AU2016231327B2 - Modified von Willebrand factor having improved half-life - Google Patents

Modified von Willebrand factor having improved half-life Download PDF

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Publication number
AU2016231327B2
AU2016231327B2 AU2016231327A AU2016231327A AU2016231327B2 AU 2016231327 B2 AU2016231327 B2 AU 2016231327B2 AU 2016231327 A AU2016231327 A AU 2016231327A AU 2016231327 A AU2016231327 A AU 2016231327A AU 2016231327 B2 AU2016231327 B2 AU 2016231327B2
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AU
Australia
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leu
val
cys
ser
gly
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AU2016231327A
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AU2016231327A1 (en
Inventor
Gerhard Dickneite
Uwe Kalina
Michael Moses
Sabine Pestel
Stefan Schulte
Thomas Weimer
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CSL Behring Lengnau AG
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CSL Behring Lengnau AG
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Assigned to CSL Behring Lengnau AG reassignment CSL Behring Lengnau AG Alteration of Name(s) of Applicant(s) under S113 Assignors: CSL BEHRING RECOMBINANT FACILITY AG
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2016231327A 2015-03-06 2016-03-04 Modified von Willebrand factor having improved half-life Ceased AU2016231327B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15158065.1 2015-03-06
EP15158065 2015-03-06
PCT/EP2016/054647 WO2016142288A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Publications (2)

Publication Number Publication Date
AU2016231327A1 AU2016231327A1 (en) 2017-10-26
AU2016231327B2 true AU2016231327B2 (en) 2018-08-09

Family

ID=52629450

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016231327A Ceased AU2016231327B2 (en) 2015-03-06 2016-03-04 Modified von Willebrand factor having improved half-life

Country Status (12)

Country Link
US (1) US11155601B2 (enExample)
EP (1) EP3265483B1 (enExample)
JP (1) JP2018510212A (enExample)
KR (1) KR20170125941A (enExample)
CN (1) CN107406493B (enExample)
AU (1) AU2016231327B2 (enExample)
BR (1) BR112017018468A2 (enExample)
CA (1) CA2978374A1 (enExample)
DK (1) DK3265483T3 (enExample)
ES (1) ES2772933T3 (enExample)
SG (1) SG11201706659WA (enExample)
WO (1) WO2016142288A1 (enExample)

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* Cited by examiner, † Cited by third party
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WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
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KR20210134642A (ko) * 2019-02-01 2021-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf (rvwf)를 이용한 예방 치료 방법
US20220395560A1 (en) * 2019-02-01 2022-12-15 Takeda Pharmaceutical Company Limited METHODS OF PROPHYLACTIC TREATMENT USING RECOMBINANT VWF (rVWF)
WO2021001522A1 (en) * 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
EP4058049A1 (en) * 2019-11-11 2022-09-21 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii

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Also Published As

Publication number Publication date
BR112017018468A2 (pt) 2018-04-17
DK3265483T3 (da) 2020-03-02
JP2018510212A (ja) 2018-04-12
EP3265483B1 (en) 2019-12-11
CA2978374A1 (en) 2016-09-15
SG11201706659WA (en) 2017-09-28
WO2016142288A1 (en) 2016-09-15
US20180051067A1 (en) 2018-02-22
CN107406493A (zh) 2017-11-28
EP3265483A1 (en) 2018-01-10
CN107406493B (zh) 2021-08-13
HK1244292A1 (en) 2018-08-03
US11155601B2 (en) 2021-10-26
AU2016231327A1 (en) 2017-10-26
KR20170125941A (ko) 2017-11-15
ES2772933T3 (es) 2020-07-08

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