CN107412533A - A kind of composition acted on beneficial lung, anti-fog haze and preparation method thereof - Google Patents

A kind of composition acted on beneficial lung, anti-fog haze and preparation method thereof Download PDF

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Publication number
CN107412533A
CN107412533A CN201710238533.7A CN201710238533A CN107412533A CN 107412533 A CN107412533 A CN 107412533A CN 201710238533 A CN201710238533 A CN 201710238533A CN 107412533 A CN107412533 A CN 107412533A
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parts
lung
fog haze
freeze
garlic
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Inventor
谢文英
郭振生
李亮
尚立芝
王俊月
张良芝
包海燕
薛红利
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Henan University of Traditional Chinese Medicine HUTCM
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Henan University of Traditional Chinese Medicine HUTCM
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of composition acted on beneficial lung, anti-fog haze, its raw material is made up of the component of following parts by weight:10~20 parts of folium panacis japonici cum caule, 5~15 parts of the root bark of shaggy-fruited dittany, 5~10 parts of EXOCARPIUM CITRULLI, 5~10 parts of red pears, 3~5 parts of ternip, 3~5 parts of semen armeniacae amarae, 3~5 parts of fresh fructus hippophae, 1~3 part of perillaseed, 1~3 part of lepidium seed, 1~2 part of garlic, 0.5~1 part of rock sugar.In addition, present invention also offers a kind of preparation method of the composition acted on beneficial lung, anti-fog haze.The composite formula that there is beneficial lung, anti-fog haze to act on of the present invention is reasonable, can improve patients with COPD lung effect, reduce the release of body inflammatory factor, improve immunity of organisms anti-inflammatory, delay lung injury, repairs and improves lung effect.

Description

A kind of composition acted on beneficial lung, anti-fog haze and preparation method thereof
Technical field
The invention belongs to health product technology field, and in particular to a kind of composition acted on beneficial lung, anti-fog haze.
Background technology
Haze refers to the suspended particulate substance in air, and the particulate matter of diameter≤10 micron is referred to as " thick suspended particulate substance (PM10) ", the particulate matter of diameter≤2.5 micron is referred to as " thin suspended particulate substance (PM2.5) ", and the smaller particulate matter of diameter enters lung Portion is deeper, and PM10 can enter lung by breathing, and PM2.5 can then be directly entered alveolar, it might even be possible to enters through alveolar Blood.These particulate matters can make body Oxidation-antioxidation system unbalance after entering human body, and then cause lung injury, Response to oxidative stress can also be started, body is locally discharged a large amount of inflammatory mediators causes inflammatory damage.Therefore, the breathing system of human body System is most susceptible to infringement, Long Term Contact and the progression of fibrosis that can cause lung tissue in this particle substance environment.
The traditional Chinese medical science thinks that haze is tangible turbid pathogenic factor, attacks human body and causes a disease.Contain a variety of poisonous and harmful elements in haze, directly Connect respiratory system to be inhaled into vivo, substantial amounts of particulate component and can absorbing toxin, stopped in deep lung, and block mechanism of qi, Damage lung network.Therefore, haze causes a disease, and dryness evil feature is more obvious.For its property when dry, dry be yang pathogens, change burn Tianjin, may occur in which mouth and nose Pathogenic performance one drying of one dryness evil such as eyes are dry and astringent, pharyngalgia, dry throat, dry cough, phlegm are few and viscous as;" lung being a delicate viscus, happiness Moisten and dislike dry ", dryness evil most easily hinders lung, and tracheitis, laryngitis, asthma, chronic obstructive pulmonary disease etc. occurs in permanent stimulate, or even forms lung cancer etc. More serious disease.At present the treatment method on beneficial lung, anti-fog haze be medication, although method of administration can make symptom obtain compared with Good improvement, but the palatability of medicine is poor, and cost is high, is not easy to daily health care.
The content of the invention
The invention provides a kind of composition acted on beneficial lung, anti-fog haze, solves beneficial lung, anti-fog in the prior art The treatment method of haze is medication, but the palatability of medicine is poor, and cost is high, the problem of being not easy to daily health caring.
First purpose of the present invention is to provide a kind of composition acted on beneficial lung, anti-fog haze, and its raw material is by following The component composition of parts by weight:10~20 parts of folium panacis japonici cum caule, 5~15 parts of the root bark of shaggy-fruited dittany, 5~10 parts of EXOCARPIUM CITRULLI, 5~10 parts of red pears, 3~5 parts of ternip, 3~5 parts of semen armeniacae amarae, 3~5 parts of fresh fructus hippophae, 1~3 part of perillaseed, 1~3 part of lepidium seed, 1~2 part of garlic, ice 0.5~1 part of sugar.
Preferably, the composition acted on beneficial lung, anti-fog haze is made up of the component of following parts by weight:Folium panacis japonici cum caule 15 parts, 10 parts of the root bark of shaggy-fruited dittany, 8 parts of EXOCARPIUM CITRULLI, 5 parts of red pears, 4 parts of ternip, 4 parts of semen armeniacae amarae, 5 parts of fresh fructus hippophae, 2 parts of perillaseed, Roripa 2 parts of Li, 1 part of garlic, 1 part of rock sugar.
Second object of the present invention is to provide a kind of preparation method of the composition acted on beneficial lung, anti-fog haze, bag Include following steps:
Step 1, each component is weighed according to following weight point:10~20 parts of folium panacis japonici cum caule, 5~15 parts of the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI 5 ~10 parts, 5~10 parts of red pears, 3~5 parts of ternip, 3~5 parts of semen armeniacae amarae, 3~5 parts of fresh fructus hippophae, 1~3 part of perillaseed, lepidium seed 1 ~3 parts, 1~2 part of garlic, 0.5~1 part of rock sugar;
Step 2, mixed after the folium panacis japonici cum caule weighed in step 1, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, lepidium seed being crushed respectively Together, then it is charged with and is measured equivalent to folium panacis japonici cum caule, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, 4~6 times of lepidium seed gross weight The ethanol that concentration is 60~80% soaks 2~3h, reheats refluxing extraction 2~3 times, extracts 2~3h every time, merges all carry Liquid is taken, is filtered, filtrate concentrates at 70~80 DEG C removes ethanol, obtains the concentrated liquid of tradition Chinese medicine;
Step 3, the red pears weighed in step 1, ternip, fresh fructus hippophae are cleaned, takes its pulp, be put into juice extractor and squeeze Juice, coarse particles are obtained, the rock sugar weighed is added in step 1 into coarse particles, stirring makes rock sugar dissolve completely, obtains thick mixing slurry Material, colloid mill is crossed by thick mixed slurry, obtains thin mixed slurry, then by thin mixed slurry dries pulverizing, is crossed 40 mesh sieves, obtained vegetable Fruit powder;
Step 4, by the semen armeniacae amarae weighed in step 1 clear water rinsed clean, 3~5 times of water is added to soak 2~3h, then Slurry is polished into, obtains semen armeniacae amarae slurry;
Step 5, the garlic weighed in step 1 is cleaned, shreds, be put into container, twist juice, filtering, collection obtains garlic Juice;
Step 6, by the semen armeniacae amarae slurry of the concentrated liquid of tradition Chinese medicine of step 2, the vegetables and fruits powder of step 3, step 4, the garlic juice of step 5 Mixing, stirs, obtains mixed material, be then freeze-dried mixed material, obtains freeze-dried powder, and the freeze-dried powder is to have The composition acted on beneficial to lung, anti-fog haze.
Preferably, any one following formulation can be made in the freezing powder:Tablet, capsule, granule, pill divide Discrete piece.
Preferably, the operating procedure being freeze-dried in the step 6 is as follows:
By mixed material at -30 DEG C precooling 3h, be then placed in freeze dryer, be cooled to -30 DEG C rapidly in 2h, wait to mix After compound material is changed into block structure, 0 DEG C is warming up in 3h, is then cooled to -30 DEG C rapidly in 0.5h, material to be mixed becomes After loose ice-like structure, vacuum system is opened, vacuum is slowly increased to 30Pa in 30min, is then turned on heating system, makes Mixed material is to slowly warm up to 40 DEG C in 4h, and vacuum and temperature-resistant is maintained in 5h, vacuum system is then shut off, makes pressure Power slowly returns to normal pressure, that is, obtains the freeze-dried powder of mixed material.
Present invention side solves:
Folium panacis japonici cum caule:It is bitter, sweet, cold.With tonifying Qi, beneficial lung, driving away summer heat, the effect of promoting the production of body fluid.
The root bark of shaggy-fruited dittany:It is bitter, salty, cold.The effect of with heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances.
EXOCARPIUM CITRULLI:It is sweet, cool, nontoxic.With the hot relieving restlessness of change, go the effect of wind dampness removing.
Red pears:It is sweet, slightly sour, cool.The effect of with fluid dryness, clearing heat and eliminating phlegm.
Ternip:It is sweet, pungent, cool.With clearing heat and promoting fluid, cooling blood and hemostasis, lower gas it is wide in, it is relieving dyspepsia, Appetizing spleen-tonifying, pleasant The effect of resolving sputum.
Semen armeniacae amarae:It is hardship, tepor, slightly poisonous.With moistening lung, relieving asthma the effect of.
Fructus hippophae:It is sweet, sour, warm.With gut purge, detoxification, purify the blood liquid the effect of.
Perillaseed:It is pungent, warm.It is relieving cough and asthma with sending down abnormally ascending dissolving phlegm, the effect of relaxing bowel.
Lepidium seed:It is pungent, bitter, cold.With lung sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema, let out by heresy the effect of.
Garlic:It is pungent, warm.Helped digestion with middle benefit gas, row stagnant gas, warming spleen and stomach, disperse accumulations, removing toxic substances, desinsection the effect of.
Rock sugar:It is sweet, flat.With tonifying middle-Jiao and Qi and stomach moistening lung, nourishing Yin and promoting production of body fluid, the effect of moistening the lung and relieve the cough.
The advantages of summary Chinese medicine and food materials of the present invention, complement each other, enhance original drug effect, and many-sided tune Control, the effect of reaching nourishing Yin and moistening lung, clearing cough-relieving, the red dry throat of pharynx caused by effectively alleviating haze weather, cough, cough up phlegm etc. no Suitable symptom.
Folium panacis japonici cum caule has the effect of using tonifying Qi reinforcing lungs, nourishing Yin and promoting production of body fluid in the present composition, and the root bark of shaggy-fruited dittany has heat-clearing and damp-drying drug, dispelled The effect of wind is antipruritic, removing toxic substances, Papillary can nourishing Yin and moistening lung, heat-clearing and damp-drying drug, fundamentally lift body healthy tendency, strengthen lung Function, it is for monarch drug in a prescription;EXOCARPIUM CITRULLI, which has, to be changed hot relieving restlessness, goes the effect of wind dampness removing, and perillaseed has sending down abnormally ascending dissolving phlegm, relieving cough and asthma, The effect of relaxing bowel, lepidium seed have lung sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema, the effect of letting out by heresy, and three shares can dispelling wind Radiate, be clearing heat and detoxicating, effectively alleviating damage of the outside foul smell to lung, be for ministerial drug;Red pears have fluid dryness, clearing heat and eliminating phlegm The effect of, ternip has the effect of clearing heat and promoting fluid, cooling blood and hemostasis, fructus hippophae has detoxification, purify the blood liquid the effect of, garlic has The effect of removing toxic substances, desinsection, rock sugar has tonifying middle-Jiao and Qi, nourishing Yin and promoting production of body fluid, and the effect of moistening the lung and relieve the cough, several drugses are shared with heat-clearing Moistening lung, relieving sore-throat open the effect of sound, can effectively alleviate cough, expectoration caused by haze, be for adjutant.All medicines share is played clearly altogether The effect of sound is opened in hot moistening lung, preventing phlegm from forming and stopping coughing, clearing, for the dry throat caused by haze, pharynx itch, cough, expectoration, unsmooth breath etc. Malaise symptoms and related complication tool have some improvement, prevented or and therapeutic action.
Compared with prior art, the beneficial effects of the present invention are:
1) composition that there is beneficial lung, anti-fog haze to act on of the invention is that natural plants processing configuration forms, and is not occurred Any chemical change, any chemical addition agent is not added yet, can ensure that raw material nutrient is not lost in, at the same aromatic flavour, mouthfeel It is good, be advantageous to take, and the raw material of the present invention is easy to get, and preparation technology is simple, easily implements.
The composition that there is beneficial lung, anti-fog haze to act on of the present invention uses the composition of integration of drinking and medicinal herbs, to being exhaled caused by PM2.5 Inhaling road inflammation has obvious preventive and therapeutic effect, can suppress the secretion of inflammatory factor and various cellular contents, effectively removes lung's rubbish, Promote the healing and growth of cell, protect lung tissue, reduce injury of lungs, in addition, the composition of the present invention is taken by daily, Long-term clearing lung-heat, anti-fog haze effect can be played.
Embodiment
In order that those skilled in the art more fully understand that technical scheme can be practiced, with reference to specific The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Experimental method described in various embodiments of the present invention, it is conventional method unless otherwise specified, it is used lyophilized in experiment Machine is model 1~2LD of ALPHA plus of German CHRIST companies production freeze dryer.
Embodiment 1
A kind of composition acted on beneficial lung, anti-fog haze, its raw material are made up of the component of following parts by weight:Folium panacis japonici cum caule 15 parts, 10 parts of the root bark of shaggy-fruited dittany, 8 parts of EXOCARPIUM CITRULLI, 5 parts of red pears, 4 parts of ternip, 4 parts of semen armeniacae amarae, 5 parts of fresh fructus hippophae, 2 parts of perillaseed, Roripa 2 parts of Li, 1 part of garlic, 1 part of rock sugar.
Specifically prepare in accordance with the following steps:
Step 1, each component is weighed according to following weight point:15 parts of folium panacis japonici cum caule, 10 parts of the root bark of shaggy-fruited dittany, 8 parts of EXOCARPIUM CITRULLI, red pears 5 parts, 4 parts of ternip, 4 parts of semen armeniacae amarae, 5 parts of fresh fructus hippophae, 2 parts of perillaseed, 2 parts of lepidium seed, 1 part of garlic, 1 part of rock sugar;
Step 2, mixed after the folium panacis japonici cum caule weighed in step 1, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, lepidium seed being crushed respectively Together, be then charged with equivalent to folium panacis japonici cum caule, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, 5 times of lepidium seed gross weight amount it is dense Spend and soak 2h for 70% ethanol, reheat refluxing extraction 3 times, extract 2h every time, merge all extract solutions, filter, filtrate Concentration removes ethanol at 80 DEG C, obtains the concentrated liquid of tradition Chinese medicine;
Step 3, the red pears weighed in step 1, ternip, fresh fructus hippophae are cleaned, takes its pulp, be put into juice extractor and squeeze Juice, coarse particles are obtained, the rock sugar weighed is added in step 1 into coarse particles, stirring makes rock sugar dissolve completely, obtains thick mixing slurry Material, colloid mill is crossed by thick mixed slurry, obtains thin mixed slurry, then by thin mixed slurry dries pulverizing, is crossed 40 mesh sieves, obtained vegetable Fruit powder;
Step 4, by the semen armeniacae amarae weighed in step 1 clear water rinsed clean, add 4 times of water to soak 3h, be then polished into Slurry, obtain semen armeniacae amarae slurry;
Step 5, the garlic weighed in step 1 is cleaned, shreds, be put into container, twist juice, filtering, collection obtains garlic Juice;
Step 6, by the semen armeniacae amarae slurry of the concentrated liquid of tradition Chinese medicine of step 2, the vegetables and fruits powder of step 3, step 4, the garlic juice of step 5 Mixing, stirs, obtains mixed material, be then freeze-dried mixed material, obtains freeze-dried powder, and the freeze-dried powder is to have The composition acted on beneficial to lung, anti-fog haze.
Add appropriate amount of auxiliary materials after above-mentioned freeze-dried powder is crushed, mix, pelletize, sieve, dry, then by obtained particulate matter through entering One step tabletting, dry, that is, the composition that there is beneficial lung, anti-fog haze to act on of tablet form is made.
Embodiment 2
A kind of composition acted on beneficial lung, anti-fog haze, its raw material are made up of the component of following parts by weight:Folium panacis japonici cum caule 20 parts, 5 parts of the root bark of shaggy-fruited dittany, 5 parts of EXOCARPIUM CITRULLI, 10 parts of red pears, 3 parts of ternip, 5 parts of semen armeniacae amarae, 3 parts of fresh fructus hippophae, 3 parts of perillaseed, Roripa 1 part of Li, 2 parts of garlic, 0.5 part of rock sugar.
Specifically prepare in accordance with the following steps:
Step 1, each component is weighed according to following weight point:20 parts of folium panacis japonici cum caule, 5 parts of the root bark of shaggy-fruited dittany, 5 parts of EXOCARPIUM CITRULLI, red pears 10 parts, 3~part of ternip, 5 parts of semen armeniacae amarae, 3 parts of fresh fructus hippophae, 3 parts of perillaseed, 1 part of lepidium seed, 2 parts of garlic, 0.5 part of rock sugar;
Step 2, mixed after the folium panacis japonici cum caule weighed in step 1, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, lepidium seed being crushed respectively Together, be then charged with equivalent to folium panacis japonici cum caule, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, 6 times of lepidium seed gross weight amount it is dense Spend and soak 3h for 60% ethanol, reheat refluxing extraction 2 times, extract 3h every time, merge all extract solutions, filter, filtrate Concentration removes ethanol at 70 DEG C, obtains the concentrated liquid of tradition Chinese medicine;
Step 3, the red pears weighed in step 1, ternip, fresh fructus hippophae are cleaned, takes its pulp, be put into juice extractor and squeeze Juice, coarse particles are obtained, the rock sugar weighed is added in step 1 into coarse particles, stirring makes rock sugar dissolve completely, obtains thick mixing slurry Material, colloid mill is crossed by thick mixed slurry, obtains thin mixed slurry, then by thin mixed slurry dries pulverizing, is crossed 40 mesh sieves, obtained vegetable Fruit powder;
Step 4, by the semen armeniacae amarae weighed in step 1 clear water rinsed clean, add 5 times of water to soak 2h, be then polished into Slurry, obtain semen armeniacae amarae slurry;
Step 5, the garlic weighed in step 1 is cleaned, shreds, be put into container, twist juice, filtering, collection obtains garlic Juice;
Step 6, by the semen armeniacae amarae slurry of the concentrated liquid of tradition Chinese medicine of step 2, the vegetables and fruits powder of step 3, step 4, the garlic juice of step 5 Mixing, stirs, obtains mixed material, be then freeze-dried mixed material, obtains freeze-dried powder, and the freeze-dried powder is to have The composition acted on beneficial to lung, anti-fog haze.
Add appropriate amount of auxiliary materials after above-mentioned freeze-dried powder is crushed, mixing, pelletize, sieve, dry, i.e., it is obtained corpuscular with benefit Lung, the composition of anti-fog haze effect.
It should be noted that in above-described embodiment, the operating procedure being freeze-dried in step 6 is as follows:
By mixed material at -30 DEG C precooling 3h, be then placed in freeze dryer, be cooled to -30 DEG C rapidly in 2h, wait to mix After compound material is changed into block structure, 0 DEG C is warming up in 3h, is then cooled to -30 DEG C rapidly in 0.5h, material to be mixed becomes After loose ice-like structure, vacuum system is opened, vacuum is slowly increased to 30Pa in 30min, is then turned on heating system, makes Mixed material is to slowly warm up to 40 DEG C in 4h, and vacuum and temperature-resistant is maintained in 5h, vacuum system is then shut off, makes pressure Power slowly returns to normal pressure, that is, obtains the freeze-dried powder of mixed material.
Embodiment 1~2 has prepared the composition that there is beneficial lung, anti-fog haze to act on to work well, of the invention by ancestral State's Traditional Chinese Medicine helps this solid just theoretical and modern Nutrition and Metabolism regulation and control theory to organically combine, and medication is combined with dietotherapy, opened up One new beneficial lung, anti-fog haze approach, and the present invention using a variety of medicinal materials and food materials come clearing lung-heat moistening lung, for haze to lung The reason for portion is damaged, on the premise of body is not injured, fundamentally realizes the daily health caring of lung.In addition, institute of the present invention Medicinal material and food materials are respectively provided with the characteristics of in good taste, are suitable for taking for most of crowds, are with a wide range of applications.
The usage and dosage for the composition that the present invention acts on beneficial lung, anti-fog haze are as follows:Orally, three times a day, every time 3 ~5g, half an hour, once a dose after meal in the morning, afternoon and evening, and even served 30 days is a course for the treatment of, and depending on state of an illness weight, 3~5 courses for the treatment of are used in conjunction i.e. It can fully recover.In the later stage, take once a day, dose 3g, late one after each meal, long-term use can consolidate curative effect.
The present invention's has the anti-fog haze effect observation of composition that beneficial lung, anti-fog haze act on:
1st, the selection standard of experimental subjects:
(1) non-infectious cough;
(2) have an obvious weather conditions, upper respiratory tract malaise symptoms appear in air have the weather of severe or serious haze it Afterwards, " haze " is main pathogenic factors;
(3) throat sign is obvious:It is pharyngeal to itch, or pain, or dry throat, sense of obstruction, foreign body sensation, most typically symptom are exactly to feel Have phlegm be bonded at it is pharyngeal think that expectoration does not go out come but cough, not expectoration come be difficult again by;
(4) antibiotic therapeutic effect unobvious or invalid;
(5) choke cough, irritable cough, have it is light have a weight, patient's cough of weight to pectoralgia, or even cough is to lying awake all night, have asthma Sensation of asphyxia.
2nd, test method
Randomly select the people of subject 100 by above-mentioned standard, the age at 18~60 years old, M-F 1:1, to embodiment The composition curative effect that there is beneficial lung, anti-fog haze to act on prepared by 1 is observed.Subject is oral for each person every day three times, 3~5g every time, half an hour, once a dose after meal in the morning, afternoon and evening, continuously takes 10 days, and the 1st, 3,5,7,10 day carry out questionnaire with Track is investigated, to observe practical effect.
3rd, criterion of therapeutical effect
(1) it is clearly better:Cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, lung are uncomfortable, uncomfortable in chest, throat foreign body sensation Etc. symptom subject feel be improved significantly, sense of discomfort, which is substantially all, to be reduced or eliminated, the feelings not deteriorated further Condition;
(2) alleviated:Cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, lung are uncomfortable, uncomfortable in chest, throat foreign body sensation There is major part to be reduced or eliminated etc. symptom, partial symptoms improve unobvious;
(3) DeGrain:Cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, lung are uncomfortable, uncomfortable in chest, throat foreign matter The symptoms such as sense are almost without fairly obvious change.
4th, experimental result
The observation result for the composition that the embodiment 1 of table 1 is prepared
As it can be seen from table 1 the composition effect for just starting to take embodiment 1 is not highly desirable, first day is taken always Effective percentage is 20%, and curative effect is obviously improved after continuously taking 5 days, total effective rate 40%, continuously takes the total effective rate of 10 days For 66%.It in summary it can be seen, the present composition improves significantly for a series of malaise symptoms tools caused by haze Or therapeutic action.
Although preferred embodiments of the present invention have been described, but those skilled in the art once know basic creation Property concept, then can make other change and modification to these embodiments.So appended claims be intended to be construed to include it is excellent Select embodiment and fall into having altered and changing for the scope of the invention.
Obviously, those skilled in the art can carry out the essence of various changes and modification without departing from the present invention to the present invention God and scope.So, if these modifications and variations of the present invention belong to the scope of the claims in the present invention and its equivalent technologies Within, then the present invention is also intended to comprising including these changes and modification.

Claims (5)

1. it is a kind of with beneficial lung, anti-fog haze act on composition, it is characterised in that its raw material by following parts by weight component group Into:10~20 parts of folium panacis japonici cum caule, 5~15 parts of the root bark of shaggy-fruited dittany, 5~10 parts of EXOCARPIUM CITRULLI, 5~10 parts of red pears, 3~5 parts of ternip, bitter apricot 3~5 parts of benevolence, 3~5 parts of fresh fructus hippophae, 1~3 part of perillaseed, 1~3 part of lepidium seed, 1~2 part of garlic, 0.5~1 part of rock sugar.
2. the composition according to claim 1 acted on beneficial lung, anti-fog haze, it is characterised in that its raw material is by following The component composition of parts by weight:15 parts of folium panacis japonici cum caule, 10 parts of the root bark of shaggy-fruited dittany, 8 parts of EXOCARPIUM CITRULLI, 5 parts of red pears, 4 parts of ternip, semen armeniacae amarae 4 Part, 5 parts of fresh fructus hippophae, 2 parts of perillaseed, 2 parts of lepidium seed, 1 part of garlic, 1 part of rock sugar.
3. the preparation method of the composition according to claim 1 acted on beneficial lung, anti-fog haze, it is characterised in that tool Body is implemented according to following steps:
Step 1, each component is weighed according to following parts by weight:10~20 parts of folium panacis japonici cum caule, 5~15 parts of the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI 5~10 Part, 5~10 parts of red pears, 3~5 parts of ternip, 3~5 parts of semen armeniacae amarae, 3~5 parts of fresh fructus hippophae, 1~3 part of perillaseed, lepidium seed 1~3 Part, 1~2 part of garlic, 0.5~1 part of rock sugar;
Step 2, one is blended in after the folium panacis japonici cum caule weighed in step 1, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, lepidium seed being crushed respectively Rise, be then charged with equivalent to folium panacis japonici cum caule, the root bark of shaggy-fruited dittany, EXOCARPIUM CITRULLI, perillaseed, the concentration of 4~6 times of amounts of lepidium seed gross weight 2~3h is soaked for 60~80% ethanol, refluxing extraction is reheated 2~3 times, extracts 2~3h every time, merge all extractions Liquid, filtering, filtrate concentrates at 70~80 DEG C removes ethanol, obtains the concentrated liquid of tradition Chinese medicine;
Step 3, the red pears weighed in step 1, ternip, fresh fructus hippophae are cleaned, takes its pulp, be put into juice extractor and squeeze the juice, obtain To coarse particles, the rock sugar that weighs is added in step 1 into coarse particles, and stirring makes rock sugar dissolve completely, obtains thick mixed slurry, will Thick mixed slurry crosses colloid mill, obtains thin mixed slurry, then by thin mixed slurry dries pulverizing, crosses 40 mesh sieves, obtain vegetables and fruits powder;
Step 4, by the semen armeniacae amarae weighed in step 1 clear water rinsed clean, add 3~5 times of water to soak 2~3h, then polish Into slurry, semen armeniacae amarae slurry is obtained;
Step 5, the garlic weighed in step 1 is cleaned, shreds, be put into container, twist juice, filtering, collection obtains garlic juice;
Step 6, the garlic juice of the semen armeniacae amarae slurry of the concentrated liquid of tradition Chinese medicine of step 2, the vegetables and fruits powder of step 3, step 4, step 5 is mixed Close, stir, obtain mixed material, be then freeze-dried mixed material, obtain freeze-dried powder, the freeze-dried powder is to have Beneficial lung, the composition of anti-fog haze effect.
4. the preparation method of the composition according to claim 3 acted on beneficial lung, anti-fog haze, it is characterised in that institute Any one following formulation can be made by stating freeze-dried powder:Tablet, capsule, granule, pill or dispersible tablet.
5. the preparation method of the composition according to claim 3 acted on beneficial lung, anti-fog haze, it is characterised in that institute It is as follows to state the concrete operation step being freeze-dried in step 6:
By mixed material at -30 DEG C precooling 3h, be then placed in freeze dryer, be cooled to -30 DEG C rapidly in 2h, thing to be mixed After material is changed into block structure, 0 DEG C is warming up in 3h, is then cooled to -30 DEG C rapidly in 0.5h, material to be mixed is changed into pine After dissipating ice-like structure, vacuum system is opened, vacuum is slowly increased to 30Pa in 30min, is then turned on heating system, makes mixing Material is to slowly warm up to 40 DEG C in 4h, and vacuum and temperature-resistant is maintained in 5h, vacuum system is then shut off, delays pressure Slowly normal pressure is returned to, that is, obtains the freeze-dried powder of mixed material.
CN201710238533.7A 2017-04-13 2017-04-13 A kind of composition acted on beneficial lung, anti-fog haze and preparation method thereof Pending CN107412533A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535629A (en) * 2016-01-19 2016-05-04 成都普瑞法科技开发有限公司 Traditional Chinese medicinal composition with fog and haze resistant effect

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535629A (en) * 2016-01-19 2016-05-04 成都普瑞法科技开发有限公司 Traditional Chinese medicinal composition with fog and haze resistant effect

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