CN106109302A - A kind of Argireline stock solution and preparation method thereof - Google Patents
A kind of Argireline stock solution and preparation method thereof Download PDFInfo
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- CN106109302A CN106109302A CN201610555392.7A CN201610555392A CN106109302A CN 106109302 A CN106109302 A CN 106109302A CN 201610555392 A CN201610555392 A CN 201610555392A CN 106109302 A CN106109302 A CN 106109302A
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- argireline
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- stock solution
- glycerol
- butanediol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Gerontology & Geriatric Medicine (AREA)
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Abstract
The invention discloses a kind of Argireline stock solution and preparation method thereof.A kind of Argireline stock solution; said composition includes following key component: Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.2～0.7%; butanediol/water/peony root extractive 0.1～0.5%; acetyl group hexapeptide 80.5～1.6%; yeast extract 0.4～1.6%; salicylic acid/dextrin/xanthan gum/amylopectin 0.2～0.7%, carnosine 0.1～0.21%.The Argireline stock solution that the present invention makes has good anti-ageing moisture-keeping efficacy.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of Argireline stock solution and preparation method thereof.
Background technology
Argireline is a kind creotoxin composition, has creotoxin repertoire, and without any toxicity, is non-toxic substance
Matter.Although Main Ingredients and Appearance is the biogenetic products combined by six amino acid range. often quilt and bacillus botulinus are mentioned in the same breath, it
Mechanism the most entirely different. Argireline can intercept the signal of muscle contraction, alleviates the power of muscle contraction, and then improves microgroove
The degree of depth and length.It has replaced creotoxin to become noticeable beauty treatment new lover.
It has similar can suppress neurotransmitter, the conduction function between block nerves muscle, it is to avoid muscle is excessively received
Contracting, prevents from microgroove and is formed.Hexa-atomic victory peptide can subtract the strength that can delay muscle contraction, allows loosening all muscles, reduces dynamic stricture of vagina
Occur and eliminate microgroove；Effectively reorganize collagen elastic force, the activity of elastin can be increased, make face's lines loosen, wrinkle
It is lax that stricture of vagina smooths improvement.Can be used in cosmetics, as crease-resistant composition, and excellent.
" a kind of anti-wrinkle eye cream " (application publication number: CN103417427A), discloses a kind of anti-wrinkle eye cream, containing six victory
Peptide-3, have the repeatedly action hindering muscle, reach to alleviate the effect of wrinkle, be effective against muscularity wrinkle, but because of
The limitation of its product itself, can only act on eye；" anti-wrinkle face pack ointment " (application publication number: CN105362168A), open
A kind of anti-wrinkle face pack ointment, it is possible to play the effect of skin moistening wrinkle removing, effectively slow down aging, but undeclared its with after the need of
Clean.
Therefore the invention discloses a kind of Argireline stock solution being applied directly to face, there is good anti-ageing moisturizing merit
Effect.
Summary of the invention
It is an object of the invention to provide a kind of Argireline stock solution, while there is anti-ageing moisture-keeping functions.
It is a further object of the present invention to provide the preparation method of above-mentioned Argireline stock solution.
The Argireline stock solution of the present invention, is made up of the material of following mass percent:
Carbomer 0.46～0.65%, hyaluronate sodium 0.24～0.43%, sodium polyacrylate/Polyethylene Glycol-5M0.01
～0.03%, butanediol 2～8%, glycerol 2～8%, triethanolamine 0.2～0.8%, Bis(hydroxymethyl)imidazolidinyl urea/iodine third
Alkynol butyl mephenesin Carbamate 0.1～0.3%, Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate 0.05～0.18%, sweet
Oil polymethacrylates/propylene glycol/Gantrez AN-119 0.5～1.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate
0.2～0.7%, butanediol/water/peony root extractive 0.1～0.5%, Argireline 0.5～1.6%, yeast extract
0.4～1.6%, salicylic acid/dextrin/xanthan gum/amylopectin 0.2～0.7%, carnosine 0.1～0.21%, surplus is water.
The preparation method of above-mentioned Argireline stock solution comprises the steps:
1) carbomer, hyaluronate sodium, sodium polyacrylate/Polyethylene Glycol-5M, butanediol 5, glycerol are added to as A
In aqueous phase pot, being heated to 90 degree, insulated and stirred 30 minutes, wherein, carbomer is that homogenizing adds the most afterwards；
2) add B phase after being cooled to less than 40 degree after vacuum froth breaking to stir.Wherein B phase is triethanolamine；
3) add that C, D are biphase stirs.Wherein C phase is Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl ammonia first
Acid esters, Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate, D phase is glycerol polymethacrylates/propylene glycol/PVM/
MA copolymer, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate；
4) add E phase and F phase, stir.Wherein E phase is butanediol/water/peony root extractive, acetyl group hexapeptide, ferment
Female extract；F phase is salicylic acid/dextrin/xanthan gum/amylopectin, carnosine.
5) discharging.
Below the main composition in the present invention is introduced:
1) Argireline, is the effective biologically active polypeptide extracted from natural plants (Physcomitrrella)
Sequence, this composition both can reduce existing facial wrinkles, can effectively prevent again new wrinkle from producing.Its birth, indicates anti-
Wrinkle Wrinkle removing cosmetic from traditional activated thing to the transformation of biological active matter.It is a kind of effective, safe defying age biological active matter,
Energy aufhellung wrinkle depth, in terms of suppression histrionic muscles contraction, especially imitates near eyes and forehead etc. histrionic muscles inhibitory action
Really, it is similar to botulinal wrinkle removal effect, but it is more safe and effective.
2) yeast extract, is a kind of active matter extracted from unartificial yeast, mainly by by yeast cells
Protein degradation is aminoacid and peptide, and nucleolysis is nucleotide, and is extracted together with other active matters in yeast cells
Obtain.At present, have been achieved by isolated experiment and human experimentation has separately verified the white-skinned face function of pure natural yeast extract.
In vitro tissue slicing experiment result shows, compared with placebo, mass fraction be 0.5% and 1.0% yeast extract water-soluble
Liquid is respectively 55.8% (p < 0.05) and 81.2% (p ＜ 0.01) to melanic suppression ratio, and mass fraction is the song of 1.0%
Aqueous acid (positive control) is 25.9% (p ＜ 0.05) to melanic suppression ratio.In double blinding human experimentation, compare use
The skin of placebo side, use mass fraction be the skin brightness of 3% yeast extract skin whitener during whole test in
Growth trend, in time testing 42d, remains in that the growth (p ＜ 0.05) of more than 30%；Melanin index (MI) value of skin
During whole test on a declining curve, when 42d, remain in that the decline (p < 0.05) of 38%.Visible yeast extract
There is the white-skinned face function (p < 0.05) being significantly higher than matched group.
3) carnosine, the dipeptides being made up of β-alanyl-L-histidin, carnosine is proved to be potent antioxidant, energy
Enough effective quenching activity oxygen-derived free radicals, protect cell membrane；Carnosine can suppress saccharification react as good anti-gfycation agent, effectively
Cancellation light base free radical, moreover it is possible to prevent the crosslinking of the macromole such as collagen protein, reduces the generation of wrinkle；Carnosine forms as skin
A part, natural, safety, impaired skin tissue can be helped to repair, improve skin immunocompetence；Carnosine heavy metal ion
There is complexing, be possible not only to play the effect of dispelling toxicity, detoxicating, also can help to maintain formula in cosmetics series
Stability.
The invention has the beneficial effects as follows:
Aufhellung wrinkle depth, suppression is near the contraction of eyes and forehead etc. histrionic muscles；Effectively cancellation light base free radical, also
The crosslinking of the macromole such as collagen protein can be prevented, reduce the generation of wrinkle；Repair impaired skin tissue, improve the immunity of skin
Power；Skin whitening, replenishing water and preserving moisture.
Detailed description of the invention
Preparation method:
1) carbomer, hyaluronate sodium, sodium polyacrylate/Polyethylene Glycol-5M, butanediol 5, glycerol, deionized water are made
Being added in aqueous phase pot for A, be heated to 90 degree, insulated and stirred 30 minutes, wherein, carbomer is that homogenizing adds the most afterwards；
2) add B phase after being cooled to less than 40 degree after vacuum froth breaking to stir.Wherein B phase is triethanolamine；
3) add that C, D are biphase stirs.Wherein C phase is Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl ammonia first
Acid esters, Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate, D phase is glycerol polymethacrylates/propylene glycol/PVM/
MA copolymer, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate；
4) add E phase and F phase, stir.Wherein E phase is butanediol/water/peony root extractive, acetyl group hexapeptide, ferment
Female extract；F phase is salicylic acid/dextrin/xanthan gum/amylopectin, carnosine.
5) discharging.
Embodiment 1
Carbomer 0.46%, hyaluronate sodium 0.24%, sodium polyacrylate/Polyethylene Glycol-5M0.01%, butanediol 2%,
Glycerol 2%, triethanolamine 0.2%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.1%, the different thiophene of methyl
Oxazoline ketone/iodine propilolic alcohol butyl mephenesin Carbamate 0.05%, glycerol polymethacrylates/propylene glycol/Gantrez AN-119
0.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.2%, butanediol/water/peony root extractive 0.1%, acetyl group six
Peptide-80.5%, yeast extract 0.4%, salicylic acid/dextrin/xanthan gum/amylopectin 0.2%, carnosine 0.1%, surplus is for going
Ionized water.
Embodiment 2
Carbomer 0.65%, hyaluronate sodium 0.43%, sodium polyacrylate/Polyethylene Glycol-5M0.03%, butanediol 8%,
Glycerol 8%, triethanolamine 0.8%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.3%, the different thiophene of methyl
Oxazoline ketone/iodine propilolic alcohol butyl mephenesin Carbamate 0.18%, glycerol polymethacrylates/propylene glycol/Gantrez AN-119
1.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.7%, butanediol/water/peony root extractive 0.5%, acetyl group six
Peptide-81.6%, yeast extract 1.6%, salicylic acid/dextrin/xanthan gum/amylopectin 0.7%, carnosine 0.21%, surplus is
Deionized water.
Embodiment 3
Carbomer 0.52%, hyaluronate sodium 0.35%, sodium polyacrylate/Polyethylene Glycol-5M0.02%, butanediol 5%,
Glycerol 5%, triethanolamine 0.5%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.2%, the different thiophene of methyl
Oxazoline ketone/iodine propilolic alcohol butyl mephenesin Carbamate 0.1%, glycerol polymethacrylates/propylene glycol/Gantrez AN-119 1%, wheat
Bud oligosaccharide glucoside/hydrogenated starch hydrolysate 0.5%, butanediol/water/peony root extractive 0.3%, Argireline 1%,
Yeast extract 1%, salicylic acid/dextrin/xanthan gum/amylopectin 0.5%, carnosine 0.15%, surplus is deionized water.
Experimentation:
1) face skin compacts and lifts test
Test number: 30
Test object: 20-60 year between women
Cycle on probation: 2 months
Using method: take 2～3 every day after face cleaning and be uniformly applied to face, near the eyes, rubs a little by absorbing.
Test result: after 2 months, has 26 tested personnel to feel the effect having lifting.2) wrinkle, microgroove improve experiment
Object on probation: Argireline stock solution prepared by each embodiment try out object be age 25-68 year women 100.
Cycle on probation: 2 months
Using method: take 2～3 every night after face cleaning and be uniformly applied to face, near the eyes, rubs a little by absorbing.
Using effect is as shown in table 1:
Table 1 whitening anti-wrinkling is tested
| Effect | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Face substantially moistens | 99 | 99 | 98 |
| Face skin compacts, flexible | 96 | 97 | 94 |
| Obscure minimizing, skin is glossy | 95 | 94 | 92 |
| Without significant change | 1 | 2 | 1 |
After Shi Yong, all do not find zest and allergic phenomena.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that, for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the guarantor of the present invention
Protect scope.
Claims (4)
1. an Argireline stock solution, it is characterised in that described Argireline stock solution consists of the following composition: carbomer 0.46～
0.65%, hyaluronate sodium 0.24～0.43%, sodium polyacrylate/Polyethylene Glycol-5M0.01～0.03%, butanediol 2～
8%, glycerol 2～8%, triethanolamine 0.2～0.8%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate
0.1～0.3%, Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate 0.003～0.008%, glycerol polymethylacrylic acid
Ester/propylene glycol/Gantrez AN-119 0.5～1.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.2～0.7%, fourth two
Alcohol/water/peony root extractive 0.1～0.5%, Argireline 0.5～1.6%, yeast extract 0.4～1.6%, bigcatkin willow
Acid/dextrin/xanthan gum/amylopectin 0.2～0.7%, carnosine 0.1～0.21%, surplus is deionized water.
Argireline stock solution the most according to claim 1, it is characterised in that described Argireline stock solution consists of the following composition:
Carbomer 0.5～0.6%, hyaluronate sodium 0.31～0.41%, sodium polyacrylate/Polyethylene Glycol-5M0.02～0.03%, fourth
Glycol 3～6%, glycerol 3～6%, triethanolamine 0.3～0.6%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl ammonia
Formic acid esters 0.15～0.25%, Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate 0.08～0.15%, the poly-methyl of glycerol
Acrylate/propylene glycol/Gantrez AN-119 0.8～1.2%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.3～
0.5%, butanediol/water/peony root extractive 0.2～0.3%, Argireline 0.8～1.2%, yeast extract 0.8～
1.2%, salicylic acid/dextrin/xanthan gum/amylopectin 0.4～0.6%, carnosine 0.14～0.18%, surplus is deionized water.
Argireline stock solution the most according to claim 2, it is characterised in that described Argireline stock solution consists of the following composition:
Carbomer 0.52%, hyaluronate sodium 0.35%, sodium polyacrylate/Polyethylene Glycol-5M0.02%, butanediol 5%, glycerol 5%,
Triethanolamine 0.5%, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.2%, Methylisothiazolinone/
Iodine propilolic alcohol butyl mephenesin Carbamate 0.1%, glycerol polymethacrylates/propylene glycol/Gantrez AN-119 1%, Fructus Hordei Germinatus oligose
Glucoside/hydrogenated starch hydrolysate 0.5%, butanediol/water/peony root extractive 0.3%, Argireline 1%, yeast carries
Taking thing 1%, salicylic acid/dextrin/xanthan gum/amylopectin 0.5%, carnosine 0.15%, surplus is deionized water.
4. the preparation method of the Argireline stock solution described in any one of claims 1 to 3, it is characterised in that comprise the steps:
1) using carbomer, hyaluronate sodium, sodium polyacrylate/Polyethylene Glycol-5M, butanediol 5, glycerol, deionized water as A phase
Adding in aqueous phase pot, be heated to 90 degree, insulated and stirred 30 minutes, wherein, carbomer is that homogenizing adds the most afterwards；
2) add B phase after being cooled to less than 40 degree after vacuum froth breaking to stir.Wherein B phase is triethanolamine；
3) add that C, D are biphase stirs.Wherein C phase be Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate,
Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate, D phase is glycerol polymethacrylates/propylene glycol/PVM/MA copolymerization
Thing, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate；
4) add E phase and F phase, stir.Wherein E phase is that butanediol/water/peony root extractive, acetyl group hexapeptide, yeast carry
Take thing；F phase is salicylic acid/dextrin/xanthan gum/amylopectin, carnosine.
5) discharging.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511171A (en) * | 2016-12-06 | 2017-03-22 | 广州聚禅现代农业研究院有限公司 | Amaranth polysaccharide-containing beautifying lotion |
| CN106726989A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of method that garden pea extract is extracted from garden pea and its application |
| CN107890456A (en) * | 2017-11-21 | 2018-04-10 | 上海合轩品牌管理有限公司 | A kind of eye cream and preparation method thereof |
| CN107898659A (en) * | 2017-12-28 | 2018-04-13 | 浙江黛美蒂娅化妆品有限公司 | Co-Q10 freezes sudden strain of a muscle and releases piece and preparation method thereof |
| CN107898658A (en) * | 2017-12-13 | 2018-04-13 | 南昌师范学院 | Argireline anti-wrinkle synergy stoste composition |
| CN108524373A (en) * | 2018-06-28 | 2018-09-14 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing anti-wrinkle eye cream and preparation method thereof |
| CN108653006A (en) * | 2018-06-28 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing all about eyes and preparation method thereof |
| CN108670876A (en) * | 2018-08-15 | 2018-10-19 | 杭州满天颂生物科技有限公司 | Cosmetics and preparation method thereof with maintenance skin effect |
| CN109010793A (en) * | 2017-06-09 | 2018-12-18 | 杨平 | A kind of active peptide nursing condensation |
| CN110840786A (en) * | 2019-09-03 | 2020-02-28 | 江苏国实电子商务有限公司 | Blue copper peptide essence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106511171A (en) * | 2016-12-06 | 2017-03-22 | 广州聚禅现代农业研究院有限公司 | Amaranth polysaccharide-containing beautifying lotion |
| CN106726989A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of method that garden pea extract is extracted from garden pea and its application |
| CN109010793A (en) * | 2017-06-09 | 2018-12-18 | 杨平 | A kind of active peptide nursing condensation |
| CN107890456A (en) * | 2017-11-21 | 2018-04-10 | 上海合轩品牌管理有限公司 | A kind of eye cream and preparation method thereof |
| CN107898658A (en) * | 2017-12-13 | 2018-04-13 | 南昌师范学院 | Argireline anti-wrinkle synergy stoste composition |
| CN107898659A (en) * | 2017-12-28 | 2018-04-13 | 浙江黛美蒂娅化妆品有限公司 | Co-Q10 freezes sudden strain of a muscle and releases piece and preparation method thereof |
| CN108653006A (en) * | 2018-06-28 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing all about eyes and preparation method thereof |
| CN108524373A (en) * | 2018-06-28 | 2018-09-14 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing anti-wrinkle eye cream and preparation method thereof |
| CN108670876A (en) * | 2018-08-15 | 2018-10-19 | 杭州满天颂生物科技有限公司 | Cosmetics and preparation method thereof with maintenance skin effect |
| CN110840786A (en) * | 2019-09-03 | 2020-02-28 | 江苏国实电子商务有限公司 | Blue copper peptide essence and preparation method thereof |
| CN111000793A (en) * | 2019-12-27 | 2020-04-14 | 广州市玉鑫化妆品有限公司 | Anti-aging wrinkle-removing essence capable of rapidly lifting V face and preparation method thereof |
| CN111679028A (en) * | 2020-07-24 | 2020-09-18 | 上海市食品药品检验所 | High performance liquid chromatography tandem mass spectrometry detection method for four peptides in cosmetics |
| CN111679028B (en) * | 2020-07-24 | 2023-03-21 | 上海市食品药品检验研究院 | High performance liquid chromatography tandem mass spectrometry detection method for four peptides in cosmetics |
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