CN107412124A - A kind of anti-seborrhea shampoo of the active component containing American cockroach - Google Patents
A kind of anti-seborrhea shampoo of the active component containing American cockroach Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
The present invention relates to a kind of anti-seborrhea shampoo of active component containing American cockroach, belong to daily chemical product technical field.The shampoo is made of Asian puccoon fine powder or extract, dandelion fine powder or extract, honeysuckle fine powder or extract, chrysanthemum fine powder or extract, climbing groundsel fine powder or extract, American-cockroach-extract, anion surfactant, zwitterionic surfactant, nonionic surfactant, matrix, chelating agent, NMF, nertralizer, thickener, foam stabilizer, nutritional agents, preservative, essence and water.The product can treat seborrheic skin inflammation, moisten scalp and hair, improve greasy, matt, hair loss phenomenon, application easy to spread.
Description
Technical field
The invention belongs to daily chemical product technical field, is related to a kind of shampoo for treating seborrheic skin inflammation, and in particular to
A kind of anti-grease dew dermatitis shampoo of the active component containing American cockroach.
Background technology
Shampoo is indispensable requisites in our daily lifes, can remove surface from hair and scalp during use
Greasy dirt and scurf, and hair, scalp and health of human body are had no adverse effects.Shampoo species is various, by formulation and function point
Mainly to have transparent shampoo, paste shampoo, pearl shining shampoo dew, amending shampoo, anti-dandruff shampoo, special shampoo etc..
In recent years, because the raising of people's quality of the life, shampoos increase, increasing requirement is it is also proposed to shampoo.
Both need shampoo that there is the anti-dandruff effect of preferable decontamination, and need it that there is preferable performance of keeping humidity again, while also need to hair
There is good cardability after washing；Also treat some scalp macula phenomenons.
Treatment seborrheic skin is scorching now coordinates the massage gallbladder channel of foot-Shaoyang (Jianjing point, point gb 20, point gb 8), governor vessel (wind
Mansion cave, Baihui acupoint, Shenting point), extra nerve points, i.e. points not mentioned in the ancient medical classics (temple), but scalp shouting pain occurs in therapeutic process, scalp lastblock
One piece of red measles, not only pain but also itch, phenomena such as easily losing hair.Therefore how overcome the deficiencies in the prior art is current daily use chemicals
The problem of articles for use technology urgent need to resolve.
The content of the invention
The invention aims to solve the deficiencies in the prior art, there is provided a kind of active component containing American cockroach it is anti-grease
Property of overflowing dermatitis shampoo, the shampoo can efficiently treat seborrheic skin inflammation, and solution hair is withered, kidney-yin deficiency causes hair unglazed
The problem of damp, greasy；Product of the present invention can moisten scalp and hair, improve matt, hair loss phenomenon.
To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of anti-seborrhea shampoo of the active component containing American cockroach, including according to the as follows of mass percentage
Component：
It is further preferred that the anti-seborrhea shampoo of the active component containing American cockroach, including according to
The following component of mass percentage：
It is further preferred that the preparation method of described American-cockroach-extract is：American cockroach is using ethanol as extraction
Solvent alcohol extracting, extract are condensed into medicinal extract shape, that is, obtain American-cockroach-extract.
It is further preferred that the preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated and soak at 44-46 DEG C
3-4 hours are carried, are filtered afterwards, filter residue is dried in 49-51 DEG C of baking oven；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 0.5-3:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:20-40mL, at a temperature of 59-61 DEG C
58-62min is extracted, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:20-40mL, 58-62min is extracted at a temperature of 59-61 DEG C, filter, obtain liquor B and
Filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:20-40mL, 58-62min is extracted at a temperature of 59-61 DEG C, filter, obtain liquor C and
Filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 80 DEG C ± 1 DEG C, obtains U.S.
The big Lian extracts in continent.
The concentration of each component in the present invention in each cushioning liquid is not specifically limited, only restricted to pH value.
The present invention is rotated using Rotary Evaporators and not concentrated during extracting, and is not turned on vavuum pump.
It is further preferred that anion surfactant is ammonium lauryl sulfate (K12A), aliphatic alcohol polyethenoxy
Ether sodium sulfate (AES), sodium laureth sulfate (SLES), aliphatic alcohol polyoxyvinethene phosphate (MAEP) and fatty alcohol polyoxy second
One or more of mixing in alkene ether ammonium sulfate (AESA)；
Zwitterionic surfactant is sodium lauroyl sarcosine (LS-30), Cocoamidopropyl betaine (CAB), the moon
Osmanthus acyl glutamic acid sodium (LG-95P), cocounut oil acyl both sexes base diethyl acid disodium (CAD) and dodecanamide propyl hydroxy sulfo lycine
(LHSB) one or more of mixing in；
Nonionic surfactant be APG (APG), polyethylene glycol (PEG), cocounut oil diglycollic amide (CDEA,
6501) one or more of mixing and in pungent Plantacare 818.
It is further preferred that chelating agent is disodium ethylene diamine tetraacetate (EDTA-2Na) and ethylenediamine tetra-acetic acid
(EDTA) one or two kinds of mixing in；Matrix is one or two kinds of mixing in simethicone emulsion and amino silicon oil emulsion；
NMF is mixing one or more of in trimethylglycine, glycerine and propane diols；Nertralizer be triethanolamine, citric acid,
One or more of mixing in sodium citrate, sodium hydroxide and potassium hydroxide.
It is further preferred that thickener is cation guar gum, Macrogol 6000 double stearates (638 thickenings
Agent), amine oxide (OA), mixing one or more of in sodium chloride and cetanol；Foam stabilizer is Cocoamidopropyl betaine
(CAB) one or two kinds of mixing and in cocounut oil diglycollic amide (6501)；Nutritional agents is a kind of in D-pantothenyl aleohol and collagen
Or two kinds of mixing；Preservative be Kathon CG, KF88, methylchloroisothiazandnone, methylisothiazolinone, sodium benzoate, to hydroxyl
One or more of mixing in yl benzoic acid methyl esters and propylparaben.
It is further preferred that essence is rosemary essence, spearmint essence, Lancome essence, sesame flavor, Mint Essence, chrysanthemum
One or more of mixing in extrait and cream jasmin france；Water is one or more of in deionized water, mineral water and distilled water
Mixing；Water is mixing one or more of in deionized water, mineral water and distilled water.
It is further preferred that described anion surfactant is ammonium lauryl sulfate；Described amphion
Surfactant is lauroyl propylhomoserin sodium (LS-30)；Described nonionic surfactant is APG (APG)；It is described
Chelating agent be disodium ethylene diamine tetraacetate (EDTA-2Na)；Described matrix is dimethicone；Described NMF is three
Methylglycine；Described nertralizer is triethanolamine；Described thickener is cation guar gum；Described foam stabilizer is coconut palm
Oleamide CAB (CAB).
It is further preferred that the preparation method of described extract is：It is permanent that Chinese herbal medicine is first put into 39-42 DEG C of biology
Warm drying box continues drying out 4.8-5.3 hours, is crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, is steamed in rotation
Send out swirling recirculation flow extraction in instrument and three times, each 3.8-4.2 hours, merge extract, be concentrated into moisture and be evaporated and produce traditional Chinese medicine extraction
Thing；
For the first time and second of quality for extracting water used is 5.8-6.2 times of Chinese herbal medicine quality；Used in third time extraction
The quality of water be 3.8-4.2 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
Asian puccoon, major function：Clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing.For blood-heat and toxin exuberance, atropurpureus macula, measles is not
Thoroughly, sore, eczema, scald.
Dandelion, major function：It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.For furuncle swelling toxin, acute mastitis, scrofula, mesh
It is red, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Chrysanthemum, major function：Wind heat-clearing is dissipated, flat liver improving eyesight is clearing heat and detoxicating.For anemopyretic cold, dizziness of having a headache, hot eyes swells
Bitterly, eyes is dim-sighted, sore and toxic.
Honeysuckle, major function：It is clearing heat and detoxicating, dispelling wind and heat from the body.For carbuncle swells furunculosis, numbness, erysipelas, toxic-heat and blood stasis, wind are swallowed
Thermal sensation emits, warm disease heating.
Climbing groundsel fine powder, major function：Clearing heat and detoxicating, improving eyesight, dampness removing.For carbuncle sore tumefacting virus, cold, fever, hot eyes swells
Bitterly, dysentery, skin eczema.
Each Chinese herbal medicine fine powder of the present invention can use commercially available dry finished product to crush and be made.
The present invention is not particularly limited to essence, or spices.
The present invention is not particularly limited to the preparation method of product, can be with using the shampoo preparation method of routine
To be mixed using conventional physical mechanical, but not limited to this.
Amino acid during up to 18 have been detected in American-cockroach-extract of the present invention, and the micro member of a variety of needed by human body
Element, wherein the cystine contained is mainly used in treating various alopecia symptoms, promote the growth of epidermal cell, improve hair follicle, promote
Natural on-off cycles of hair growth, anti-alopecia-stopping, moreover it is possible to anti-inflammatory, sterilization, available for treating alopecia seborrheica.
Compared with prior art, its advantage is the present invention：
The present invention except add American cockroach semi-bionic extraction method active component, have anti-seborrhea, it is anti-oxidant, repair
Outside the effect nursed again, Radix Arnebiae extract, dandelion extract, Honegsukle flower P.E, chrysanthemum extract, climbing groundsel also added
Extract compatibility, there is anti-bacterial, anti-itching, reduce fat secretion, releive scalp sensitivity, nourishing, antagonism free radical, firm root of hair, add
The effect of strong curative effect.
Embodiment
With reference to embodiment, the present invention is described in further detail.
It will be understood to those of skill in the art that the following example is merely to illustrate the present invention, and it should not be regarded as limiting this hair
Bright scope.In the examples where no specific technique or condition is specified, according to the technology or condition described by document in the art
Or carried out according to product description.Material therefor or the unreceipted production firm person of equipment, it is that can be obtained by buying
Conventional products.
Embodiment 1
| Material name | Mass percent (amounts to 100%) |
| Asian puccoon fine powder | 0.1% |
| Dandelion fine powder | 2.0% |
| Honeysuckle fine powder | 0.1% |
| Chrysanthemum fine powder | 2.0% |
| Climbing groundsel fine powder | 0.1% |
| American-cockroach-extract | 1.0% |
| Anion surfactant：Ammonium lauryl sulfate | 5% |
| Zwitterionic surfactant：Sodium lauroyl sarcosine | 10% |
| Nonionic surfactant：APG | 1.5% |
| Matrix：Simethicone emulsion | 2% |
| Chelating agent：Disodium ethylene diamine tetraacetate | 0.08% |
| NMF：Trimethylglycine | 3% |
| Nertralizer：Triethanolamine | 0.1% |
| Thickener：Cation guar gum | 1.5% |
| Foam stabilizer：Cocoamidopropyl betaine | 1.0% |
| Nutritional agents：D-pantothenyl aleohol | 2% |
| Preservative | 0% |
| Essence：Rosemary essence | 0.3% |
| Water：Deionized water | Surplus |
The preparation method of American-cockroach-extract is：American cockroach is condensed into by Extraction solvent alcohol extracting, extract of ethanol
Medicinal extract shape, that is, obtain American-cockroach-extract.
Embodiment 2
The preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated at 44 DEG C and extract 3
Hour, filter afterwards, filter residue is dried in 49 DEG C of baking ovens；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 0.5:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:20mL, extracted at a temperature of 59 DEG C
58min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:20mL, 58min is extracted at a temperature of 59 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:20mL, 58min is extracted at a temperature of 59 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 79 DEG C, obtains American cockroach
Extract.
The preparation method of described extract is：Chinese herbal medicine is first put into 40 DEG C of biological temperature-constant drying boxes, and to continue drying out 5 small
When, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, swirling recirculation flow extracts three times, often in Rotary Evaporators
Secondary 4 hours, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 6 times of Chinese herbal medicine quality；Third time extracts water used
Quality is 4 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
Embodiment 3
The preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated at 46 DEG C and extract 4
Hour, filter afterwards, filter residue is dried in 51 DEG C of baking ovens；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 3:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:40mL, extracted at a temperature of 61 DEG C
62min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:40mL, 62min is extracted at a temperature of 61 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:40mL, 62min is extracted at a temperature of 61 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 81 DEG C, obtains American cockroach
Extract.
The preparation method of described extract is：Chinese herbal medicine is first put into 41 DEG C of biological temperature-constant drying boxes and continues drying out 4.9
Hour, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, swirling recirculation flow extracts three times in Rotary Evaporators,
3.9 hours every time, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 5.9 times of Chinese herbal medicine quality；Third time extracts water used
Quality be 3.9 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
Embodiment 4
The preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated and extract at 45 DEG C
3.5 hours, filter afterwards, filter residue is dried in 50 DEG C of baking ovens；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 2.4:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:30mL, extracted at a temperature of 60 DEG C
60min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 80 DEG C, obtains American cockroach
Extract.
The preparation method of described extract is：Chinese herbal medicine is first put into 42 DEG C of biological temperature-constant drying boxes persistently do it is 5.3 small
When, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, swirling recirculation flow extracts three times, often in Rotary Evaporators
Secondary 4.2 hours, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 6.2 times of Chinese herbal medicine quality；Third time extracts water used
Quality be 4.2 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
Embodiment 5
| Material name | Mass percent (amounts to 100%) |
| Radix Arnebiae extract | 2.0% |
| Dandelion extract | 0.2% |
| Honegsukle flower P.E | 1.5% |
| Chrysanthemum extract | 0.2% |
| Herba Senecionis Scandentis extract | 2.5% |
| American-cockroach-extract | 0.15% |
| Anion surfactant：Ammonium lauryl sulfate | 10% |
| Zwitterionic surfactant：Sodium lauroyl sarcosine | 4% |
| Nonionic surfactant：APG | 5% |
| Matrix：Simethicone emulsion | 1% |
| Chelating agent：Disodium ethylene diamine tetraacetate | 0.4% |
| NMF：Trimethylglycine | 1.5% |
| Nertralizer：Triethanolamine | 0.8% |
| Thickener：Cation guar gum | 0.2% |
| Foam stabilizer：Cocoamidopropyl betaine | 2.5% |
| Nutritional agents：D-pantothenyl aleohol | 0.12% |
| Preservative：Propylparaben | 0.2% |
| Essence：Spearmint essence | 0.1% |
| Water：Deionized water | Surplus |
The preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated and extract at 45 DEG C
3.5 hours, filter afterwards, filter residue is dried in 50 DEG C of baking ovens；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 2.4:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:30mL, extracted at a temperature of 60 DEG C
60min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 80 DEG C, obtains American cockroach
Extract.
The preparation method of described extract is：Chinese herbal medicine is first put into 39 DEG C of biological temperature-constant drying boxes and continues drying out 4.8
Hour, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, swirling recirculation flow extracts three times in Rotary Evaporators,
3.8 hours every time, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 5.8 times of Chinese herbal medicine quality；Third time extracts water used
Quality be 3.8 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
Embodiment 6
The preparation method of described American-cockroach-extract comprises the following steps：
Step (1), will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach after crushing
Polypide powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated and extract at 45 DEG C
3.5 hours, filter afterwards, filter residue is dried in 50 DEG C of baking ovens；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 2.4:12；
Step (2), 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby
With；
Step (3), the filter residue after being dried in step (1) is added to the pH=2.0 of step (2) preparation cushioning liquid
In, the mass volume ratio of the cushioning liquid of filter residue and pH=2.0 after drying is 1g:30mL, extracted at a temperature of 60 DEG C
60min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added in the pH=7.5 cushioning liquid of step (2) preparation afterwards, filter residue A's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added in the pH=8.3 cushioning liquid of step (2) preparation afterwards, filter residue B's and pH=7.5 is slow
The mass volume ratio for rushing solution is 1g:30mL, 60min is extracted at a temperature of 60 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 80 DEG C, obtains American cockroach
Extract.
The preparation method of described extract is：Chinese herbal medicine is first put into 40 DEG C of biological temperature-constant drying boxes, and to continue drying out 5 small
When, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, swirling recirculation flow extracts three times, often in Rotary Evaporators
Secondary 4 hours, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 6 times of Chinese herbal medicine quality；Third time extracts water used
Quality is 4 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
The preparation method of 6 embodiments of the above uses the routine fashion of the art, without particular/special requirement.
Test example 1：The clean result evaluation of shampoo of the present invention
(1) outward appearance of shampoo, viscosity, the physical and chemical index such as the stability of foam, dissolubility are above GB (T2015 rule
It is fixed)；After shampoo of the present invention being used continuously 40 days by the voluntary people of trier 48, situation feedback is as shown in table 1.
The trier's situation feedback form (unit of table 1.：Number)
(2) this product microorganism and heavy metal reach and are better than national standard, testing result such as table 2
Table 2
Test example 2 causes the symptom treatment effect of alopecia seborrheica
First, subjects：Feel it is sensitive to environmental stimuli, occur the scales of skin that peel off, erythema, itch, it is greasy, matt, lose hair
Etc. symptom.
2nd, inclusive criteria
1. 18-54 years old ages, number 74.
2. the voluntary participation experiment of 8 weeks by a definite date；
3. overall health of patients is good, no allergies；
3rd, test method
Control group 1：Shampoo purchased in market
Control group 2：The shampoo of control group 2 and the difference of embodiment 6 are not add American-cockroach-extract；
Control group 3：The shampoo of control group 3 and the difference of embodiment 5 are not add each Chinese herbal medicine extract
Test group：The shampoo of the anti-seborrhea of the active component containing American cockroach prepared by embodiment 1-6
Wash once daily within 1st week, the 2nd week every 1 day once, 3-8 week three-times-weekly.Two groups of patients treat 8 weeks as one
The course for the treatment of, the dosage washed hair every time are 5-10mL.
2. result of the test is tested and assessed
(1) 72 tester, it is respectively 48 and 24 to include the test group of analysis and control group, and 48 people are divided into six small
Group, wherein the shampoo of special implementing example 6 that 1 people's hair loss phenomenon is more serious, other 47 washing with 1-6 of the embodiment of the present invention respectively
Become visible, all testers subjective symptom, objective sign VAS value changes such as table 3 during research.
3 all testers of table subjective symptom, objective sign VAS value changes during research
Remarks：Invalid (feeling not to be resistant to the number of seborrheic dermatitis)；Effectively (feel anti-grease to a certain extent to overflow
The number of property dermatitis)；Significantly (think to can be very good anti-seborrhea number).
Patient's curative effect compares：Total effective rate is 45.8% after control group treatment, and test group total effective rate average is
91.7%, the statistically significant (P of comparing difference<0.05).
(2) symptom contrast is as shown in table 4 before and after using shampoo
Table 4 is contrasted using symptom before and after shampoo
Experimental result：1. embodiment 1-6 compares with control group 1 as can be seen from Table 3 preferable anti-seborrhea
Effect；The effect of embodiment 1-6 anti-seborrhea is better than control group 2,3, illustrates that American-cockroach-extract extracts with Asian puccoon
Thing, dandelion extract, Honegsukle flower P.E, chrysanthemum extract, Herba Senecionis Scandentis extract compatibility have good synergy.
2. as can be seen from Table 4, shampoo of the invention is with being free of American cockroach, Asian puccoon, dandelion, chrysanthemum, gold and silver
The shampoo purchased in market (control group 1) of flower extract is compared, have it is preferably anti-dandruff, it is anti-so as to reach the effect of the erythema that disappears except itch
The purpose of seborrhea；Compared from embodiment 1-6 with control group 2 with 3, corresponding extract arranges in pairs or groups mutually use than being used alone
When effect it is more preferable.
General principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (10)
1. the anti-seborrhea shampoo of a kind of active component containing American cockroach, it is characterised in that including according to quality percentage
The following component of number meter：
Asian puccoon fine powder or extract 0.1 ~ 2.5%；
Dandelion fine powder or extract 0.1 ~ 2.0%；
Honeysuckle fine powder or extract 0.1 ~ 2.0%；
Chrysanthemum fine powder or extract 0.1 ~ 2.0%；
Climbing groundsel fine powder or extract 0.1 ~ 3%；
American-cockroach-extract 0.1 ~ 1.0%；
Anion surfactant 5 ~ 12%；
Zwitterionic surfactant 3 ~ 10%；
Nonionic surfactant 1.5 ~ 6%；
Matrix 0.5 ~ 2%；
Chelating agent 0.08 ~ 0.5%；
NMF 1 ~ 3%；
Nertralizer 0.1 ~ 1.0%；
Thickener 0.1 ~ 1.5%；
Foam stabilizer 1.0 ~ 3.0%；
Nutritional agents 0.1 ~ 2%；
Preservative 0 ~ 0.3%；
Essence 0 ~ 0.3%；
Water surplus；
Amount to 100%.
2. the anti-seborrhea shampoo of the active component according to claim 1 containing American cockroach, it is characterised in that bag
Include the following component according to mass percentage：
Asian puccoon fine powder or extract 0.2 ~ 2.0%；
Extract dandelion fine powder or extract 0.2 ~ 1.5%；
Honeysuckle fine powder or extract 0.2 ~ 1.5%；
Chrysanthemum fine powder or extract 0.2 ~ 1.5%；
Climbing groundsel fine powder or extract 0.2 ~ 2.5%；
American-cockroach-extract 0.15 ~ 0.8%；
Anion surfactant 4 ~ 10%；
Zwitterionic surfactant 4 ~ 8%；
Nonionic surfactant 2 ~ 5%；
Matrix 1 ~ 1.5%；
Chelating agent 0.1-0.4%
NMF 1.5 ~ 2.5%；
Nertralizer 0.15 ~ 0.8%；
Thickener 0.2 ~ 1.4%；
Foam stabilizer 1.2 ~ 2.5%；
Nutritional agents 0.12 ~ 1.8%；
Preservative 0.1 ~ 0.2%；
Essence 0.1 ~ 0.2%；
Water surplus；
Amount to 100%.
3. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In the preparation method of described American-cockroach-extract is：American cockroach is condensed into by Extraction solvent alcohol extracting, extract of ethanol
Medicinal extract shape, that is, obtain American-cockroach-extract.
4. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In the preparation method of described American-cockroach-extract comprises the following steps：
Step（1）, will dry American cockroach polypide and be crushed to particle size is 60-200um, the American cockroach polypide after crushing
Powder is poured into Rotary Evaporators sample bottle, is then added the ethanol that volumetric concentration is 95%, is rotated at 44-46 DEG C and extract 3-4
Hour, filter afterwards, filter residue is dried in 49-51 DEG C of baking oven；
The mass ratio for the ethanol that described American cockroach polypide powder is 95% with volumetric concentration is 0.5-3:12；
Step（2）, 3 kinds of cushioning liquid that pH is 2.0,7.5,8.3 are configured to respectively with citric acid, disodium hydrogen phosphate, it is standby；
Step（3）, by step（1）Filter residue after middle drying is added to step（2）In the cushioning liquid of pH=2.0 of preparation, drying
The mass volume ratio of filter residue afterwards and the cushioning liquid of pH=2.0 is 1g:20-40mL, 58- is extracted at a temperature of 59-61 DEG C
62min, filtering, obtains filtrate A and filter residue A；
Filter residue A is added to step afterwards（2）In the cushioning liquid of pH=7.5 of preparation, filter residue A and the cushioning liquid of pH=7.5
Mass volume ratio be 1g:20-40mL, 58-62min is extracted at a temperature of 59-61 DEG C, filter, obtain liquor B and filter residue B；
Filter residue B is added to step afterwards（2）In the cushioning liquid of pH=8.3 of preparation, filter residue B and the cushioning liquid of pH=7.5
Mass volume ratio be 1g:20-40mL, 58-62min is extracted at a temperature of 59-61 DEG C, filter, obtain liquor C and filter residue C；
Filtrate A, liquor B and liquor C are merged, after being condensed into medicinal extract, is dried under conditions of 80 DEG C ± 1 DEG C, it is big to obtain America
Lian extracts.
5. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In anion surfactant is ammonium lauryl sulfate, sodium sulfate of polyethenoxy ether of fatty alcohol, sodium laureth sulfate, fat
One or more of mixing in fat alcohol polyoxyethylene ether phosphate and AESA；
Zwitterionic surfactant is sodium lauroyl sarcosine, Cocoamidopropyl betaine, sodium lauroyl glutamate, coconut palm
One or more of mixing in oleoyl both sexes base diethyl acid disodium and dodecanamide propyl hydroxy sulfo lycine；
Nonionic surfactant be it is a kind of in APG, polyethylene glycol, cocounut oil diglycollic amide and pungent Plantacare 818 or
Several mixing.
6. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In chelating agent is mixing one or two kinds of in disodium ethylene diamine tetraacetate and ethylenediamine tetra-acetic acid；Matrix is dimethicone
One or two kinds of mixing in emulsion and amino silicon oil emulsion；NMF be it is a kind of in trimethylglycine, glycerine and propane diols or
Several mixing；Nertralizer is one or more of in triethanolamine, citric acid, sodium citrate, sodium hydroxide and potassium hydroxide
Mixing.
7. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In, thickener be it is a kind of in cation guar gum, Macrogol 6000 double stearate, amine oxide, sodium chloride and cetanols or
Several mixing；Foam stabilizer is mixing one or two kinds of in Cocoamidopropyl betaine and cocounut oil diglycollic amide；Nutrition
Agent is mixing one or two kinds of in D-pantothenyl aleohol and collagen；Preservative is Kathon CG, KF88, methylchloroisothiazandnone, first
One or more of mixing in base OIT, sodium benzoate, methyl p-hydroxybenzoate and propylparaben.
8. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In, essence be one in rosemary essence, spearmint essence, Lancome essence, sesame flavor, Mint Essence, chrysanthemum essence and cream jasmin france
Kind or several mixing；Water is mixing one or more of in deionized water, mineral water and distilled water.
9. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In described anion surfactant is ammonium lauryl sulfate；Described zwitterionic surfactant is lauroyl
Propylhomoserin sodium；Described nonionic surfactant is APG；Described chelating agent is disodium ethylene diamine tetraacetate；Described
Matrix is dimethicone；Described NMF is trimethylglycine；Described nertralizer is triethanolamine；Described thickening
Agent is cation guar gum；Described foam stabilizer is Cocoamidopropyl betaine.
10. the anti-seborrhea shampoo of the active component according to claim 1 or 2 containing American cockroach, its feature exist
In the preparation method of described extract is：Chinese herbal medicine is first put into 39-42 DEG C of biological temperature-constant drying box and continues drying out 4.8-
5.3 hours, crushed afterwards with the broken machine of plant ultra-micropowder, using water as Extraction solvent, the swirling recirculation flow extraction three in Rotary Evaporators
It is secondary, each 3.8-4.2 hours, merge extract, be concentrated into moisture and be evaporated and produce Chinese medical extract；
For the first time and second of quality for extracting water used is 5.8-6.2 times of Chinese herbal medicine quality；Third time extracts water used
Quality be 3.8-4.2 times of Chinese herbal medicine quality；
Described Chinese herbal medicine is Asian puccoon, chrysanthemum, honeysuckle, dandelion or climbing groundsel.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107929139A (en) * | 2017-12-15 | 2018-04-20 | 福建省为民生物科技有限公司 | A kind of anti-damage shampoo |
| CN107970198A (en) * | 2018-01-03 | 2018-05-01 | 昆明赛诺制药股份有限公司 | A kind of moist reparation hair conditioner of the extract containing American cockroach |
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| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
| CN115770207A (en) * | 2022-11-28 | 2023-03-10 | 云南昱宁和健康管理有限公司 | Hair care and hair fixing shampoo and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929139A (en) * | 2017-12-15 | 2018-04-20 | 福建省为民生物科技有限公司 | A kind of anti-damage shampoo |
| CN107970198A (en) * | 2018-01-03 | 2018-05-01 | 昆明赛诺制药股份有限公司 | A kind of moist reparation hair conditioner of the extract containing American cockroach |
| CN110093704A (en) * | 2019-04-28 | 2019-08-06 | 福建润博实业有限公司 | A kind of comfortable school uniform of pro-skin and preparation method thereof |
| CN111529475A (en) * | 2020-05-27 | 2020-08-14 | 云南中医药大学 | Compound rehabilitation new liquid mouth wash and preparation method thereof |
| CN111632016A (en) * | 2020-07-15 | 2020-09-08 | 云南柏莎健康产业有限公司 | Rose-fragrance-type bioactive hair-washing and hair-protecting antibacterial liquid |
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
| CN114848680B (en) * | 2021-02-03 | 2023-07-25 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
| CN115770207A (en) * | 2022-11-28 | 2023-03-10 | 云南昱宁和健康管理有限公司 | Hair care and hair fixing shampoo and preparation method thereof |
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