspirate supernatant,
Centrifuge, rotating speed 3000r/min, it is layered after centrifuging 20-30min, filters again, take supernatant, is concentrated, obtain after purification
Vegetable active extract solution；
4）Papain, capsaicine, ursin, Vitamin C, niacinamide are gradually added into the vegetable active after purification
In extract solution, appropriate amount of deionized water is added, lasting stirring, to whole dissolvings, that is, obtains light spot, spot-eliminating composition.
As the further scheme of the present invention：Step 1）In, weigh following raw material respectively according to parts by weight：Radix glycyrrhizae 0.5-2
Part, Ligusticum wallichii 0.5-2 parts, radix scutellariae 0.5-2 parts, ginseng 0.8-1.2 parts, aloe 0.5-2 parts, kuh-seng 0.8-1.2 parts, papain
4-8 parts, capsaicine 0.1-0.2 parts, ursin 4-6 parts, Vitamin C 1-5 parts, niacinamide 0.5-1 parts.
As the further scheme of the present invention：Capsaicine uses the water-soluble capsaicine of the peppery degree of 8-12%.
As the further scheme of the present invention：Capsaicine uses the water-soluble capsaicine of 10% peppery degree.
As the further scheme of the present invention：Also include preparing light spot, spot-eliminating composition and cosmetic production is made
Product.
As the further scheme of the present invention：The formulation of product is water aqua type product, emulsion-type product, oily cerul class product
Or powder class product.
As the further scheme of the present invention：Water aqua type product includes patch-lightening essence liquid, light spot water；Emulsion-type product includes
Light spot emulsion, light spot frost；Oily cerul class product includes light spot cream；Powder class product includes light spot muffin, light spot loose powder.
Another object of the present invention is to provide obtained light spot, spot-eliminating composition according to the method described above.
Another object of the present invention is to provide light spot, spot-eliminating composition is preparing treatment light spot, nti-freckle daily chemical products and external application
Application in medicine.
The present invention is simultaneously by stimulating circulation, suppressing tyrosinase activity, promote melanin reduction decomposition, suppression black
Pigment migration, remove the number of ways reduction black prime number such as unnecessary superoxide radical, the metabolism for accelerating horn cell black particles
Amount, so as to desalinate removal color spot.
Wherein, active component capsaicine has and stimulated circulation, the effect of uniform bright color, in conjunction with a variety of nti-freckles
Chinese medical extract, whitening active ingredients, by different approaches, the collaboration mutually promoted well is played during color spot is desalinated
Effect, reaches good freckle effect.
Ursin, aloe with kuh-seng are synthesized by suppressing the propagation of tyrosinase activity and melanocyte, black to reduce
The generation of element is so as to reaching the effect of whitening spot-removing.
There is Vitamin C the melanin for suppressing the free radical facilitation formed to melanin and generating oneself quickly to be gone back
Original is reduced and eliminated, and reaches the effect of quick whitening.
Niacinamide suppresses the melanin that has generated to be shifted to skin surface, the effect of so as to reach net skin.
Panaxoside in ginseng can improve body superoxide dismutase (SOD) activity and remove unnecessary super oxygen freedom
Base, free radical number reduce the generation that can reduce melanocyte, so as to reach the effect of desalination color spot.
Papain increases the degraded of horn cell black particles, accelerates skin metabolism, inactivation epidermis is come off in time,
Reach whitening and softening skin, nti-freckle dirt, improve skin and other effects.
Scutelloside in radix scutellariae, there is freckle removing and whitening, antiallergy, the effect of sun-proof and antibiotic and sterilizing, have available for preparation
The cosmetics of certain curative effect.
Licoflavone in radix glycyrrhizae is a kind of good whitening composition, also suppresses tyrosine while uvioresistant is helped
The activity of enzyme, moreover it is possible to improve the skin of coarse, water shortage and inflammation, be a kind of multiple functional plant whitening composition.
Ligustrazine in Ligusticum wallichii：The promoting flow of qi and blood circulation, wind-expelling pain-stopping, apocenosis of putting on flesh, disappear extravasated blood, has skin anti-aging and brightens
Effect.Ligustrazine (50~400tag/m1) under relatively low comparatively safe concentration can effectively suppress melanocyte proliferation, drop
Low tyrosinase activity, so as to reduce B16 cell.
Compared with prior art, the beneficial effects of the invention are as follows：
The method applied in the present invention is the deep layer whitening spot-removing method that benefit tune from inside to outside combines.It is safe and non-toxic pair first
Effect, reaches a kind of the delicate of real meaning by skin-active foster skin；By the recovery of cell viability, make the calm color spot one of deep layer
Put in order and move to skin surface, then the excretion from appropriate papain synthesis, color spot is gradually desalinated until removing；Adopt
With natural extract, can excessive generation that is sun-proof, preventing pigment, i.e., suppress the element of three enzyme one in right amount, it is a kind of balance to skin
Concept, it does not change the normal apoptotic program of cell, thus caused whitening, freckle effect are that comparison is definite, make skin
Skin gloss, exquisiteness, a kind of delicate noble texture.The inventive method technique is simple, easy to operate, is adapted to industrialized production,
And cost is relatively low, light spot positive effect.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of light spot, nti-freckle composition preparation method, comprise the following steps：
1）Weigh following raw material respectively according to parts by weight：0.5 part of radix glycyrrhizae, 0.5 part of Ligusticum wallichii, 0.5 part of radix scutellariae, 0.5 part of ginseng, aloe
0.5 part, 0.5 part of kuh-seng, 1 part of papain, 0.08 part of capsaicine, 3 parts of ursin, 1 part of Vitamin C, 0.5 part of niacinamide.
2）Radix glycyrrhizae, Ligusticum wallichii, radix scutellariae, ginseng, aloe, kuh-seng are mixed, crushed, crosses 20 mesh sieves, adds the total matter of above-mentioned raw materials
The ultra-pure water of 25 times of amount, 30-60min is decocted, above-mentioned steps is repeated after filtering and is decocted, decocted 4 times altogether, merged and decoct
Liquid, concentrate, filtering, obtain the preliminary extract solution of vegetable active that relative density is 0.9-1.2mg/ml.
3）The preliminary extract solution of above-mentioned vegetable active is placed on 8h in 0 DEG C of environment, is layered, is taken out, Aspirate supernatant, from
Scheming centrifuges, rotating speed 3000r/min, is layered after centrifuging 25min, filters again, take supernatant, concentrates, obtains plant after purification
Thing active extract.
4）Papain, capsaicine, ursin, Vitamin C, niacinamide are gradually added into the plant after purification
In active extract, appropriate amount of deionized water is added, lasting stirring, to whole dissolvings, that is, obtains light spot, spot-eliminating composition.
Capsaicine uses the water-soluble capsaicine of 8% peppery degree.
Embodiment 2
In the embodiment of the present invention, a kind of light spot, nti-freckle composition preparation method, preparation process is consistent with embodiment 1.It is different
Be step 1）In weigh following raw material respectively according to parts by weight：3 parts of radix glycyrrhizae, 3 parts of Ligusticum wallichii, 3 parts of radix scutellariae, 1.5 parts of ginseng, aloe
3 parts, 1.5 parts of kuh-seng, 12 parts of papain, 0.4 part of capsaicine, 8 parts of ursin, 10 parts of Vitamin C, 2 parts of niacinamide.Capsicum
Element uses the water-soluble capsaicine of 12% peppery degree.
Embodiment 3
In the embodiment of the present invention, a kind of light spot, nti-freckle composition preparation method, preparation process is consistent with embodiment 1.It is different
Be step 1）In weigh following raw material respectively according to parts by weight：0.5 part of radix glycyrrhizae, 0.5 part of Ligusticum wallichii, 0.5 part of radix scutellariae, ginseng 0.8
Part, 0.5 part of aloe, 0.8 part of kuh-seng, 4 parts of papain, 0.1 part of capsaicine, 4 parts of ursin, 1 part of Vitamin C, niacinamide
1 part.Capsaicine uses the water-soluble capsaicine of 9% peppery degree.
Embodiment 4
In the embodiment of the present invention, a kind of light spot, nti-freckle composition preparation method, preparation process is consistent with embodiment 1.It is different
Be step 1）In weigh following raw material respectively according to parts by weight：2 parts of radix glycyrrhizae, 2 parts of Ligusticum wallichii, 2 parts of radix scutellariae, 1.2 parts of ginseng, aloe
2 parts, 1.2 parts of kuh-seng, 8 parts of papain, 0.2 part of capsaicine, 6 parts of ursin, 5 parts of Vitamin C, 0.5 part of niacinamide.Capsicum
Element uses the water-soluble capsaicine of 11% peppery degree.
Embodiment 5
In the embodiment of the present invention, a kind of light spot, nti-freckle composition preparation method, preparation process is consistent with embodiment 1.It is different
Be step 1）In weigh following raw material respectively according to parts by weight：1 part of radix glycyrrhizae, 1 part of Ligusticum wallichii, 1 part of radix scutellariae, 0.8 part of ginseng, aloe
1 part, 0.8 part of kuh-seng, 6 parts of papain, 0.15 part of capsaicine, 5 parts of ursin, 3 parts of Vitamin C, 0.7 part of niacinamide.It is peppery
Green pepper element uses the water-soluble capsaicine of 10% peppery degree.
The present composition is to use above-mentioned both effectiveness composition, adds the product that cosmetics are often formed with auxiliaries.Pin
To the application characteristic of the present composition, the preparation method of said composition is additionally provided.This method reasonable compatibility, make light spot, dispel
Spot, whitening, cosmetic result are more stable controllable.
Method one：By light spot, spot-eliminating composition according to conventional methods, it is made water aqua type product, for example, it is patch-lightening essence liquid, light
Spot water etc..
Method two：By light spot, spot-eliminating composition according to conventional methods, emulsion-type product, such as light spot emulsion, light spot is made
Frost etc..
Method three：By light spot, spot-eliminating composition according to conventional methods, oily cerul class product, such as light spot cream is made.
Method four：By light spot, spot-eliminating composition according to conventional methods, powder class product is made, such as light spot muffin, light spot dissipate
Powder etc..
Following examples are that different dosage forms are made according to conventional methods using light spot, spot-eliminating composition made from embodiment 5.
It is described in detail below.
Essence prepared by 6 light spot of embodiment, spot-eliminating composition
Product formula is：Light spot, spot-eliminating composition 20.45%, butanediol 5%, amino acid humectant 2%, water-soluble SIMMONDSIA CHINENSIS SEED OIL
1%, carbomer 2%, azone 0.8%, bisabolol 1%, attached pastil is appropriate, Preservative qs, deionized water surplus
Preparation method：By light spot, spot-eliminating composition, butanediol, amino acid humectant, water-soluble SIMMONDSIA CHINENSIS SEED OIL, carbomer, nitrogen
Ketone, bisabolol, essence and preservative are sequentially added in deionized water, are to dose the next item down again after being completely dissolved uniformly every time
Dissolving, patch-lightening essence liquid is produced after dissolving.
Face cream prepared by 7 light spot of embodiment, spot-eliminating composition
Product formula is：Light spot, spot-eliminating composition 20.45%, butanediol 5%, amino acid humectant 2%, hippophae rhamnoides fruit oil 10% are celestial graceful
G57 1.5%, carbomer 0.3%, azone 0.8%, bisabolol 1%, attached pastil is appropriate, Preservative qs, deionized water surplus.
Preparation method：
1 mixes Seabuckthorn Oil with celestial graceful emulsifying agent, stirs, as oil phase.
2 by light spot, spot-eliminating composition, butanediol, amino acid humectant, carbomer, azone, bisabolol, essence and anti-
Rotten agent is sequentially added in deionized water, is to dose the next item down dissolving after being completely dissolved uniformly again every time, this mixing after dissolving
Liquid is aqueous phase.
3 are slowly added to aqueous phase solution in oil phase, lasting stirring, make emulsification complete, to lotion uniform and smooth.
Facial mask prepared by 8 light spot of embodiment, spot-eliminating composition
Product formula is：Light spot, spot-eliminating composition 20.45%, butanediol 5%, amino acid humectant 2%, ice crystal forming agent 1.2%,
Azone 0.8%, bisabolol 1%, attached pastil is appropriate, Preservative qs, deionized water surplus.
Preparation method：By light spot, spot-eliminating composition, butanediol, amino acid humectant, azone, bisabolol, essence and prevent
Rotten agent is sequentially added in deionized water, is to dose the next item down dissolving after being completely dissolved uniformly again every time, is eventually adding ice crystal shape
Into agent, continuing stirring until gel mask viscosity is not increasing, that is, completes the making of spot-relieving face mask.
Number on probation totally 30, it is divided into 3 groups, every group of 10 people, tries out the light spot product in embodiment 1,2,3 respectively, continue
After 30 days, statistical result showed, wherein effective 23, effective 6, invalid 1.Wherein total effective rate is 97%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (9)
1. the preparation method of the composition of a kind of light spot, nti-freckle, it is characterised in that comprise the following steps：
1）Weigh following raw material respectively according to parts by weight：Radix glycyrrhizae 0.5-3 parts, Ligusticum wallichii 0.5-3 parts, radix scutellariae 0.5-3 parts, ginseng 0.5-
1.5 parts, aloe 0.5-3 parts, kuh-seng 0.5-1.5 parts, papain 1-12 parts, capsaicine 0.08-0.4 parts, ursin 3-8
Part, Vitamin C 1-10 parts, niacinamide 0.5-2 parts；
2）Radix glycyrrhizae, Ligusticum wallichii, radix scutellariae, ginseng, aloe, kuh-seng are mixed, crushed, crosses 20 mesh sieves, adds above-mentioned raw materials gross mass 20-
30 times of ultra-pure water, 30-60min is decocted, above-mentioned steps is repeated after filtering and is decocted, decocted 3-5 times altogether, merged and decoct
Liquid, concentrate, filtering, obtain the preliminary extract solution of vegetable active that relative density is 0.9-1.2mg/ml；
3）The preliminary extract solution of above-mentioned vegetable active is placed on 6-12h in -5 ~ 5 DEG C of environment, is layered, is taken out, Aspirate supernatant,
Centrifuge, rotating speed 3000r/min, it is layered after centrifuging 20-30min, filters again, take supernatant, is concentrated, obtain after purification
Vegetable active extract solution；
4）Papain, capsaicine, ursin, Vitamin C, niacinamide are gradually added into the vegetable active after purification
In extract solution, appropriate amount of deionized water is added, lasting stirring, to whole dissolvings, that is, obtains light spot, spot-eliminating composition.
2. the preparation method of the composition of light spot according to claim 1, nti-freckle, it is characterised in that step 1）In, according to
Parts by weight weigh following raw material respectively：Radix glycyrrhizae 0.5-2 parts, Ligusticum wallichii 0.5-2 parts, radix scutellariae 0.5-2 parts, ginseng 0.8-1.2 parts, aloe
0.5-2 parts, kuh-seng 0.8-1.2 parts, papain 4-8 parts, capsaicine 0.1-0.2 parts, ursin 4-6 parts, Vitamin C 1-5
Part, niacinamide 0.5-1 parts.
3. the preparation method of the composition of light spot according to claim 1, nti-freckle, it is characterised in that capsaicine uses 8-
The water-soluble capsaicine of 12% peppery degree.
4. the preparation method of the composition of light spot according to claim 3, nti-freckle, it is characterised in that capsaicine uses 10%
The water-soluble capsaicine of peppery degree.
5. according to the preparation method of any described light spots of claim 1-4, the composition of nti-freckle, it is characterised in that also include
Light spot, spot-eliminating composition and cosmetic are prepared product is made.
6. the preparation method of the composition of light spot according to claim 5, nti-freckle, it is characterised in that the formulation of product is
Water aqua type product, emulsion-type product, oily cerul class product or powder class product.
7. the preparation method of the composition of light spot according to claim 6, nti-freckle, it is characterised in that water aqua type product bag
Include patch-lightening essence liquid, light spot water；Emulsion-type product includes light spot emulsion, light spot frost；Oily cerul class product includes light spot cream；Powder class
Product includes light spot muffin, light spot loose powder.
8. using light spot, spot-eliminating composition made from the preparation method as described in claim 1-7 is any.
9. the composition of light spot as claimed in claim 8, nti-freckle is preparing treatment light spot, nti-freckle daily chemical products and external used medicine
In application.
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| CN201710762920.0A CN107468575A (en) | 2017-08-30 | 2017-08-30 | A kind of composition and its preparation method and application of light spot, nti-freckle |
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| CN201710762920.0A CN107468575A (en) | 2017-08-30 | 2017-08-30 | A kind of composition and its preparation method and application of light spot, nti-freckle |
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| CN (1) | CN107468575A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464669A (en) * | 2019-08-16 | 2019-11-19 | 香港科技大学深圳研究院 | A kind of whitening agent and application thereof, whitening apply some make up and whitening medical product |
| CN112716847A (en) * | 2021-01-14 | 2021-04-30 | 广州妍叶生物科技有限公司 | Whitening and repairing mask and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104971016A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Firming and repairing fair mask product and preparation method thereof |
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| CN104971016A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Firming and repairing fair mask product and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464669A (en) * | 2019-08-16 | 2019-11-19 | 香港科技大学深圳研究院 | A kind of whitening agent and application thereof, whitening apply some make up and whitening medical product |
| CN112716847A (en) * | 2021-01-14 | 2021-04-30 | 广州妍叶生物科技有限公司 | Whitening and repairing mask and preparation method thereof |
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Application publication date: 20171215 |