CN107440932B - Skin care product composition containing folic acid, facial mask and preparation method of facial mask - Google Patents
Skin care product composition containing folic acid, facial mask and preparation method of facial mask Download PDFInfo
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- CN107440932B CN107440932B CN201710685496.4A CN201710685496A CN107440932B CN 107440932 B CN107440932 B CN 107440932B CN 201710685496 A CN201710685496 A CN 201710685496A CN 107440932 B CN107440932 B CN 107440932B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention provides a skin care composition containing folic acid, which comprises the following components: 0.001 to 1 part by weight of folic acid and/or folic acid derivatives and x parts by weight of branched amino acids; x is greater than 0 and less than or equal to 5. Compared with the prior art, the folic acid and/or folic acid derivatives and branched chain amino acid in a specific ratio are combined, and the obtained skin care product composition has a good effect by utilizing the synergistic effect of the components; the branched chain amino acid is the most effective nutritional supplement important for human bodies, can enable organisms to naturally strengthen muscles or obtain more energy without any side effect, can enter the skin through the horny layer to provide cell energy, can supply folic acid and/or folic acid derivatives to repair damaged DNA energy, exerts a DNA protection effect, promotes collagen to enhance the level of cell energy supply, effectively shortens the time of cell repair, and greatly improves the bioavailability of folic acid.
Description
Technical Field
The invention relates to the technical field of daily necessities, in particular to a folic acid-containing skin care product composition, a facial mask and a preparation method thereof.
Background
Folic acid is an efficient skin care component, can combine water which is 5000 times of the self weight of the folic acid, has good moisturizing performance, can promote the generation of natural moisturizing factors NMF in skin cutin so as to form a protective film, can reduce the percutaneous water loss under the condition of not changing sebum secretion, and ensures that the skin recovers tender and smooth. In addition, folic acid has strong promotion effect on physiological processes such as DNA synthesis, cell metabolism and the like, and can promote DNA chain scission to be recombined, so that skin injury caused by ultraviolet rays is effectively repaired, the skin is restored to be smooth, and the softness and elasticity are regained. Moreover, the red blood cells in the human body are renewed about once every four months, and if folic acid is lacked, the generation of the red blood cells is disturbed, so that the volume of the red blood cells is increased and decreased, and the symptoms of pale face and the like are further caused. In conclusion, the folic acid can be added into the facial mask to moisten and nourish the facial skin, thereby achieving the effect of improving the skin quality.
However, the use of folic acid alone is inefficient and often requires the addition of large amounts of folic acid.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a skin care product composition containing folic acid, a facial mask and a preparation method thereof.
The invention provides a skin care composition containing folic acid, which comprises the following components:
0.001 to 1 part by weight of folic acid and/or folic acid derivatives and x parts by weight of branched amino acids; x is greater than 0 and less than or equal to 15.
Preferably, the branched chain amino acid is selected from one or more of leucine, isoleucine and valine.
Preferably, the folic acid derivative is selected from tetrahydrofolic acid, 5-methyltetrahydrofolic acid, 6-S-5-methyltetrahydrofolic acid, leucovorin, calcium folinate or calcium levofolinate.
Preferably, the method comprises the following steps:
0.001 to 1 part by weight of folic acid and/or folic acid derivatives;
0 to 5 parts by weight of leucine;
0-5 parts by weight of isoleucine;
0 to 5 parts by weight of valine;
and the content of leucine, isoleucine and valine is not 0 at the same time.
The invention also provides the application of the composition in preparing cosmetics.
The invention also provides a cosmetic comprising the composition.
Preferably, the cosmetic is a mask, cream or milk.
The invention also provides a mask, which comprises a solvent and the following components:
x is greater than 0 and less than or equal to 15.
Preferably, the skin conditioning agent is selected from one or more of cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, amaranthus caudatus seed extract, ulmus pumila root extract, p-hydroxyacetophenone, panthenol, allantoin, shea butter, polyglycerol-10 oleate, hydrogenated lecithin, dipotassium glycyrrhizinate, and creatine;
the pH value regulator is selected from one or more of tromethamine, sodium hydroxide, potassium hydroxide, arginine and triethanolamine;
the chelating agent is selected from one or more of trisodium EDTA, disodium EDTA and tetrasodium EDTA;
the humectant is selected from one or more of glycerol, betaine, butanediol, sodium hyaluronate, 1, 2-hexanediol, methyl propylene glycol, glyceryl polyether-26, propylene glycol, polyglycerol-10 and luba gum oil;
the surfactant is selected from PEG-60 hydrogenated castor oil and/or acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;
the aromatic is selected from essence and/or essential oil;
the thickening agent is selected from one or more of xanthan gum, carrageen crispus, hydroxyethyl cellulose and carbomer;
the solvent is water.
The invention also provides a preparation method of the facial mask, which comprises the following steps:
mixing a solvent, 0.001-1 part by weight of folic acid and/or folic acid derivatives, x part by weight of branched chain amino acid, 2-30 parts by weight of a skin conditioner, 0-5 parts by weight of a pH regulator, 0.05-0.1 part by weight of a chelating agent, 1-20 parts by weight of a humectant, 0.1-5 parts by weight of a surfactant, 0-0.5 part by weight of an aromatic and 0.05-5 parts by weight of a thickener to obtain a mask; x is greater than 0 and less than or equal to 15. .
Compared with the prior art, the invention provides a skin care product composition containing folic acid, which comprises the following components: 0.001 to 1 part by weight of folic acid and/or folic acid derivatives and x parts by weight of branched amino acids; x is greater than 0 and less than or equal to 5. According to the invention, the folic acid and/or folic acid derivatives and the branched chain amino acid are combined according to a specific proportion, and the synergistic interaction of the components is utilized, so that the obtained skin care product composition has a good effect; the branched chain amino acid is the most effective nutritional supplement important for human bodies, can enable organisms to naturally strengthen muscles or obtain more energy without any side effect, can enter the skin through the horny layer to provide cell energy, can supply folic acid and/or folic acid derivatives to repair damaged DNA energy, exerts a DNA protection effect, promotes collagen to enhance the level of cell energy supply, effectively shortens the time of cell repair, and greatly improves the bioavailability of folic acid.
Detailed Description
The invention provides a skin care composition containing folic acid, which comprises the following components:
0.001 to 1 part by weight of folic acid and/or folic acid derivatives and x parts by weight of branched amino acids; x is greater than 0 and less than or equal to 15.
The skin care composition provided by the invention comprises 0.001-1 part by weight of folic acid and/or folic acid derivatives, preferably comprises 0.001-0.5 part by weight of folic acid and/or folic acid derivatives, and more preferably comprises 0.001-0.1 part by weight of folic acid and/or folic acid derivatives; in some embodiments provided herein, the folic acid and/or folic acid derivatives are preferably present in an amount of 0.001 parts by weight; in some embodiments provided herein, the folic acid and/or folic acid derivatives are preferably present in an amount of 0.01 parts by weight; in some embodiments provided herein, the folic acid and/or folic acid derivatives are preferably present in an amount of 0.1 parts by weight; in other embodiments provided herein, the folic acid and/or folic acid derivatives are preferably present in an amount of 1 part by weight; the folic acid derivative is not particularly limited as long as it is a folic acid derivative known to those skilled in the art, but in the present invention, tetrahydrofolic acid, 5-methyltetrahydrofolic acid, 6-S-5-methyltetrahydrofolic acid, leucovorin, calcium folinate, or calcium levofolinate is preferable.
The skin care composition provided by the invention comprises x parts by weight of branched-chain amino acid, wherein x is more than 0 and less than or equal to 15, preferably comprises 0.05-15 parts by weight of branched-chain amino acid, more preferably comprises 0.05-10 parts by weight of branched-chain amino acid, still more preferably comprises 0.05-6 parts by weight of branched-chain amino acid, and most preferably comprises 4-5 parts by weight of branched-chain amino acid; the branched-chain amino acid is a branched-chain amino acid well known to those skilled in the art, and is not particularly limited, and in the present invention, a branched-chain amino acid is preferably a branched-chain amino acid among essential amino acids, and more preferably one or more of leucine, isoleucine, and valine; in this case, the skin care composition provided by the present invention preferably includes: 0.001 to 1 part by weight of folic acid and/or folic acid derivatives; 0 to 5 parts by weight of leucine; 0-5 parts by weight of isoleucine; 0 to 5 parts by weight of valine; and the content of leucine, isoleucine and valine is not 0 at the same time; in some embodiments provided herein, the leucine is preferably present in an amount of 1.099 parts by weight; in some embodiments provided herein, the leucine is preferably present in an amount of 2 parts by weight; in some embodiments provided herein, the leucine is preferably present in an amount of 3 parts by weight; in some embodiments provided herein, the leucine is preferably present in an amount of 0 parts by weight; in other embodiments provided herein, the leucine is preferably present in an amount of 5 parts by weight; in some embodiments provided herein, the isoleucine is preferably present in an amount of 2 parts by weight; in some embodiments provided herein, the isoleucine is preferably present in an amount of 3 parts by weight; in some embodiments provided herein, the isoleucine is preferably present in an amount of 1 part by weight; in some embodiments provided herein, the isoleucine is preferably present in an amount of 0 parts by weight; in other embodiments provided herein, the isoleucine is preferably present in an amount of 5 parts by weight; in some embodiments provided herein, the valine is preferably present in an amount of 2 parts by weight; in some embodiments provided herein, the valine is preferably present in an amount of 0 parts by weight; in some embodiments provided herein, the valine is preferably present in an amount of 1.1 parts by weight; in some embodiments provided herein, the valine is preferably present in an amount of 4.09 parts by weight; in some embodiments provided herein, the valine is preferably present in an amount of 5 parts by weight. According to the invention, the obtained skin care product composition has a good effect by combining the folic acid and/or the folic acid derivative and the branched chain amino acid with a specific proportion and utilizing the synergistic interaction of the components; the branched chain amino acid is the most effective nutritional supplement important for human bodies, can enable organisms to naturally strengthen muscles or obtain more energy without any side effect, can enter the skin through the horny layer to provide cell energy, can supply folic acid and/or folic acid derivatives to repair damaged DNA energy, exerts a DNA protection effect, promotes collagen to enhance the level of cell energy supply, effectively shortens the time of cell repair, and greatly improves the bioavailability of folic acid.
The skin care composition provided by the invention can also comprise auxiliary materials acceptable in skin care products, or comprise other components and auxiliary agents which are well known to those skilled in the art and can be used for skin care.
The invention provides application of the skin care product composition containing folic acid in preparation of cosmetics.
The invention also provides a cosmetic comprising the skin care composition in any one of the technical schemes.
Preferably, the cosmetic is a mask, cream or milk.
Wherein the cream is preferably a facial cream; the milk is preferably body milk.
While specific bases for creams and body milks may be well known to those skilled in the art, the inventors are not limited thereto.
The invention provides a facial mask, which comprises a solvent and the following components:
x is greater than 0 and less than or equal to 15.
Wherein the folic acid and/or folic acid derivatives and the branched chain amino acids are the same as described above and are not repeated herein.
In the mask provided by the invention, the content of the folic acid and/or the folic acid derivative is preferably 0.01-1 part by weight, more preferably 0.01-0.5 part by weight, and most preferably 0.01-0.1 part by weight; the content of the branched chain amino acid is preferably 0.05 to 5 parts by weight, more preferably 0.05 to 3 parts by weight, and most preferably 0.07 to 0.1 part by weight.
The folic acid, the folic acid derivatives and the branched chain amino acids are added at low temperature during the preparation process.
According to the invention, the content of the skin conditioner is preferably 2 to 25 parts by weight, more preferably 2 to 20 parts by weight, still more preferably 2 to 10 parts by weight, still more preferably 2 to 5 parts by weight, and most preferably 2.32 to 5 parts by weight; the skin conditioning agent is not particularly limited as long as it is well known to those skilled in the art, and in the present invention, one or more of cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, amaranthus caudatus seed extract, ulmus pumila root extract, p-hydroxyacetophenone, panthenol, allantoin, shea butter, polyglycerol-10 oleate, hydrogenated lecithin, dipotassium glycyrrhizinate, and creatine are preferable.
The cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, Amaranthus caudatus seed extract and Ulmus pumila root extract are added at low temperature during preparation; the hydroxyacetophenone and the panthenol are added at a high temperature in the preparation process; the allantoin is added at elevated temperature during the preparation process.
The content of the pH regulator is preferably 0.01 to 4 parts by weight, more preferably 0.01 to 3 parts by weight, still more preferably 0.01 to 2 parts by weight, still more preferably 0.01 to 0.1 part by weight, and most preferably 0.012 to 0.03 part by weight; the pH adjuster is not particularly limited as long as it is well known to those skilled in the art, and in the present invention, one or more of tromethamine, sodium hydroxide, potassium hydroxide, arginine, and triethanolamine are preferable.
The tromethamine is added under the condition of medium-high temperature in the preparation process.
The content of the chelating agent is preferably 0.05-0.08 weight part, and more preferably 0.05-0.06 weight part; the chelating agent is not particularly limited as long as it is a chelating agent well known to those skilled in the art, and in the present invention, one or more of trisodium EDTA, disodium EDTA, and tetrasodium EDTA are preferable.
The trisodium EDTA is added in the preparation process under the condition of high temperature.
The content of the humectant is preferably 5-20 parts by weight, more preferably 10-20 parts by weight, still more preferably 13-16 parts by weight, and most preferably 14.17-15 parts by weight; the humectant is well known to those skilled in the art, and is not particularly limited, and in the present invention, one or more of glycerin, betaine, butylene glycol, sodium hyaluronate, 1, 2-hexanediol, methyl propylene glycol, glyceryl polyether-26, propylene glycol, polyglycerin-10, and luba gum oil are preferable.
The glycerol, the betaine, the butanediol, the sodium hyaluronate, the 1, 2-hexanediol and the methyl propylene glycol are added under the condition of high temperature in the preparation process.
The content of the surfactant is preferably 0.1 to 2 parts by weight, more preferably 0.1 to 1 part by weight, still more preferably 0.2 to 0.5 part by weight, and most preferably 0.35 to 0.4 part by weight; the surfactant is not particularly limited as long as it is well known to those skilled in the art, and PEG-60 hydrogenated castor oil and/or acrylic/C10-30 alkanol acrylate crosspolymer is preferred in the present invention.
The PEG-60 hydrogenated castor oil is added under the condition of medium and high temperature in the preparation process; the acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer is added under the condition of high temperature in the preparation process.
The content of the aromatic is preferably 0 to 0.3 part by weight, more preferably 0.1 to 0.2 part by weight, and still more preferably 0.15 part by weight; the aromatic may be one known to those skilled in the art, and is not particularly limited, and in the present invention, essence and/or essential oil is preferable.
The essence and the essential oil are added at low temperature in the preparation process.
The content of the thickener is preferably 0.05 to 3 parts by weight, more preferably 0.1 to 2 parts by weight, still more preferably 0.1 to 1 part by weight, still more preferably 0.1 to 0.5 part by weight, and most preferably 0.15 to 0.2 part by weight; the thickener is not particularly limited as long as it is well known to those skilled in the art, and in the present invention, one or more of xanthan gum, carrageen, hydroxyethyl cellulose and carbomer are preferable.
The xanthan gum and the carrageen are added under the condition of high temperature in the preparation process.
The solvent is not particularly limited as long as it is well known to those skilled in the art, and in the present invention, water is preferred; the amount of the solvent is preferably such that the above components are 100 parts by weight to make up.
According to the facial mask provided by the invention, the folic acid and/or folic acid derivatives and branched chain amino acid are combined according to a specific proportion, and the obtained facial mask has good whitening and anti-aging effects by utilizing the synergistic effect of each component; the branched chain amino acid is the most effective nutritional supplement important for human bodies, can enable organisms to naturally strengthen muscles or obtain more energy without any side effect, can enter the skin through the horny layer to provide cell energy, can supply folic acid and/or folic acid derivatives to repair damaged DNA energy, exerts a DNA protection effect, promotes collagen to enhance the level of cell energy supply, effectively shortens the time of cell repair, greatly improves the bioavailability of folic acid, and can obtain higher beautifying and anti-aging effects only by adding a small amount of folic acid and the branched chain amino acid under the synergistic effect.
The invention also provides a preparation method of the facial mask, which comprises the following steps: mixing a solvent, 0.001-1 part by weight of folic acid and/or folic acid derivatives, x part by weight of branched chain amino acid, 2-30 parts by weight of a skin conditioner, 0-5 parts by weight of a pH regulator, 0.05-0.1 part by weight of a chelating agent, 1-20 parts by weight of a humectant, 0.1-5 parts by weight of a surfactant, 0-0.5 part by weight of an aromatic and 0.05-5 parts by weight of a thickener to obtain a mask; x is greater than 0 and less than or equal to 15.
Wherein, the thickening agent, the humectant, the chelating agent, the solvent, the skin conditioning agent, the surfactant, the pH regulator, the folic acid and/or the folic acid derivative, the branched chain amino acid and the aromatic are the same as the above, and are not repeated.
Preferably, the preparation is carried out as follows: s1) mixing and heating the solvent and the raw materials which need to be added under the high temperature condition to obtain an A phase solution; s2), cooling the phase A solution, and mixing the raw material to be added under the medium-high temperature condition with the phase A solution to obtain a phase B raw material; s3) cooling the phase B raw material, and mixing the phase B raw material with the raw material which needs to be added under the low temperature condition to obtain the facial mask.
The raw materials added under the low temperature condition comprise folic acid, folic acid derivatives and branched chain amino acid, cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, a Amaranthus caudatus seed extract, a Ulmus pumila root extract, and essence and essential oil in an aromatic; the raw materials added under the medium-high temperature condition comprise hydroxyacetophenone and panthenol in a skin conditioner, tromethamine in a pH regulator and PEG-60 hydrogenated castor oil in a surfactant; the raw materials added under the high temperature condition comprise allantoin in a skin conditioner, trisodium EDTA in a chelating agent, glycerin, betaine, butanediol, sodium hyaluronate, 1, 2-hexanediol and methyl propylene glycol in a humectant, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer in a surfactant, and xanthan gum and carrageen crispus in a thickening agent.
Mixing and heating a solvent and raw materials to be added at a high temperature to obtain an A phase solution; the heating temperature is preferably 80 ℃ to 90 ℃.
And (3) cooling the phase A solution, preferably to 50-65 ℃, adding the raw materials which need to be added under the medium-high temperature condition, and mixing to obtain the phase B solution.
And continuously cooling the B phase solution, preferably continuously cooling to 40-50 ℃, and then adding the raw materials to be added under the low temperature condition, mixing and stirring to obtain the facial mask.
The evaluation method of the skin care composition in the examples of the present invention mainly proceeds as follows:
the skin care composition and the evaluation of the effect of the skin care product comprising the composition in the examples were carried out by human trial test:
(1) skin whitening effect measurement:
and selecting the crowds with dark skin color, sunburn, chloasma and acne marks to participate in the test of the whitening effect of the skin care sample. The skin care samples in the examples and the comparative examples were used for each group of 20 persons, and the average value of variations in ITA and the average value of variations in the number of spots before and after 4 weeks of continuous use of the skin care samples were measured and calculated using the individual type angle of ITA.
(2) And (3) determining the anti-aging effect:
and selecting a population with consistent skin types and working outdoors to take the test of the anti-aging effect of the skin care sample. Grouping according to the number of test samples, wherein 20 persons are used in each group, the skin care samples in the examples and the comparative examples are used in each group, and after 4 weeks, the humidity of the skin and the roughness of the skin are measured by a skin tester, and the average values are calculated respectively; wherein the humidity test parameters and the roughness test parameters are shown in the following table.
Table 1 humidity test parameters
TABLE 2 roughness test parameters
In order to further illustrate the present invention, the following examples are provided to describe the folic acid-containing skin care composition, facial mask and preparation method thereof in detail.
Examples 1 to 7 and comparative examples 1 to 2
A skin care composition.
(1) Formulation of
(2) The preparation method comprises the following steps: mixing the above components with 0.5g sodium bicarbonate, adding distilled water to desired volume of 100ml, and mixing to obtain skin care composition.
(3) Effect testing
Examples 8 to 10 and comparative examples 3 to 4
A facial mask is provided.
(1) Formulation of
(2) The preparation method comprises the following steps:
accurately weighing xanthan gum, Chondrus CRISPUS (Chondrus CRISPUS), acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, glycerol, betaine, allantoin, butanediol, sodium hyaluronate, 1, 2-hexanediol, and methyl propylene glycol; dispersing uniformly, adding water and EDTA trisodium, stirring and heating to 85 ℃.
Cooling to 65 deg.C, adding panthenol, tromethamine, PEG-60 hydrogenated castor oil and p-hydroxyacetophenone, and stirring.
Cooling to 45 deg.C, and adding folic acid, leucine, isoleucine, valine, cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, Amaranthus CAUDATUS (Amaranthus CAUDATUS) seed extract, Ulmus DAVIDIANA (Ulmus DAVIDIANA) root extract, and essence (daily use).
Stirring evenly, and discharging.
(3) Effect testing
Examples 11 to 13 and comparative examples 5 to 6
A body lotion.
(1) Formulation of
(2) The preparation method comprises the following steps:
phase A: mixing water, glycerol and xanthan gum, stirring, and heating to 85 deg.C.
Phase B: mixing stearyl alcohol, isopropyl palmitate, oleum Hippophae, isooctyl palmitate, PS-100, isopropyl myristate, Brij 721, Brij 72, and shea butter, stirring, and heating to 85 deg.C.
Phase B was added to phase A, stirred and homogenized for 5 minutes.
Cooling to 45 deg.C, and adding methylisothiazolinone/iodopropynyl butylcarbamate, creatine, folic acid, leucine, isoleucine, valine and essence. Discharging.
(3) Effect testing
Examples 14 to 16 and comparative examples 7 to 8
A facial cream.
(1) Formulation of
(2) The preparation method comprises the following steps:
phase A: adding water, carbomer 940 (carbomer), EDTA-disodium, glycerol and propylene glycol into water phase pot, stirring and heating to 85 deg.C.
Phase B: adding Cera flava, C16-18 alcohol, shea butter, self-emulsifying monoglyceride A165, synthetic squalane, and DC-345 into oil phase pot, stirring, heating to 85 deg.C, and stirring to dissolve.
Stirring phase A, adding phase B, stirring, and homogenizing for 5 min. Cooling to 65 ℃, adding
Acrylic acid polymer (305), and homogenized for 2 minutes after stirring.
Cooling to 60 deg.C, adding triethanolamine, and stirring.
Cooling to 45 deg.C, adding folic acid, leucine, isoleucine, valine, antiseptic and essence, and discharging.
(3) Effect testing
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A skin care product composition containing folic acid is characterized by comprising the following components in parts by weight:
0.001-1 part by weight of folic acid and/or folic acid derivatives, 1.099 parts by weight of leucine, 2 parts by weight of isoleucine and 2 parts by weight of valine.
2. The skin care composition of claim 1, wherein the folic acid derivative is selected from the group consisting of tetrahydrofolic acid, 5-methyltetrahydrofolic acid, 6-S-5-methyltetrahydrofolic acid, leucovorin, calcium folinate, and calcium levofolinate.
3. Use of the folic acid containing skin care composition according to any one of claims 1 to 2 for the preparation of a cosmetic.
4. A cosmetic comprising the folic acid-containing skin care composition according to any one of claims 1 to 2.
5. The cosmetic according to claim 4, which is a mask, cream or milk.
6. The mask is characterized by comprising a solvent and the following components in parts by weight:
0.001-1 part by weight of folic acid and/or folic acid derivatives;
1.099 parts by weight of leucine;
2 parts of isoleucine;
2 parts by weight of valine;
2-30 parts of a skin conditioner;
0-5 parts of a pH regulator;
0.05-0.1 part by weight of a chelating agent;
1-20 parts by weight of a humectant;
0.1-5 parts by weight of a surfactant;
0-0.5 parts by weight of an aromatic;
0.05-5 parts of thickening agent.
7. The mask of claim 6, wherein the skin conditioning agent is selected from the group consisting of one or more of cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, Amaranthus caudatus seed extract, Ulmus pumila root extract, p-hydroxyacetophenone, panthenol, allantoin, shea butter, polyglycerol-10 oleate, hydrogenated lecithin, dipotassium glycyrrhizinate, and creatine;
the pH value regulator is selected from one or more of tromethamine, sodium hydroxide, potassium hydroxide, arginine and triethanolamine;
the chelating agent is selected from one or more of trisodium EDTA, disodium EDTA and tetrasodium EDTA;
the humectant is selected from one or more of glycerol, betaine, butanediol, sodium hyaluronate, 1, 2-hexanediol, methyl propylene glycol, glyceryl polyether-26, propylene glycol, polyglycerol-10 and luba gum oil;
the surfactant is selected from PEG-60 hydrogenated castor oil and/or acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;
the aromatic is selected from essence and/or essential oil;
the thickening agent is selected from one or more of xanthan gum, carrageen crispus, hydroxyethyl cellulose and carbomer;
the solvent is water.
8. A method for preparing the mask pack of claim 6, comprising:
mixing a solvent, 0.001-1 part by weight of folic acid and/or folic acid derivatives, 1.099 parts by weight of leucine, 2 parts by weight of isoleucine, 2 parts by weight of valine, 2-30 parts by weight of a skin conditioner, 0-5 parts by weight of a pH regulator, 0.05-0.1 part by weight of a chelating agent, 1-20 parts by weight of a humectant, 0.1-5 parts by weight of a surfactant, 0-0.5 part by weight of an aromatic and 0.05-5 parts by weight of a thickener to obtain the facial mask.
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| CN108210349A (en) * | 2018-03-09 | 2018-06-29 | 上海粉蝶化妆品有限公司 | A kind of facial mask liquid |
| CN109172422B (en) * | 2018-10-31 | 2021-06-15 | 成都珂萝瑞诗化妆品有限公司 | Hyaluronic acid mask liquid and preparation method thereof |
| CN110302090A (en) * | 2018-12-24 | 2019-10-08 | 中健(广州)生物医药研究院有限公司 | Application of the L-5- methyl tetrahydrofolate glucosamine salt in cosmetics |
| CN111631985B (en) * | 2020-06-18 | 2022-08-05 | 北京斯利安药业有限公司 | Anti-wrinkle composition containing folic acid, eye cream and preparation method thereof |
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