CN107348218A - A kind of high antimicrobial nano feed addictive and its application process in broiler feeding - Google Patents
A kind of high antimicrobial nano feed addictive and its application process in broiler feeding Download PDFInfo
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- CN107348218A CN107348218A CN201710704171.6A CN201710704171A CN107348218A CN 107348218 A CN107348218 A CN 107348218A CN 201710704171 A CN201710704171 A CN 201710704171A CN 107348218 A CN107348218 A CN 107348218A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
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Abstract
The invention discloses a kind of high antimicrobial nano feed addictive and its application process in broiler feeding, high antimicrobial nano feed addictive is the compound of Nanometer Copper and nano zine oxide, wherein, Nanometer Copper is 1 with nano zine oxide weight ratio：1~6.A kind of application process of high antimicrobial nano feed addictive of the present invention is 1~20 Day-old Broiler Chickens, and on the basis of chicken feed basal diet, the high antimicrobial nano feed addictives of 1~20mg are added in every kilogram of basal diet；21~45 Day-old Broiler Chickens, on the basis of chicken feed basal diet, the high antimicrobial nano feed addictives of 25~45mg are added in every kilogram of basal diet.A kind of high antimicrobial nano feed addictive of the present invention is applied to broiler feeding, broiler chicken courses of infection can not only be prevented and treated, strengthen broiler chicken immunologic function and antistress function, growth of meat chicken can also be effectively facilitated, improve efficiency of feed utilization, and drug resistance is not produced, it is a kind of green, the functional feedstuff additive of safety.
Description
Technical field
The invention belongs to feed and fowl raising technical field, and in particular to a kind of high antimicrobial nano feed addictive and its
Application process in broiler feeding.
Background technology
Medicated feed additive (particularly antibiotic) has played great work in terms of disease preventing and treating, raising production performance
With being one of the most widely used additive kind in current broiler fodder.It is estimated that about more than 80% broiler fodder
In all with the addition of antibiotic.But long-term use of or drug abuse additive, it is caused the problem of it is more and more prominent.By sustainable development
To the growing interest of food health and security, various countries (are particularly for medicated premix by the influence of exhibition trend and consumer
Antibiotic) application limit more and more stricter, such as the total ban of Sweden and the U.S. use antibiotic in feed, Russian
Prohibitted the use of medical antibiotic as feed addictive Deng the East European countries, European Union now only allow using Monensin (sodium salt),
4 kinds of salinomycin (sodium), flavomycoin and avilamycin (avilamycin) antibiotic, use of other various countries to antibiotic also have sternly
The regulation of lattice.But many difficulties will be brought to animal epidemic control by cancelling antibiotic.Such as after Sweden cancels feeding antibiotic, control
Treatment adds 44% with the amount of penicillin；After Denmark disables antibiotic in 2000, the antibiotic for treatment and prevention is also with frightened
The speed of people increases.Meanwhile breeding performonce fo animals will be caused to decline after cancelling antibiotic, increase the production cost of animal product.
How to obtain one kind have no toxic side effect, noresidue, growth of animal can be promoted, and can improves the addition of animal food quality
Agent, have become an important issue of scientific research and field of livestock production.
Nano material refer in three dimensions at least one dimension be in nanoscale scope (1~100nm) or by
The material that they are formed as basic component units.Nano-space is the relatively independent middle neck between both macro and micro
Domain.Nano-particle has small-size effect, surface and interfacial effect, quantum size effect and macro quanta tunnel effect, makes
Nano-particle has many special natures not available for conventional particle.Research shows, metal nanoparticle such as silver, zinc, copper
Deng having good antibiotic property.Wherein, nano silver antimicrobials excellent performance, but silver is noble metal, and application cost is higher, and Ag+
Can be with the Cl in aqueous medium-、HS-、S2-And SO4 2-Reacted etc. a variety of anion, form AgCl and Ag not soluble in water2S, from
And lose antibacterial activity.Compared with Nano Silver, Nanometer Copper and Nano-Zinc cost are relatively low, and bactericidal effect is only second to Nano Silver, and has
Have higher chemical stability and environmental safety, secondly, copper and zinc are the necessary trace elements of human body, harm to the human body compared with
It is small, had broad application prospects in field of fodder.
The content of the invention
It is an object of the present invention in view of the shortcomings of the prior art, there is provided a kind of high antimicrobial nano feed addictive and its
Application process in broiler feeding, the feed addictive can not only prevent and treat courses of infection, and enhancing broiler chicken body is exempted from
Epidemic disease function and antistress function, moreover it is possible to effectively facilitate growth of meat chicken, improve efficiency of feed utilization, and do not produce drug resistance, be a kind of
The functional feedstuff additive of green, safety.
The present invention is achieved through the following technical solutions：
A kind of high antimicrobial nano feed addictive, including following raw materials：Nanometer Copper, nano zine oxide, wherein, Nanometer Copper with
Nano zine oxide weight ratio is 1：1~6.
Preferably, a kind of high antimicrobial nano feed addictive, including following raw materials：Nanometer Copper, nano zine oxide, wherein,
Nanometer Copper is 1 with nano zine oxide weight ratio：3.
A kind of application process of high antimicrobial nano feed addictive in broiler feeding：The Day-old Broiler Chickens feed of 1 age in days~20
Formula be that the addition of 1~20mg high antimicrobial nano feeds is added on the basis of chicken feed basal diet, in every kilogram of basal diet
Agent；The formula of the Day-old Broiler Chickens feed of 21 ages in days~45 is on the basis of chicken feed basal diet, to be added in every kilogram of basal diet
The high antimicrobial nano feed addictives of 25~45mg.
Preferably, the Day-old Broiler Chickens basal diet formula of 1 age in days~20 is：Corn 55%, wheat bran 6%, dregs of beans 32%,
Fish meal 3%, stone flour 1.3%, calcium bicarbonate 1.2%, salt 0.3%, methionine 0.2%, premix 1%.
Preferably, the Day-old Broiler Chickens basal diet formula of 21 age in days~45 is：Corn 60%, wheat bran 6%, dregs of beans
27.2%, fish meal 2.5%, stone flour 1.5%, calcium bicarbonate 1.3%, salt 0.3%, methionine 0.2%, premix 1%.
Preferably, the premix is：Iron 60mg, manganese 110mg, iodine 1.1mg, vitamin A 4500IU, vitamin D3
1000IU, vitamin E 30IU, vitamin K 1.3mg, vitamin B12.2mg, vitamin B210mg, vitamin B310mg,
Vitamin B550mg, vitamin B64mg, vitamin B111mg, vitamin B121.013mg, Choline Chloride 400mg, biotin
0.04mg。
Nanometer Copper：Copper is distributed mainly in liver, brain, kidney, the heart, the pigment part of eye and the hair of animal, is both a variety of enzymes
Important component, be again hematopoiesis and prevent trace element necessary to alimentary anemia；Copper can be catalyzed ferroheme and red blood cell
Formation, and can safeguards the integrality of eucaryotic cell structure and function, to the hematolymphiod function of animal body, nerve cell, bone,
Connective tissue and hair grow and breeding performonce fo animals have positive facilitation.Nanometer Copper is reduced by copper ion
It is made into zerovalent copper, compared with traditional elemental copper, Nanometer Copper also has in addition to the nutrition physiology effect with common elemental copper
Small-size effect and surface-active effect, in animal body, it can be reduced by Passive diffusion or itself unique absorption pattern
To carrier, the needs of energy and consumption, its absorption and use efficiency is improved, reduces the addition in feed, so as to improve animal
Production cultivation comprehensive benefit.Secondly, Nanometer Copper also has significant antibacterial action, and research shows, its to staphylococcus aureus,
The pathogens such as Escherichia coli, Pseudomonas aeruginosa have excellent restraining and sterilizing bacteria effect.
Nano zine oxide：Zinc is the composition or activating agent of many enzymes of animal body, be archaeal dna polymerase, RNA polymerase,
The important composition composition of thymidine, nucleotidase, participate in a series of processes such as DNA replication dna, transcription and regulation protein synthesis.
Nano zine oxide, it is nonpoisonous and tasteless, nonirritant, it can effectively kill staphylococcus aureus, Candida albicans, Escherichia coli etc.
Pathogen, and there is slow release long-acting due to its spongy multi-cellular structure.Nano zine oxide Antibacterial Mechanism includes：I zinc from
Sub- active antibacterial mechanism：Bacterium is generally negatively charged, and the zinc ion of positively charged is firmly tied by Coulomb attraction with bacterial cell membrane
Be combined into cell, reacted with the sulfydryl in cell, make protein denaturation so that bacterium lose division growth ability and
Death, after thalline is killed, zinc ion is contacted by sedimentation equilibrium again separate out with other bacterium colonies, and it is thin to carry out a new round
Bacterium is killed；Secondly, zinc ion can also destroy electric transmission system, respiratory system and the transport of substances system of microorganism；II light is urged
Change Antibacterial Mechanism：After nano zine oxide receives the irradiation of light, the electron hole with strong oxidizing property, oxidation Decomposition bacterium are produced
Cell membrane and cell membrane, play bactericidal action；III active oxygen Antibacterial Mechanism：Nano zine oxide contacts meeting with water in atmosphere
Produce the H with strong oxidizing property2O2, the materials such as bacteria cell wall are destroyed, so as to reach sterilization purpose.
Beneficial effects of the present invention：
1st, the effect of of the invention composition Nanometer Copper and nano zine oxide there is good stability, Cell permeable, medicine
Slow release and concerted effect, thus more significant biological effect can be played when being contacted with pathogenic microorganism, there is stronger antibacterial
Activity.Secondly, nanoscale trace element can not be directly permeated by ion exchange, greatly improve the speed of body absorption with
Utilization rate, 1~3 times is improved than inorganic microelement utilization rate.
2nd, a kind of high antimicrobial nano feed addictive of the invention is applied to broiler feeding, can not only prevent and treat meat
Chicken courses of infection, strengthen broiler chicken immunologic function and antistress function, moreover it is possible to growth of meat chicken is effectively facilitated, improves efficiency of feed utilization,
And drug resistance is not produced, it is a kind of green, the functional feedstuff additive of safety.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1~3
A kind of high antimicrobial nano feed addictive of the present invention and its application in broiler feeding are listed in table 1
3 specific embodiments of method.
Table 1
In above-described embodiment 1~3, the age in days basal diet formula of 1 age in days~20 is：Corn 55%, wheat bran 6%, dregs of beans
32%, fish meal 3%, stone flour 1.3%, calcium bicarbonate 1.2%, salt 0.3%, methionine 0.2%, premix 1%；21 ages in days~
45 age in days basal diet formulas are：Corn 60%, wheat bran 6%, dregs of beans 27.2%, fish meal 2.5%, stone flour 1.5%, calcium bicarbonate
1.3%, salt 0.3%, methionine 0.2%, premix 1%；Premix is：Iron 60mg, manganese 110mg, iodine 1.1mg, vitamin
A4500IU, vitamin D31000IU, vitamin E 30IU, vitamin K 1.3mg, vitamin B12.2mg, vitamin B2
10mg, vitamin B310mg, vitamin B550mg, vitamin B64mg, vitamin B111mg, vitamin B121.013mg
Choline Chloride 400mg, biotin 0.04mg.
Comparative example 1~3
A kind of high antimicrobial nano feed addictive of the present invention and its application in broiler feeding are listed in table 2
3 specific comparative examples of method, in comparative example, feed addictive functional component Nanometer Copper and nano zine oxide are replaced with into sulfuric acid
Copper and zinc sulfate.
Table 2
In above-mentioned comparative example 1~3, the age in days basal diet formula of 1 age in days~20 is：Corn 55%, wheat bran 6%, dregs of beans
32%, fish meal 3%, stone flour 1.3%, calcium bicarbonate 1.2%, salt 0.3%, methionine 0.2%, premix 1%；21 ages in days~
45 age in days basal diet formulas are：Corn 60%, wheat bran 6%, dregs of beans 27.2%, fish meal 2.5%, stone flour 1.5%, calcium bicarbonate
1.3%, salt 0.3%, methionine 0.2%, premix 1%；Premix is：Iron 60mg, manganese 110mg, iodine 1.1mg, vitamin A
4500IU, vitamin D31000IU, vitamin E 30IU, vitamin K 1.3mg, vitamin B12.2mg, vitamin B2
10mg, vitamin B310mg, vitamin B550mg, vitamin B64mg, vitamin B111mg, vitamin B121.013mg
Choline Chloride 400mg, biotin 0.04mg.
Application Example
A kind of high antimicrobial nano feed addictive of the present invention and its application process in broiler feeding are to growth of meat chicken
The influence of performance
1st, test index
Meat chicken growth performance：Survival rate, daily gain, per day feed intake, feed-weight ratio.
2nd, test sample
Broiler fodder prepared by embodiment 1~3 and comparative example 1~3.
3rd, method of testing
3.1 experiment packet
From 3 Day-old Broiler Chickens similar in health, body weight, 6 groups are divided into, every group of 3 repetitions are each to repeat 10 chickens (public affairs
Mother's mixing is young), every group feeds embodiment 1~3 and comparative example 1~3 respectively in the age in days of 3 ages in days~20 and 21 ages in days~45 age in days
Prepared respective stage broiler fodder.
3.2 feeding management
This feeding experiment pre-feeding period is 3 days, subsequently enters formal test.Repeat to weigh to each, calculate initial
Body weight, gives normally brood required temperature, humidity and illumination, free choice feeding and drinking-water, and hen house performs the immune of routine and disappeared
Malicious program.Test chicken free water during experiment, daily management are routinely carried out with health and epidemic prevention.
3.3 index determining
On-test, claimed each 3 ages in days and 45 age in days live-weights for repeating experiment chick in the morning on an empty stomach with the end of, calculates every
The average daily gain of Broiler chicks.Accurate recording tests the broiler chicken death rate of each repetition and daily feed consumption, and asks experiment
Total feed consumption amount and per day feed intake；In units of group, feed-weight ratio is calculated according to the feed intake of Broiler chicks and weightening.
Daily gain=(the whole weight-experiment starting weight of experiment)/(testing age-experiment beginning age in days all day)
Per day feed intake=(formula feed amount-residual feed amount)/(raising number of days × raising chicken number)
Feed-weight ratio=average daily gain/average daily gain
4th, test result：Testing result is as shown in table 3 below.
The broiler chicken survival rate of table 3, daily gain, per day feed intake, feed-weight ratio measurement result
Compared with comparative example, embodiment 1~3 can significantly improve the survival rate and daily gain of broiler chicken, and reduction is put down broiler chicken day
Equal feed intake and feed-weight ratio, wherein, the action effect of embodiment 2 is most notable, and compared with comparative example 2, broiler chicken survival rate improves
3.9%, daily gain improves 2.9g/d, and per day feed intake reduces 0.8g/d, and feed-weight ratio reduces by 0.25, shows that high antimicrobial nano is raised
Nanometer Copper and nano zine oxide weight ratio are 1 in material：High antimicrobial nano in 3,1 ages in days~every kilogram of basal diet of 20 Day-old Broiler Chickens
Feed addictive addition is 15mg, high antimicrobial nano feed addictive in 21 ages in days~every kilogram of basal diet of 45 Day-old Broiler Chickens
Addition is 36mg, for the optimal raising proportioning of the high antimicrobial nano feed addictive of the present invention.
5th, conclusion
The high antimicrobial nano feed addictive and its application process in broiler feeding of the present invention, can significantly improve meat
The survival rate and daily gain of chicken, broiler chicken feed-weight ratio and per day feed intake are reduced, the prolonged application present invention, is advantageous to improve feed
Utilization rate, aquaculture cost is reduced, is increased economic efficiency.
Claims (6)
1. a kind of high antimicrobial nano feed addictive, it is characterised in that including following raw materials：Nanometer Copper, nano zine oxide, its
In, Nanometer Copper is 1 with nano zine oxide weight ratio：1~6.
2. a kind of high antimicrobial nano feed addictive according to claim 1, it is characterised in that including following raw materials：Receive
Rice copper, nano zine oxide, wherein, Nanometer Copper is 1 with nano zine oxide weight ratio：3.
3. a kind of application process of the high antimicrobial nano feed addictive in broiler feeding as claimed in claim 1 or 2, it is special
Sign is, the formula of the Day-old Broiler Chickens feed of 1 age in days~20 is, on the basis of chicken feed basal diet, in every kilogram of basal diet
Add the high antimicrobial nano feed addictives of 1~20mg；The formula of the Day-old Broiler Chickens feed of 21 ages in days~45 is, in chicken feed basis day
On the basis of grain, the high antimicrobial nano feed addictives of 25~45mg are added in every kilogram of basal diet.
4. a kind of application process of the high antimicrobial nano feed addictive according to claim 3 in broiler feeding, it is special
Sign is, the Day-old Broiler Chickens basal diet formula of 1 age in days~20 is：Corn 55%, wheat bran 6%, dregs of beans 32%, fish meal 3%,
Stone flour 1.3%, calcium bicarbonate 1.2%, salt 0.3%, methionine 0.2%, premix 1%.
5. a kind of application process of the high antimicrobial nano feed addictive according to claim 3 in broiler feeding, it is special
Sign is, the Day-old Broiler Chickens basal diet formula of 21 age in days~45 is：Corn 60%, wheat bran 6%, dregs of beans 27.2%, fish meal
2.5%, stone flour 1.5%, calcium bicarbonate 1.3%, salt 0.3%, methionine 0.2%, premix 1%.
6. application process of a kind of high antimicrobial nano feed addictive in broiler feeding according to claim 4 or 5, its
It is characterised by, the premix is：Iron 60mg, manganese 110mg, iodine 1.1mg, vitamin A 4500IU, vitamin D31000IU,
Vitamin E 30IU, vitamin K 1.3mg, vitamin B12.2mg, vitamin B210mg, vitamin B310mg, vitamin B5
50mg, vitamin B64mg, vitamin B111mg, vitamin B121.013mg, Choline Chloride 400mg, biotin 0.04mg.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108041288A (en) * | 2017-12-14 | 2018-05-18 | 佛山市三水区嘉信农业技术研究院（普通合伙） | A kind of application process of high antibacterial feed nano additive in raising dairy cattle |
| CN111227129A (en) * | 2020-03-13 | 2020-06-05 | 湖南新五丰股份有限公司 | Low-zinc-oxide piglet creep feed |
| CN111972557A (en) * | 2020-09-04 | 2020-11-24 | 新疆畜牧科学院畜牧研究所 | Whole-plant corn silage formula for 7-13 month-old bred donkeys |
| WO2021255646A1 (en) * | 2020-06-15 | 2021-12-23 | Margana Bio Technologies Ltd. | A copper based composition for animal consumption |
| EP3811934A4 (en) * | 2018-06-22 | 2022-06-08 | Suzhou Guanjie Nano Materials Technology Co., Ltd. | Use of composite nanoparticle of carbon and copper |
| CN115316549A (en) * | 2022-08-25 | 2022-11-11 | 李雄 | Feed additive for improving reproductive capacity of cocks and preparation method thereof |
-
2017
- 2017-08-16 CN CN201710704171.6A patent/CN107348218A/en active Pending
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108041288A (en) * | 2017-12-14 | 2018-05-18 | 佛山市三水区嘉信农业技术研究院（普通合伙） | A kind of application process of high antibacterial feed nano additive in raising dairy cattle |
| EP3811934A4 (en) * | 2018-06-22 | 2022-06-08 | Suzhou Guanjie Nano Materials Technology Co., Ltd. | Use of composite nanoparticle of carbon and copper |
| CN111227129A (en) * | 2020-03-13 | 2020-06-05 | 湖南新五丰股份有限公司 | Low-zinc-oxide piglet creep feed |
| WO2021255646A1 (en) * | 2020-06-15 | 2021-12-23 | Margana Bio Technologies Ltd. | A copper based composition for animal consumption |
| CN111972557A (en) * | 2020-09-04 | 2020-11-24 | 新疆畜牧科学院畜牧研究所 | Whole-plant corn silage formula for 7-13 month-old bred donkeys |
| CN115316549A (en) * | 2022-08-25 | 2022-11-11 | 李雄 | Feed additive for improving reproductive capacity of cocks and preparation method thereof |
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Application publication date: 20171117 |