CN104147245A - Salsola collina composition, preparation method of salsola collina comoposition and application of salsola collina in preparing weight-losing and lipid-lowering medicines - Google Patents
Salsola collina composition, preparation method of salsola collina comoposition and application of salsola collina in preparing weight-losing and lipid-lowering medicines Download PDFInfo
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Abstract
The invention relates to a natural medicinal composition, a preparation method of the natural medicinal composition and an application of the natural medicinal composition in preparing weight-losing and lipid-lowering medicines. The natural medicinal composition is prepared from salsola collina ethanol extract, green tea extract and salvia miltiorrhiza leaf extract in a ratio of (4-5):(1-2):(2-3), is capable of reducing body weight and inhibiting rising of the blood lipid level, and can be used for preparing weight-losing and lipid-lowering medicines. The composition is easily available in raw materials at low cost, has the advantages of low cost, simple preparation method, good treatment effect and no toxic or side effect, and is convenient for application and popularization.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to a kind of natural drug composition being made up of Herba Salsolae Collinae ethanol extraction, green tea extract and Radix Salviae Miltiorrhizae leaf extract, the preparation method of this natural drug composition and this natural drug composition are in the application for Weight-lossing hypolipemic medicine preparation.
Background technology
Along with the shortage of change and the physical training of growth in the living standard, diet structure, hyperlipidemia and fat sickness rate are more and more higher, and are day by day subject to people's attention.Obesity does not refer to that simple body weight increases, but the superfluous state of body fat tissue savings.According to the statistical data of World Health Organization (WHO) (WTO), global overweight/obesity population constantly rises, and expects global overweight adult in 2015 and will reach 3,200,000,000, and fat adult will reach 800,000,000.Investigation demonstration, China's dyslipidemia number of patients, up to 11,600,000,000, has 2,500 ten thousand people to suffer from hypertension and hyperlipemia in 35 years old above crowd simultaneously.Fat and hyperlipidemia can cause serious consequence, comprises coronary artery disease, apoplexy, type 2 diabetes mellitus, heart failure, hypertension, reproduction and gastrointestinal cancer, cholelithiasis, fatty liver diseases.
The main fat-reducing medicament of application comprises Statins, the special class of shellfish etc. clinically at present, and life-time service can produce obvious lungs toxicity.Conventional slimming medicine mainly accelerates the approach such as excretion, increase heat exhaustion by appetite-suppressing, increase output, increase enterogastric peristalsis and plays a role, but has certain side effect, affects physical and healthy.Therefore, finding Weight-reducing and lipid-lowering medicine is safely and effectively the focus that vast medical worker pays close attention to.
Herba Salsolae Collinae another name is pricked fluffy, is pricked Herba Artemisiae Sieversianae, bright of Pilus Sus domestica tassel, Artemisia scoparia, trident, is the herb of chenopod Herba Salsolae Collinae.Its sweet in the mouth cool in nature, main chemical compositions comprises betanin, succinic acid, oxalic acid, polysaccharide (being made up of arabinose, galactose, xylose and galacturonic acid), nimbecetin and flavanolignan etc.Research finds, Herba Salsolae Collinae has the effects such as suppressing the hyperactive liver and subsiding YANG, loosening bowel to relieve constipation and blood pressure lowering, clinically cures mainly hypertension, dizzy, insomnia, headache etc.Green tea be Chinese output at most, drink the most a kind of tea, the clear leaf of soup is green, nutritious.Scientific research result shows, the natural materials composition retaining in green tea all has special-effect to anti-aging, anti-cancer, anticancer, sterilization, antiinflammatory etc.Modern science studies confirm that in a large number, Folium Camelliae sinensis contains and the closely-related biochemical of health really, not only having refreshes oneself clears away heart-fire, clearing away summer-heat, eliminate indigestion and phlegm, go greasy fat-reducing, the pharmacological action such as the relieving restlessness that clears away heart-fire, removing toxic substances relieving alcoholic intoxication, promoting the production of body fluid to quench thirst, pathogenic fire reducing improving eyesight, dysentery relieving dehumidifying, also to modern disease as diseases such as Radiation sickness, cardiovascular and cerebrovascular disease, cancers, have certain pharmacological effect.Radix Salviae Miltiorrhizae leaf is the tender leaf of Labiatae salvia Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge.), and its cold nature, bitter in the mouth, nontoxic enter the heart, liver two warps.Modern pharmacological research is found, Radix Salviae Miltiorrhizae leaf energy promoting blood flow to regulate menstruation, and stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind, to regulating blood fat, promotes the recovery of cardiovascular and cerebrovascular disease, improves microcirculation, resisting oxidation and delaying senility, the effects such as the profit of calming the nerves dormancy are obvious.
The inventor, through research and the experiment of a large amount of each formula proportion, has finally obtained optimal drug ratio compositions of the present invention, and has proved that it has good therapeutic effect to hyperlipidemia and obesity, has completed the present invention thus.
Summary of the invention
First object of the present invention is to provide a kind of natural drug composition, and the raw material of said composition is cheap and easy to get, determined curative effect, safe and reliable, is convenient to application, has good reduction blood fat and the effect of fat-reducing.
Second object of the present invention is to provide the preparation method of above-mentioned natural drug composition.
The 3rd object of the present invention is to provide the application of above-mentioned natural drug composition in preparation lipid-lowering diet drug.
A kind of natural drug composition provided by the invention, by Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract by weight in 4-5: the ratio of 1-2: 2-3 forms.
Above-mentioned natural drug composition, wherein the usage ratio of Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract is 5: 2: 3.
Wherein, Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract can, by well known to a person skilled in the art the conventional method acquisition of purifying, also can obtain identical curative effect.The method of below listing is only that inventor thinks and preferred method is not intended to the extracting method of each composition in this natural drug composition to make special restriction.
Preferably, in above-mentioned natural drug composition, the preparation method of Herba Salsolae Collinae ethanol extraction is:
Get Herba Salsolae Collinae, dry, pulverize, sieve, be placed in round-bottomed flask, add 6-8 doubly to measure 65% ethanol, in electric jacket, heat back and extract 2 times, be respectively 2h, 1h at every turn.Filter merging filtrate, reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is Herba Salsolae Collinae ethanol extraction.
In above-mentioned natural drug composition, the preparation method of green tea extract is:
Get green tea, add 8-10 doubly to measure 60% ethanol, at 50 DEG C, under the supersonic frequency of 80KHz, carry out supersound extraction 60min, cross leaching filtrate.Reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is green tea extract.
In above-mentioned natural drug composition, the preparation method of Radix Salviae Miltiorrhizae leaf extract is:
Get Radix Salviae Miltiorrhizae leaf, add 10 times of amount distilled water immersion 30min, on the electric furnace that adds asbestos gauge, heating decocts 1.5h, silk is crossed leaching filtrate, medicinal residues add 6 times of amount distilled water again and decoct 1h, filter with method, merge twice filtrate, heating is concentrated into small size, add appropriate ethanol and make to reach 75% containing alcohol amount, leave standstill after 24h, Rotary Evaporators reclaims ethanol, be concentrated into thick paste, the dry Radix Salviae Miltiorrhizae leaf extract that is of low-temperature reduced-pressure.
The present invention also provides the preferred preparation method of this natural drug composition, comprising:
(1) preparation of Herba Salsolae Collinae ethanol extraction
Get Herba Salsolae Collinae, dry, pulverize, sieve, be placed in round-bottomed flask, add 6-8 doubly to measure 65% ethanol, in electric jacket, heat back and extract 2 times, be respectively 2h, 1h at every turn.Filter merging filtrate, reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is Herba Salsolae Collinae ethanol extraction.
(2) preparation of green tea extract
Get green tea, add 8-10 doubly to measure 60% ethanol, at 50 DEG C, under the supersonic frequency of 80KHz, carry out supersound extraction 60min, cross leaching filtrate.Reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is green tea extract.
(3) preparation method of Radix Salviae Miltiorrhizae leaf extract is:
Get Radix Salviae Miltiorrhizae leaf, add 10 times of amount distilled water immersion 30min, on the electric furnace that adds asbestos gauge, heating decocts 1.5h, silk is crossed leaching filtrate, medicinal residues add 6 times of amount distilled water again and decoct 1h, filter with method, merge twice filtrate, heating is concentrated into small size, add appropriate ethanol and make to reach 75% containing alcohol amount, leave standstill after 24h, Rotary Evaporators reclaims ethanol, be concentrated into thick paste, the dry Radix Salviae Miltiorrhizae leaf extract that is of low-temperature reduced-pressure.
(4) choose in proportion Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract and evenly mix, to obtain final product.
The preparation method of natural drug composition, also comprise: the product that step (4) is made adopts conventional capsule encapsulation technology to make the capsule that contains natural drug composition 200mg specification, or makes the tablet containing natural drug composition 200mg specification by wet granulation technology.
The present invention also comprises the purposes of natural drug composition in preparation lipid-lowering diet drug.
The instructions of taking of natural drug composition of the present invention is capsule or tablet, 600mg for each person every day, point three one after each meals.
The beneficial effect of natural drug composition of the present invention aspect lowering blood-fat and reducing weight is as follows:
1. natural drug composition of the present invention has good functions of lowering blood-fat and reducing weight, and the raw material of said composition is cheap and easy to get, determined curative effect, safe and reliable, is convenient to application.
2. the inventor combines Herba Salsolae Collinae ethanol extraction, green tea extract and Radix Salviae Miltiorrhizae leaf extract originally, and determine the consumption proportion between these components by great many of experiments, make said composition bring into play good synergism, potentiation is obvious, obtains unexpected Weight-reducing and lipid-lowering effect.
Detailed description of the invention
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and promote the beneficial effect in intestinal motility in blood fat reducing.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Herba Salsolae Collinae ethanol extraction
Get Herba Salsolae Collinae, dry, pulverize, sieve, be placed in round-bottomed flask, add 6-8 doubly to measure 65% ethanol, in electric jacket, heat back and extract 2 times, be respectively 2h, 1h at every turn.Filter merging filtrate, reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is Herba Salsolae Collinae ethanol extraction.
(2) preparation of green tea extract
Get green tea, add 8-10 doubly to measure 60% ethanol, at 50 DEG C, under the supersonic frequency of 80KHz, carry out supersound extraction 60min, cross leaching filtrate.Reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, is green tea extract.
(3) preparation method of Radix Salviae Miltiorrhizae leaf extract
Get Radix Salviae Miltiorrhizae leaf, add 10 times of amount distilled water immersion 30min, on the electric furnace that adds asbestos gauge, heating decocts 1.5h, silk is crossed leaching filtrate, medicinal residues add 6 times of amount distilled water again and decoct 1h, filter with method, merge twice filtrate, heating is concentrated into small size, add appropriate ethanol and make to reach 75% containing alcohol amount, leave standstill after 24h, Rotary Evaporators reclaims ethanol, be concentrated into thick paste, the dry Radix Salviae Miltiorrhizae leaf extract that is of low-temperature reduced-pressure.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule of the present invention
Take respectively Herba Salsolae Collinae ethanol extraction 100mg, green tea extract 40mg and Radix Salviae Miltiorrhizae leaf extract 60mg prepared by above-mentioned steps, take starch 215mg, dextrin 85mg simultaneously, mix homogeneously, filled capsules, makes the capsule of each pure heavy 500mg.
(2) preparation of natural drug composition tablet of the present invention
Take respectively Herba Salsolae Collinae ethanol extraction 100mg, green tea extract 40mg and Radix Salviae Miltiorrhizae leaf extract 60mg prepared by above-mentioned steps, take starch 210mg, dextrin 84mg simultaneously, mix homogeneously, spray into 85% ethanol wet granulation, dry, after granulate, add 6mg magnesium stearate mix homogeneously, tabletting, makes the tablet of every pure heavy 500mg.
Test example 1: the pharmacodynamic study of Herba Salsolae Collinae compositions effect for reducing fat
1. test material
Herba Salsolae Collinae, purchased from the large pharmacy of Qingdao, Shandong Province all living creatures, through being accredited as the herb of chenopod Herba Salsolae Collinae
Green tea, place of production Laoshan;
Radix Salviae Miltiorrhizae leaf, purchased from Mengyin County, Shandong Province pharmaceuticals, through being accredited as the leaf of labiate Radix Salviae Miltiorrhizae;
Be prepared into Herba Salsolae Collinae compositions by above-mentioned embodiment;
Simvastatin sheet, the anti-Pharmaceutical Group in Shandong, Shandong;
A clean level Kunming mouse, weight 18～22g, male and female half and half, are provided by medicine inspecting institute of Qingdao City animal center, and adaptability is fed after 5～7d for experiment.
2. test method
72 mices are divided into 6 groups at random, 12 every group, are respectively that blank group, high blood lipid model group, fat-eliminating tea are little, Herba Salsolae Collinae compositions group (0.5mg/10g, 1mg/10g and 2mg/10g) and simvastatin group (10 μ g/10g).Each administration group gavage every day gives relative medicine, and blank group and high blood lipid model group give equivalent distilled water, continuously 7d.After last administration 2h, each group except blank group lumbar injection equivalent normal saline, all disposable lumbar injection 75% egg yolk emulsions (0.1ml/10g) of all the other each groups.After 20h, respectively organize mice and get blood, the centrifugal 10min of 3500r/min, gets serum, adopts Hitachi's 7080 automatic clinical chemistry analyzers to measure T-CHOL (TC) and triglyceride (TG) content.
3. result of the test
The results are shown in Table 1.This experiment adopts egg yolk normal saline intraperitoneal injection successfully to set up mice absorbability acute hyperlipemia, and model group mice serum TC and TG all significantly raise (comparing P < 0.01 with blank group).Herba Salsolae Collinae compositions small dose group mice serum TC and TG are without significant change (with relatively P > 0.05 of model group), in, heavy dose of group has in various degree decline (with relatively P < 0.01 of model group), presents dose-dependence.Prompting Herba Salsolae Collinae compositions has certain protective effect to hyperlipemia in mice.
The impact of table 1 Herba Salsolae Collinae compositions on hyperlipemia in mice serum total cholesterol and content of triglyceride
Note: with the comparison of blank group:
△p < 0.05,
△ △p < 0.01; With model group comparison:
*p < 0.05,
*p < 0.01; With the comparison of small dose group compound group:
#p < 0.05,
##p < 0.01; With the comparison of middle dosage composition group:
$p < 0.05.
Test example 2: the pharmacodynamic study of Herba Salsolae Collinae compositions fat-reducing and antihyperglycemic
1. test material
Herba Salsolae Collinae, purchased from the large pharmacy of Qingdao, Shandong Province all living creatures, through being accredited as the herb of chenopod Herba Salsolae Collinae;
Green tea, place of production Laoshan;
Radix Salviae Miltiorrhizae leaf, purchased from Mengyin County, Shandong Province pharmaceuticals, through being accredited as the leaf of labiate Radix Salviae Miltiorrhizae;
Be prepared into Herba Salsolae Collinae natural drug composition by above-mentioned embodiment;
Green source of students diet tea, Beijing Out Shure Health Care Products Co., Ltd;
A clean level SD male rat, in 10～11 weeks age, weight 70～90g, is provided by medicine inspecting institute of Qingdao City animal center, and adaptability is fed after 5～7d for testing.
2. test method
Get 80 of male SD rats, be divided at random two groups of normal diet group (15) and high lipid food (80% normal feedstuff, 10% yolk powder and 10% Adeps Sus domestica) groups (65), weigh weekly 1 time, feed 40d left and right continuously, (t inspection when high lipid food group rat rises appreciably compared with normal diet group rat body weight, P < 0.05), obesity rat model forms.Then from high fat nutrient fodder group, screen 50 of the larger and approaching obese model rats of body weight, be divided at random 5 groups, it is Herba Salsolae Collinae natural drug composition low dose, middle dosage and heavy dose of group, green source of students diet tea (positive control) group and obese model group, every group 10, per os gavages respectively natural drug composition (7.5mg/100g, 15mg/100g and 30mg/100g) or green source of students diet tea (5g/100g), every day 1 time, normal diet group (Normal group) and obese model group are given respectively the distilled water of same volume, 30d continuously, continue to give high lipid food, and regularly weigh, after 30d, rat is weighed, get blood separation of serum, measure T-CHOL (TC) and triglyceride (TG) content.
3. result of the test
The results are shown in Table 2 and table 3.As can be seen from Table 2, gavage after each group of medicine, approximately since the 2nd week, each medicine group body weight started to decline, and average body weight average is to some extent lower than obese model group.Especially since 24d, in, heavy dose of compositions group rat body weight is significantly lower than obese model group (P < 0.01), more there was no significant difference (P > 0.05) its effect is suitable with green source of students diet tea with Normal group, and shows dose-effect relationship.As can be seen from Table 3, gavage after Herba Salsolae Collinae natural drug composition 30d, obese rat serum total cholesterol and triglyceride all have decline to some extent, significantly lower than obese model group (P < 0.05-0.01), heavy dose of group effect is the most obvious, and (the green source of students diet tea of P > 0.05 also has the effect that reduces obese rat serum total cholesterol and triglyceride to compare there was no significant difference with Normal group.
The impact of table 2 Herba Salsolae Collinae compositions on obese rat body weight
Note: with Normal group comparison,
*p < 0.05,
*p < 0.01; With the comparison of obese model group,
#p < 0.05,
##p < 0.01
The impact of table 3 Herba Salsolae Collinae compositions on obese rat T-CHOL and triglyceride
Note: with Normal group comparison,
*p < 0.05,
*p < 0.01; With the comparison of obese model group,
#p < 0.01
Test example 3: the studies on acute toxicity of Herba Salsolae Collinae compositions of the present invention
1. experimental animal:
Kunming mouse, body weight 20 ± 2g, purchased from medicine inspecting institute of Qingdao City Experimental Animal Center.
2. trial drug:
Herba Salsolae Collinae compositions of the present invention.
3. test method:
According to " acute toxicity test " of Ministry of Health of the People's Republic of China, Standardization Administration of China's issuing and implementation on May 1st, 2004, Herba Salsolae Collinae compositions of the present invention is carried out to acute toxicity test.Because being subject to drug level and volume restrictions, cannot measure LD50, therefore adopt maximum tolerated dose method.Get 20 of Kunming mouses, male and female half and half, gavage gives the Herba Salsolae Collinae compositions of 2mg/10g body weight.With observation post administration mice active state, diet, feces, breathing, body weight and death condition, Continuous Observation 14d.
4. result of the test
Well-grown after the administration of each group mouse stomach, body weight increases, and behavior is normal, is showed no death and abnormal response.By after sacrifice of animal, the each main organs no abnormality seen of naked eyes and pathological observation changes.
Result shows, Herba Salsolae Collinae compositions maximal dose oral application of the present invention, is not found body to produce toxic reaction without obvious damage to animal, is a kind of safe and reliable novel Weight-lossing hypolipemic medicine compositions.
Claims (5)
1. can be used for a natural drug composition prepared by Weight-lossing hypolipemic medicine, it is characterized in that said composition by Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract by weight in 4-5: the ratio of 1-2: 2-3 forms;
Wherein the preparation method of Herba Salsolae Collinae ethanol extraction is:
Get Herba Salsolae Collinae, dry, pulverize, sieve, be placed in round-bottomed flask, add 6-8 doubly to measure 65% ethanol, in electric jacket, heat back and extract 2 times, be respectively 2h, 1h at every turn.Filter merging filtrate, reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, to obtain final product;
Wherein the preparation method of green tea extract is:
Get green tea, add 8-10 doubly to measure 60% ethanol, at 50 DEG C, under the supersonic frequency of 80KHz, carry out supersound extraction 60min, cross leaching filtrate.Reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, to obtain final product;
Wherein the preparation method of Radix Salviae Miltiorrhizae leaf extract is:
Get Radix Salviae Miltiorrhizae leaf, add 10 times of amount distilled water immersion 30min, on the electric furnace that adds asbestos gauge, heating decocts 1.5h, silk is crossed leaching filtrate, medicinal residues add 6 times of amount distilled water again and decoct 1h, filter with method, merge twice filtrate, heating is concentrated into small size, add appropriate ethanol and make to reach 75% containing alcohol amount, leave standstill after 24h, Rotary Evaporators reclaims ethanol, be concentrated into thick paste, low-temperature reduced-pressure is drying to obtain.
2. natural drug composition as claimed in claim 1, wherein the usage ratio of Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract is 5: 2: 3.
3. the preparation method of natural drug composition as claimed in claim 1 or 2, is characterized in that the method comprises:
(1) preparation of Herba Salsolae Collinae ethanol extraction
Get Herba Salsolae Collinae, dry, pulverize, sieve, be placed in round-bottomed flask, add 6-8 doubly to measure 65% ethanol, in electric jacket, heat back and extract 2 times, be respectively 2h, 1h at every turn.Filter merging filtrate, reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, to obtain final product;
(2) preparation of green tea extract
Get green tea, add 8-10 doubly to measure 60% ethanol, at 50 DEG C, under the supersonic frequency of 80KHz, carry out supersound extraction 60min, cross leaching filtrate.Reclaim ethanol with Rotary Evaporators, concentrated, drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves, to obtain final product;
(3) preparation of Radix Salviae Miltiorrhizae leaf extract
Get Radix Salviae Miltiorrhizae leaf, add 10 times of amount distilled water immersion 30min, on the electric furnace that adds asbestos gauge, heating decocts 1.5h, silk is crossed leaching filtrate, medicinal residues add 6 times of amount distilled water again and decoct 1h, filter with method, merge twice filtrate, heating is concentrated into small size, add appropriate ethanol and make to reach 75% containing alcohol amount, leave standstill after 24h, Rotary Evaporators reclaims ethanol, be concentrated into thick paste, low-temperature reduced-pressure is drying to obtain.
(4) choose in proportion Herba Salsolae Collinae ethanol extraction, green tea extract, Radix Salviae Miltiorrhizae leaf extract and evenly mix, to obtain final product.
4. the preparation method of natural drug composition as claimed in claim 3, also comprise: the product that step (4) is made adopts conventional capsule encapsulation technology to make the capsule that contains natural drug composition 200mg or 400mg specification, or makes the tablet containing natural drug composition 200mg or 400mg specification by wet granulation technology.
5. the natural drug composition as described in claim 1-2 any one is in the purposes of preparing in Weight-lossing hypolipemic medicine.
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