CN107406493B - 具有改善的半衰期的经修饰的血管性血友病因子 - Google Patents

具有改善的半衰期的经修饰的血管性血友病因子 Download PDF

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CN107406493B
CN107406493B CN201680014025.4A CN201680014025A CN107406493B CN 107406493 B CN107406493 B CN 107406493B CN 201680014025 A CN201680014025 A CN 201680014025A CN 107406493 B CN107406493 B CN 107406493B
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CN107406493A (zh
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M·莫塞斯
S·舒尔特
G·迪肯内特
U·卡琳娜
S·佩斯特尔
T·韦默
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Kangnobel Linnau Co Ltd
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Switzerland Jette Bellin Bioproducts Reorganization Equipment Jsc
CSL Behring Recombinant Facility AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201680014025.4A 2015-03-06 2016-03-04 具有改善的半衰期的经修饰的血管性血友病因子 Active CN107406493B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15158065.1 2015-03-06
EP15158065 2015-03-06
PCT/EP2016/054647 WO2016142288A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

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CN107406493A CN107406493A (zh) 2017-11-28
CN107406493B true CN107406493B (zh) 2021-08-13

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CN201680014025.4A Active CN107406493B (zh) 2015-03-06 2016-03-04 具有改善的半衰期的经修饰的血管性血友病因子

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US (1) US11155601B2 (enExample)
EP (1) EP3265483B1 (enExample)
JP (1) JP2018510212A (enExample)
KR (1) KR20170125941A (enExample)
CN (1) CN107406493B (enExample)
AU (1) AU2016231327B2 (enExample)
BR (1) BR112017018468A2 (enExample)
CA (1) CA2978374A1 (enExample)
DK (1) DK3265483T3 (enExample)
ES (1) ES2772933T3 (enExample)
SG (1) SG11201706659WA (enExample)
WO (1) WO2016142288A1 (enExample)

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WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
US10632176B2 (en) 2017-07-07 2020-04-28 Baxalta Incorporated Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF
RS66972B1 (sr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc Metode lečenja hemofilije a
KR20210134642A (ko) * 2019-02-01 2021-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf (rvwf)를 이용한 예방 치료 방법
US20220395560A1 (en) * 2019-02-01 2022-12-15 Takeda Pharmaceutical Company Limited METHODS OF PROPHYLACTIC TREATMENT USING RECOMBINANT VWF (rVWF)
WO2021001522A1 (en) * 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
EP4058049A1 (en) * 2019-11-11 2022-09-21 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii

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CN102161692A (zh) * 2011-03-08 2011-08-24 中国人民解放军第三军医大学 改造的止血多肽及其运用
CN102648212A (zh) * 2009-11-13 2012-08-22 基立福疗法公司 包含冯维勒布兰德因子(vWF)的制剂及其相关制备方法、试剂盒和用途
WO2014173873A1 (en) * 2013-04-22 2014-10-30 Csl Behring Gmbh Complex
WO2014198699A2 (en) * 2013-06-12 2014-12-18 Novo Nordisk A/S Compounds suitable for treatment of haemophilia
CN104302296A (zh) * 2012-05-08 2015-01-21 德国杰特贝林生物制品有限公司 用于治疗血友病a和/或冯维勒布兰德病的糖组合物

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BR112017018468A2 (pt) 2018-04-17
DK3265483T3 (da) 2020-03-02
JP2018510212A (ja) 2018-04-12
EP3265483B1 (en) 2019-12-11
CA2978374A1 (en) 2016-09-15
SG11201706659WA (en) 2017-09-28
WO2016142288A1 (en) 2016-09-15
AU2016231327B2 (en) 2018-08-09
US20180051067A1 (en) 2018-02-22
CN107406493A (zh) 2017-11-28
EP3265483A1 (en) 2018-01-10
HK1244292A1 (en) 2018-08-03
US11155601B2 (en) 2021-10-26
AU2016231327A1 (en) 2017-10-26
KR20170125941A (ko) 2017-11-15
ES2772933T3 (es) 2020-07-08

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