CN107441140A - Antipruritic analgesic composition for treating herpes zoster and preparation method thereof - Google Patents
Antipruritic analgesic composition for treating herpes zoster and preparation method thereof Download PDFInfo
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- CN107441140A CN107441140A CN201710718257.4A CN201710718257A CN107441140A CN 107441140 A CN107441140 A CN 107441140A CN 201710718257 A CN201710718257 A CN 201710718257A CN 107441140 A CN107441140 A CN 107441140A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract
The present invention relates to a kind of antipruritic analgesic composition and preparation method thereof for being used to treat herpes zoster, raw material components by weight, including：The parts by weight of honey 80~120, the parts by weight of borneol 40~60, the parts by weight of frankincense 80~120, the parts by weight of earthworm 90~110, the parts by weight of carthamin 95~105, the parts by weight of Mentholum 15~25 and the parts by weight of vegetable oil 80~120.Antipruritic analgesic composition selection provided by the present invention for treating herpes zoster is natural, prescription proportioning science, and safe without toxic side effect, it is used as externally applied drug, has excellent inhibiting bacteria and diminishing inflammation, antalgesic-antipruritic effect, and easy to use, effect is rapidly.The symptoms such as herpes zoster, bleb, scald and bedsore can not only be effectively treated provided by the present invention for the antipruritic analgesic composition for treating herpes zoster, and the infringement to human intestines and stomach's function that oral drugs are brought is avoided, it is with a wide range of applications.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of antipruritic analgesic drug product group for being used to treat herpes zoster
Compound and preparation method thereof.
Background technology
It is well known that herpes zoster belongs to virus infected herpes disease, it is to be invaded to feel god by varicella-zoster virus
Through caused, thus acute herpes zoster is set to turn into a kind of viral disease of most pain feature, the normal acute attack of this disease, fash
It is distributed more along a certain peripheral nerve, arrangement becomes band, and the neuromere inflammation necrosis invaded, produces distinctive neuralgia, its pain is
It is very violent, make patient overwhelmed with sorrow.The post herpetic neuralgia that especially acute herpes zoster is left, its pain are 1~2
Year, long then more than ten years.Its violent pain, it can not endure and irreversible.
In addition, the patient with cold and dampness has surpassed 1,000,000,000 people in the world, the incidence of disease height of cold and dampness, patient groups are wide
It is general.Wet chill is caused by exopathogen invasion and attack channels and collaterals and qi and blood impatency are not smooth, and the main symptom that shows is limbs, joint and muscular sensation
Pain and numbness, joint joint stuffiness and chance cold then pain, heat then delay pain, and limbs joint is ached, migration is indefinite, is regardless of bottom left
The right side, the heavy swelling and pain of limbs joint, arthroncus, four limbs inconvenient activity etc..At the same time, due to accidental wound in daily life
Harmful or other various reasons easily cause the damage of human body a part, main to include dodging muscle, crouching muscle, sprain, damage, (powder of fracturing
Except fragility fracture) and all closed traumas etc.；Showing symptom is：Local hemorrhage and cause swelling and cause injury pain,
Some patientss there is also the wound caused by open wound and inflammation occur, or Bones and joints disconnection, fracture etc. occur.
Based on above-mentioned symptom, medicine existing for market is many at present, but has that curative effect is single, side effect is big, takes effect mostly
Compared with it is slow, contraindication is more；Or because Long-term Oral causes the ill-effect such as taste and hepatic and renal function decline.Therefore exploitation one kind makes
With convenience, effect is rapid and the comprehensive externally-applied medicinal composition of effect is particularly important.
The content of the invention
For in the prior art the defects of, the present invention is intended to provide a kind of be used to treat the antipruritic analgesic drug product of herpes zoster
Composition and preparation method thereof.Antipruritic analgesic composition selection provided by the present invention for treating herpes zoster is natural,
Prescription matches science, and safe without toxic side effect, it has excellent inhibiting bacteria and diminishing inflammation, antalgesic-antipruritic effect, and make as externally applied drug
With convenient, effect rapidly.Can not only be effective provided by the present invention for the antipruritic analgesic composition for treating herpes zoster
Treat the symptoms such as herpes zoster, bleb, scald and bedsore, and avoid that oral drugs bring to human intestines and stomach's function
Infringement, is with a wide range of applications.
Therefore, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, raw material components
By weight, including：The parts by weight of honey 80~120, the parts by weight of borneol 40~60, the parts by weight of frankincense 80~120, earthworm 90~
110 parts by weight, the parts by weight of carthamin 95~105, the parts by weight of Mentholum 15~25 and the parts by weight of vegetable oil 80~120.
In the further embodiment of the present invention, raw material components include：The parts by weight of honey 100, the parts by weight of borneol 50, breast
Fragrant 100 parts by weight, the parts by weight of earthworm 100, the parts by weight of carthamin 100, the parts by weight of Mentholum 20 and the parts by weight of vegetable oil 100.
In the further embodiment of the present invention, honey is included in schisandra honey, Mel Jujubae, honey of lungan flowers and sophorae honey
One or more.
In the further embodiment of the present invention, vegetable oil includes olive oil.
Second aspect, the present invention provide a kind of preparation side for being used to treat the antipruritic analgesic composition of herpes zoster
Method, comprise the following steps：S101：Each raw material components are weighed in proportion, afterwards by the raw material components in addition to honey and vegetable oil
Clean and crush；S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate；S103：By filtrate and honeybee
Honey and vegetable oil are well mixed, and obtain the antipruritic analgesic composition for treating herpes zoster.
In the further embodiment of the present invention, in S102, extraction specifically includes：Extract solution is water, and Extracting temperature is
80 DEG C~90 DEG C, extraction time is 50min~100min.
The third aspect, externally applied drug is being prepared provided by the present invention for the antipruritic analgesic composition for treating herpes zoster
And its application in externally applied drug additive.
In the further embodiment of the present invention, externally applied drug includes treatment herpes zoster, bleb, scald and bedsore
Externally applied drug.
Above-mentioned technical proposal provided by the invention has advantages below：
(1) applicant has found by many experiments：Antipruritic analgesic drug product provided by the present invention for treating herpes zoster
Composition selection is natural, prescription proportioning science, safe without toxic side effect, and it has excellent inhibiting bacteria and diminishing inflammation, stopped as externally applied drug
Pain itching-relieving efficacies, and easy to use, effect is rapidly；The diseases such as herpes zoster, bleb, scald and bedsore can not only effectively be treated
Shape, and the infringement to human intestines and stomach's function that oral drugs are brought is avoided, it is with a wide range of applications.
(2) xenon can also effectively be treated provided by the present invention for treating the antipruritic analgesic composition of herpes zoster
Gas, rhinitis, hemorrhoid, pernio, strain, tympanitis, psoriasis, nettle rash, epifolliculitis, have a pain in the back, arthralgia, fall damage
The symptoms such as wound, pruitus or relaxing tumor pain, and the infringement to human intestines and stomach's function that oral drugs are brought is avoided, have
It is widely applied value.
(3) preparation method provided by the invention is used, the same of each bulk drug active component can retained to greatest extent
When, the active ingredient in each raw material components can be fully discharged so that be finally prepared be used for treat banding
The antipruritic analgesic composition of bleb has excellent effect；In addition, the preparation method process stabilizing, yield are high, quality is good,
Energy consumption is low, raw material are extensive, process is simply saved；It can complete to produce using existing equipment, equipment requirement be reduced, to ring
Border no pollution, so as to be with a wide range of applications.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
Experimental method in following embodiments, it is conventional method unless otherwise specified.
Test material used, is to be commercially available from conventional reagent shop unless otherwise specified in following embodiments.
Quantitative test in following examples, it is respectively provided with and repeats to test three times, data is to repeat the average value of experiment three times
Or mean+SD.
The present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, and raw material components are by weight
Meter, including：The parts by weight of honey 80~120, the parts by weight of borneol 40~60, the parts by weight of frankincense 80~120, the weight of earthworm 90~110
Part, the parts by weight of carthamin 95~105, the parts by weight of Mentholum 15~25 and the parts by weight of vegetable oil 80~120.Wherein, honey bag
Include the one or more in schisandra honey, Mel Jujubae, honey of lungan flowers and sophorae honey；Vegetable oil includes olive oil.
In addition, for the antipruritic analgesic composition for being used to treat herpes zoster of the present invention, the special design of the present invention
Preparation method, comprises the following steps：
S101：Each raw material components are weighed in proportion, afterwards by the raw material components cleaning in addition to honey and vegetable oil and powder
It is broken.
S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate.Wherein, extraction specifically includes：
Extract solution is water, and Extracting temperature is 80 DEG C~90 DEG C, and extraction time is 50min~100min.
S103：Filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic drug product for treating herpes zoster
Composition.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, and raw material components are by weight
Meter, including：The parts by weight of sophorae honey 100, the parts by weight of borneol 50, the parts by weight of frankincense 100, the parts by weight of earthworm 100, the weight of carthamin 100
Measure part, the parts by weight of Mentholum 15~25 and the parts by weight of olive oil 100.
By above-mentioned raw materials component, using preparation method provided by the invention, prepare in the present invention be used for treat banding blister
The antipruritic analgesic composition of rash：
S101：Each raw material components are weighed in proportion, afterwards by the raw material components cleaning in addition to honey and vegetable oil and powder
It is broken.
S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate.Wherein, extraction specifically includes：
Extract solution is water, and Extracting temperature is 80 DEG C, extraction time 100min.
S103：Filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic drug product for treating herpes zoster
Composition.
Embodiment two
The present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, and raw material components are by weight
Meter, including：The parts by weight of honey of lungan flowers 120, the parts by weight of borneol 40, the parts by weight of frankincense 120, the parts by weight of earthworm 90, the weight of carthamin 105
Part, the parts by weight of Mentholum 15 and the parts by weight of olive oil 120.
By above-mentioned raw materials component, using preparation method provided by the invention, prepare in the present invention be used for treat banding blister
The antipruritic analgesic composition of rash：
S101：Each raw material components are weighed in proportion, afterwards by the raw material components cleaning in addition to honey and vegetable oil and powder
It is broken.
S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate.Wherein, extraction specifically includes：
Extract solution is water, and Extracting temperature is 80 DEG C, extraction time 100min.
S103：Filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic drug product for treating herpes zoster
Composition.
Embodiment three
The present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, and raw material components are by weight
Meter, including：The parts by weight of schisandra honey 80, the parts by weight of borneol 60, the parts by weight of frankincense 80, the parts by weight of earthworm 110, the weight of carthamin 95
Part, the parts by weight of Mentholum 25 and the parts by weight of olive oil 80.
By above-mentioned raw materials component, using preparation method provided by the invention, prepare in the present invention be used for treat banding blister
The antipruritic analgesic composition of rash：
S101：Each raw material components are weighed in proportion, afterwards by the raw material components cleaning in addition to honey and vegetable oil and powder
It is broken.
S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate.Wherein, extraction specifically includes：
Extract solution is water, and Extracting temperature is 85 DEG C, extraction time 80min.
S103：Filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic drug product for treating herpes zoster
Composition.
Example IV
The present invention provides a kind of antipruritic analgesic composition for being used to treat herpes zoster, and raw material components are by weight
Meter, including：The parts by weight of schisandra honey 110, the parts by weight of borneol 55, the parts by weight of frankincense 95, the parts by weight of earthworm 105, the weight of carthamin 95
Measure part, the parts by weight of Mentholum 20 and the parts by weight of olive oil 110.
By above-mentioned raw materials component, using preparation method provided by the invention, prepare in the present invention be used for treat banding blister
The antipruritic analgesic composition of rash：
S101：Each raw material components are weighed in proportion, afterwards by the raw material components cleaning in addition to honey and vegetable oil and powder
It is broken.
S102：Raw material components after crushing are extracted, filters afterwards and collects filtrate.Wherein, extraction specifically includes：
Extract solution is water, and Extracting temperature is 88 DEG C, extraction time 60min.
S103：Filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic drug product for treating herpes zoster
Composition.
In addition, the antipruritic analgesic drug product group for being used to treat herpes zoster that the embodiment of the present invention one to example IV is obtained
Compound, by function assessment experiment come its effect of system evaluation：
First, toxicity test
Test method：The small white mouse 40 that body weight from health is 1.8~2.2kg, it is divided into 4 groups, every group 10, distinguishes
The antipruritic analgesic composition that embodiment one to example IV on probation is prepared.Specifically, small white mouse is lost hair or feathers, depilation area is
3cm × 3cm, the antipruritic analgesic composition 3g of the present invention is taken to be applied to depilation position afterwards, twice daily；Observation 20 days, little Bai
Mouse health existence, it is without any side effects；Anatomic observation blood picture, liver function, each organs and tissues state, with normal small white mouse ratio
Compared with indifference.It is demonstrated experimentally that slimming externally applied drug provided by the invention is nontoxic.
2nd, each embodiment is used for the trial effect evaluation for treating the antipruritic analgesic composition of herpes zoster
400 (M-Fs 1 of the call-up age Patients with Herpes Zoster of 25~60 years old:1).The equal table of clinical symptoms of patient
It is now different degrees of myalgia and numbness, heating, weak, general malaise, poor appetite, regional nodes's swelling and pain, affected part
The symptoms such as skin burns, hyperesthesia or neuralgia.Specifically, patient is divided into 4 groups, every group of 100 people, by first group to
Four groups of antipruritic analgesic compositions for being used to treat herpes zoster smeared respectively in embodiment one to example IV, every time
3g, daily once in the morning and once at night, uniformly it is applied to painful area.Continuous stopping provided by the present invention for treatment herpes zoster on probation
Itch analgesic composition 10 days, record the symptom of each patient, specific data are as shown in table 1.
It is used for the effect of antipruritic analgesic composition for treating herpes zoster according to following Standard Judgement：
Curative effect is judged as：
It is effective：Myalgia and numbness, heating, weak, general malaise, poor appetite, regional nodes's swelling and pain, affected part skin
The symptoms such as skin is scorching hot, hyperesthesia or neuralgia significantly improve；Take a turn for the better：Myalgia and numbness, heating, weak, general malaise,
The symptom such as poor appetite, regional nodes's swelling and pain, illing skin is scorching hot, hyperesthesia or neuralgia has taken a turn for the better；It is invalid：Symptom
Without improvement.
1 each embodiment of table is used for the antipruritic analgesic composition trial effect evaluation table for treating herpes zoster
| Effective/people | Improvement/people | Invalid/people | |
| Embodiment one | 89 | 11 | 0 |
| Embodiment two | 87 | 13 | 0 |
| Embodiment three | 88 | 12 | 0 |
| Example IV | 88 | 12 | 0 |
Certainly, except the situation that embodiment one to example IV is enumerated, the species and percentage by weight of other raw material components,
Condition and parameter in preparation process etc. are also possible.
Antipruritic analgesic composition selection provided by the present invention for treating herpes zoster is natural, prescription proportioning section
Learn, safe without toxic side effect, it has excellent inhibiting bacteria and diminishing inflammation, antalgesic-antipruritic effect, and easy to use, work as externally applied drug
With rapid；The symptoms such as herpes zoster, bleb, scald and bedsore can not only be effectively treated, and avoid oral drugs band
The infringement to human intestines and stomach's function come, is with a wide range of applications.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, specific features, structure, material or the feature of description can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the different embodiments or example and the feature of different embodiments or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (8)
- A kind of 1. antipruritic analgesic composition, it is characterised in that raw material components by weight, including：It is the parts by weight of honey 80~120, the parts by weight of borneol 40~60, the parts by weight of frankincense 80~120, the parts by weight of earthworm 90~110, red Flower glucoside 95~105 parts by weight, the parts by weight of Mentholum 15~25 and the parts by weight of vegetable oil 80~120.
- 2. antipruritic analgesic composition according to claim 1, it is characterised in that：It is the parts by weight of honey 100, the parts by weight of borneol 50, the parts by weight of frankincense 100, the parts by weight of earthworm 100, the parts by weight of carthamin 100, thin The parts by weight of lotus ice 20 and the parts by weight of vegetable oil 100.
- 3. antipruritic analgesic composition according to claim 1 or 2, it is characterised in that：The honey includes the one or more in schisandra honey, Mel Jujubae, honey of lungan flowers and sophorae honey.
- 4. antipruritic analgesic composition according to claim 1 or 2, it is characterised in that：The vegetable oil includes olive oil.
- 5. the preparation method of any one of Claims 1 to 4 antipruritic analgesic composition, it is characterised in that including following Step：S101：Each raw material components are weighed in proportion, and the raw material components in addition to honey and vegetable oil are cleaned and crushed afterwards；S102：Raw material components after the crushing are extracted, filters afterwards and collects filtrate；S103：The filtrate is well mixed with honey and vegetable oil, obtains the antipruritic analgesic composition.
- 6. the preparation method of antipruritic analgesic composition according to claim 5, it is characterised in that：In the S102, the extraction specifically includes：Extract solution is water, and Extracting temperature is 80 DEG C~90 DEG C, and extraction time is 50min~100min.
- 7. the antipruritic analgesic composition described in any one of Claims 1 to 4 is preparing externally applied drug and its externally applied drug additive In application.
- 8. application according to claim 7, it is characterised in that：The externally applied drug includes the externally applied drug of herpes zoster, bleb, scald and bedsore.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710718257.4A CN107441140A (en) | 2017-08-21 | 2017-08-21 | Antipruritic analgesic composition for treating herpes zoster and preparation method thereof |
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| CN201710718257.4A CN107441140A (en) | 2017-08-21 | 2017-08-21 | Antipruritic analgesic composition for treating herpes zoster and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634429A (en) * | 2004-10-25 | 2005-07-06 | 陈艳华 | Medicine composition for treating furuncle, abscess, carbuncle, furuncle, burn and scald |
| CN100998620A (en) * | 2006-12-28 | 2007-07-18 | 江蕾 | External use medicine for treating herpes zoster |
| KR20130095010A (en) * | 2012-02-17 | 2013-08-27 | 재단법인 산청한방약초연구소 | Natural anti-herpes virus agent and compositions comprising thereof |
-
2017
- 2017-08-21 CN CN201710718257.4A patent/CN107441140A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634429A (en) * | 2004-10-25 | 2005-07-06 | 陈艳华 | Medicine composition for treating furuncle, abscess, carbuncle, furuncle, burn and scald |
| CN100998620A (en) * | 2006-12-28 | 2007-07-18 | 江蕾 | External use medicine for treating herpes zoster |
| KR20130095010A (en) * | 2012-02-17 | 2013-08-27 | 재단법인 산청한방약초연구소 | Natural anti-herpes virus agent and compositions comprising thereof |
Non-Patent Citations (3)
| Title |
|---|
| 李万瑶: "《蜜蜂与人类健康》", 30 June 2010, 中医古籍出版社 * |
| 胡丽华: "冰红止痛酊剂治疗带状疱疹后遗神经痛325例", 《光明中医》 * |
| 高学敏: "《中医药学高级丛书 中药学 下》", 30 November 2000, 人民卫生出版社 * |
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Application publication date: 20171208 |
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| RJ01 | Rejection of invention patent application after publication |