CN104147245B - A kind of salsola collina composition, its preparation method and its application in Weight-lossing hypolipemic medicine is prepared - Google Patents
A kind of salsola collina composition, its preparation method and its application in Weight-lossing hypolipemic medicine is prepared Download PDFInfo
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Abstract
The present invention relates to a kind of natural drug composition, its preparation method and its application in Weight-lossing hypolipemic medicine is prepared.The natural drug composition is made up of salsola collina ethanol extract, green-tea extract, red sage root leaf extract in 45: 12: 23 ratio, and said composition can lose weight and suppress the rise of blood lipid level, available for preparing Weight-lossing hypolipemic medicine.The raw material that said composition is used is cheap and easy to get, and cost is relatively low, and preparation method is simple, and therapeutic effect is good, no obvious toxic-side effects, is easy to apply and promotes.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to one kind by salsola collina ethanol extract, green tea
The natural drug composition that extract and red sage root leaf extract are constituted, the preparation method of the natural drug composition and this is natural
Application of the pharmaceutical composition in being prepared for Weight-lossing hypolipemic medicine.
Background technology
With the improvement of living standards, the shortage of change and the physical training of diet structure, high fat of blood and fat hair
Sick rate more and more higher, and it is increasingly subject to the attention of people.Obesity does not refer to simple increased weight, but body fat tissue is accumulated
Store superfluous state.According to the World Health Organization (WTO) statistics, global overweight/obesity population constantly rises, it is contemplated that arrive
Global overweight adult is up to 3,200,000,000 within 2015, and obese adults are up to 800,000,000.Investigation display, China's dyslipidemia is ill
Number is up in 11,600,000,000, the crowd of more than 35 years old has 25,000,000 people while with hypertension and hyperlipidemia.Fat and high blood
Fat can cause serious consequence, including coronary artery disease, apoplexy, diabetes B, heart failure, hypertension, reproduction and stomach and intestine
Road cancer, gall stone, fatty liver diseases.
The main fat-reducing medicament clinically applied at present includes Statins, fibrates etc., and long-term use can be produced significantly
Lungs toxicity.Conventional slimming medicine is then main to be accelerated excretion by appetite-suppressing, increase discharge rate, increase enterogastric peristalsis, increases
The approach such as heating amount consumption play a role, but have certain side effect, influence muscle power and health.Therefore, find safe and effective
Weight-reducing and lipid-lowering medicine be numerous medical personals concern focus.
Salsola collina alias pricks fluffy, pricks crowndaisy chrysanthemum, pig hair tassel, Artemisia scoparia, bright of trident, is the complete of chenopod salsola collina
Grass.Its is cool in nature sweet, and main chemical compositions include glycine betaine, butanedioic acid, oxalic acid, glycan (by arabinose, galactolipin, xylose
With galacturonic acid composition), Kaempferol and flavanolignan etc..Research find, salsola collina have it is calming the liver, relax bowel and
The effects such as decompression, clinic cures mainly hypertension, dizziness, insomnia, headache etc..Green tea be Chinese yield at most, drink it is the most extensive
A plant tea, the clear leaf of soup is green, nutritious.Scientific research result shows, the natural materials composition retained in green tea, to health care
Always, anti-cancer, anticancer, sterilization, anti-inflammatory etc. have special-effect.Modern science numerous studies confirm that tealeaves contains and human body really
The closely related biochemical of health, not only clear away heart-fire with refreshing oneself, clearing away summerheat, eliminate indigestion and phlegm, eliminating greasiness fat-reducing, relieving restlessness that clears away heart-fire,
The pharmacological actions such as removing toxic substances is sobered up, promoted the production of body fluid to quench thirst, fall fire improving eyesight, stop dysentery dehumidifying, also to modern diseases such as Radiation sickness, cardiovascular and cerebrovascular
The diseases such as disease, cancer, there is certain pharmacological effect.Red sage root leaf is the Lamiaceae Salvia platymiscium red sage root (Salvia
Miltiorrhiza Bunge.) tender leaf, it is its cold nature, bitter, nontoxic, enter the heart, the warp of liver two.Modern pharmacological research is found, red
Join leaf energy promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, nourishing blood and tranquilization, to regulation blood fat, promotes cardiovascular and cerebrovascular diseases
Recovery, improve microcirculation, resisting oxidation and delaying senility, calm the nerves profit sleep the effects such as it is obvious.
The present inventor passes through the research and experiment of substantial amounts of each formula rate, finally obtains the optimal drug ratio of the present invention
Example composition, and it is demonstrated to high fat of blood and obesity with good therapeutic effect, it this completes the present invention.
The content of the invention
First purpose of the invention is to provide a kind of natural drug composition, and the raw material of said composition is cheap and easy to get, treat
Effect is definite, safe and reliable, is easy to application, the effect with good reduction blood fat and fat-reducing.
Second purpose of the invention is the preparation method for providing above-mentioned natural drug composition.
3rd purpose of the invention is to provide application of the above-mentioned natural drug composition in lipid-lowering diet drug is prepared.
A kind of natural drug composition that the present invention is provided, is carried by salsola collina ethanol extract, green-tea extract, red sage root leaf
Thing is taken to be constituted by weight in 4-5: 1-2: 2-3 ratio.
Above-mentioned natural drug composition, wherein salsola collina ethanol extract, green-tea extract, the consumption of red sage root leaf extract
Ratio is 5: 2: 3.
Wherein, salsola collina ethanol extract, green-tea extract, red sage root leaf extract can be by as well known to those skilled in the art
Conventional method carry out purification acquisition, can also obtain identical curative effect.The method being listed below is only that inventor thinks more excellent
The method of choosing, is not intended to make special limitation to the extracting method of each composition in the natural drug composition.
Preferably, the preparation method of salsola collina ethanol extract is in above-mentioned natural drug composition：
Salsola collina is taken, be dry, pulverize, sieves, is placed in round-bottomed flask, 6-8 times is added and measures 65% ethanol, in electric jacket
Extraction 2 times is heated back, every time respectively 2h, 1h.Merging filtrate is filtered, ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure
Into dry extract, crush, cross 100 mesh sieves, as salsola collina ethanol extract.
The preparation method of green-tea extract is in above-mentioned natural drug composition：
Green tea is taken, 8-10 times is added and measures 60% ethanol, ultrasonic extraction is carried out under 50 DEG C, 80KHz supersonic frequency
60min, filters to take filtrate.Ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure into dry extract, crushed, and crosses 100 mesh sieves, i.e.,
For green-tea extract.
The preparation method of red sage root leaf extract is in above-mentioned natural drug composition：
Red sage root leaf, plus 10 times of amount distilled water immersion 30min are taken, 1.5h, silk are decocted in heating on the electric furnace for add asbestos gauge
Filtrate is filtered to take, the dregs of a decoction add 6 times of amount distilled water to decoct 1h again, with method filtering, merge filtrate twice, and heating is concentrated into small size,
Plus ethanol in proper amount makes alcohol content up to 75%, stands after 24h, Rotary Evaporators reclaim ethanol, are concentrated into thick paste, and low-temperature reduced-pressure is dried
As red sage root leaf extract.
Present invention also offers the preferred preparation method of the natural drug composition, including：
(1) preparation of salsola collina ethanol extract
Salsola collina is taken, be dry, pulverize, sieves, is placed in round-bottomed flask, 6-8 times is added and measures 65% ethanol, in electric jacket
Extraction 2 times is heated back, every time respectively 2h, 1h.Merging filtrate is filtered, ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure
Into dry extract, crush, cross 100 mesh sieves, as salsola collina ethanol extract.
(2) preparation of green-tea extract
Green tea is taken, 8-10 times is added and measures 60% ethanol, ultrasonic extraction is carried out under 50 DEG C, 80KHz supersonic frequency
60min, filters to take filtrate.Ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure into dry extract, crushed, and crosses 100 mesh sieves, i.e.,
For green-tea extract.
(3) preparation method of red sage root leaf extract is：
Red sage root leaf, plus 10 times of amount distilled water immersion 30min are taken, 1.5h, silk are decocted in heating on the electric furnace for add asbestos gauge
Filtrate is filtered to take, the dregs of a decoction add 6 times of amount distilled water to decoct 1h again, with method filtering, merge filtrate twice, and heating is concentrated into small size,
Plus ethanol in proper amount makes alcohol content up to 75%, stands after 24h, Rotary Evaporators reclaim ethanol, are concentrated into thick paste, and low-temperature reduced-pressure is dried
As red sage root leaf extract.
(4) salsola collina ethanol extract, green-tea extract, red sage root leaf extract are chosen in proportion uniformly to mix, produce.
The preparation method of natural drug composition, in addition to：By product made from step (4) using conventional capsule embedding
The capsule containing natural drug composition 200mg specifications is made in technology, or is made by wet granulation technology containing natural drug combination
The tablet of thing 200mg specifications.
Present invention additionally comprises purposes of the natural drug composition in lipid-lowering diet drug is prepared.
The instructions of taking of natural drug composition of the present invention is capsule or tablet, for each person every day 600mg, in three times after meal
Take.
Natural drug composition of the present invention having the beneficial effect that in terms of lowering blood-fat and reducing weight：
1. natural drug composition of the present invention has a good functions of lowering blood-fat and reducing weight, the raw material of said composition is cheap and easy to get,
It is determined curative effect, safe and reliable, it is easy to application.
2. salsola collina ethanol extract, green-tea extract and red sage root leaf extract are originally combined by the present inventor,
And the consumption proportion between these components is determined by many experiments, said composition has been played good synergy, synergy
Substantially, unexpected Weight-reducing and lipid-lowering effect is obtained.
Embodiment
The preparation of natural drug composition of the present invention is expanded on further below by embodiment and test example, and it is in drop
Fat promotes the beneficial effect in intestinal motility.
Embodiment
The first step：The preparation of various extracts
(1) preparation of salsola collina ethanol extract
Salsola collina is taken, be dry, pulverize, sieves, is placed in round-bottomed flask, 6-8 times is added and measures 65% ethanol, in electric jacket
Extraction 2 times is heated back, every time respectively 2h, 1h.Merging filtrate is filtered, ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure
Into dry extract, crush, cross 100 mesh sieves, as salsola collina ethanol extract.
(2) preparation of green-tea extract
Green tea is taken, 8-10 times is added and measures 60% ethanol, ultrasonic extraction is carried out under 50 DEG C, 80KHz supersonic frequency
60min, filters to take filtrate.Ethanol is reclaimed with Rotary Evaporators, concentration is dried under reduced pressure into dry extract, crushed, and crosses 100 mesh sieves, i.e.,
For green-tea extract.
(3) preparation method of red sage root leaf extract
Red sage root leaf, plus 10 times of amount distilled water immersion 30min are taken, 1.5h, silk are decocted in heating on the electric furnace for add asbestos gauge
Filtrate is filtered to take, the dregs of a decoction add 6 times of amount distilled water to decoct 1h again, with method filtering, merge filtrate twice, and heating is concentrated into small size,
Plus ethanol in proper amount makes alcohol content up to 75%, stands after 24h, Rotary Evaporators reclaim ethanol, are concentrated into thick paste, and low-temperature reduced-pressure is dried
As red sage root leaf extract.
Second step：The preparation of preparation
(1) preparation of natural drug composition capsule of the present invention
Salsola collina ethanol extract 100mg, green-tea extract 40mg and the red sage root leaf for weighing above-mentioned steps preparation respectively are carried
Thing 60mg is taken, while weighing starch 215mg, dextrin 85mg, is well mixed, is filled capsule, each pure heavy 500mg capsule is made
Agent.
(2) preparation of natural drug composition tablet of the present invention
Salsola collina ethanol extract 100mg, green-tea extract 40mg and the red sage root leaf for weighing above-mentioned steps preparation respectively are carried
Thing 60mg is taken, while weighing starch 210mg, dextrin 84mg, is well mixed, sprays into 85% ethanol wet granulation, dry, after whole grain
Add 6mg magnesium stearates to be well mixed, every pure heavy 500mg tablet is made in tabletting.
Test example 1：The pharmacodynamic study of salsola collina composition effect for reducing fat
1. test material
Salsola collina, purchased from the big pharmacy of Shandong Province Qingdao all living creatures, is identified as the herb of chenopod salsola collina
Green tea, place of production Laoshan；
Red sage root leaf, purchased from Shandong Province Mengyin County pharmaceuticals, is identified as the leaf of the labiate red sage root；
Salsola collina composition is prepared into by the embodiment above；
Simvastatin Tablets, Shandong Shandong Pharmaceutical Group；
Cleaning grade Kunming mouse, 18~22g of weight, male and female half and half are provided by medicine inspecting institute of Qingdao City animal center, are fitted
Answering property is fed to be used to test after 5~7d.
2. test method
72 mouse are randomly divided into 6 groups, every group 12, respectively blank control group, high blood lipid model group, fat-eliminating tea it is small,
Salsola collina composition group (0.5mg/10g, 1mg/10g and 2mg/10g) and Simvastatin group (10 μ g/10g).Each administration group is daily
Gavage gives relative medicine, and blank control group and high blood lipid model group give equivalent distilled water, continuous 7d.In last dose 2h
Afterwards, each group is in addition to blank control group intraperitoneal injection normal saline, and 75% egg-nog is disposably injected intraperitoneally in remaining each group
Liquid (0.1ml/10g).After 20h, each group mouse takes blood, and 3500r/min centrifugation 10min take serum, full-automatic using Hitachi 7080
Biochemical Analyzer determines T-CHOL (TC) and triglycerides (TG) content.
3. result of the test
It the results are shown in Table 1.This experiment is successfully established the acute high fat of mouse absorbability using yolk physiological saline intraperitoneal injection
Mass formed by blood stasis, model group mice serum TC and TG significantly raise (being compared P ＜ 0.01 with blank control group).Small dose of salsola collina composition
Amount group mice serum TC and TG without significant changes (being compared P ＞ 0.05 with model group), and in, under heavy dose of group then has in various degree
Drop (being compared P ＜ 0.01 with model group), dose-dependence is presented.Prompting salsola collina composition has necessarily to hyperlipemia in mice
Protective effect.
Influence of the salsola collina composition of table 1 to hyperlipemia in mice serum total cholesterol and content of triglyceride
Note：Compared with blank control group：△P ＜ 0.05,△△P ＜ 0.01；Compared with model group：*P ＜ 0.05,**P ＜
0.01；Compared with small dose group compound group：#P ＜ 0.05,##P ＜ 0.01；Compared with middle dose group compound group：$P ＜ 0.05.
Test example 2：The pharmacodynamic study of salsola collina composition fat-reducing and antihyperglycemic
1. test material
Salsola collina, purchased from the big pharmacy of Shandong Province Qingdao all living creatures, is identified as the herb of chenopod salsola collina；
Green tea, place of production Laoshan；
Red sage root leaf, purchased from Shandong Province Mengyin County pharmaceuticals, is identified as the leaf of the labiate red sage root；
Salsola collina natural drug composition is prepared into by the embodiment above；
Green source of students slim tea, Beijing Out Shure Health Care Products Co., Ltd；
Cleaning grade SD male rats, 10~11 week old, 70~90g of weight is provided by medicine inspecting institute of Qingdao City animal center,
Adaptability is fed to be used to test after 5~7d.
2. test method
Male SD rat 80 is taken, normal diet group (15) and high lipid food (80% basal feed, 10% is randomly divided into
Yolk powder and 10% lard) two groups of group (65), weigh weekly 1 time, continuous feeding 40d or so, high lipid food group rat is more general
When logical feed group rat body weight rises appreciably (t is examined, P ＜ 0.05), obesity rat model is formed.Then from high fat nutrient fodder
The larger and close obese model rat 50 of body weight is screened in group, 5 groups are randomly divided into, i.e. salsola collina natural drug composition is small
Dosage, middle dosage and heavy dose of group, green source of students slim tea (positive control) group and obese model group, every group 10, oral difference
Natural drug composition (7.5mg/100g, 15mg/100g and 30mg/100g) or green source of students slim tea (5g/100g) are gavaged, often
It 1 time, the distilled water of normal diet group (Normal group) and obese model group respectively to same volume, continuous 30d continues to give
High lipid food, and periodically weigh, rat weight after 30d takes blood system from serum, determines T-CHOL (TC) and triglycerides
(TG) content.
3. result of the test
It the results are shown in Table 2 and table 3.From table 2 it can be seen that gavaging after each group medicine, each medicine group body about since the 2nd week
Begin to decline again, average weight is less than obese model group to some extent.Especially since 24d, in, heavy dose of composition
Group rat body weight is substantially less than obese model group (P ＜ 0.01), and (the P ＞ that compared then that there was no significant difference with Normal group
0.05) its effect is suitable with green source of students slim tea, and shows dose-effect relationship.From table 3 it can be seen that gavaging salsola collina crude drug
After compositions 30d, obese rat serum total cholesterol and triglycerides have to be declined to some extent, is substantially less than fat mould
Type group (P ＜ 0.05-0.01), heavy dose group effect is most obvious, and being compared that there was no significant difference with Normal group, (P ＞ 0.05 are green
Source of students slim tea also plays the role of reduction obese rat serum total cholesterol and triglycerides.
Influence of the salsola collina composition of table 2 to obese rat body weight
Note：Compared with Normal group,*P ＜ 0.05,**P ＜ 0.01；Compared with obese model group,#P ＜ 0.05,##P ＜
0.01
Influence of the salsola collina composition of table 3 to obese rat T-CHOL and triglycerides
Note：Compared with Normal group,*P ＜ 0.05,**P ＜ 0.01；Compared with obese model group,#P ＜ 0.01
Test example 3：The studies on acute toxicity of salsola collina composition of the present invention
1. experimental animal：
Kunming mouse, 20 ± 2g of body weight, purchased from medicine inspecting institute of Qingdao City Experimental Animal Center.
2. trial drug：
The salsola collina composition of the present invention.
3. test method：
According to Ministry of Health of the People's Republic of China, Standardization Administration of China's issuing and implementation on May 1st, 2004
" acute toxicity test ", to the present invention salsola collina composition carry out acute toxicity test.Because being limited by drug concentration and volume
System, it is impossible to determine LD50, therefore use maximum tolerated dose method.Take Kunming mouse 20, male and female half and half, gavage gives 2mg/
The salsola collina composition of 10g body weight.With observation post administration mouse active state, diet, excrement, breathing, body weight and death condition, connect
Continuous observation 14d.
4. result of the test
Well-grown after the administration of each group mouse stomach, increased weight, behavior is normal, is showed no dead and abnormal response.Will
After animal is put to death, naked eyes and each main organs no abnormality seen of pathological observation change.
As a result show, salsola collina composition maximum dose oral application of the invention, to animal without obvious infringement, do not find
Toxic reaction is produced to body, is a kind of safe and reliable new Weight-lossing hypolipemic medicine composition.
Claims (2)
1. a kind of natural drug composition prepared for Weight-lossing hypolipemic medicine, it is characterised in that said composition is by salsola collina ethanol
Extract, green-tea extract, red sage root leaf extract are constituted in 4-5: 1-2: 2-3 ratio by weight；
The preparation method of wherein salsola collina ethanol extract is：
Salsola collina is taken, be dry, pulverize, sieves, is placed in round-bottomed flask, 6-8 times is added and measures 65% ethanol, is heated in electric jacket
Refluxing extraction 2 times, respectively 2h, 1h, filter merging filtrate every time, and ethanol is reclaimed with Rotary Evaporators, and concentration is dried under reduced pressure into
Dry extract, is crushed, and is crossed 100 mesh sieves, is produced；
The preparation method of wherein green-tea extract is：
Green tea is taken, 8-10 times is added and measures 60% ethanol, ultrasonic extraction 60min, mistake are carried out under 50 DEG C, 80KHz supersonic frequency
Leaching filtrate, ethanol is reclaimed with Rotary Evaporators, and concentration is dried under reduced pressure into dry extract, crushed, crosses 100 mesh sieves, produce；
The preparation method of wherein red sage root leaf extract is：
Red sage root leaf, plus 10 times of amount distilled water immersion 30min are taken, 1.5h, silk filtering are decocted in heating on the electric furnace for add asbestos gauge
Filtrate is taken, the dregs of a decoction add 6 times of amount distilled water to decoct 1h again, with method filtering, merge filtrate twice, heating concentration, plus ethanol in proper amount make
Alcohol content is stood after 24h up to 75%, is reclaimed ethanol with Rotary Evaporators, is concentrated into thick paste, low-temperature reduced-pressure is drying to obtain；
Salsola collina ethanol extract, green-tea extract are chosen in proportion uniformly to mix with red sage root leaf extract, are produced for losing weight
Natural drug composition prepared by fat-reducing medicament；
It is described to be made for natural drug composition prepared by Weight-lossing hypolipemic medicine using conventional capsule encapsulation technology containing day
The capsule of right pharmaceutical composition 200mg or 400mg specification, or 200mg containing natural drug composition is made by wet granulation technology
Or the tablet of 400mg specifications.
2. a kind of natural drug composition prepared for Weight-lossing hypolipemic medicine as claimed in claim 1, wherein salsola collina second
Alcohol extracting thing, green-tea extract, the usage ratio of red sage root leaf extract are 5: 2: 3 by weight.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509619A (en) * | 2002-12-20 | 2004-07-07 | 四川简阳翠屏湖生态资源开发有限公司 | Red rooted salvia |
| CN1608523A (en) * | 2003-10-20 | 2005-04-27 | 郑华 | Production process of fleeceflower root tea beverage |
| CN103250821A (en) * | 2013-04-17 | 2013-08-21 | 安徽省石台县日新茶叶实业有限公司 | Lipid-lowering weight reducing tea and preparation method thereof |
-
2013
- 2013-11-28 CN CN201310632279.0A patent/CN104147245B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509619A (en) * | 2002-12-20 | 2004-07-07 | 四川简阳翠屏湖生态资源开发有限公司 | Red rooted salvia |
| CN1608523A (en) * | 2003-10-20 | 2005-04-27 | 郑华 | Production process of fleeceflower root tea beverage |
| CN103250821A (en) * | 2013-04-17 | 2013-08-21 | 安徽省石台县日新茶叶实业有限公司 | Lipid-lowering weight reducing tea and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| "丹参叶中水溶性成分提取工艺研究";史国玉等;《山东中医杂志》;20120205;第31卷(第2期);第132-134页 * |
| "猪毛菜不同提取物对高血压模型大鼠血压和心率的影响";刘建学等;《食品科学》;20071115;第28卷(第11期);第558-560页 * |
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Effective date of registration: 20220718 Address after: 710016 B 1616, Tiandi Times Plaza, Fengcheng two road, Weiyang District, Xi'an, Shaanxi. Patentee after: Liu Jiaojiao Address before: Room 622, Sunshine Building, No. 10 Beijing Road, Huangdao District (former Jiaonan City), Qingdao, Shandong 266500 Patentee before: Wang Hongbo Patentee before: Gong Yanling |