CN108743687A - Treat the medicinal liquor and the preparation method and application thereof of rheumathritis - Google Patents
Treat the medicinal liquor and the preparation method and application thereof of rheumathritis Download PDFInfo
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of medicinal liquor and the preparation method and application thereof for treating rheumathritis.Raw material components include：9 mass parts of safflower, 6 mass parts of pawpaw, 6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong, 500 mass parts of white wine and tiger 500 mass parts of urine.The medicinal liquor for the treatment of rheumathritis provided by the invention, raw material components selection is natural, prescription matches science, safe without toxic side effect；It is easy to use, effect is rapid as externally applied drug, have it is excellent it is promoting blood circulation and removing blood stasis, dredge the channels and other effects, can effectively treat rheumatoid arthritis and/or rheumatic arthritis.In addition, using preparation method provided by the invention, the active ingredient in each raw material component can fully be released while retaining each bulk pharmaceutical chemicals active constituent to greatest extent, so that the medicinal liquor being finally prepared is had the effect of excellent；And medicinal liquor, as externally applied drug, the damage to human intestines and stomach's function that can significantly avoid conventional oral class medicine band from is with a wide range of applications.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of medicinal liquor and preparation method thereof for treating rheumathritis
With application.
Background technology
It is well known that rheumatic arthritis is a kind of common acute or chronic connective tissue inflammation.Usually said wind
Wet arthritis is one of main performance of rheumatic fever, and clinic is characterized by migrans miserable, the red and swollen, pain in joint and muscle.
Related with A group beta hemolytic streptococcus infection, the factors such as cold, humidity can induce this disease.Lower limb large joint such as knee joint, ankle
It is most often involved in joint.Although the incidence of rheumatic fever has been remarkably decreased in recent decades, atypia rheumatic fever and chronic rheumatoid
Property arthritis is not rare.
According to investigations, the patient for suffering from rheumatic Bi syndrome in the world has surpassed 1,000,000,000 people, the incidence height of rheumatic Bi syndrome, patient groups
Extensively.Wet chill is caused by exopathogen invades channels and collaterals and qi and blood impatency is unsmooth, and the main symptom that shows is limbs, joint and muscle sense
Feel pain and numbness, joint joint stuffiness and meet cold then pain, heat and then delay pain, limbs joint is ached, migration is indefinite, is regardless of up and down
Left and right, the heavy swelling and pain of limbs joint, arthroncus, four limbs inconvenient activity etc..Meanwhile the bad social habit of modern leads
Also increasingly rejuvenation generalizes the spinal disease of cause.
Based on above-mentioned symptom, there are many drug existing for market at present, but that there are curative effects is single mostly, side effect is big, takes effect
Compared with slow, contraindication is more.Therefore, a kind of easy to use, effect of exploitation is rapidly and the comprehensive external used medicine of effect is particularly important.
Invention content
For the defects in the prior art, the present invention is intended to provide a kind of medicinal liquor for treating rheumathritis and its preparation side
Method and application.The medicinal liquor for the treatment of rheumathritis provided by the invention, raw material components selection is natural, prescription matches science, safety
It has no toxic side effect；It is easy to use, effect is rapid as externally applied drug, have it is excellent it is promoting blood circulation and removing blood stasis, dredge the channels and other effects,
Rheumatoid arthritis and/or rheumatic arthritis can effectively be treated.In addition, medicinal liquor of the present invention is as externally applied drug, it can be notable
The damage to human intestines and stomach's function for avoiding conventional oral class medicine band from, is with a wide range of applications.
For this purpose, the present invention provides the following technical solutions：
In a first aspect, the present invention provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：
5~20 mass parts of safflower, 5~15 mass parts of pawpaw, 5~10 mass parts of Radix Angelicae Pubescentis, 8~20 mass parts of Rhizoma Chuanxiong, white wine 400~600
Mass parts and tiger 400~600 mass parts of urine.
Preferably, the medicinal liquor for treating rheumathritis includes following raw material components：9 mass parts of safflower, 6 mass parts of pawpaw,
6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong, 500 mass parts of white wine and tiger 500 mass parts of urine.
Preferably, the medicinal liquor for treating rheumathritis includes following raw material components：20 mass parts of safflower, 5 mass parts of pawpaw,
10 mass parts of Radix Angelicae Pubescentis, 8 mass parts of Rhizoma Chuanxiong, 600 mass parts of white wine and tiger 400 mass parts of urine.
Preferably, the medicinal liquor for treating rheumathritis includes following raw material components：5 mass parts of safflower, 15 mass parts of pawpaw,
5 mass parts of Radix Angelicae Pubescentis, 20 mass parts of Rhizoma Chuanxiong, 400 mass parts of white wine and tiger 600 mass parts of urine.
The each raw material component for preparing medicinal liquor of the present invention is to be used as to match according to mass parts, can be according to corresponding ratio in production
Example increase or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production can also gram be unit, quality can
To increase or reduce, but the quality proportioning constant rate between each composition.
Second aspect, the present invention provide a kind of preparation method of medicinal liquor that treating rheumathritis, include the following steps：
S1：Each raw material component is weighed in proportion, it is spare after the raw material components in addition to white wine and tiger urine are cleaned, crushed later；S2：It will
Raw material components after crushing are soaked, and carry out decoction extraction later, are filtered and are collected filtrate；S3：By filtrate, white wine and tiger urine
It is uniformly mixed, the medicinal liquor for the rheumathritis that obtains medical treatment.
Preferably, in S1：Each raw material component is crushed to 60~200 mesh.
Preferably, in S2：The time of immersion is 50~80min；The time for decocting extraction is 100~300min.
Preferably, in S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed.
The third aspect, medicinal liquor provided by the invention is in the medicine for preparing treatment rheumatoid arthritis and/or rheumatic arthritis
Application in object and/or medicated premix.Specifically, in clinical application, the dosage of medicinal liquor of the present invention is every time 3~5mL, often
Day is once in the morning and once at night.In addition, cardiac, hepatopath and nephrotic's disabling.
Above-mentioned technical proposal provided by the invention has the following advantages：
(1) applicant has found by many experiments：The medicinal liquor for the treatment of rheumathritis provided by the invention, raw material components choosing
Material is natural, prescription matches science, safe without toxic side effect；It rapidly, has excellent as externally applied drug, easy to use, effect
It is promoting blood circulation and removing blood stasis, dredge the channels and other effects, can effectively treat rheumatoid arthritis and/or rheumatic arthritis.In addition, of the invention
Medicinal liquor is as externally applied drug, the damage to human intestines and stomach's function that can significantly avoid conventional oral class medicine band from, and has extensive
Application value.
(2) preparation method provided by the invention is used, the same of each bulk pharmaceutical chemicals active constituent can retained to greatest extent
When, the active ingredient in each raw material component can be fully released, it is excellent to make the medicinal liquor being finally prepared have
Effect；In addition, the preparation method process stabilizing, yield are high, high-quality, low energy consumption, raw material are extensive, process is simply saved；
Production can be completed using existing equipment, reduce equipment requirement, to zero environmental, to have a wide range of applications valence
Value.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Specific implementation mode
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical scheme of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following embodiment, is all provided with
Three repeated experiments are set, data are the average value or mean+SD of three repeated experiments.
Safflower as used in the following examples, Radix Angelicae Pubescentis, Rhizoma Chuanxiong meet each medicine of text of Chinese Pharmacopoeia (version in 2015)
Pertinent regulations under material item.Before feeding intake, by identification, ingredients material object is consistent with title, and quality complies with standard.
The present invention provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：Safflower 5~20
Mass parts, 5~15 mass parts of pawpaw, 5~10 mass parts of Radix Angelicae Pubescentis, 8~20 mass parts of Rhizoma Chuanxiong, 400~600 mass parts of white wine and tiger
Urinate 400~600 mass parts.
In addition, the medicinal liquor of the treatment rheumathritis for the present invention, the present invention specially devise preparation method, including with
Lower step：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine and tiger urine are cleaned later, are crushed to 60
It is spare after~200 mesh.
S2：Raw material components after crushing are soaked into 50~80min, decoct 100~300min of extraction later, filtering is simultaneously
Collect filtrate；
S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed, the medicine for the rheumathritis that obtains medical treatment
Wine.
It illustrates With reference to embodiment：
Embodiment one
The present embodiment provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：9 matter of safflower
Measure part, 6 mass parts of pawpaw, 6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong, 500 mass parts of white wine and tiger 500 mass parts of urine.
According to above-mentioned raw materials component, the medicinal liquor for the treatment of rheumathritis is prepared：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine and tiger urine are cleaned later, are crushed to 60
It is spare after mesh.
S2：Raw material components after crushing are soaked into 60min, extraction 200min is decocted later, filters and collect filtrate；
S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed, the medicine for the rheumathritis that obtains medical treatment
Wine.
Embodiment two
The present embodiment provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：20 matter of safflower
Measure part, 5 mass parts of pawpaw, 10 mass parts of Radix Angelicae Pubescentis, 8 mass parts of Rhizoma Chuanxiong, 600 mass parts of white wine and tiger 400 mass parts of urine.
According to above-mentioned raw materials component, the medicinal liquor for the treatment of rheumathritis is prepared：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine and tiger urine are cleaned later, are crushed to
It is spare after 200 mesh.
S2：Raw material components after crushing are soaked into 50min, extraction 300min is decocted later, filters and collect filtrate；
S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed, the medicine for the rheumathritis that obtains medical treatment
Wine.
Embodiment three
The present embodiment provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：5 matter of safflower
Measure part, 15 mass parts of pawpaw, 5 mass parts of Radix Angelicae Pubescentis, 20 mass parts of Rhizoma Chuanxiong, 400 mass parts of white wine and tiger 600 mass parts of urine.
According to above-mentioned raw materials component, the medicinal liquor for the treatment of rheumathritis is prepared：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine and tiger urine are cleaned later, are crushed to 60
It is spare after mesh.
S2：Raw material components after crushing are soaked into 80min, extraction 100min is decocted later, filters and collect filtrate；
S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed, the medicine for the rheumathritis that obtains medical treatment
Wine.
In addition, in order to further highlight the advantage of technical solution of the present invention, following comparative example is set.It should be noted that
Following comparative examples change relative parameters setting on the basis of embodiment one and form.
Comparative example one
This comparative example provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：9 matter of safflower
Measure part, 6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong, 500 mass parts of white wine and tiger 500 mass parts of urine.
According to above-mentioned raw materials component, the medicinal liquor for the treatment of rheumathritis is prepared：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine and tiger urine are cleaned later, are crushed to 60
It is spare after mesh.
S2：Raw material components after crushing are soaked into 60min, extraction 200min is decocted later, filters and collect filtrate；
S3：By filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed, the medicine for the rheumathritis that obtains medical treatment
Wine.
Comparative example two
This comparative example provides a kind of medicinal liquor for treating rheumathritis, raw material components in parts by mass, including：9 matter of safflower
Measure part, 6 mass parts of pawpaw, 500 mass parts of 6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong and white wine.
According to above-mentioned raw materials component, the medicinal liquor for the treatment of rheumathritis is prepared：
S1：Each raw material component is weighed in proportion, and the raw material components in addition to white wine are cleaned later, are crushed to 60 mesh standby
With.
S2：Raw material components after crushing are soaked into 60min, extraction 200min is decocted later, filters and collect filtrate；
S3：By filtrate and white wine according to 1:1 mass ratio is uniformly mixed, the medicinal liquor for the rheumathritis that obtains medical treatment.
In addition, the medicinal liquor for the treatment rheumathritis that various embodiments of the present invention and comparative example are prepared, passes through function
It learns experiment and carrys out system evaluation its effect：
One, toxicity test
Test method：The small white mouse 30 for selecting the weight of health to be 1.8~2.2kg is divided into 3 groups, every group 10, distinguishes
The medicinal liquor for the treatment rheumathritis that embodiment one to embodiment three on probation is prepared.Specifically, small white mouse is lost hair or feathers, is lost hair or feathers
Area is 3cm × 3cm, takes the medicinal liquor 3mL of the treatment rheumathritis of the present invention to be applied to depilation position later, twice daily；
Observation 30 days, small white mouse health existence are without any side effects；Blood picture, liver function, each organs and tissues state is dissected and observed,
The indifference compared with normal small white mouse.It is demonstrated experimentally that medicinal liquor provided by the invention is nontoxic.
Two, the trial effect evaluation of the medicinal liquor of each embodiment treatment rheumathritis
Rheumatoid arthritis and each 50 of rheumatoid arthritis patients are collected, each patient exists different degrees of：Part
Property waist-leg painful swelling of joints, and when blowing and raining patient understand general joint tingle unbearably, trick pain even modification, movement not
It is convenient.Specifically, all kinds of volunteers are divided into 5 groups, i.e., every group includes rheumatoid arthritis patients 10 and rheumatism joint
Scorching patient 10.Wherein, first group to third component not Shi Yong the embodiment of the present invention one to embodiment three medicinal liquor；4th group and
The medicinal liquor of 5th group of comparative example one and comparative example two on probation.Medicinal liquor of the present invention is tried out after 15 days, observes result.
The effect of the medicinal liquor of rheumathritis is treated according to following Standard Judgement：
Curative effect is judged as：
It is effective：Locality waist-leg painful swelling of joints, and when blowing and raining patient understand general joint tingle unbearably, trick pain
Pain even modification, the symptoms such as movement inconvenience significantly improve；It improves：Locality waist-leg painful swelling of joints, and patient when blowing and raining
Can general joint tingle unbearably, the even modification of trick pain, the movement symptoms such as inconvenience are improved；In vain：Symptom without
Improve.
1 each embodiment of table treats the medicinal liquor trial effect evaluation table of rheumathritis
Certainly, the case where being enumerated in addition to embodiment one to embodiment three, the type and weight percent of other raw material components,
Condition and parameter in preparation process etc. are also possible.
The medicinal liquor for the treatment of rheumathritis provided by the invention, raw material components selection is natural, prescription matches science, safe nothing
Toxic side effect；It is easy to use, effect is rapid as externally applied drug, have it is excellent it is promoting blood circulation and removing blood stasis, dredge the channels and other effects, energy
Enough effectively treatment rheumatoid arthritis and/or rheumatic arthritis.In addition, medicinal liquor of the present invention can significantly be kept away as externally applied drug
Exempt from the damage to human intestines and stomach's function that conventional oral class medicine band is come, is with a wide range of applications.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (9)
1. a kind of medicinal liquor for treating rheumathritis, which is characterized in that raw material components in parts by mass, including：
5~20 mass parts of safflower, 5~15 mass parts of pawpaw, 5~10 mass parts of Radix Angelicae Pubescentis, 8~20 mass parts of Rhizoma Chuanxiong, white wine 400~
600 mass parts and tiger 400~600 mass parts of urine.
2. the medicinal liquor for the treatment of rheumathritis according to claim 1, it is characterised in that：
9 mass parts of safflower, 6 mass parts of pawpaw, 6 mass parts of Radix Angelicae Pubescentis, 9 mass parts of Rhizoma Chuanxiong, 500 mass parts of white wine and tiger 500 matter of urine
Measure part.
3. the medicinal liquor for the treatment of rheumathritis according to claim 1, it is characterised in that：
20 mass parts of safflower, 5 mass parts of pawpaw, 10 mass parts of Radix Angelicae Pubescentis, 8 mass parts of Rhizoma Chuanxiong, 600 mass parts of white wine and tiger urine 400
Mass parts.
4. the medicinal liquor for the treatment of rheumathritis according to claim 1, it is characterised in that：
5 mass parts of safflower, 15 mass parts of pawpaw, 5 mass parts of Radix Angelicae Pubescentis, 20 mass parts of Rhizoma Chuanxiong, 400 mass parts of white wine and tiger urine 600
Mass parts.
5. any one of Claims 1 to 4 it is described treatment rheumathritis medicinal liquor preparation method, which is characterized in that including with
Lower step：
S1：Each raw material component is weighed in proportion, it is spare after the raw material components in addition to white wine and tiger urine are cleaned, crushed later；
S2：Raw material components after the crushing are soaked, carry out decoction extraction later, filters and collects filtrate；
S3：The filtrate, white wine and tiger urine are uniformly mixed, the medicinal liquor of the treatment rheumathritis is obtained.
6. the preparation method of the medicinal liquor for the treatment of rheumathritis according to claim 5, it is characterised in that：
In the S1：
Each raw material component is crushed to 60~200 mesh.
7. the preparation method of the medicinal liquor for the treatment of rheumathritis according to claim 5, it is characterised in that：
In the S2：
The time of the immersion is 50~80min；The time for decocting extraction is 100~300min.
8. the preparation method of the medicinal liquor for the treatment of rheumathritis according to claim 5, it is characterised in that：
In the S3：
By the filtrate, white wine and tiger urine according to 1:1:1 mass ratio is uniformly mixed.
9. any one of Claims 1 to 4 medicinal liquor is in the drug for preparing treatment rheumatoid arthritis and/or rheumatic arthritis
And/or the application in medicated premix.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201811004918.8A CN108743687A (en) | 2018-08-30 | 2018-08-30 | Treat the medicinal liquor and the preparation method and application thereof of rheumathritis |
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| CN201811004918.8A CN108743687A (en) | 2018-08-30 | 2018-08-30 | Treat the medicinal liquor and the preparation method and application thereof of rheumathritis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618594A (en) * | 2021-01-19 | 2021-04-09 | 深圳市古方中药饮片有限公司 | Plaster capable of treating and improving rheumatism |
-
2018
- 2018-08-30 CN CN201811004918.8A patent/CN108743687A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618594A (en) * | 2021-01-19 | 2021-04-09 | 深圳市古方中药饮片有限公司 | Plaster capable of treating and improving rheumatism |
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Application publication date: 20181106 |