CN101804111A - Traditional Chinese medicine for treating high blood pressure and preparation method thereof - Google Patents
Traditional Chinese medicine for treating high blood pressure and preparation method thereof Download PDFInfo
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- CN101804111A CN101804111A CN 201010166453 CN201010166453A CN101804111A CN 101804111 A CN101804111 A CN 101804111A CN 201010166453 CN201010166453 CN 201010166453 CN 201010166453 A CN201010166453 A CN 201010166453A CN 101804111 A CN101804111 A CN 101804111A
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Abstract
The invention provides a traditional Chinese medicine composition for treating high blood pressure with obvious effect and little toxic and side effect and a preparation method thereof, aiming at mainly solving the technical problems that the existing western medicine for preventing and treating high blood pressure has large toxic and side effect and the patient has dependence if using for long time, and the like. The traditional Chinese medicine composition for treating high blood pressure is characterized by comprising the following raw materials by weight ratio: 4-8g of eucommia bark, 5-10g of radix achyranthis bidentatae, 2-6g of epimedium herb, 2-9g of Chinese angelica, 5-8g of chrysanthemum, 2-12g of semen cassiae, 6-12g of hawthorn fruit, 8-13g of radix puerariae and 1-3g of red yeast. The preparation method comprises the steps: extracting volatile oil from the Chinese angelica, combining seven types of medicines such as dregs of Chinese angelica and eucommia bark, radix achyranthis bidentatae, epimedium herb, chrysanthemum, semen cassiae, hawthorn fruit and radix puerariae, adding ten times of water, extracting for two times with two hours for each time, and filtering; combining the filtrate of the two times; under the temperature of 60 DEG C, decompressing and concentrating the combined filtrate till the relative density is about 1.15-1.20, adding three times alcohol of 75%, standing for 24 hours, and taking supernate for spare use; drying the supernate, and filtering; and taking down the sieved matters, adding red yeast and volatile oil of Chinese angelica, mixing for 30 minutes, dry-granulating and palletizing.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation with Chinese medicine preparation and preparation method thereof, concrete is hypertensive Chinese medicine preparation of a kind of treatment and preparation method thereof.
Background technology
Hypertension is one of modal cardiovascular disease, and not only the prevalence height can also cause the serious heart, brain, kidney complication, is the main hazard factor of apoplexy, coronary heart disease.In the hyperpietic, most of people do not have the clear and definite cause of disease, and this is called essential hypertension; About 5% patient's hypertension is arranged in addition owing to diseases such as pheochromocytoma cause, be called secondary hypertension.What we said usually all is essential hypertension.
The hypertension pathological changes is called essential hypertension, accounts for the hyperpietic more than 90%, and hypertension is a kind of clinical common syndrome based on the systemic arterial blood pressure rising, and its pathogenic factor is not clear fully as yet at present.According to interrelated data, hypertension is by some congenital hereditary gene, a kind of multi-factor disease that causes with multiple pathogenic supercharging factor and physiological decompression factor interaction under all multifactor impacts, makes body cause the regulatory function imbalance institute of blood pressure.In recent years, many scholars think that the imbalance of higher nerve systemic-function then may be the main mechanism of its morbidity.Extraneous and intrinsic various pessimal stimulations, as sodium salt content height, smoking in the suitable rest of psychentonia, excited, neurotypes, inherited genetic factors, age, sex, occupation and environment, shortage and motion, the diet, drink, obesity, diabetes, hyperlipidemia, uric acid increase etc., all can cause nervous system and endocrine control imbalance, make that vasomotor centre gets muddled under cerebral cortex and the cortex, cause the whole body arteriolospasm, peripheral vascular resistance continues to increase, and goes down just to have formed hypertension for a long time.
Hypertension is a series of changes that raise of human body systolic pressure and diastolic pressure and the multiple disease that causes thus, and it not only singly refers to the rising of blood pressure, the very infringements of vitals such as the people body-centered that also refers to be caused by it, brain, kidney.In general, blood pressure can raise with the age, be difficult in the clear and definite boundary in standardized road between normal arterial pressure and the hypertension, hypertensive diagnostic criteria also has a lot, in recent years for the most frequently used diagnostic criteria be: the adult measures blood pressure three times at same date not, get its meansigma methods, high pressure (systolic pressure) 〉=18.6 kPa (140 millimetres of mercury) or low pressure (diastolic pressure) 〉=12 kPa (90 millimetres of mercury) meet wherein one or two and can be diagnosed as hypertension.
What symptom can hypertension often have?
Most of hypertensive patients do not have tangible symptom in early days, situations such as slight headache, dizziness, tinnitus, cardiopalmus, dim eyesight, weak, asthma, numb limbs and tense tendons may just appear, this situation occurring will in time seek medical advice, if because early stage controlling blood pressure is effectively developed as one pleases and just might be caused diseases such as coronary heart disease, apoplexy and renal failure.
What more will arouse attention is, is not have hypertension without hypertension symptom, though some patient's blood pressure is very high, also can not feel not quite the thing, and therefore, even without sense of discomfort, regular health check-up and observation blood pressure also are very necessary.
Which harm does hypertension have?
Continued the increasing of blood pressure all has infringement to heart, brain, kidney and eyes.The angina pectoris that hypertension causes, acute myocardial infarction plug and heart failure; Can cause cerebral hemorrhage, cerebral infarction and temporal cerebral ischemia seizure; Hypertension also can cause kidney damage, causes ball sclerosis on the kidney, along with disease progression, occurs renal failure at last; In addition, hypertension can cause retinal arteriosclerosis, and severe patient can cause retinal hemorrhage or thromboembolism, visual deterioration occurs, even blind.
It is main that present treatment hypertension generally adopts Western medicine depressor, and Western medicine all has certain side effect mostly, can directly injure patient's physiological function itself.In a single day Western medicine is taken in addition, arbitrarily drug withdrawal, if drug withdrawal, the state of an illness can be repeatedly, even increase the weight of year by year.Therefore, western medicine expense height, cure rate is low.
Summary of the invention
The present invention mainly solves the existing hypertension of preventing and treating and gets that the Western medicine toxic and side effects is big, patient's life-time service has technical problems such as dependency, so that hypertensive Chinese medicine composition of treatment that a kind of effect is remarkable, toxic and side effects is little and preparation method thereof to be provided.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: treat hypertensive Chinese medicine medicine, it is characterized in that the Chinese medicine medicine is formed as follows in weight ratio: Cortex Eucommiae 4-8g, Radix Achyranthis Bidentatae 5-10g, Herba Epimedii 2-6g, Radix Angelicae Sinensis 2-9g, Flos Chrysanthemi 5-8g, Semen Cassiae 2-12g, Fructus Crataegi 6-12g, Radix Puerariae 8-13g, Monas cuspurpureus Went 1-3g.Described medicament is diffusing, sheet, ball, capsule, electuary, oral liquid and honeyed pill.
Treat the preparation method of hypertensive Chinese medicine medicine: Radix Angelicae Sinensis extracts volatile oil earlier, and the Radix Angelicae Sinensis medicinal residues and the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Epimedii, Flos Chrysanthemi, Semen Cassiae, Fructus Crataegi, Radix Puerariae 7 flavor medicines merge, and add 10 times of water gagings of medical material and extract twice, each two hours, filter.Merge filtrate twice.At 60 ℃, vacuum 0.08Mpa, the filtrate decompression after merging is concentrated into relative density is about 1.15-1.20, the ethanol that adds 3 times of amounts 75% left standstill 24 hours, and it is standby to get supernatant.After the supernatant oven dry, pulverize, sieve.Extracting screen underflow adds Monas cuspurpureus Went, Radix Angelicae Sinensis volatile oil mixes dry granulation after 30 minutes, granulate.If make tablet, tabletting then, coating is promptly.
Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening; The Radix Achyranthis Bidentatae liver and kidney tonifying, strong waist knee joint and invigorating blood circulation; The Herba Epimedii kidney-replenishing, bone and muscle strengthening; Chinese angelica blood supplementing is invigorated blood circulation, and moisturizes laxation; Flos Chrysanthemi liver heat removing and eyesight improving, Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation; The Fructus Crataegi invigorating the stomach and promoting digestion, the circulation of qi promoting dissipating blood stasis; Radix Puerariae promotes the production of body fluid and brings down a fever; The Monas cuspurpureus Went blood circulation promoting and blood stasis dispelling; Strengthening the spleen to promote digestion.The Cortex Eucommiae, Radix Achyranthis Bidentatae, the shared reinforcement Liver and kidney of Herba Epimedii, the effect of strong muscles and bones is strengthened, but also encourages the merit of Radix Angelicae Sinensis blood circulation promoting and enriching; Flos Chrysanthemi, Semen Cassiae are with the effect that makes eye bright with strengthening removing heat from the liver; Fructus Crataegi, Radix Puerariae, Monas cuspurpureus Went strengthening the spleen and stomach help digestion facilitating digestion; Monas cuspurpureus Went also can soften cardiovascular, blood fat reducing, and the same usefulness of all medicines can thoroughly be cured hypertension.
Medicine of the present invention is oral, every day 2-3 time, and each 2-3 gram finished product, 40 days is a course of treatment, and common 1-2 course of treatment is effective, and pertinacious disease needs 3-4 the course of treatment.
Clinical trial data:
Blood pressure relatively before and after the treatment: (mmHg)
After treating before the number treatment
325 diastolic pressures 172.23 ± 12.81 120.82 ± 11.51
Systolic pressure 102.35 ± 11.58 80.82 ± 11.01
Produce effects 265 examples, obvious effective rate 81.5%; Effective 59 examples, effective percentage 18.2%; Invalid 1 example, inefficiency are 0.3%.
Description of drawings
Fig. 1 is the process chart of the preparation method of the hypertensive Chinese medicine medicine of treatment.
The specific embodiment
Embodiment 1
Get Cortex Eucommiae 4g, Radix Achyranthis Bidentatae 5g, Herba Epimedii 2g, Radix Angelicae Sinensis 2g, Flos Chrysanthemi 5g, Semen Cassiae 2g, Fructus Crataegi 6g, Radix Puerariae 8g, Monas cuspurpureus Went 1g.Radix Angelicae Sinensis is put into extraction pot and extracted volatile oil, and is standby; The Radix Angelicae Sinensis medicinal residues and the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Epimedii, Flos Chrysanthemi, Semen Cassiae, Fructus Crataegi, Radix Puerariae 7 flavor medicines merge, and place multi-function extractor, and the purified water extraction of 10 times of amounts of adding medical material 2 times each 2 hours, gets extracting solution, with 200 order stainless steel sift net filtrations.Merge filtrate twice, above-mentioned filtrate is added in the concentrator concentrating under reduced pressure.60 ℃ of thickening temperatures, vacuum 0.08Mpa is concentrated into relative density and is about 1.15-1.20 (recording under 60 ℃), gets extractum.The ethanol that gained extractum is added 3 times of amounts 75% left standstill 24 hours, and it is standby to get supernatant, and residue discards.Reclaim ethanol, get thick paste.After thick paste placed sterilization vacuum drying oven (vacuum 0.08Mpa, 60 ℃) oven dry, put in the efficient universal pulverizer and pulverize, cross 80 mesh sieves, powder gets dry extract.Volatile oil and Monas cuspurpureus Went are added in the dried cream powder, to mixer, mixed 20 minutes, use dry granulation behind the mix homogeneously, cross 20 mesh sieve granulate, send subsequent processing.Can be proportionally and medical adjuvant uniform mixing commonly used, twist into pill.If or make tablet, tabletting then, coating promptly.Make various dosage forms at last, the packing warehouse-in.
Embodiment 2
Get Cortex Eucommiae 6g, Radix Achyranthis Bidentatae 8g, Herba Epimedii 4g, Radix Angelicae Sinensis 6g, Flos Chrysanthemi 7g, Semen Cassiae 6g, Fructus Crataegi 8g, Radix Puerariae 10g, Monas cuspurpureus Went 2g.Radix Angelicae Sinensis is put into extraction pot and extracted volatile oil, and is standby; The Radix Angelicae Sinensis medicinal residues and the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Epimedii, Flos Chrysanthemi, Semen Cassiae, Fructus Crataegi, Radix Puerariae 7 flavor medicines merge, and place multi-function extractor, and the purified water extraction of 10 times of amounts of adding medical material 2 times each 2 hours, gets extracting solution, with 200 order stainless steel sift net filtrations.Merge filtrate twice, above-mentioned filtrate is added in the concentrator concentrating under reduced pressure.60 ℃ of thickening temperatures, vacuum 0.08Mpa is concentrated into relative density and is about 1.15-1.20 (recording under 60 ℃), gets extractum.The ethanol that gained extractum is added 3 times of amounts 75% left standstill 24 hours, and it is standby to get supernatant, and residue discards.Reclaim ethanol, get thick paste.After thick paste placed sterilization vacuum drying oven (vacuum 0.08Mpa, 60 ℃) oven dry, put in the efficient universal pulverizer and pulverize, cross 80 mesh sieves, powder gets dry extract.Volatile oil and Monas cuspurpureus Went are added in the dried cream powder, to mixer, mixed 30 minutes, use dry granulation behind the mix homogeneously, cross 20 mesh sieve granulate, send subsequent processing.Can be proportionally and medical adjuvant uniform mixing commonly used, twist into pill.If or make tablet, tabletting then, coating promptly.Make various dosage forms at last, the packing warehouse-in.
Embodiment 3
Get Cortex Eucommiae 8g, Radix Achyranthis Bidentatae 10g, Herba Epimedii 6g, Radix Angelicae Sinensis 9g, Flos Chrysanthemi 8g, Semen Cassiae 12g, Fructus Crataegi 12g, Radix Puerariae 13g, Monas cuspurpureus Went 3g.Radix Angelicae Sinensis is put into extraction pot and extracted volatile oil, and is standby; The Radix Angelicae Sinensis medicinal residues and the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Epimedii, Flos Chrysanthemi, Semen Cassiae, Fructus Crataegi, Radix Puerariae 7 flavor medicines merge, and place multi-function extractor, and the purified water extraction of 10 times of amounts of adding medical material 2 times each 2 hours, gets extracting solution, with 200 order stainless steel sift net filtrations.Merge filtrate twice, above-mentioned filtrate is added in the concentrator concentrating under reduced pressure.60 ℃ of thickening temperatures, vacuum 0.08Mpa is concentrated into relative density and is about 1.15-1.20 (recording under 60 ℃), gets extractum.The ethanol that gained extractum is added 3 times of amounts 75% left standstill 24 hours, and it is standby to get supernatant, and residue discards.Reclaim ethanol, get thick paste.After thick paste placed sterilization vacuum drying oven (vacuum 0.08Mpa, 60 ℃) oven dry, put in the efficient universal pulverizer and pulverize, cross 80 mesh sieves, powder gets dry extract.Volatile oil and Monas cuspurpureus Went are added in the dried cream powder, to mixer, mixed 30 minutes, use dry granulation behind the mix homogeneously, cross 20 mesh sieve granulate, send subsequent processing.Can be proportionally and medical adjuvant uniform mixing commonly used, twist into pill.If or make tablet, tabletting then, coating promptly.Make various dosage forms at last, the packing warehouse-in.
Though disclosed the preferred embodiments of the present invention for explanation; but those of ordinary skill in the art understands; under the situation that does not break away from claims institute's restricted portion of the present invention and spirit, various improvement, to increase and substitute all be possible, all within protection scope of the present invention.
Claims (4)
1. treat hypertensive Chinese medicine medicine for one kind, it is characterized in that: the Chinese medicine medicine is formed as follows in weight ratio: Cortex Eucommiae 4-8g, Radix Achyranthis Bidentatae 5-10g, Herba Epimedii 2-6g, Radix Angelicae Sinensis 2-9g, Flos Chrysanthemi 5-8g, Semen Cassiae 2-12g, Fructus Crataegi 6-12g, Radix Puerariae 8-13g, Monas cuspurpureus Went 1-3g.
2. the hypertensive Chinese medicine medicine of treatment as claimed in claim 1 is characterized in that: described medicament is diffusing, sheet, ball, capsule, granule, oral liquid and honeyed pill.
3. the preparation method of the hypertensive Chinese medicine medicine of treatment as claimed in claim 1 is characterized in that: Radix Angelicae Sinensis extracts volatile oil earlier; The Radix Angelicae Sinensis medicinal residues and the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Epimedii, Flos Chrysanthemi, Semen Cassiae, Fructus Crataegi, Radix Puerariae 7 flavor medicines merge, and add 10 times of water gagings of medical material and extract twice, each two hours, filter; Merge filtrate twice; At 60 ℃, vacuum 0.08Mpa, the filtrate decompression after merging is concentrated into relative density is about 1.15-1.20, the ethanol that adds 3 times of amounts 75% left standstill 24 hours, and it is standby to get supernatant; After the supernatant oven dry, pulverize, sieve; Extracting screen underflow adds Monas cuspurpureus Went, Radix Angelicae Sinensis volatile oil mixes dry granulation after 30 minutes, granulate.
4. the preparation method of the hypertensive Chinese medicine medicine of treatment as claimed in claim 3 is characterized in that: make diffusing, sheet, ball, capsule, granule, oral liquid and honeyed pill again.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213355A (en) * | 2017-05-22 | 2017-09-29 | 刘仲永 | A kind of Chinese medicine for nursing one's health blood pressure |
| CN108310159A (en) * | 2018-04-24 | 2018-07-24 | 王岩 | A kind of plaster of blood pressure lowering and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824177A (en) * | 2005-12-23 | 2006-08-30 | 成都市圣惠堂中药科技有限公司 | Medicinal composition for treating hypertension, its preparation method and use |
| CN1907357A (en) * | 2006-08-11 | 2007-02-07 | 傅建熙 | Compound recipe pollen extract oral liquid for regulating blood pressure and blood fat, and process for preparing same |
| CN101632734A (en) * | 2009-06-11 | 2010-01-27 | 杭州六易科技有限公司 | Method for preparing compound antihypertensive tablet |
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2010
- 2010-05-10 CN CN2010101664533A patent/CN101804111B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824177A (en) * | 2005-12-23 | 2006-08-30 | 成都市圣惠堂中药科技有限公司 | Medicinal composition for treating hypertension, its preparation method and use |
| CN1907357A (en) * | 2006-08-11 | 2007-02-07 | 傅建熙 | Compound recipe pollen extract oral liquid for regulating blood pressure and blood fat, and process for preparing same |
| CN101632734A (en) * | 2009-06-11 | 2010-01-27 | 杭州六易科技有限公司 | Method for preparing compound antihypertensive tablet |
Non-Patent Citations (2)
| Title |
|---|
| 《中华中医药学会第七届全国中医心病学术研讨会（2004.安阳）论文集》 20041231 郑梅生 治疗高血压中药的研究 , 2 * |
| 《吉林医药学院学报》 20060331 徐立光 等 中药治疗高血压的概况 51-52 第27卷, 第1期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213355A (en) * | 2017-05-22 | 2017-09-29 | 刘仲永 | A kind of Chinese medicine for nursing one's health blood pressure |
| CN108310159A (en) * | 2018-04-24 | 2018-07-24 | 王岩 | A kind of plaster of blood pressure lowering and preparation method thereof |
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| Publication number | Publication date |
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| CN101804111B (en) | 2011-12-07 |
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