CN107440932A - A kind of composite skin care product containing folic acid, facial mask and preparation method thereof - Google Patents
A kind of composite skin care product containing folic acid, facial mask and preparation method thereof Download PDFInfo
- Publication number
- CN107440932A CN107440932A CN201710685496.4A CN201710685496A CN107440932A CN 107440932 A CN107440932 A CN 107440932A CN 201710685496 A CN201710685496 A CN 201710685496A CN 107440932 A CN107440932 A CN 107440932A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- folic acid
- skin care
- care product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a kind of composite skin care product containing folic acid, including：0.001~1 parts by weight folic acid and/or folic acid derivatives and the branched-chain amino acid of x parts by weight；The x is more than 0 and is less than or equal to 5.Compared with prior art, the present invention utilizes the synergistic function of each composition so that the composite skin care product obtained has preferable effect by the way that the folic acid of specific proportioning and/or folic acid derivatives are combined with branched-chain amino acid；Wherein branched-chain amino acid is the important maximally effective nutritional supplement of human body; organism can be made to strengthen muscle naturally, without any side effect or obtain more multi-energy; and branched-chain amino acid can be entered in skin by cuticula; cellular energy is provided; folic acid and/or the DNA energy that folic acid derivatives reparation is damaged are can be supplied to, applies DNA protecting effects, promotes the level of collagen enhancing cellular energy supply; effectively shorten the time of cell repair, and greatly improve the bioavailability of folic acid.
Description
Technical field
The present invention relates to commodity technical field, more particularly, to a kind of composite skin care product containing folic acid, facial mask and its
Preparation method.
Background technology
Folic acid is a kind of efficient skin care ingredient, can combine the moisture of up to 5000 times own wts, is had good
Performance of keeping humidity, the generation of NMF NMF in skin keratin can be promoted, so as to form diaphragm, and skin can not changed
Fat reduces percutaneous water loss in the case of secreting, and allows skin to recover water tender soft and smooth.Moreover, folic acid synthesizes to DNA, cell is newly old
The physiology courses such as metabolism have extremely strong facilitation, can promote DNA chain ruptures further in conjunction with so as to effectively repair because ultraviolet is made
Into skin injury, allow skin to reply smooth, recapture resilient flexible.Furthermore the renewal in about every four months of the red blood cell of human body is once,
If lacking folic acid, red blood cell can be disturbed to generate, red blood cell volume become big, tailed off, and then the symptom such as pale occur.It is comprehensive
Upper described, folic acid can be added in facial mask, moisten nutrition skin of face, so as to reach the effect for improving skin quality.
But folic acid is used alone, its utilization rate is relatively low, generally requires to add a large amount of folic acid.
The content of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of composite skin care product containing folic acid, facial mask
And preparation method thereof, the folic acid biological utilization rate of the composite skin care product provided by the invention containing folic acid is higher.
The invention provides a kind of composite skin care product containing folic acid, including：
0.001~1 parts by weight folic acid and/or folic acid derivatives and the branched-chain amino acid of x parts by weight；The x is less than more than 0
Equal to 15.
Preferably, one or more of the branched-chain amino acid in leucine, isoleucine and valine.
Preferably, the folic acid derivatives be selected from tetrahydrofolic acid, 5-methyltetrahydrofolate, 6-S-5- methyl tetrahydrofolates,
Formyl tetrahydrofolic acid, Calciumlevofolinate or levoleucovorin calcium.
Preferably, including：
The folic acid and/or folic acid derivatives of 0.001~1 parts by weight；
The leucine of 0~5 parts by weight；
The isoleucine of 0~5 parts by weight；
The valine of 0~5 parts by weight；
And during the content difference of leucine, isoleucine and valine be 0.
Present invention also offers application of the above-mentioned composition in cosmetics are prepared.
Present invention also offers a kind of cosmetics, including combinations of the above thing.
Preferably, the cosmetics are facial mask, frost or breast.
Present invention also offers a kind of facial mask, including solvent and following component：
The x is more than 0 and is less than or equal to 15.
Preferably, the skin conditioning agent is selected from cysteine, phenylalanine, alanine, methionine, glycine, smart ammonia
Acid, lysine, tyrosine, proline, aspartic acid, histidine, amaranthus caudatus seed extract, Japanese elm root extract, para hydroxybenzene
In ethyl ketone, panthenol, allantoin, Butyrospermum parkii fruit fat, Natrulon H-10 oleate, hydrolecithin, dipotassium glycyrrhizinate and creatine
It is one or more；
The one kind of the pH value regulator in tromethamine, sodium hydroxide, potassium hydroxide, arginine and triethanolamine
It is or a variety of；
One or more of the chelating agent in EDTA trisodiums, EDETATE SODIUM and the sodium of EDTA tetra-；
The NMF is selected from glycerine, glycine betaine, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl propanediol, sweet
One or more in oily polyethers -26, propane diols, Natrulon H-10 and reed fragrant plant glue oil；
The surfactant is selected from PEG-60 rilanit specials and/or acrylic acid (ester) class/C10-30 alkylol acrylamides acid
Ester cross-linked polymer；
The aromatic is selected from essence and/or essential oil；
One or more of the thickener in xanthans, Chondrus crispus, hydroxyethyl cellulose and carbomer；
The solvent is water.
Present invention also offers a kind of preparation method of facial mask, including：
By solvent, the folic acid of 0.001~1 parts by weight and/or folic acid derivatives, the branched-chain amino acid of x parts by weight, 2~30
The skin conditioning agent of parts by weight, the pH adjusting agent of 0~5 parts by weight, the chelating agent of 0.05~0.1 parts by weight, 1~20 parts by weight
NMF, the surfactant of 0.1~5 parts by weight, the aromatic of 0~0.5 parts by weight and the thickener of 0.05~5 parts by weight mix
Close, obtain facial mask；The x is more than 0 and is less than or equal to 15..
Compared with prior art, the invention provides a kind of composite skin care product containing folic acid, including：0.001~1 weight
Part folic acid and/or folic acid derivatives and the branched-chain amino acid of x parts by weight；The x is more than 0 and is less than or equal to 5.The present invention is by by spy
Fixed proportioning folic acid and/or folic acid derivatives is combined with branched-chain amino acid, utilizes the synergistic function of each composition so that
The composite skin care product obtained has preferable effect；Wherein branched-chain amino acid is that the important maximally effective nutrition of human body is mended
Agent, organism can be made to strengthen muscle naturally, without any side effect or obtain more multi-energy, and branched-chain amino acid can lead to
Cross cuticula to enter in skin, there is provided cellular energy, can be supplied to folic acid and/or the DNA energy that folic acid derivatives reparation is damaged, apply
Add DNA protecting effects, promote the level of collagen enhancing cellular energy supply, effectively shorten the time of cell repair, and greatly
The big bioavailability for improving folic acid.
Embodiment
The invention provides a kind of composite skin care product containing folic acid, including：
0.001~1 parts by weight folic acid and/or folic acid derivatives and the branched-chain amino acid of x parts by weight；The x is less than more than 0
Equal to 15.
Composite skin care product provided by the invention includes the folic acid and/or folic acid derivatives of 0.001~1 parts by weight, preferably
Folic acid and/or folic acid derivatives including 0.001~0.5 parts by weight, folic acid more preferably including 0.001~0.1 parts by weight and/
Or folic acid derivatives；In some embodiments provided by the invention, the content of the folic acid and/or folic acid derivatives is preferably
0.001 parts by weight；In some embodiments provided by the invention, the content of the folic acid and/or folic acid derivatives is preferably
0.01 parts by weight；In some embodiments provided by the invention, the content of the folic acid and/or folic acid derivatives is preferably 0.1
Parts by weight；In other embodiments provided by the invention, the content of the folic acid and/or folic acid derivatives is preferably 1 weight
Part；The folic acid derivatives are folic acid derivatives well known to those skilled in the art, special limitation are had no, in of the invention
Preferably tetrahydrofolic acid, 5-methyltetrahydrofolate, 6-S-5- methyl tetrahydrofolates, formyl tetrahydrofolic acid, Calciumlevofolinate or left-handed
Calciumlevofolinate.
Composite skin care product provided by the invention includes the branched-chain amino acid of x parts by weight, and the x is less than or equal to more than 0
15, the branched-chain amino acid of 0.05~15 parts by weight is preferably included, more preferably includes the branched-chain amino acid of 0.05~10 parts by weight, then
The branched-chain amino acid of 0.05~6 parts by weight is preferably included, most preferably includes the branched-chain amino acid of 4~5 parts by weight；The side chain ammonia
Base acid is branched-chain amino acid well known to those skilled in the art, has no special limitation, is preferably required ammonia in the present invention
One or more in branched-chain amino acid in base acid, more preferably leucine, isoleucine and valine；Now, it is of the invention
The composite skin care product of offer preferably includes：The folic acid and/or folic acid derivatives of 0.001~1 parts by weight；0~5 parts by weight it is bright
Propylhomoserin；The isoleucine of 0~5 parts by weight；The valine of 0~5 parts by weight；And the content of leucine, isoleucine and valine
It is asynchronously 0；In some embodiments provided by the invention, the content of the leucine is preferably 1.099 parts by weight；In this hair
In some embodiments of bright offer, the content of the leucine is preferably 2 parts by weight；In some embodiments provided by the invention
In, the content of the leucine is preferably 3 parts by weight；In some embodiments provided by the invention, the content of the leucine
Preferably 0 parts by weight；In other embodiments provided by the invention, the content of the leucine is preferably 5 parts by weight；At this
Invent in some embodiments provided, the content of the isoleucine is preferably 2 parts by weight；In some implementations provided by the invention
In example, the content of the isoleucine is preferably 3 parts by weight；In some embodiments provided by the invention, the isoleucine
Content be preferably 1 parts by weight；In some embodiments provided by the invention, the content of the isoleucine is preferably 0 weight
Part；In other embodiments provided by the invention, the content of the isoleucine is preferably 5 parts by weight；There is provided in the present invention
Some embodiments in, the content of the valine is preferably 2 parts by weight；It is described in some embodiments provided by the invention
The content of valine is preferably 0 parts by weight；In some embodiments provided by the invention, the content of the valine is preferably
1.1 parts by weight；In some embodiments provided by the invention, the content of the valine is preferably 4.09 parts by weight；In this hair
In some embodiments of bright offer, the content of the valine is preferably 5 parts by weight.The present invention by it is specific proportioning folic acid and/
Or folic acid derivatives combine with branched-chain amino acid, the synergistic function of each composition is utilized so that the skin care item combination obtained
Thing has preferable effect；Wherein branched-chain amino acid is the important maximally effective nutritional supplement of human body, and organism can be made natural
Ground, strengthen muscle without any side effect or obtain more multi-energy, and branched-chain amino acid can be entered in skin by cuticula,
Cellular energy is provided, folic acid and/or the DNA energy that folic acid derivatives reparation is damaged is can be supplied to, applies DNA protecting effects, promote
The level of collagen enhancing cellular energy supply, effectively shortens the time of cell repair, and greatly improve the biology of folic acid
Utilization rate.
Composite skin care product provided by the invention may also include acceptable auxiliary material on skin care item, or including remaining component and
Auxiliary agent, it is well known to those skilled in the art to can be used for skin care.
The invention provides the composite skin care product containing folic acid described in above-mentioned technical proposal any one to prepare cosmetic
Application in product.
Present invention also offers a kind of cosmetics, including the composite skin care product described in above-mentioned technical proposal any one.
Preferably, the cosmetics are facial mask, frost or breast.
Wherein described frost is preferably face cream；The breast is preferably body lotion.
And can be for face cream and the actual substrate of body lotion it is well known to those skilled in the art, to this present inventor not
It is defined.
The invention provides a kind of facial mask, including solvent and following component：
The x is more than 0 and is less than or equal to 15.
Wherein, the folic acid and/or folic acid derivatives are same as above with branched-chain amino acid, will not be repeated here.
In facial mask provided by the invention, the content of the folic acid and/or folic acid derivatives is preferably 0.01~1 weight
Part, more preferably 0.01~0.5 parts by weight, most preferably 0.01~0.1 parts by weight；The content of the branched-chain amino acid is preferably
0.05~5 parts by weight, more preferably 0.05~3 parts by weight, most preferably 0.07~0.1 parts by weight.
The folic acid, folic acid derivatives and branched-chain amino acid add under cryogenic in preparation process.
According to the present invention, the content of the skin conditioning agent is preferably 2~25 parts by weight, more preferably 2~20 parts by weight,
It is further preferably 2~10 parts by weight, is further preferably 2~5 parts by weight, most preferably 2.32~5 parts by weight；The skin conditioning agent is
Skin conditioning agent well known to those skilled in the art, special limitation is had no, be preferably cysteine, phenylpropyl alcohol in the present invention
Propylhomoserin, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, amaranthus caudatus
Seed extract, Japanese elm root extract, parahydroxyacet-ophenone, panthenol, allantoin, Butyrospermum parkii fruit fat, Natrulon H-10 oleate,
One or more in hydrolecithin, dipotassium glycyrrhizinate and creatine.
The cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, dried meat ammonia
Acid, aspartic acid, histidine, amaranthus caudatus seed extract, Japanese elm root extract add in preparation process in cryogenic conditions；It is described
Hydroxy acetophenone, panthenol add in preparation process in high temperature condition；The allantoin is in preparation process in hot conditions
Add.
The content of the pH adjusting agent is preferably 0.01~4 parts by weight, more preferably 0.01~3 parts by weight, further preferably for
0.01~2 parts by weight, it is further preferably 0.01~0.1 parts by weight, most preferably 0.012~0.03 parts by weight；The pH adjusting agent
For pH adjusting agent well known to those skilled in the art, special limitation is had no, is preferably tromethamine, hydrogen-oxygen in the present invention
Change the one or more in sodium, potassium hydroxide, arginine and triethanolamine.
The tromethamine adds in preparation process under the conditions of high temperature.
The content of the chelating agent is preferably 0.05~0.08 parts by weight, more preferably 0.05~0.06 parts by weight；It is described
Chelating agent is chelating agent well known to those skilled in the art, has no special limitation, be preferably in the present invention EDTA trisodiums,
EDETATE SODIUM and the one or more in the sodium of EDTA tetra-.
The EDTA trisodiums add under the high temperature conditions in preparation process.
The content of the NMF is preferably 5~20 parts by weight, more preferably 10~20 parts by weight, is further preferably 13~16
Parts by weight, most preferably 14.17~15 parts by weight；The NMF is NMF well known to those skilled in the art, and
It is preferably glycerine, glycine betaine, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl-prop two in the present invention without special limitation
One or more in alcohol, glycerin polyether -26, propane diols, Natrulon H-10 and reed fragrant plant glue oil.
The glycerine, glycine betaine, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl propanediol in preparation process,
Add under the high temperature conditions.
The content of the surfactant is preferably 0.1~2 parts by weight, more preferably 0.1~1 parts by weight, further preferably for
0.2~0.5 parts by weight, most preferably 0.35~0.4 parts by weight；The surfactant is table well known to those skilled in the art
Face activating agent, has no special limitation, be preferably in the present invention PEG-60 rilanit specials and/or acrylic acid (ester) class/
C10-30 alkylol acrylamide acid esters cross-linked polymers.
The PEG-60 rilanit specials add in preparation process under the conditions of high temperature；Acrylic acid (ester) class/
C10-30 alkylol acrylamide acid esters cross-linked polymers add under the high temperature conditions in preparation process.
The content of the aromatic is preferably 0~0.3 parts by weight, more preferably 0.1~0.2 parts by weight, further preferably for
0.15 parts by weight；The aromatic is aromatic well known to those skilled in the art, special limitation is had no, in of the invention
Preferably essence and/or essential oil.
The essence and essential oil add under cryogenic in preparation process.
The content of the thickener is preferably 0.05~3 parts by weight, more preferably 0.1~2 parts by weight, is further preferably 0.1
~1 parts by weight, it is further preferably 0.1~0.5 parts by weight, most preferably 0.15~0.2 parts by weight；The thickener is this area skill
Thickener known to art personnel, special limitation is had no, be preferably xanthans, Chondrus crispus, ethoxy in the present invention
Cellulose and the one or more in carbomer.
The xanthans, Chondrus crispus add under the high temperature conditions in preparation process.
The solvent is solvent well known to those skilled in the art, has no special limitation, is preferably in the present invention
Water；It is 100 parts by weight that the amount of the solvent, which preferably supplies said components,.
Facial mask provided by the invention is combined by specific proportioning folic acid and/or folic acid derivatives with branched-chain amino acid, is utilized
The synergistic function of each composition so that the facial mask obtained has preferable whitening and anti-aging effect；Wherein side chain ammonia
Base acid is the important maximally effective nutritional supplement of human body, and organism can be made to strengthen muscle naturally, without any side effect
Or obtain more multi-energy, and branched-chain amino acid can by cuticula enter skin in, there is provided cellular energy, can be supplied to folic acid and/
Or the DNA energy that folic acid derivatives reparation is impaired, apply DNA protecting effects, promote collagen enhancing cellular energy supply
Level, effectively shorten the time of cell repair, and greatly improve the bioavailability of folic acid, it is only necessary to add a small amount of folic acid and
Branched-chain amino acid synergy can obtain higher whitening and anti-aging effect.
Present invention also offers a kind of preparation method of above-mentioned facial mask, including：By solvent, the folic acid of 0.001~1 parts by weight
And/or the pH of folic acid derivatives, the branched-chain amino acid of x parts by weight, the skin conditioning agent of 2~30 parts by weight, 0~5 parts by weight is adjusted
Save agent, the chelating agent of 0.05~0.1 parts by weight, the NMF of 1~20 parts by weight, the surfactant of 0.1~5 parts by weight, 0~
The aromatic of 0.5 parts by weight mixes with the thickener of 0.05~5 parts by weight, obtains facial mask；The x is more than 0 and is less than or equal to 15.
Wherein, the thickener, NMF, chelating agent, solvent, skin conditioner, surfactant, pH adjusting agent, leaf
Acid and/or folic acid derivatives, branched-chain amino acid and aromatic are same as above, will not be repeated here.
Preferably, prepare in accordance with the following methods：S1) the raw material Hybrid Heating for adding solvent and needing under the high temperature conditions
Obtain A phase solution；S2) after the cooling of A phases solution, it would be desirable to which the raw material added under the conditions of high temperature mixes with A phase solution, obtains
B phase raw materials；S3) after the cooling of B phases raw material, B phases raw material is mixed with the raw material for needing to add under cryogenic, obtains facial mask.
The raw material added under the cryogenic conditions includes folic acid, folic acid derivatives and branched-chain amino acid, in skin conditioning agent
Cysteine, phenylalanine, alanine, methionine, glycine, arginine, lysine, tyrosine, proline, asparagus fern ammonia
Acid, histidine, amaranthus caudatus seed extract, Japanese elm root extract, essence and essential oil in aromatic；Add under the conditions of the high temperature
The raw material entered includes hydroxy acetophenone, panthenol in skin conditioning agent, the tromethamine in pH adjusting agent, in surfactant
PEG-60 rilanit specials；The raw material added under the hot conditions includes the allantoin in skin conditioning agent, in chelating agent
EDTA trisodiums, glycerine, glycine betaine in NMF, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl propanediol, surface are lived
Property agent in acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers, xanthans, ripple angle fork in thickener
Dish.
By solvent and the raw material Hybrid Heating added under the high temperature conditions is needed, obtains A phase solution；The temperature of the heating
Preferably 80 DEG C~90 DEG C.
A phases solution is cooled, is preferably cooled to 50 DEG C~65 DEG C, adds the raw material for needing to be added under the conditions of high temperature,
Mixing, obtains B phase solution.
B phase solution is continued to cool, preferably continues to be cooled to 40 DEG C~50 DEG C, then adding needs to add under cryogenic
The raw material entered mixes, and obtains facial mask.
The evaluation method of skin care compositions in the embodiment of the present invention is substantially carried out following aspect：
In embodiment skin care item compound and its effect assessment including said composition skin care item by normal individual trial test into
OK：
(1) skin whitening effects determine：
Selection is with the colour of skin is obscure, the crowd of sunburn, chloasma, acne print participates in the test of skin care sample whitening effect.Press
Test specimen number is grouped, every group of 20 people, and each group is respectively using the skin care sample in embodiment and comparative example, using ITA
Body type angle determines and calculates ITA change average value and the change of spot number of the continuous use skin care sample before and after 4 weeks and is averaged
Value.
(2) antiageing effect determines：
Select that skin quality is consistent, often participates in the test of skin care sample antiageing effect in the crowd of outside work.By test sample
Product number is grouped, every group of 20 people, and each group using the skin care sample in embodiment and comparative example, after 4 weeks, uses skin test respectively
The humidity of instrument measure skin and the roughness of skin, and average value is calculated respectively；Wherein humidity measurement parameter and roughness test
Parameter is as shown in the table.
The humidity measurement parameter of table 1
The roughness test parameter of table 2
In order to further illustrate the present invention, the skin care item provided by the invention containing folic acid are combined with reference to embodiments
Thing, facial mask and preparation method thereof are described in detail.
Embodiment 1~7 and comparative example 1~2
A kind of composite skin care product.
(1) it is formulated
(2) preparation method：Each composition is mixed with 0.5g sodium acid carbonates, and is settled to 100ml with distilled water and mixes, i.e.,
It can obtain composite skin care product.
(3) measure of merit
Embodiment 8~10 and comparative example 3~4
A kind of facial mask.
(1) it is formulated
(2) preparation method：
Precise xanthans, Chondrus crispus (CHONDRUS CRISPUS), acrylic acid (ester) class/C10-30 alkanols third
Olefin(e) acid ester cross-linked polymer, glycerine, glycine betaine, allantoin, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl propanediol；
It is uniformly dispersed, adds water, EDTA trisodiums, be heated with stirring to 85 DEG C.
65 DEG C are cooled to, panthenol, tromethamine, PEG-60 rilanit specials and parahydroxyacet-ophenone is added, stirs.
Continue to be cooled to 45 DEG C, add folic acid, leucine, isoleucine, valine, cysteine, phenylalanine, the third ammonia
Acid, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, amaranthus caudatus
(AMARANTHUS CAUDATUS) seed extract, Japanese elm (ULMUS DAVIDIANA) root extract, (daily) essence.
Stir, discharging.
(3) measure of merit
Embodiment 11~13 and comparative example 5~6
A kind of body lotion.
(1) it is formulated
(2) preparation method：
A phases：Water, glycerine, xanthan gum are mixed, are heated with stirring to 85 DEG C.
B phases：Octadecyl alcolol, isopropyl palmitate, Seabuckthorm Seed Oil, isobutyl palmitate, PS-100, isopropyl myristate,
Brij 721, Brij 72, shea butter mix, and are heated with stirring to 85 DEG C.
B is added to A phases, homogeneous 5 minutes after stirring.
Be cooled to 45 DEG C, add methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate, creatine, folic acid, leucine,
Isoleucine and valine, essence.Discharging.
(3) measure of merit
Embodiment 14~16 and comparative example 7~8
A kind of face cream.
(1) it is formulated
(2) preparation method：
A phases：Jiang Shui, card ripple 940 (carbomer), EDTA- disodiums, glycerine, propane diols add aqueous phase pot, are heated with stirring to 85
℃。
B phases：Beeswax, C16-18 alcohol, shea butter, self-emulsifying monoglyceride A165, synthesis saualane, DC-345 are added into oil
Phase pot, 85 DEG C are heated with stirring to, stir evenly dissolving.
A phases open stirring, after addition B phases stir, homogeneous 5 minutes.65 degree are cooled to, is added
Acrylate copolymer (305), homogeneous 2 minutes after stirring.
60 DEG C are cooled to, triethanolamine is added, is sufficiently stirred.
45 DEG C are cooled to, folic acid, leucine, isoleucine, valine, preservative, essence, discharging will be added.
(3) measure of merit
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
- A kind of 1. composite skin care product containing folic acid, it is characterised in that including：0.001~1 parts by weight folic acid and/or folic acid derivatives and the branched-chain amino acid of x parts by weight；The x is less than or equal to more than 0 15。
- 2. composite skin care product according to claim 1, it is characterised in that the branched-chain amino acid is selected from leucine, different Leucine and the one or more in valine.
- 3. composite skin care product according to claim 1, it is characterised in that the folic acid derivatives be selected from tetrahydrofolic acid, 5-methyltetrahydrofolate, 6-S-5- methyl tetrahydrofolates, formyl tetrahydrofolic acid, Calciumlevofolinate or levoleucovorin calcium.
- 4. composite skin care product according to claim 1, it is characterised in that including：The folic acid and/or folic acid derivatives of 0.001~1 parts by weight；The leucine of 0~5 parts by weight；The isoleucine of 0~5 parts by weight；The valine of 0~5 parts by weight；And during the content difference of leucine, isoleucine and valine be 0.
- 5. application of the composite skin care product containing folic acid in cosmetics are prepared described in Claims 1 to 4 any one.
- 6. a kind of cosmetics, including the composite skin care product containing folic acid described in Claims 1 to 4 any one.
- 7. cosmetics according to claim 6, the cosmetics are facial mask, frost or breast.
- 8. a kind of facial mask, it is characterised in that including solvent and following component：The x is more than 0 and is less than or equal to 15.
- 9. facial mask according to claim 8, it is characterised in that the skin conditioning agent be selected from cysteine, phenylalanine, Alanine, methionine, glycine, arginine, lysine, tyrosine, proline, aspartic acid, histidine, the extraction of amaranthus caudatus seed Thing, Japanese elm root extract, parahydroxyacet-ophenone, panthenol, allantoin, Butyrospermum parkii fruit fat, Natrulon H-10 oleate, hydrogenation ovum One or more in phosphatide, dipotassium glycyrrhizinate and creatine；The one kind or more of the pH value regulator in tromethamine, sodium hydroxide, potassium hydroxide, arginine and triethanolamine Kind；One or more of the chelating agent in EDTA trisodiums, EDETATE SODIUM and the sodium of EDTA tetra-；The NMF is selected from glycerine, glycine betaine, butanediol, Sodium Hyaluronate, 1,2- hexylene glycols, methyl propanediol, glycerine and gathered One or more in ether -26, propane diols, Natrulon H-10 and reed fragrant plant glue oil；The surfactant is selected from PEG-60 rilanit specials and/or acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters is handed over Linked polymer；The aromatic is selected from essence and/or essential oil；One or more of the thickener in xanthans, Chondrus crispus, hydroxyethyl cellulose and carbomer；The solvent is water.
- A kind of 10. preparation method of the facial mask described in claim 8, it is characterised in that including：By solvent, the folic acid of 0.001~1 parts by weight and/or folic acid derivatives, the branched-chain amino acid of x parts by weight, 2~30 weight Part skin conditioning agent, the pH adjusting agents of 0~5 parts by weight, 0.05~0.1 parts by weight chelating agent, 1~20 parts by weight moisturizing Agent, the surfactant of 0.1~5 parts by weight, the aromatic of 0~0.5 parts by weight mix with the thickener of 0.05~5 parts by weight, Obtain facial mask；The x is more than 0 and is less than or equal to 15.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710685496.4A CN107440932B (en) | 2017-08-11 | 2017-08-11 | Skin care product composition containing folic acid, facial mask and preparation method of facial mask |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710685496.4A CN107440932B (en) | 2017-08-11 | 2017-08-11 | Skin care product composition containing folic acid, facial mask and preparation method of facial mask |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107440932A true CN107440932A (en) | 2017-12-08 |
| CN107440932B CN107440932B (en) | 2022-02-01 |
Family
ID=60491957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710685496.4A Active CN107440932B (en) | 2017-08-11 | 2017-08-11 | Skin care product composition containing folic acid, facial mask and preparation method of facial mask |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107440932B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210349A (en) * | 2018-03-09 | 2018-06-29 | 上海粉蝶化妆品有限公司 | A kind of facial mask liquid |
| CN109172422A (en) * | 2018-10-31 | 2019-01-11 | 成都珂萝瑞诗化妆品有限公司 | A kind of hyaluronic acid facial mask liquid and preparation method thereof |
| CN110302090A (en) * | 2018-12-24 | 2019-10-08 | 中健(广州)生物医药研究院有限公司 | Application of the L-5- methyl tetrahydrofolate glucosamine salt in cosmetics |
| CN111631985A (en) * | 2020-06-18 | 2020-09-08 | 北京斯利安药业有限公司 | Anti-wrinkle composition containing folic acid, eye cream and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060110415A1 (en) * | 2004-11-22 | 2006-05-25 | Bioderm Research | Topical Delivery System for Cosmetic and Pharmaceutical Agents |
| CN101628008A (en) * | 2009-08-07 | 2010-01-20 | 深圳职业技术学院 | Nutritional bathing agent |
| CN102949300A (en) * | 2011-08-31 | 2013-03-06 | 上海艾芮尔化妆品有限公司 | Cosmetic taking vitamin B and amino acid as main raw materials |
| CN105213253A (en) * | 2015-09-29 | 2016-01-06 | 上海上美化妆品有限公司 | A kind of compound recipe Synsepalum duleificum leaf extract and the application in skin-lightening cosmetic thereof |
| CN106236674A (en) * | 2016-09-22 | 2016-12-21 | 上海新高姿化妆品有限公司 | A kind of compositions with white-skinned face function and the application in cosmetics thereof |
| CN106727147A (en) * | 2016-12-30 | 2017-05-31 | 首都医科大学附属北京中医医院 | Draft American ginseng beautifying skin improves medicine and cosmetic applications and preparation |
| CN106726686A (en) * | 2017-01-19 | 2017-05-31 | 弎西艾斯（苏州）生物科技有限公司 | A kind of human skin cell's growth-promoting media |
-
2017
- 2017-08-11 CN CN201710685496.4A patent/CN107440932B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060110415A1 (en) * | 2004-11-22 | 2006-05-25 | Bioderm Research | Topical Delivery System for Cosmetic and Pharmaceutical Agents |
| CN101628008A (en) * | 2009-08-07 | 2010-01-20 | 深圳职业技术学院 | Nutritional bathing agent |
| CN102949300A (en) * | 2011-08-31 | 2013-03-06 | 上海艾芮尔化妆品有限公司 | Cosmetic taking vitamin B and amino acid as main raw materials |
| CN105213253A (en) * | 2015-09-29 | 2016-01-06 | 上海上美化妆品有限公司 | A kind of compound recipe Synsepalum duleificum leaf extract and the application in skin-lightening cosmetic thereof |
| CN106236674A (en) * | 2016-09-22 | 2016-12-21 | 上海新高姿化妆品有限公司 | A kind of compositions with white-skinned face function and the application in cosmetics thereof |
| CN106727147A (en) * | 2016-12-30 | 2017-05-31 | 首都医科大学附属北京中医医院 | Draft American ginseng beautifying skin improves medicine and cosmetic applications and preparation |
| CN106726686A (en) * | 2017-01-19 | 2017-05-31 | 弎西艾斯（苏州）生物科技有限公司 | A kind of human skin cell's growth-promoting media |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210349A (en) * | 2018-03-09 | 2018-06-29 | 上海粉蝶化妆品有限公司 | A kind of facial mask liquid |
| CN109172422A (en) * | 2018-10-31 | 2019-01-11 | 成都珂萝瑞诗化妆品有限公司 | A kind of hyaluronic acid facial mask liquid and preparation method thereof |
| CN109172422B (en) * | 2018-10-31 | 2021-06-15 | 成都珂萝瑞诗化妆品有限公司 | Hyaluronic acid mask liquid and preparation method thereof |
| CN110302090A (en) * | 2018-12-24 | 2019-10-08 | 中健(广州)生物医药研究院有限公司 | Application of the L-5- methyl tetrahydrofolate glucosamine salt in cosmetics |
| CN111631985A (en) * | 2020-06-18 | 2020-09-08 | 北京斯利安药业有限公司 | Anti-wrinkle composition containing folic acid, eye cream and preparation method thereof |
| CN111631985B (en) * | 2020-06-18 | 2022-08-05 | 北京斯利安药业有限公司 | Anti-wrinkle composition containing folic acid, eye cream and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107440932B (en) | 2022-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107440932A (en) | A kind of composite skin care product containing folic acid, facial mask and preparation method thereof | |
| CN104856928B (en) | A kind of removing wrinkle and resisting aging aging cosmetic and preparation method thereof | |
| CN110025528A (en) | A kind of anti-oxidant cleawhite over-night essences and preparation method thereof without deionized water | |
| CN110339149A (en) | A kind of facial treatment essence cream of the anti-ageing low sensitization of the whitening of the product containing lactobacillus fermentation | |
| JP2011516585A (en) | Skin care composition and method of use thereof | |
| CN107375180A (en) | A kind of composite skin care product, facial mask and preparation method thereof | |
| CN106109302A (en) | A kind of Argireline stock solution and preparation method thereof | |
| CN107308020B (en) | Stable polypeptide composition and application thereof | |
| CN109528576A (en) | Antiallergic maintenance composition and its application | |
| CN110215423A (en) | The anti-ageing composition of reparation containing various plants extract, preparation method and application | |
| CN114224779A (en) | Eye repair composition and application thereof | |
| CN110215428A (en) | A kind of skin nursing facial mask of aerospace grade | |
| CN110123705A (en) | A kind of moisture-keeping crease-shedding composition and skin care item | |
| CN110393689A (en) | It is a kind of to have effects that anti-ageing essence composition and preparation method thereof | |
| CN109260116A (en) | It is a kind of containing plant extracts to peptide skin base solution and its production technology | |
| US8906426B2 (en) | Water-free, emulsifier-free, and preservative-free vehicle for active ingredients | |
| CA3067905A1 (en) | Putrescine topical formulations | |
| CN102137839A (en) | Use of an N-acyl amino acid selected from among N-palmitoyl alanine, N-palmitoyl glycine, and N-palmitoyl isoleucine as a regulating active agent of the genetic profile of senescent replicating fibroblasts of the human skin dermis | |
| CN113768853B (en) | Whitening and freckle-removing composition, and preparation method and application thereof | |
| CN110478288A (en) | A kind of skin anti-aging composition | |
| CN112675060B (en) | Composition and skin care product for resisting skin aging and preparation method thereof | |
| JP4137062B2 (en) | Γ-polyglutamic acid (γ-PGA, H form), γ-polyglutamate and γ-polyglutamate hydrogels for use as super humectants in cosmetics and personal care products | |
| JP2005239645A (en) | Composition for promoting collagen synthesis | |
| CN109453067A (en) | One kind attaining clear and rich face cream of face and preparation method thereof | |
| CN108619047A (en) | A kind of cosmetic formulations of anti-aging and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |