CN114431340A

CN114431340A - Application of catechin in preparation of animal feed additive and feed thereof

Info

Publication number: CN114431340A
Application number: CN202210090822.8A
Authority: CN
Inventors: 林映才; 张罕星
Original assignee: Guangzhou Weitejia Bioengineering Co ltd
Current assignee: Guangzhou Weitejia Bioengineering Co ltd
Priority date: 2022-01-26
Filing date: 2022-01-26
Publication date: 2022-05-06

Abstract

The invention provides application of catechin to preparation of animal feed additives and feed, wherein the catechin is one or more of epigallocatechin gallate, epigallocatechin, epicatechin and epicatechin gallate, and is applied to preparation of the feed additives for improving the constitution of newborn animals. When the catechin animal feed additive is applied to preparing catechin feed, the addition amount of catechin is 0.05-20% of the total mass of the feed, and by increasing the absorption of parent nutrient elements, the absorption of the nutrient elements of the daughters in the parent and the formation of an immune system are promoted, and the storage of the daughters nutrient elements is increased, so that the physique of the primary animals is improved, the weight of the primary animals is increased, and the survival rate of the primary animals is increased.

Description

Application of catechin in preparation of animal feed additive and feed thereof

Technical Field

The invention relates to the technical field of animal feed additives, in particular to application of catechin in preparation of an animal feed additive and feed thereof.

Background

Animal husbandry is an important component of agricultural basic industry, the development level of the animal husbandry is directly related to the agricultural production level, the animal husbandry is an important mark of national living standard, the animal husbandry production of developed countries accounts for more than 50% of agricultural production proportion, such as 50.1% of the United states, 59.8% of the United kingdom, and more developed countries of animal husbandry account for more than 70% of agricultural proportion, such as New Zealand and Australia. And the animal husbandry output value in China only accounts for about 35 percent of the agricultural output value, so that the animal husbandry is developed vigorously in China and is worth doing much. In the production process of animal husbandry in China, a plurality of problems exist, such as: high weak litter rate and stillbirth rate, low immunity of newborn animals, weak constitution, high death rate, low hatching rate and the like. Maternal nutrition is crucial to growth and development of offspring, and can affect placenta size, transport efficiency of nutrients and oxygen in placenta and nutrition distribution of fetus during pregnancy. How to reduce weak litter size and stillbirth rate, improve the constitution of the newborn animals and the survival rate of the postnatal animals, solve the problems existing in the production process of the animals, and is always the key problem concerned by the animal husbandry in China.

The feed additive is a small amount or trace substance added in the production, processing and using processes of feed, and the feed additive is small in dosage but remarkable in effect. The feed additive is a raw material inevitably used in modern feed industry, and has obvious effects on strengthening the nutritive value of basic feed, improving the production performance of animals, ensuring the health of the animals, saving the feed cost, improving the quality of animal products and the like. With the development of multiple subjects such as animal nutrition, physiology, feedlot, biochemistry, bioengineering, pharmacology, microbiology and the like, the existing feed additive combines multiple subjects and multiple new technologies. From the past to the present, people are dedicated to the development and production of more scientific and technical and specialized feed additives so as to solve the problems of high weak piglet rate, low immunity of newborn animals, weak constitution, high mortality rate and the like in the animal breeding process.

Catechins, also known as catechins and catechins (cardhieaacid), are phenolic active substances extracted from natural plants such as tea leaves. It has effects in scavenging free radicals, improving intestinal microorganism distribution and resisting bacteria, and can stimulate animal brain center to stimulate animal to produce excitement and hunger sensation and increase animal feed intake. In addition, catechin also has effects of promoting immune organ development, improving immune organ injury condition, and increasing overall immunity level. In the prior art, catechin is used for researching animal reproductive performance, but catechin is lacked for improving the storage of nutrient elements and the immune formation of a daughter, reducing the weak young rate and the dead young rate in the lactation period and improving the survival rate and the hatching rate.

Disclosure of Invention

The catechins applied to the animal feed additive can increase the absorption of parent nutrient elements, further promote the absorption of nutrient elements and the formation of an immune system in a parent body of a daughter, and increase the storage of the nutrient elements of the daughter, thereby improving the physique and the weight of a newborn animal and solving the problem of low survival rate of the newborn animal.

In order to achieve the aim, the invention provides an application of catechin in preparing animal feed additives, wherein the catechin is one or more of epigallocatechin gallate, epigallocatechin, epicatechin and epicatechin gallate, and the catechin is uniformly mixed with auxiliary agents to obtain the catechin animal feed additives.

Further preferably, the auxiliary agent comprises one or more of iron salt, iodine salt, selenium-rich matter, zinc salt, vitamin D, vitamin B12 and organic acid.

More preferably, the mass ratio of the catechin to the auxiliary is 3-6: 1, the mass ratio of iron salt, iodized salt, selenium-rich matter, zinc salt, vitamin D, vitamin B12 and organic acid in the auxiliary agent is 40: 100: 3: 60: 15: 20.

Further preferably, the application of the catechin in preparing the animal feed additive is applied to preparing the catechin animal feed additive for improving the constitution of the newborn animals.

Preferably, the feed additive enriches the nutrient components of the feed, stimulates the animal to eat the central pivot, ensures the intestinal function of the animal, increases the absorption of the nutrient elements of the parent, further promotes the absorption of the nutrient elements of the daughter in the parent and the formation of an immune system, increases the storage of the nutrient elements of the daughter, thereby improving the physique of the newborn animal, increasing the weight of the newborn animal and improving the survival rate of the newborn animal.

The invention also provides a catechin animal feed which comprises the catechin animal feed additive and is suitable for mammals and poultry.

Further preferably, the catechin animal feed is prepared by the following method:

s1, preparing a coating material and dissolving the coating material to form a coating solution;

s2, placing the catechin animal feed additive into a coating solution for coating, taking out the coating solution for volatilization to remove the solvent, and obtaining the coated feed additive;

and S3, mixing the coated feed additive and the basic feed according to the mass ratio by using the mass calculation of the catechin animal feed additive to obtain the animal feed.

Further preferably, the specific methods in steps S1 and S2 are:

s1, preparing a coating solution A formed by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B;

s2, placing the feed additive into the coating solution B for coating, taking out and drying, then placing the feed additive into the coating solution A for secondary coating, taking out and volatilizing to remove the solvent, thus obtaining the coated feed additive.

More preferably, in the catechin animal feed, the addition amount of catechin is 0.05-5% of the total mass of the feed.

Further preferably, the basic feed comprises an energy feed, a protein feed, a trace element premix feed and a vitamin premix feed in a mass ratio of 6: 3: 0.5.

The invention has the beneficial effects that: the invention applies the catechin as the feed additive to the feed to prepare the tea animal feed for children, on one hand, the tea animal feed can stimulate the brain center of animals, so that the fed animals generate excitation and hunger sensation and the food intake of the animals is improved; secondly, the growth of harmful bacteria can be inhibited, the propagation of beneficial bacteria is not damaged, the ecological balance of intestinal tracts is maintained, a biological protection barrier is formed, the immunity of the organism of a parent body is improved, the circulation of the intestinal tracts is improved, and the gastrointestinal function of the parent body is enhanced, so that the absorption of the parent body to nutrient elements is promoted; in addition, the invention also applies the catechin and the auxiliary agent in a matching way, and increases the amount of specific elements in the feed. The nutrient elements are absorbed by the parent body from the aspects of feed, feed intake and substance absorption, so that the absorption of elements required by growth and development of the daughter body from the parent body is promoted, the growth and development of the daughter body are promoted, the physique and the weight of the newborn pup are improved, the element storage capacity of the daughter body is increased, the absorption of milk synthetic substances by the parent body is promoted, the substance components in breast milk are increased, the element requirements of the pup in the stages from birth to weaning and before feeding are ensured, the growth and development of the pup are promoted, the immunity level of the pup is improved, the weak young rate and the dead young rate in the lactation period are reduced, and the survival rate is improved.

The feed additive containing catechin is mixed with the basic feed in a coating form, so that the enteric solubility of the feed additive can be ensured, the combination of amylase and catechin is reduced, the intestinal utilization rate of the feed additive is ensured, and the action rate of catechin and the absorption rate of nutrient elements by fed animals are improved.

Detailed Description

The embodiments described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without any inventive step, shall fall within the scope of the present invention.

The invention relates to an application of catechin in preparing animal feed additives, wherein the catechin is one or more of epigallocatechin gallate, epigallocatechin, epicatechin and epicatechin gallate, and is applied to preparing the feed additives for improving the physique of newborn animals.

Catechins, also known as catechin and catechin (Caredhieacid), are phenolic active substances extracted from natural plants such as tea. It has effects in scavenging free radicals, improving intestinal microorganism distribution and resisting bacteria, and can stimulate animal brain center to stimulate animal to produce excitement and hunger sensation and increase animal feed intake. In addition, catechin also has effects of promoting immune organ development, improving immune organ injury condition, and increasing overall immunity level.

The animal feed additive is prepared by uniformly mixing catechin and an auxiliary agent, wherein the auxiliary agent comprises one or more of iron salt, iodine salt, selenium-rich matter, zinc salt, vitamin D, vitamin B12 and organic acid, and the mass ratio of the catechin to the auxiliary agent is 1: 1 to 5. The zinc salt is organic zinc, has far lower stimulation to animal tissue cells and gastrointestinal mucosa than inorganic zinc, has good anti-inflammatory and antibacterial properties, can promote cell division and reproduction and regeneration of epithelial tissue cells, and has good therapeutic effect on gastric ulcer of animals. The selenium salt is selenoprotein and/or selenium-enriched yeast, has low toxicity and high physiological activity and utilization rate, and the selenium-enriched yeast is rich in protein, sugar and 18 vitamins, can be used as a selenium source and also provides other beneficial nutrients.

Iron is an important component for forming hemoglobin, myoglobin, cytochrome and various oxidases, and is used as an oxygen carrier to ensure the normal delivery of oxygen in body tissues; participate in complex redox processes in vivo. Iron deficiency or poor utilization of iron leads to disturbance of metabolic processes such as oxygen transport, storage, carbon dioxide transport, oxidation reduction and the like, and affects growth and even causes various diseases such as anemia. The body can reuse the iron released from the red pigment, so that the iron demand of the adult healthy animals is very low. The growth and development of young animals require more iron, and the iron in breast milk generally cannot meet the requirements.

Iodine is an important constituent of thyroxine. Most of iodine in animals exists in thyroid gland, so that thyroxine is synthesized and metabolism is regulated. Its functions include promoting protein synthesis, activating more than 100 enzymes, regulating energy conversion, promoting growth and development, enhancing immunity, maintaining central nervous system structure, and ensuring normal mental state, physical form and metabolism. The iodine deficiency of female animals easily causes early embryo death, embryo absorption, abortion, and production of hairless pigs, generalized myxedema, thickened skin, thick neck, weak piglets, and low survival rate. Iodine deficiency in piglets leads to growth retardation.

Selenium is an essential element of animals and is a component of glutathione peroxidase, which can decompose intracellular peroxides, prevent oxidative damage reactions to cell membrane lipids, and protect biological membranes from damage. Selenium deficiency may cause liver necrosis, seriously affecting the growth and development of young animals and even causing death.

Zinc is mainly distributed in bones, livers and furs in the bodies of animals. Mainly exists in the form of enzyme, is a composition of various DNA and RNA synthetases, transport enzymes and digestive enzymes, plays a main role in the metabolism of three major substances, and is also an activator of various metalloenzymes in vivo, so that the immunocompetence of an organism can be improved.

The main physiological function of vitamin D is to regulate the metabolism of calcium and phosphorus, in particular to promote the absorption of calcium and phosphorus by the small intestine; regulate the excretion of calcium and phosphorus by the kidney; controlling the storage of calcium and phosphorus in bones and the concentration of calcium and phosphorus in blood, etc. When vitamin D is insufficient, the animal cannot be well utilized even if calcium and phosphorus are sufficient, the deposition of calcium, phosphorus and magnesium in bones is reduced, osteogenesis of young animals is hindered, rickets and osteomalacia occur, tooth dysplasia and growth is hindered.

Vitamin B12 is involved in metabolism of one-carbon group in the body, is a coenzyme for transferring methyl group, and is linked with the action of folic acid to influence the formation of active methyl group and metabolism of other one-carbon group required for biosynthesis in the body. And are therefore involved in many metabolic processes. The most important of them is involved in the biosynthesis of nucleic acids and proteins (called animal protein factors) and promote the development and maturation of erythrocytes. When vitamin B12 is deficient, animal pernicious anemia can be caused, female animal vitamin B12 is deficient, conception rate is reduced, young animal vitamin B12 is deficient, protein deposition is reduced, and growth is retarded or even stopped.

The organic acid can promote the absorption of iron and other elements by animals, can also reduce the pH value in the digestive tract, is a necessary condition for activating the animal in pepsin and maintaining higher activity, is beneficial to softening feed and dissolving and hydrolyzing nutrients, and also has the barrier function of preventing pathogenic microorganisms from entering the body through the digestive tract, improves the digestive function of animals, regulates the microorganisms in the digestive tract and ensures the function of the digestive tract.

The invention also provides a catechin animal feed which is prepared by the following method:

s2, placing the feed additive into a coating solution for coating, taking out the feed additive and volatilizing to remove the solvent to obtain a coated feed additive;

and S3, mixing the coated feed additive and the basic feed according to the mass ratio by mass of the feed additive to obtain the animal feed.

Further preferably, the specific methods in steps S1 and S2 are:

In the catechin animal feed, the additive amount of catechin accounts for 0.05-5% of the total mass of the feed.

Further preferably, the basic feed comprises an energy feed, a protein feed, a trace element premix and a vitamin premix at a mass ratio of 6: 3: 0.5.

The feed additive containing catechin is mixed with the basic feed in a coating form, so that the enteric solubility of the feed additive can be ensured, the combination of amylase and catechin is reduced, the intestinal utilization rate of the feed additive is ensured, and the action rate of catechin and the absorption rate of nutrient elements by fed animals are improved. The feed additive and feed can be applied to mammals and poultry.

Example 1

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing epigallocatechin gallate 250mg, epigallocatechin 250mg and epicatechin 250mg to obtain catechin mixture, mixing ferrous gluconate 60mg and iodine 100mg

Adding iodized salt, 4mg selenium-enriched yeast, 80mg zinc glycyrrhetate, 80mg vitamin D, 25mg vitamin B12 and 30mg citric acid, mixing uniformly to obtain adjuvant, and mixing catechin and adjuvant uniformly to obtain the feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part by mass of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts by mass of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out the feed additive for drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times for each time of 3-8 seconds, taking out the feed additive for volatilization, and removing the solvent to obtain the coated feed additive.

Example 2

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing 125mg of epigallocatechin gallate, 125mg of epigallocatechin, 125mg of epicatechin, and 125mg of epicatechin gallate to obtain catechin mixture, mixing 30mg of ferrous gluconate and 100mg of iodine content

The iodized salt, 3mg of selenium-enriched yeast, 50mg of zinc glycyrrhetate, 50mg of vitamin D, 10mg of vitamin B12 and 20mg of succinic acid are mixed uniformly to obtain an auxiliary agent, and the catechin and the auxiliary agent are mixed uniformly to obtain the feed additive. Dissolving 2 parts of zein and 1 part of plasticizer in 0.5 part by massForming a coating solution A in an organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts by mass of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out the feed additive for drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times, and taking out the feed additive for volatilizing to remove the solvent, thereby obtaining the coated feed additive.

Example 3

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing 350mg of epigallocatechin, 250mg of epicatechin and 400mg of epicatechin gallate to obtain catechin mixture, and mixing 40mg of ferrous gluconate and 120mg of iodine content

The iodized salt, the selenium-enriched yeast 4mg, the zinc glycyrrhetate 60mg, the vitamin D60 mg, the vitamin B12 20mg and the citric acid 20mg are mixed uniformly to obtain the auxiliary agent, and the catechin and the auxiliary agent are mixed uniformly to obtain the feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part by mass of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts by mass of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out the feed additive for drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times for 3-8 seconds each time, taking out the feed additive for volatilization, and removing the solvent to obtain the coated feed additive.

Example 4

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing epigallocatechin gallate 300mg, epigallocatechin 250mg, epicatechin 350mg and epicatechin gallate 200mg to obtain catechin mixture, and mixing ferrous gluconate 60mg and iodine 90mg

Iodized salt of (1), and selenium-enriched yeast 3mg80mg zinc glycyrrhetate, 80mg vitamin D, 15mg vitamin B12 and 30mg citric acid are mixed uniformly to obtain an auxiliary agent, and catechin and the auxiliary agent are mixed uniformly to obtain the feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out the feed additive for drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times, and taking out the feed additive for volatilizing to remove the solvent, thereby obtaining the coated feed additive.

Example 5

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing epigallocatechin gallate 450mg and epicatechin 750mg to obtain catechin mixture, and mixing zinc glycyrrhetate 60mg, ferrous succinate 50mg, L-selenomethionine 2mg, selenium-rich yeast 2mg and iodine content 200mg

The iodized salt is mixed evenly to obtain the auxiliary agent, and the catechin is mixed evenly with the auxiliary agent to obtain the feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out the feed additive for drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times for 3-8 seconds each time, taking out the feed additive for volatilization, and removing the solvent to obtain the coated feed additive.

Example 6

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing 375mg of epigallocatechin gallate, 375mg of epigallocatechin, 375mg of epicatechin, and 375mg of epicatechin gallate to obtain catechin mixture, and mixing 40mg of glucoseFerrous sulfate, 100mg iodine content

The iodized salt, 3mg of selenium-enriched yeast, 60mg of zinc glycyrrhetate, 60mg of vitamin D, 15mg of vitamin B12 and 20mg of succinic acid are mixed uniformly to obtain an auxiliary agent, and the catechin and the auxiliary agent are mixed uniformly to obtain the feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein the coating time is 2-5 seconds each time, taking out and drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times, and the coating time is 3-8 seconds each time, taking out and volatilizing to remove the solvent, thus obtaining the coated feed additive.

Example 7

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing 30mg ferrous gluconate and 120mg iodine content

Mixing iodized salt, 2mg selenium-enriched yeast, 50mg zinc glycyrrhizate, 50mg vitamin D, 10mg vitamin B12 and 10mg pyruvic acid to obtain adjuvant, and mixing 900mg epigallocatechin gallate with adjuvant to obtain feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein each coating time is 2-5 seconds, taking out and drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times for each coating time is 3-8 seconds, taking out and volatilizing to remove the solvent to obtain the coated feed additive.

Example 8

This example provides an animal feed additive comprising catechins, which is prepared as follows: mixing 300mg of epigallocatechin gallate, 300mg of epigallocatechin, 300mg of epicatechin and 300mg of epicatechin gallate to obtain catechin feed additive. Preparing a coating solution A by dissolving 2 parts by mass of zein and 1 part by mass of plasticizer in 0.5 part of organic solvent, and dissolving 1 part by mass of pectin and 1 part by mass of plasticizer in 98 parts of water to form a coating solution B; and (3) placing the feed additive into the coating solution B for coating for 1-2 times, wherein each coating time is 2-5 seconds, taking out and drying after coating, placing the feed additive into the coating solution A for coating for 1-2 times for each coating time is 3-8 seconds, taking out and volatilizing to remove the solvent to obtain the coated feed additive.

Further, the coated feed additives prepared in the embodiments 1 to 8 are respectively and uniformly mixed with a proper amount of basal feed to obtain 1 to 8(1kg) of feed, wherein the mass ratio of the basal feed is 6: 3: 0.5: 0.5 of corn flour, bean pulp, trace element premix and vitamin premix feed. Wherein the microelement premix and the vitamin premix compound feed have no special requirements and are conventional products in the market.

Carrying out verification of the effect of the feed 1-8 on improving the physique of the newborn animal:

the method comprises the steps of feeding 180 sows in a 2-5-second gestation period according to a conventional method, randomly dividing the sows into a control group and a test group, feeding 1-8 basic feeds and 1-8 feeds for each group of 20 repeated sows, and feeding the control group and the test group 1-8 basic feeds respectively until the piglets are fed with breast milk within 21 days after farrowing and within 21 days after the piglets are born.

Recording period: starting artificial insemination of the sow and ending 21 days after delivery.

Recording indexes:

(1) litter size of sow, daily average feed intake (kg) of sow, newborn weight (g) of piglet, newborn weak litter size, dead litter size, piglet weight (kg) after 21 days, weak litter size after 21 days, dead litter size after 21 days, and diarrhea number after 21 days; each data is an average number.

(2) The element storage and immunity level of newborn piglets and the element storage and immunity level of 21-day piglets.

(3) Colostrum of sow and the element level in normal milk after 21 days.

(4) Intestinal flora parameters (with fecal flora as a test result) and fecal scores of sows before pregnancy, at day 28 of pregnancy, at day 108 of pregnancy/delivery, at day 2 of delivery, and at day 21 of delivery.

Stool scoring criteria were as follows:

score value	Definition of	Basis for rating (stool appearance)
			1 minute (1)	Diarrhea relieving medicine	Liquid, unformed, liquid-dung separation
2 is divided into	Mild diarrhea	No deformation and no separation of liquid and excrement
			3 points of	Is normal	Shaping, moderate size and softness of feces
4 is divided into	Mild constipation	The feces are slightly hard and small
			5 points of	Severe constipation	The feces are hard, very small and cylindrical

TABLE 1 farrowing performance and piglet index of control group and test group 1-8 sows

TABLE 2 storage of trace elements and immune levels in the newborn piglets born by the control group and the test groups 1-8 sows

TABLE 3 storage of trace elements and immune level of piglets born by 1-8 sows in control group and test group in 21 days

TABLE 4 elemental levels in colostrum and normal milk after 21 days in control and test groups of 1-8 sows

TABLE 5 elemental levels in normal milk after 21 days for control and test groups of 1-8 sows

TABLE 6 sow fecal flora condition table

As can be seen from the above table 1, the daily average feed intake of the sows of the test groups 1-8 in the test period is higher than that of the sows of the control group, which shows that the catechin animal feed can improve the feed intake, and in addition, the weak litter size and the dead litter size of the piglets produced by the sows of the test groups 1-8 are far smaller than those of the control group, the litter size is higher than that of the control group, but the newborn weight of the piglets is higher than that of the control group, which shows that the feed containing the catechin feed additive can promote the growth and system improvement of the piglets in the gestation period, improve the physique and the weight of the newborn piglets and improve the birth rate of the piglets in the early life compared with the feed base. In addition, the weight of the piglets is obviously higher than that of the control group after 21 days, no weak piglets exist after 21 days of piglets in the test groups 1-8, the death rate and the diarrhea condition of the piglets are far lower than those of the control group, and the piglets in the test groups 1-8 in the lactation period are superior to the piglets in the control group in terms of growth, development, constitution and the like.

As can be seen from tables 2 and 3, the storage of trace elements in vivo and the lymphocyte conversion rate of piglets in test groups 1-8 during the birth are obviously higher than those in a control group, which shows that the feed containing the catechin feed additive can promote the absorption and storage of the trace elements and the formation of an immune system of piglets in the gestation period and improve the storage amount of elements in vivo and the immune level of the piglets during the birth compared with the feed containing a basic feed. On the other hand, as can be seen from tables 4 and 5, the amounts of trace elements and immunoglobulin in the sow colostrum and normal milk of the test groups 1-8 are higher than those of the control group, which indicates that the catechin animal feed provided by the invention can improve the contents of the trace elements and immunoglobulin in the sow colostrum and normal milk and improve the survival rate of piglets.

The document reports that the lactobacillus added in the later gestation period of the sow can directly or indirectly improve the secretion of related lactation hormone, improve the lactation performance of the sow, promote the recovery of uterus and reduce the body condition loss and the oestrus interval of the sow caused by lactation. The microbial ecological balance in the intestinal tract is influenced, the quantity of harmful bacteria is increased, the intestinal mucosa is damaged and inflammatory reaction is generated, the intestinal peristalsis is weakened and slowed down, excrement stays and dries in the intestinal tract for a long time, probiotics are increased to balance intestinal flora, intestinal digestion can be promoted, constipation of sows is solved, lactic acid bacteria serving as probiotics have important effects on adjusting normal flora of the gastrointestinal tract, maintaining the microbial ecological balance, improving immunity and the like, lactic acid bacteria can generate lactic acid, the acidity of the intestinal tract is enhanced, bacteriocin is generated, the quantity of other bacteria is controlled, the growth and reproduction of harmful microorganisms are inhibited, the environment in the intestinal tract is improved, the feed conversion rate is improved, the absorption of milk synthetic substances is facilitated, the body immunity is enhanced, and the development and the lactation capacity of mammary glands are promoted. From table 5, the number of escherichia coli in the feces of the sows in the test group is not significantly different from that of the sows in the control group, but the number of lactobacillus in the feces of the sows in the test group is significantly increased relative to that of the sows in the control group, and the score of the feces of the sows in the test group is gradually close to 3, namely the feces gradually tend to be normal. The catechin animal feed can promote the growth of beneficial bacteria in the intestinal tract of pregnant sows, inhibit the growth of harmful bacteria, improve the intestinal ecological balance and has certain promotion effect on the ingestion, lactation performance and reproductive performance of the sows.

Feeding 60 cows for 2-5 times in gestation according to a conventional method, randomly dividing the cows into a control group and a test group of 9-10, repeating 20 cows in each group, feeding the basic feed and the feeds 6 and 7 respectively for the control group and the test group of 9 and 10 until 50 days after farrowing, feeding the calves with the maternal milk only within 10 days after birth, feeding the calves with the same conventional ration and the normal milk according to a conventional weaning feeding mode for 10-45 days, and weaning after 45 days.

Recording period: starting from the artificial insemination of the cow and stopping 50 days after birth.

Recording indexes:

(1) cow litter size, cow daily average feed intake (kg), calf birth weight (kg), birth weak number, dead number, calf weight (kg) after 50 days, weak litter size after 50 days, dead number after 50 days, and diarrhea number within 50 days;

(2) cow colostrum and 25 days normal milk content;

TABLE 7 comparison group and test group 1-2 cow farrowing performance and calf index

TABLE 8 elemental levels in control and test groups 1-2 bovine colostrum and after 25 days in normal milk

As shown in tables 7 and 8, the same effects as in the case of application to pigs were obtained by applying the feeds 6 and 7 to cattle: improves daily feed intake of cow, contents of elements and immunoglobulin in colostrum and normal milk, promotes development of calf immune system, and improves newborn constitution and lactation survival rate of calf.

In addition, the application of the feed to poultry-chicken is also carried out, 100 test hens are fed with the feed for one month for 5 days, and then 200 eggs laid within 5 days after the test period of each test hen are taken for industrial hatching, so that the hatching rate reaches 99%, and the hatching rate is greatly improved compared with the prior art (the conventional hatching rate is about 92%).

The trace elements such as calcium, selenium, iodine, iron, zinc and the like play an important role in the growth and development of animals, the trace elements obtained by the young animals before weaning are few from breast milk, and the trace elements in the young animals before weaning are usually in a loss state, so that the amount of the trace elements absorbed by the young animals from the mother body during gestation and the storage amount of the trace elements in the young animals during newborn have great influence on the physique of the young animals as well as the physique and the growth and development of the young animals during the period from birth to weaning and before feeding. The catechin is applied to the animal feed additive to prepare the catechin animal feed, and on one hand, the catechin animal feed can improve the food intake of animals; secondly, the growth of harmful bacteria can be inhibited, the multiplication of beneficial bacteria can be promoted, the ecological balance of intestinal tracts can be adjusted, a biological protection barrier can be formed, the organism immunity of a mother body can be improved, the intestinal circulation can be improved, the gastrointestinal function of the mother body can be enhanced, and the feed conversion rate can be improved, so that the absorption of the mother body on nutrient elements can be promoted, the synthesis of milk can be facilitated, and the development and the lactation capability of mammary glands can be promoted; in addition, the invention also applies the catechin and the auxiliary agent in a matching way, and increases the amount of specific elements in the feed. The nutrient element absorption of the parent is ensured in the aspects of feed, feed amount and material absorption, so that the absorption of the elements required by growth and development of the daughter from the parent is promoted, the growth and development of the daughter are promoted, the physique and the weight of the newborn young animal are improved, the storage amount of the daughter element is increased, the survival rate of the daughter is improved, the absorption of the mother to milk synthetic substances is promoted, the substance components in breast milk are increased, the element requirements of the young animal from birth to weaning and before feeding are ensured, the growth and development of the young animal are promoted, the immunity level of the animal is improved, the weak young rate and the dead young rate are reduced, and the survival rate is improved.

The above disclosure is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the scope of the present invention, therefore, the present invention is not limited by the appended claims.

Claims

1. The application of catechin in preparing animal feed additive is characterized in that the catechin is one or more of epigallocatechin gallate, epigallocatechin, epicatechin and epicatechin gallate, and the catechin is uniformly mixed with an auxiliary agent to obtain the catechin animal feed additive.

2. The use of catechins in the preparation of an animal feed additive as claimed in claim 1 wherein the adjuvants include one or more of iron salts, iodine salts, selenium-rich, zinc salts and vitamin D, vitamin B12, organic acids.

3. The application of catechin to preparing an animal feed additive according to claim 1, wherein the mass ratio of the catechin to the auxiliary is 3-6: 1, the mass ratio of iron salt, iodized salt, selenium-rich matter, zinc salt, vitamin D, vitamin B12 and organic acid in the auxiliary agent is 40: 100: 3: 60: 15: 20.

4. The use of catechin as claimed in claim 1 for preparing animal feed additive, wherein the catechin is used for preparing animal feed additive for improving constitution of newborn animals.

5. The application of catechin in preparing animal feed additives according to claims 1-4, wherein the feed additives improve the physique of the newborn animals, improve the weight of the newborn animals and improve the survival rate of the newborn animals by enriching feed nutrients, improving the feed intake of the mothers, ensuring the intestinal function of the animals, increasing the absorption of nutrient elements of the mothers, promoting the absorption of nutrient elements of the daughter in the mothers, forming an immune system and increasing the storage of nutrient elements of the daughter.

6. A catechin animal feed, wherein the catechin animal feed comprises the catechin animal feed additive, and the catechin animal feed is suitable for mammals and poultry.

7. The catechin animal feed of claim 7, wherein the catechin animal feed is prepared by the method comprising:

8. The catechin animal feed of claim 7, wherein the steps S1, S2 are embodied as follows:

s2, placing the feed additive into the coating solution B for coating, taking out and drying the feed additive, then placing the feed additive into the coating solution A for secondary coating, taking out and volatilizing the solvent to obtain the coated feed additive.

9. The catechin animal feed according to claim 7, wherein catechin is added in an amount of 0.05 to 5% by mass of the total mass of the feed.

10. The catechin animal feed of claim 7, wherein the basal feed comprises an energy feed, a protein feed, a trace element premix feed, and a vitamin premix feed at a mass ratio of 6: 3: 0.5.