CN107970198A - A kind of moist reparation hair conditioner of the extract containing American cockroach - Google Patents
A kind of moist reparation hair conditioner of the extract containing American cockroach Download PDFInfo
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- CN107970198A CN107970198A CN201810003454.2A CN201810003454A CN107970198A CN 107970198 A CN107970198 A CN 107970198A CN 201810003454 A CN201810003454 A CN 201810003454A CN 107970198 A CN107970198 A CN 107970198A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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Abstract
The present invention relates to a kind of moist reparation hair conditioner of extract containing American cockroach.The present invention raises American cockroach extract using the effective ingredient in the liquid and water lotion of step E discardings in a kind of preparation method for the American-cockroach-extract for treating hepatitis B disclosed in the Chinese patent of Patent No. 201210446628.5, essence.Component is：American cockroach extract 0.5 5%, prinsepia utilis royle oil 0.5 5%, octadecyltrimethylammonium chloride 10 20%, isopropyl lanolate 3 10%, glycerine 1 5%, essence 0.01 0.3%, surplus are water.The hair conditioner can be penetrated into inside the hair scale being damaged, and repair is nourished well for being had by the hair of chemistry and external cause damage.
Description
Technical field
The present invention relates to a kind of daily chemical products technical field, and in particular to a kind of moist reparation of extract containing American cockroach
Hair conditioner.
Background technology
The hair top layer of health is made of the protective film of hair the grease of one group of complete hair scale piece and naturally secret, excessively
The natural protective film of this layer can all be destroyed by washing reason, boiling hot dye, exposure in sunshine, caused cortex water loss, hair is dried up, follow the string
And flexibility.Hair conditioner is only commonly used, could persistently form the protective film of hair, hair is escaped injury.
Hair conditioner is broadly divided into following several：（1）Leave.Cleaning-free hair conditioner can prevent the hair scale piece surface of healthy hair by
To infringement, electrostatic is produced.Some components inside it may only be absorbed by hair surface, so cleaning-free hair conditioner can not rise
To the effect of radical cure damaged hair.（2）Contaminate rear profile.The shampoo for hair dyeing of specialty can stablize pigment granule with hair conditioner
Son, is allowed to be not easy to be lost in quickly.（3）Hair-waving type.After dedicated shampoo after scalding, coordinating it to fix volume degree hair conditioner makes volume
Degree maintains more long, hair is more glossy;Also, in the curly hair hair conditioner that flushing-free is smeared after wiping hair, before blowing moulding, make
Hair more moisturizing is moistened.（4）Special efficacy type.Hair is kept natural balance moistening, keep the skin wet.For hair jag, drying or
When being not easy to comb.Have and in holding head shampoo point, minimizing electrostatic simultaneously increases gloss.Protection can also be produced when hair does hot moulding
Film is especially suitable for fine and soft long hair.
Wherein,（1）Dry hair water shortage, oil starvation, one, which runs into sunlight, is easy for becoming withered, serious to be also possible to turn to be yellow,
Bifurcated, fragile easily broken, the hair conditioner for preferably having used moisturizing to act on；（2）Oily hair is often greasy tacky, preferably using oil-control
The hair conditioner of refreshing hair style, allows oily hair to keep dry and comfortable and comfortable for a long time；（3）Fragile hair quality because extremely lack nutrition so that
Loss of elasticity, it is fragile easily broken, preferably select the hair conditioner containing nutritional ingredient to nurse；（4）Dry Huang hair quality has preferably selected black hair work
Shampoo and hair conditioner hair washing, and weekly using hair conditioner of 2 beautiful depth with maintenance component.
American cockroach is Insecta Pterigota Blattaria Blattidae Periplaneta insect, is commonly called as cockroach, is body in Blattidae
The maximum insect of product, originates in South America.American cockroach is traditional Chinese medicine, be used as medicine first recorded in《Sheng Nong's herbal classic》, call " taste
It is salty, tremble with fear.Main blood stasis, disease heavily fortified point, fever and chills, break accumulation, laryngopharynx is fought, endogenous cold, s.m.p ", to treat infantile malnutrition, furunculosis, carbuncle swells, larynx
Moth, nameless sores or boils, syphilis and poisonous snake, Wu pines such as are bitten at the disease.
Modern study finds that American cockroach drying polypide extract, contains WHF（Polyalcohols, epidermal growth factor）, it is viscous
Propylhomoserin, viscous sugared propylhomoserin and a variety of amino acid isoreactivity materials, have anti-inflammatory, detumescence, promote cell Proliferation and new granulation tissue
Increase, accelerate disease damage tissue repair, accelerate slough and come off, improve the effect such as body's immunity.Study and also found, America
In the ethanol extract of big Lian, containing largely free amino acid, in addition to containing 18 kinds of amino acid needed by human, also containing a variety of
Other amino acid, up to 26 kinds of amino acid sum.Exactly these specific combination of amino acids so that American-cockroach-extract has
The significant effect for promoting damaged cell repair and neonatal cell increases.
Blue or green bur, alias rob sub- fruit,《The southern regions of the Yunnan Province book on Chinese herbal medicine》In be known as himalayan prinsepia leaf, originate in Yunnan, Guizhou and Sichuan height above sea level
The hillside of 1400m ~ 3100m and waste ground.Blue or green bur is averaged oil yield as 28%, fruit oil rich in a variety of nutrition that human body needs into
Point, it is a kind of advanced natural edible oil, has to treatment hyperlipidemia, reduction cholesterol and prevention and cure of cardiovascular disease etc. important
Booster action.The aliphatic acid of prinsepia utilis royle oil is formed with unrighted acid --- based on oleic acid and linoleic acid, the wherein content of oleic acid
33.38%th, linoleic acid content 40.82%；In addition, also containing 17.2% palmitic acid and 6% stearic acid, and contain vitamin A, dimension
The multivitamins such as raw element D, vitamin E and vitamin K, contain 3.5mg vitamin As, 2.1mg vitamins per 100g prinsepia utilis royle oils
D, 11.2mg vitamin Es and 0.30mg vitamin Ks, also containing constants such as very abundant calcium, sulphur, manganese, magnesium, potassium, phosphorus, zinc and iron
And trace element, compared with other edible oils, the wherein highest element of content is potassium, content 9.8mg/kg.
Prinsepia utilis royle oil remains pure natural bioactive ingredients, wherein containing a variety of fat-soluble dimensions being easily absorbed by the human body
Raw plain, micro- and a large amount of amino acid needed by human, and with human body lipid proportions（1:1:1）Very close aliphatic acid
Structure（1:1:0.8）, therefore its permeability is good, is easily absorbed by the skin, and can keep skin-nourishing, moisture and elasticity, improves skin
The degeneration of skin cuticula, repairs coarse skin.Scientific research finds that prinsepia utilis royle oil no matter takes orally and external application, nontoxic to human body,
Side effect；Have no stimulation to human skin；Percutaneous permeability is good, can improve cutin degeneration, has moisturizing to skin, prevents
The effect of splitting, supplementing the nutrients；There are antibacterial obvious anti-inflammatory, uvioresistant, anti-aging and improve human body microcirculation of nail fold, promote new old
Metabolism.
The Chinese patent of the Patent No. 201210446628.5 of the application of inventor 2012 disclose one kind treat it is B-mode
The preparation method of the American-cockroach-extract of hepatitis, its extraction process are as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C~90 DEG C of hot water, and temperature control dries in the range of 60 DEG C ± 5 DEG C
It is dry, crush, cross 24 mesh sieves, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step A is subjected to 3~5 refluxing extractions at a temperature of 75~80 DEG C, is carried for the first time
When taking, the ethanol of 5~8 times of amount concentration 90%~95% of overstriking powder weight, when extraction time is 4 ~ 6 small；Add every time after second
The ethanol of 3~6 times of amount concentration 90%~95% of coarse powder weight, when extraction time is 3 ~ 5 small；In extraction process, ethanol temperature is protected
Hold at 75~80 DEG C, after the completion of extraction, merge extracting solution, filter to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step B in vacuum -0.05~-0.06MPa, the bar of 50~60 DEG C of temperature
Be concentrated under reduced pressure under part, to proportion be 1.05~1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step C is added to the distilled water of 7~10 times of amounts of ethanol concentrate weight, while mixing
While after being warming up to 80 ~ 90 DEG C, stir 10~60 minutes, mixing speed is 20~60 revs/min, is made when then insulation standing 1~5 is small
Grease is layered；Lower floor's aqueous is collected, after filter paper filters, it is medicinal that ethanol 0.5 ~ 1.0 times of amount of concentrate is added in gained filtrate
Activated carbon stirs 30 ~ 60 minutes at a temperature of 40 ~ 60 DEG C, it is fully adsorbed；
E, elute：Liquid containing activated carbon obtained by step D is fitted into chromatographic column, releasing liquid, first with 10 ~ 30 times of medicinal carbon
Amount distillation water washing, water lotion discard；Again with the eluent of 30 ~ 60 times of amounts of medicinal carbon, eluent is collected, through filter paper
Filtering, must elute filtrate；
F, secondary concentration：By elution filtrate obtained by step E under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure, be concentrated into proportion for 1.20~1.30 when, the American-cockroach-extract medicinal extract of hepatitis B must be treated；
G, drying and crushing：By the American-cockroach-extract medicinal extract for the treatment of hepatitis B obtained by step F 50 DEG C~60 DEG C temperature,
It is dried in vacuo under conditions of vacuum -0.04~-0.07MPa, crushes as fine powder, that is, obtain U.S. for treating hepatitis B
The big Lian extracts finished product in continent.
The patent is inventor's granted patent.Patent application step E processes are elution：Activity will be contained obtained by step D
Charcoal liquid is fitted into chromatographic column, releases liquid, is first discarded with 10 ~ 30 times of amount distillation water washings of medicinal carbon, water lotion.By
Research experiment is found inventor for many years, in the liquid and water lotion that discard still containing many valuable American cockroaches effectively into
Part, the effective ingredient for unfortunately, how making full use of and abandoning in liquid and water lotion is abandoned really in vain, becomes inventor's
Another R＆D target.
The content of the invention
It is an object of the present invention to provide one kind disclosed in a kind of Chinese patent using Patent No. 201210446628.5 to control
The effective ingredient in the liquid and water lotion that step E is abandoned in the preparation method of the American-cockroach-extract of hepatitis B is treated,
A kind of moist reparation hair conditioner of extract containing American cockroach is developed, which can penetrate into the hair scale being damaged
Portion, repair is nourished for being had by the hair of chemistry and external cause damage well.
Above-mentioned purpose is realized by the following method in the present invention.
A kind of moist reparation hair conditioner of extract containing American cockroach, count by weight percentage, consists of the following compositions：
American cockroach extract 0.5-5%, prinsepia utilis royle oil 0.5-5%, octadecyltrimethylammonium chloride 10-20%, lanoceric acid are different
Propyl ester 3-10%, glycerine 1-5%, essence 0.01-0.3%, surplus are water.
Preferably, the moist reparation hair conditioner of a kind of extract containing American cockroach, count by weight percentage, by below into
It is grouped into：
American cockroach extract 1.5-3.2%, prinsepia utilis royle oil 1.5-3.2%, octadecyltrimethylammonium chloride 12-17%, lanolin
Isopropyl propionate 5-8%, glycerine 2.5-4%, essence 0.08-0.2%, surplus are water.
Preferably, the essence is one or more of mixings in red pomegranate essence, Tea flower essence, grapefruit essence
Thing.
The moist reparation hair conditioner of the above-mentioned extract containing American cockroach, is prepared by following technique：
S1, each component for weighing face cream by weight;
S2, add water in pot, is heated to 60-70 DEG C, adds octadecyltrimethylammonium chloride, isopropyl lanolate and sweet
Oil, stirs evenly;
S3, by liquid cooling in pot to 30-40 DEG C, add American cockroach extract, prinsepia utilis royle oil and essence, high speed homogenization stirs
Mix 5-20 minutes, cool down, to obtain the final product.
Preferably, the moist reparation hair conditioner of a kind of extract containing American cockroach, the American cockroach extract be with
The liquid and water lotion that step E is discarded in the preparation process of American-cockroach-extract disclosed in Chinese patent 201210446628.5
Refine and form according to following technique for raw material, concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C~90 DEG C of hot water, and temperature control dries in the range of 60 DEG C ± 5 DEG C
It is dry, crush, cross 24 mesh sieves, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 3~5 refluxing extractions at a temperature of 75~80 DEG C, is carried for the first time
When taking, the ethanol of 5~8 times of amount concentration 90%~95% of overstriking powder weight, when extraction time is 4 ~ 6 small；Add every time after second
The ethanol of 3~6 times of amount concentration 90%~95% of coarse powder weight, when extraction time is 3 ~ 5 small；In extraction process, ethanol temperature is protected
Hold at 75~80 DEG C, after the completion of extraction, merge extracting solution, filter to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in vacuum -0.05~-0.06MPa, the bar of 50~60 DEG C of temperature
Be concentrated under reduced pressure under part, to proportion be 1.05~1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 7~10 times of amounts of ethanol concentrate weight, while mixing
While after being warming up to 80 ~ 90 DEG C, stir 10~60 minutes, mixing speed is 20~60 revs/min, is made when then insulation standing 1~5 is small
Grease is layered；Lower floor's aqueous is collected, after filter paper filters, it is medicinal that ethanol 0.5 ~ 1.0 times of amount of concentrate is added in gained filtrate
Activated carbon stirs 30 ~ 60 minutes at a temperature of 40 ~ 60 DEG C, it is fully adsorbed；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with 10 ~ 30 times of medicinal carbon
Amount distillation water washing, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 50-200kPa, step e collects uniformly mixed liquid and water lotion passes through molecular weight cutoff
For the ultrafiltration ceramic membrane of 50kD, trapped fluid is discarded, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step a is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/10-1/30 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 5-7 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then the sodium form HD-8 strongly acidic styrenes type sun by having regenerated
Ion exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated obtained by step g by volume
3-7 times of penetrating fluid is concentrated, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, first uses volume
It is then 1- with concentration for the deionized water washing of 2-4 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amount
The ammonia spirit of 3mol/L is eluted, and the ammonia spirit dosage that concentration is 1-3mol/L is sodium form HD-8 strongly acidic styrene's types
5-8 times of cation exchange resin amount, control eluent flow rate, make the whole elution process time for 8-12 it is small when, collect elution
Liquid；
I, three-level concentrates：Eluent obtained by step h is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure is condensed into the medicinal extract that proportion is 1.20~1.30, up to American cockroach extract.
Preferably, step f techniques are UF membrane：Under pressure 80kPa, step e collects uniformly mixed liquid and washing
Liquid discards trapped fluid, collects penetrating fluid by the ultrafiltration ceramic membrane that molecular weight cutoff is 50kD.
Preferably, step g techniques are secondary concentration：By penetrating fluid obtained by step f 50~60 DEG C of temperature, vacuum-
It is concentrated under reduced pressure under the conditions of 0.05~-0.06MPa, is concentrated into the 1/20 of original volume.
Preferably, step h techniques are ion exchange：Take secondary concentration liquid obtained by step g, the salt for being 1mol/L with concentration
Concentration penetrating fluid pH value is 6.0 obtained by the sodium hydroxide regulating step g that acid and concentration are 1mol/L, then the sodium by having regenerated
Type HD-8 strongly acidic styrene's type cation exchange resin columns, sodium form HD-8 strongly acidic styrenes type cation exchange resin used
Calculate the concentration penetrating fluid obtained by step g by volume 5 times, treat sodium form HD-8 strongly acidic styrene's type cation exchange resin columns
After the completion of absorption, first washed with volume for the deionized water of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts,
Then the ammonia spirit for being 1-3mol/L with concentration is eluted, and the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8
6 times of strongly acidic styrene's type cation exchange resin amount, control eluent flow rate, make the whole elution process time small for 10
When, collect eluent.
Beneficial effects of the present invention：
1st, contain up to 26 kinds of pure natural amino acid in American cockroach extract, comprising 18 kinds of amino acid needed by human, pass through
Technique of the present invention, eliminates invalid components, total amino acid content in extract is up to 60-80%.The America of high-quality is big
Lian extracts so that the obvious effect for promoting damaged cell repair and neonatal cell growth that hair conditioner of the invention has.
2nd, the American cockroach extract that the present invention adds has extracted the American cockroach for the treatment of hepatitis B for American cockroach
Re-refined after extract medicinal extract using discarded liquid and water lotion, belong to refuse reclamation, can be to greatest extent
Using the active material in American cockroach medicinal material, so as to reach discarded object cycling and reutilization, cost is reduced, increases the utilization of resources
Rate, increases profit, the purpose of energy-saving and emission-reduction, effectively improves Competitive Products.
3rd, the moist reparation hair conditioner for the extract containing American cockroach that present invention production obtains, which can penetrate into impaired
Inside the hair scale of wound, repair is nourished well for being had by the hair of chemistry and external cause damage.
4th, using technique of the present invention extract American cockroach extract, can effectively remove American cockroach have in itself it is different
Taste and color, the American cockroach extract produced is almost colourless tasteless, as the raw material addition of production hair conditioner, produces
To the Color influences that have from American cockroach of hair conditioner color in itself, the peculiar smell also having in itself without American cockroach, disappears
Expense person is easier to receive.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is not intended to limit protection scope of the present invention.The moist reparation hair conditioner of the extract containing American cockroach prepared by following embodiments,
Preparation method is as follows：
S1, each component for weighing face cream by weight.
S2, add water in pot, is heated to 60 DEG C, add octadecyltrimethylammonium chloride, isopropyl lanolate and
Glycerine, stirs evenly.
S3, by liquid cooling in pot to 35 DEG C, add American cockroach extract, prinsepia utilis royle oil and essence, high speed homogenization
Stirring 15 minutes, cooling, to obtain the final product.
Embodiment 1
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 2%, prinsepia utilis royle oil 2%, octadecyltrimethylammonium chloride 15%, isopropyl lanolate 7%, glycerine 3%, red pomegranate are fragrant
Essence 0.1%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, is crushed,
24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 3 refluxing extractions at a temperature of 75 DEG C, when extracting for the first time, is added
The ethanol of 5 times of amount concentration 90% of coarse powder weight, when extraction time is 4 small；3 times of overstriking powder weight measures concentration every time after second
90% ethanol, when extraction time is 3 small；In extraction process, ethanol temperature is held in 75 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in 50~60 DEG C of temperature, the bar of vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure under part, to proportion be 1.05 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 7 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 80 DEG C, stir 10 minutes, mixing speed is 20 revs/min, is layered grease when then insulation standing 4 is small；Collect lower floor
Aqueous, after filter paper filters, 0.5 times of amount medicinal carbon of ethanol concentrate is added in gained filtrate and is stirred at a temperature of 40 DEG C
50 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with 10 ~ 30 times of medicinal carbon
Amount distillation water washing, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 200kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step f is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/20 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 5 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then by sodium form HD-8 strongly acidic styrene's type sun for having regenerated from
Sub-exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated dense obtained by step g by volume
4 times of contracting penetrating fluid, are first 2 with volume after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column
The deionized water washing of times sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, the ammonia for being then 1mol/L with concentration
Aqueous solution is eluted, and the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8 strongly acidic styrene's type cation exchanges
6 times of amount of resin, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent；
I, three-level concentrates：Eluent obtained by step h is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure is condensed into the medicinal extract that proportion is 1.24, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 62.6% in extract.
Embodiment 2
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 1%, prinsepia utilis royle oil 3%, octadecyltrimethylammonium chloride 10%, isopropyl lanolate 8%, glycerine 1%, the tea tree fragrance of a flower
Essence 0.2%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 90 DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, is crushed,
24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 5 refluxing extractions at a temperature of 80 DEG C, when extracting for the first time, is added
The ethanol of 8 times of amount concentration 95% of coarse powder weight, when extraction time is 6 small；6 times of overstriking powder weight measures concentration every time after second
95% ethanol, when extraction time is 5 small；In extraction process, ethanol temperature is held in 80 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in 50~60 DEG C of temperature, the bar of vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure under part, to proportion be 1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 10 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 90 DEG C, stir 60 minutes, mixing speed is 60 revs/min, is layered grease when then insulation standing 5 is small；Collect lower floor
Aqueous, after filter paper filters, 1.0 times of amount medicinal carbons of ethanol concentrate is added in gained filtrate and are stirred at a temperature of 60 DEG C
60 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 30 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 50kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step f is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/10 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 7 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then by sodium form HD-8 strongly acidic styrene's type sun for having regenerated from
Sub-exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated dense obtained by step g by volume
7 times of contracting penetrating fluid, are first 4 with volume after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column
The deionized water washing of times sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, the ammonia for being then 3mol/L with concentration
Aqueous solution is eluted, and the ammonia spirit dosage that concentration is 3mol/L is sodium form HD-8 strongly acidic styrene's type cation exchange trees
8 times of fat amount, control eluent flow rate, make the whole elution process time for 12 it is small when, collect eluent；
I, three-level concentrates：Eluent obtained by step h is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure is condensed into the medicinal extract that proportion is 1.30, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 68.2% in extract.
Embodiment 3
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 3%, prinsepia utilis royle oil 0.5%, octadecyltrimethylammonium chloride 16%, isopropyl lanolate 5%, glycerine 4%, grapefruit are fragrant
Essence 0.01%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 85 DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, is crushed,
24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 4 refluxing extractions at a temperature of 75 DEG C, when extracting for the first time, is added
The ethanol of 6 times of amount concentration 90% of coarse powder weight, when extraction time is 5 small；4 times of overstriking powder weight measures concentration every time after second
90% ethanol, when extraction time is 4 small；In extraction process, ethanol temperature is held in 80 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in 50~60 DEG C of temperature, the bar of vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure under part, to proportion be 1.1 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 8 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 85 DEG C, stir 40 minutes, mixing speed is 40 revs/min, is layered grease when then insulation standing 3 is small；Collect lower floor
Aqueous, after filter paper filters, 0.6 times of amount medicinal carbon of ethanol concentrate is added in gained filtrate and is stirred at a temperature of 50 DEG C
50 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 20 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 150kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step f is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/30 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 6 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then by sodium form HD-8 strongly acidic styrene's type sun for having regenerated from
Sub-exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated dense obtained by step g by volume
5 times of contracting penetrating fluid, are first 3 with volume after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column
The deionized water washing of times sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, is then 1.5mol/L's with concentration
Ammonia spirit is eluted, and the ammonia spirit dosage that concentration is 1.5mol/L is that sodium form HD-8 strongly acidic styrene's types cation is handed over
Change amount of resin 6 times, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent；
I, three-level concentrates：Eluent obtained by step h is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure is condensed into the medicinal extract that proportion is 1.25, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 73.9% in extract.
Embodiment 4
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 0.5%, prinsepia utilis royle oil 4%, octadecyltrimethylammonium chloride 20%, isopropyl lanolate 3%, glycerine 5%, red pomegranate
Essence 0.08%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, powder
It is broken, 24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 5 refluxing extractions at a temperature of 75 DEG C, when extracting for the first time, is added
The ethanol of 8 times of amount concentration 95% of coarse powder weight, when extraction time is 4 small；4 times of overstriking powder weight measures concentration every time after second
95% ethanol, when extraction time is 4 small；In extraction process, ethanol temperature is held in 75 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in 50~60 DEG C of temperature, the bar of vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure under part, to proportion be 1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 10 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 85 DEG C, stir 30 minutes, mixing speed is 30 revs/min, is layered grease when then insulation standing 5 is small；Collect lower floor
Aqueous, after filter paper filters, 1.0 times of amount medicinal carbons of ethanol concentrate is added in gained filtrate and are stirred at a temperature of 40 DEG C
60 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 20 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 80kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step f is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/20 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 6.0 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then the sodium form HD-8 strongly acidic styrenes type sun by having regenerated
Ion exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated obtained by step g by volume
5 times of penetrating fluid are concentrated, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, are with volume first
The deionized water washing of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, is then 1-3mol/L with concentration
Ammonia spirit eluted, the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8 strongly acidic styrene's type cations
6 times of exchanger resin amount, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent.
I, three-level concentrates：By eluent obtained by step h in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure into proportion be 1.21 medicinal extract, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 79.7% in extract.
Embodiment 5
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 5%, prinsepia utilis royle oil 1%, octadecyltrimethylammonium chloride 12%, isopropyl lanolate 10%, glycerine 2%, the tea tree fragrance of a flower
Essence 0.3%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, powder
It is broken, 24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 5 refluxing extractions at a temperature of 75 DEG C, when extracting for the first time, is added
The ethanol of 8 times of amount concentration 95% of coarse powder weight, when extraction time is 4 small；4 times of overstriking powder weight measures concentration every time after second
95% ethanol, when extraction time is 4 small；In extraction process, ethanol temperature is held in 75 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in 50~60 DEG C of temperature, the bar of vacuum -0.05~-0.06MPa
Be concentrated under reduced pressure under part, to proportion be 1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 10 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 85 DEG C, stir 30 minutes, mixing speed is 30 revs/min, is layered grease when then insulation standing 5 is small；Collect lower floor
Aqueous, after filter paper filters, 1.0 times of amount medicinal carbons of ethanol concentrate is added in gained filtrate and are stirred at a temperature of 40 DEG C
60 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 20 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 120kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step f is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/20 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 6.0 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then the sodium form HD-8 strongly acidic styrenes type sun by having regenerated
Ion exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated obtained by step g by volume
5 times of penetrating fluid are concentrated, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, are with volume first
The deionized water washing of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, is then 1-3mol/L with concentration
Ammonia spirit eluted, the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8 strongly acidic styrene's type cations
6 times of exchanger resin amount, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent.
I, three-level concentrates：By eluent obtained by step h in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure into proportion be 1.28 medicinal extract, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 79.5% in extract.
Embodiment 6
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 2%, prinsepia utilis royle oil 2%, octadecyltrimethylammonium chloride 15%, isopropyl lanolate 7%, glycerine 3%, grapefruit essence
0.1%th, surplus is water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 85 DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, is crushed,
24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 3 refluxing extractions at a temperature of 80 DEG C, when extracting for the first time, is added
The ethanol of 7 times of amount concentration 95% of coarse powder weight, when extraction time is 6 small；6 times of overstriking powder weight measures concentration every time after second
95% ethanol, when extraction time is 4 small；In extraction process, ethanol temperature is held in 75 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：Ethanol extract obtained by step b is depressurized under conditions of vacuum -0.06MPa, 55 DEG C of temperature dense
Contracting, to proportion be 1.05 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 10 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 85 DEG C, stir 40 minutes, mixing speed is 40 revs/min, is layered grease when then insulation standing 5 is small；Collect lower floor
Aqueous, after filter paper filters .0 times of addition ethanol concentrate is measured medicinal carbon and is stirred at a temperature of 45 DEG C in gained filtrate
40 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 15 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：By the ultrafiltration ceramic membrane that molecular weight cutoff is 50kD under pressure 80kPa, trapped fluid is discarded, collection is oozed
Transparent liquid.
G, secondary concentration：By penetrating fluid obtained by step f in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure, be concentrated into the 1/20 of original volume.
H, ion exchange：Secondary concentration liquid obtained by step g is taken, the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L's
Concentration penetrating fluid pH value is 6.0 obtained by sodium hydroxide regulating step g, then the sodium form HD-8 strongly acidic styrenes by having regenerated
Type cation exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated as step g by volume
5 times of gained concentration penetrating fluid, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, first use body
Product is the deionized water washing of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, is then 1- with concentration
The ammonia spirit of 3mol/L is eluted, and the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8 strongly acidic styrene's types
6 times of cation exchange resin amount, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent.
I, three-level concentrates：By eluent obtained by step h in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure into proportion be 1.30 medicinal extract, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 79.2% in extract.
Embodiment 7
Count by weight percentage, the moist reparation hair conditioner of the extract containing American cockroach, consists of the following compositions：American cockroach
Extract 4%, prinsepia utilis royle oil 5%, octadecyltrimethylammonium chloride 18%, isopropyl lanolate 6%, glycerine 2.5%, Tea Flower
Essence 0.15%, surplus are water.It is prepared into the moist reparation hair conditioner of the extract containing American cockroach.
The American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
The liquid and water lotion that step E is discarded in preparation process are refined according to following technique for raw material and formed, and concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 85 DEG C of hot water, and temperature control is dried in the range of 60 DEG C ± 5 DEG C, is crushed,
24 mesh sieves are crossed, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 3 refluxing extractions at a temperature of 80 DEG C, when extracting for the first time, is added
The ethanol of 7 times of amount concentration 95% of coarse powder weight, when extraction time is 6 small；6 times of overstriking powder weight measures concentration every time after second
95% ethanol, when extraction time is 4 small；In extraction process, ethanol temperature is held in 75 DEG C, after the completion of extraction, merges extraction
Liquid, filters to obtain ethanol extract；
C, primary concentration：Ethanol extract obtained by step b is depressurized under conditions of vacuum -0.06MPa, 55 DEG C of temperature dense
Contracting, to proportion be 1.05 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 10 times of amounts of ethanol concentrate weight, the liter when mixing
After warm to 85 DEG C, stir 40 minutes, mixing speed is 40 revs/min, is layered grease when then insulation standing 5 is small；Collect lower floor
Aqueous, after filter paper filters .0 times of addition ethanol concentrate is measured medicinal carbon and is stirred at a temperature of 45 DEG C in gained filtrate
40 minutes, it is set fully to adsorb；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with medicinal carbon 15 times measure
Water washing is distilled, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：By the ultrafiltration ceramic membrane that molecular weight cutoff is 50kD under pressure 80kPa, trapped fluid is discarded, collection is oozed
Transparent liquid.
G, secondary concentration：By penetrating fluid obtained by step f in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure, be concentrated into the 1/20 of original volume.
H, ion exchange：Secondary concentration liquid obtained by step g is taken, the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L's
Concentration penetrating fluid pH value is 6.0 obtained by sodium hydroxide regulating step g, then the sodium form HD-8 strongly acidic styrenes by having regenerated
Type cation exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated as step g by volume
5 times of gained concentration penetrating fluid, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, first use body
Product is the deionized water washing of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts, is then 1- with concentration
The ammonia spirit of 3mol/L is eluted, and the ammonia spirit dosage that concentration is 1.5mol/L is sodium form HD-8 strongly acidic styrene's types
6 times of cation exchange resin amount, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent.
I, three-level concentrates：By eluent obtained by step h in 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa conditions
Under be concentrated under reduced pressure into proportion be 1.30 medicinal extract, up to American cockroach extract.
The made hair conditioner resultant effect of the present embodiment is shown in investigation table 1.The American cockroach extract that the present embodiment is prepared
In contain up to 26 kinds of pure natural small molecule amino acid, total amino acid content is up to 79.3% in extract.
Hair conditioner resultant effect is investigated
Following with probation the effect of feeling to evaluate hair conditioner that embodiment 1-7 is produced.Using opinion poll point system,
The people of 80 25-65 Sui age brackets is chosen as object on probation, six groups is arbitrarily divided into, is prepared respectively with embodiment 1-7
Hair conditioner hair conditioning.Nursed twice after washing hair weekly, usage time is two months.Every using effect total score is 5 points：5
It is divided into best result, it is very good to represent, very satisfied；4 points are fine；3 points are to receive；Less than 3 points are bad, it is impossible to are connect
By.It is below every average, the results are shown in Table 1：
In conclusion the hair conditioner exquisiteness is soft and smooth, there are fine alimentary, moisture retention and a repair, when use, feels very smooth,
Wet comb property, dry comb property are all preferable.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be subject to claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Protection scope of the present invention is also should be regarded as into retouching.
Claims (9)
1. application of the American cockroach in hair conditioner is prepared.
2. the moist reparation hair conditioner of a kind of extract containing American cockroach, it is characterised in that count by weight percentage, by following
Component forms：
American cockroach extract 0.5-5%, prinsepia utilis royle oil 0.5-5%, octadecyltrimethylammonium chloride 10-20%, lanoceric acid are different
Propyl ester 3-10%, glycerine 1-5%, essence 0.01-0.3%, surplus are water.
3. the moist reparation hair conditioner of a kind of extract containing American cockroach according to claim 2, it is characterised in that by weight
Measure percentage to calculate, consist of the following compositions：
American cockroach extract 1.5-3.2%, prinsepia utilis royle oil 1.5-3.2%, octadecyltrimethylammonium chloride 12-17%, lanolin
Isopropyl propionate 5-8%, glycerine 2.5-4%, essence 0.08-0.2%, surplus are water.
A kind of 4. moist reparation hair conditioner of extract containing American cockroach according to Claims 2 or 3, it is characterised in that
The essence is red pomegranate essence, one or more of mixtures in Tea flower essence, grapefruit essence.
5. a kind of moist reparation hair conditioner of extract containing American cockroach according to any one in claim 2-4, its
It is characterized in that, is prepared by following technique：
S1, each component for weighing face cream by weight;
S2, add water in pot, is heated to 60-70 DEG C, adds octadecyltrimethylammonium chloride, isopropyl lanolate and sweet
Oil, stirs evenly;
S3, by liquid cooling in pot to 30-40 DEG C, add American cockroach extract, prinsepia utilis royle oil and essence, high speed homogenization stirs
Mix 5-20 minutes, cool down, to obtain the final product.
6. a kind of moist reparation hair conditioner of extract containing American cockroach according to any one in claim 2,3 or 5,
It is characterized in that, the American cockroach extract is with American-cockroach-extract disclosed in Chinese patent 201210446628.5
Preparation process in the liquids that discard of step E and water lotion refine and form according to following technique for raw material, concrete technology is as follows：
A, inactivation crushes：The fresh worm of American cockroach is killed using 80 DEG C~90 DEG C of hot water, and temperature control dries in the range of 60 DEG C ± 5 DEG C
It is dry, crush, cross 24 mesh sieves, American cockroach coarse powder is made；
B, extract：American cockroach coarse powder obtained by step a is subjected to 3~5 refluxing extractions at a temperature of 75~80 DEG C, is carried for the first time
When taking, the ethanol of 5~8 times of amount concentration 90%~95% of overstriking powder weight, when extraction time is 4 ~ 6 small；Add every time after second
The ethanol of 3~6 times of amount concentration 90%~95% of coarse powder weight, when extraction time is 3 ~ 5 small；In extraction process, ethanol temperature is protected
Hold at 75~80 DEG C, after the completion of extraction, merge extracting solution, filter to obtain ethanol extract；
C, primary concentration：By ethanol extract obtained by step b in vacuum -0.05~-0.06MPa, the bar of 50~60 DEG C of temperature
Be concentrated under reduced pressure under part, to proportion be 1.05~1.15 when, obtain ethanol concentrate；
D, degreasing is adsorbed：Ethanol concentrate obtained by step c is added to the distilled water of 7~10 times of amounts of ethanol concentrate weight, while mixing
While after being warming up to 80 ~ 90 DEG C, stir 10~60 minutes, mixing speed is 20~60 revs/min, is made when then insulation standing 1~5 is small
Grease is layered；Lower floor's aqueous is collected, after filter paper filters, it is medicinal that ethanol 0.5 ~ 1.0 times of amount of concentrate is added in gained filtrate
Activated carbon stirs 30 ~ 60 minutes at a temperature of 40 ~ 60 DEG C, it is fully adsorbed；
E, elute：Liquid containing activated carbon obtained by step d is fitted into chromatographic column, releasing liquid, then with 10 ~ 30 times of medicinal carbon
Amount distillation water washing, collects and is uniformly mixed liquid and water lotion；
F, UF membrane：Under pressure 50-200kPa, step e collects uniformly mixed liquid and water lotion passes through molecular weight cutoff
For the ultrafiltration ceramic membrane of 50kD, trapped fluid is discarded, collects penetrating fluid；
G, secondary concentration：Penetrating fluid obtained by step a is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure concentration, is concentrated into the 1/10-1/30 of original volume；
H, ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen-oxygen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
It is 5-7 to change concentration penetrating fluid pH value obtained by sodium regulating step g, then the sodium form HD-8 strongly acidic styrenes type sun by having regenerated
Ion exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated obtained by step g by volume
3-7 times of penetrating fluid is concentrated, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, first uses volume
It is then 1- with concentration for the deionized water washing of 2-4 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amount
The ammonia spirit of 3mol/L is eluted, and the ammonia spirit dosage that concentration is 1-3mol/L is sodium form HD-8 strongly acidic styrene's types
5-8 times of cation exchange resin amount, control eluent flow rate, make the whole elution process time for 8-12 it is small when, collect elution
Liquid；
I, three-level concentrates：Eluent obtained by step h is subtracted under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
Pressure is condensed into the medicinal extract that proportion is 1.20~1.30, up to American cockroach extract.
A kind of 7. moist reparation hair conditioner of extract containing American cockroach according to claim 6, it is characterised in that step
F techniques are UF membrane：Under pressure 80kPa, step e collects uniformly mixed liquid and water lotion is by molecular weight cutoff
The ultrafiltration ceramic membrane of 50kD, discards trapped fluid, collects penetrating fluid.
A kind of 8. moist reparation hair conditioner of extract containing American cockroach according to claim 6, it is characterised in that step
G techniques are secondary concentration：By penetrating fluid obtained by step f under the conditions of 50~60 DEG C of temperature, vacuum -0.05~-0.06MPa
It is concentrated under reduced pressure, is concentrated into the 1/20 of original volume.
A kind of 9. moist reparation hair conditioner of extract containing American cockroach according to claim 6, it is characterised in that step
H techniques are ion exchange：Take secondary concentration liquid obtained by step g, the hydrogen that the hydrochloric acid and concentration for being 1mol/L with concentration are 1mol/L
Concentration penetrating fluid pH value is 6.0 obtained by sodium oxide molybdena regulating step g, then sodium form HD-8 strongly acidic styrene's types by having regenerated
Cation exchange resin column, sodium form HD-8 strongly acidic styrene's types cation exchange resin used are calculated as step g institutes by volume
5 times of penetrating fluid must be concentrated, after the completion for the treatment of the absorption of sodium form HD-8 strongly acidic styrene's types cation exchange resin column, first use volume
It is then 1-3mol/ with concentration for the deionized water washing of 3 times of sodium form HD-8 strongly acidic styrene's type cation exchange resin amounts
The ammonia spirit of L is eluted, the ammonia spirit dosage that concentration is 1.5mol/L be sodium form HD-8 strongly acidic styrene's type sun from
6 times of sub-exchange resin amount, control eluent flow rate, make the whole elution process time for 10 it is small when, collect eluent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810003454.2A CN107970198B (en) | 2018-01-03 | 2018-01-03 | Moistening and repairing hair conditioner containing periplaneta americana refined extract |
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