CN104351219A - Compound abamectin preparation for aquaculture, as well as preparation method and application of compound abamectin preparation - Google Patents
Compound abamectin preparation for aquaculture, as well as preparation method and application of compound abamectin preparation Download PDFInfo
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- CN104351219A CN104351219A CN201410594605.8A CN201410594605A CN104351219A CN 104351219 A CN104351219 A CN 104351219A CN 201410594605 A CN201410594605 A CN 201410594605A CN 104351219 A CN104351219 A CN 104351219A
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Abstract
The invention provides a compound abamectin preparation for aquaculture, as well as a preparation method and application of the compound abamectin preparation. The compound abamectin preparation comprises the following components in percentage by weight: 2.5 to 3.5 percent of abamectin benzoate, 2 to 4 percent of tulathromycin, 3 to 6 percent of selamectin, 15 to 20 percent of pesticide emulsifier 0206-B, 3 to 5 percent of azone, 40 to 60 percent of absolute ethyl alcohol and 25 to 40 percent of dimethylbenzene. The compound abamectin preparation can be applied to the killing of various parasites, bacteria and viruses of aquatic animals; the three active ingredients, namely abamectin benzoate, tulathromycin and selamectin have synergistic effects, so that the compound abamectin preparation is high in efficacy, small in dosage, low in toxicity to the environment and the animals and low in the possibility of the drug resistance, and has the advantages of simple preparation method, wide insecticidal range and the like.
Description
Technical field
The invention belongs to field of veterinary, relate to a kind of Avermectin preparation, be specifically related to a kind of compound Avermectin preparation for aquaculture and its preparation method and application.
Background technology
Current, due to the generation of the disease that the parasite of aquiculture animal and bacterium, virus cause, cause very big economic loss to culture fishery.The parasites such as China Sao, anchor head Sao, Dactylogyrus, little melonworm are aquaculture common causative, very harmful.In fishing medicine insecticide, dichlorvos, owing to there is poor stability in the medicines such as malachite green, contaminated environment and harm humans are healthy and be eliminated, though there is the agent of vegetalitas fish insect killing in the control of aquatic animal disease, but it is large to there is usage amount, take effect slow, killing effect is not thorough, cost is higher, the shortcomings such as function singleness, therefore, the current overwhelming majority still uses traditional organic phosphor, polyesters insecticide, due to Pesticidal and sterilizing function singleness, when insect pest and bacterial disease occur simultaneously, need to use a large amount of desinsection and Bactericidal medicine, these substance toxicity are large, poorly water-soluble, Long-Time Service drug resistance strengthens, cause the vicious circle that dosage is used more and more, these materials are not easily degraded in the environment simultaneously, severe contamination breeding environment, and some material also can cause biological concentration, directly jeopardize the food security of the mankind and healthy, have influence on the sound development of China's aquatic products industry.
Summary of the invention
The object of the invention is to, for above-mentioned the deficiencies in the prior art, a kind of compound Avermectin preparation for aquaculture is provided, to aquatic livestock parasite desinsection and sterilizing scope is wide, drug effect is high, consumption is few and poison little to environment and animal, Chinese Sao, anchor head Sao, Dactylogyrus, little melonworm etc. that prawn, the crab pool and fish pond occur have effect of well killing, compound Avermectin preparation of the present invention also has good control efficiency to fish, shrimp, crab pool generation bacterial disease, additionally provides the preparation method and application of compound Avermectin preparation of the present invention simultaneously.
For achieving the above object, the technical scheme that the present invention takes is, for a compound Avermectin preparation for aquaculture, be made up of the component of following weight percentage: emamectin-benzoate 2.5 ~ 3.5%, Tulathromycin 2 ~ 4%, plug draw rhzomorph 3 ~ 6%, agriculture breast 0206-B 15 ~ 20%, azone 3 ~ 5%, absolute ethyl alcohol 40 ~ 60% and dimethylbenzene 25 ~ 40%.
Above-mentioned compound Avermectin preparation, the component composition of preferred following weight percentage: emamectin-benzoate 2.5%, Tulathromycin 3%, plug draw rhzomorph 5%, agriculture breast 0206-B 11%, azone 3.5%, absolute ethyl alcohol 45% and dimethylbenzene 30%.
The present invention is used for the compound Avermectin preparation of aquaculture, compound basis and each component feature are: invention formulation active principle is emamectin-benzoate, Tulathromycin and Sai La rhzomorph, Pesticidal and sterilizing economic benefits and social benefits are unified, and relative to killing effect during one-component effect more rapidly and efficiently, emamectin-benzoate is a kind of safe and efficient environment-friendly pesticide, draw rhzomorph used in combination with efficient sterilizing insecticide Tulathromycin and plug, there is good synergistic function, there is good bactericidal effect simultaneously.Tulathromycin is the macrolides semisynthetic antibiotics of animal specific, mainly acts on Actinobacillus, mycoplasma, Pasteurella, secondary haemophilus etc., has the many merits such as consumption is few, single administration, low-residual and animal specific.Azone in formula can soften the epidermis of polypide, has good permeability, improves the insecticidal effect of this formula.Several Main Ingredients and Appearances of this formula are all that low toxicity is efficient, and it is all safe for therefore moving aquaculture, can use at shrimp crab culture pond.On market some like product due to toxicity comparatively large, prawn crab is dangerous, uses and is very limited.
A preparation method for the above-mentioned compound Avermectin preparation for aquaculture, step is as follows:
1) each raw material components is taken by proportioning;
2) emamectin-benzoate is added in absolute ethyl alcohol, fully dissolve, for subsequent use;
3) Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, then step 2 is added) in solution, mix, add agriculture breast 0206-B, azone more successively, 20min is stirred at 25 ~ 30 DEG C, obtain a kind of light yellow clear liquid, be the compound Avermectin preparation of the present invention for aquaculture.
The application of the above-mentioned compound Avermectin preparation for aquaculture: the present invention is used for the compound Avermectin preparation of aquaculture, have well kill effect to the parasite that aquiculture animal occurs, killing of the Chinese Sao, the anchor head Sao that especially occur for shrimp, the crab pool and fish pond, Dactylogyrus and little melonworm etc. has good effect.Compound Avermectin preparation of the present invention, also has good control efficiency to fish, shrimp, crab pool generation bacterial disease.
When the present invention is used for the compound Avermectin preparation use of aquaculture, according to using area and damage by disease and insect degree determination consumption, evenly splash in dilute with water 500 ~ 1000 times of full pools.
A kind of compound Avermectin preparation for aquaculture of the present invention, compared with prior art, its advantage is:
1) applied widely, effectively can kill the parasite such as Chinese Sao, anchor head Sao, Dactylogyrus, little melonworm that shrimp, the crab pool and fish pond occur, also have good control efficiency to some bacteriosises, play the effect of a medicine multiple-effect.
2) Main Ingredients and Appearance of the present invention is all the biologic product of low toxicity, and insecticide Avermectin and bactericide Tulathromycin, plug draw that rhzomorph is used in combination has synergistic function, and drug effect is high, consumption is few, poison little to environment and animal, and not easily produces drug resistance.
3) drug effect is gentle, and good water solubility, is uniformly dispersed, efficacy stability, little to aquatic livestock excitant, and raw material sources are extensive, and cost is low, and preparation method is simple, easy to use.
Embodiment
Below in conjunction with example, invention is further described.
The present invention is used for the compound Avermectin preparation of aquaculture, and primary raw material source and specification, in table 1.
Table 1 primary raw material source and specification
Embodiment 1
For a compound Avermectin preparation for aquaculture, be made up of the component of following weight percentage: abamectin benzoate 2.5%, Tulathromycin 3%, plug draw rhzomorph 5%, agriculture breast 0206-B 11%, azone 3.5%, absolute ethyl alcohol 45% and dimethylbenzene 30%.
Preparation: take each raw material components by proportioning; Emamectin-benzoate is added in absolute ethyl alcohol, fully dissolve, for subsequent use; Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, then add in the ethanolic solution of the emamectin-benzoate prepared, mix, add agriculture breast 0206-B, azone more successively, 20min is stirred at 25 DEG C, obtain a kind of light yellow clear liquid, be the compound Avermectin preparation of the embodiment of the present invention 1.
The embodiment of the present invention 1 compound Avermectin preparation, can be used for killing Chinese Sao, treatment fin rot, respond well.
Embodiment 2
For a compound Avermectin preparation for aquaculture, be made up of the component of following weight percentage: emamectin-benzoate 3.5%, Tulathromycin 2%, plug draw rhzomorph 3%, agriculture breast 0206-B 8%, azone 3.5%, absolute ethyl alcohol 45% and dimethylbenzene 35%.
Preparation: with embodiment 1.
The embodiment of the present invention 2 compound Avermectin preparation, can be used for killing anchor head Sao, argulus, treatment enteritis disease, red skin disease, respond well.
Embodiment 3
For a compound Avermectin preparation for aquaculture, be made up of the component of following weight percentage: abamectin benzoate 3.5%, Tulathromycin 3.5%, plug draw rhzomorph 4%, agriculture breast 0206-B 10%, azone 5%, absolute ethyl alcohol 40% and dimethylbenzene 34%.
Preparation: with embodiment 1.
The embodiment of the present invention 3 compound Avermectin preparation, can be used for killing Dactylogyrus, little melonworm, treatment hemorrhage, respond well.
(1) the present invention tests for the compound Avermectin formulations toxic of aquaculture
1 laboratory animal and grouping: crucian 240 tail, the long 12 ~ 15cm of body, body weight 100 ~ 120g, purchased from fish farm.Indoor fishpond is raised and train after one week for experiment.Be divided into experimental group, control group and blank group at random, often group is divided into 4 groups by drug concentration, and each group chooses crucian 20 tail.
2 test methods
Test water temperature about 25 DEG C, infusion method, if 0.05,0.10,0.15,0.20ppm, totally 4 drug concentrations.
The compound Avermectin preparation that experimental group adopts the embodiment of the present invention 1 to prepare, the insecticide on what control group adopted Hubei Yu Yao company to produce can be used for shrimp, the crab pool-mixed kills peaceful, and indicate consumption identical with the present invention, blank group does not add medicine.
3 results
Increase in time under each experimental group different pharmaceutical concentration, crucian death condition is in table 2
Crucian lethality under table 2 different pharmaceutical concentration
Whole experimentation all carries out starting in aerator situation, from above-mentioned experimental result, blank group occurs without fish kills situation, purchased fry health is described and feeding manner science, the fish kills situation that experimental group and control group occur extends by drug concentration change and soak time and causes.All there is not fish kills phenomenon in concentration lower than in 0.10ppm and 72 h in experimental group, when concentration is 0.15ppm, 72 h lethality of experimental group are only 5%, uses the crucian lethality of compound Avermectin preparation of the present invention to be starkly lower than control group.
(2) aquatic livestock insect killing effect test
1 compound Avermectin preparation of the present invention is used for killing cat head Sao effect test
Fish is used in 1.1 tests: carp 200 tail, the long 20cm of body, body weight 120 ~ 150g, purchased from fish farm, be divided into experimental group and control group 1 ~ 3 at random, often group chooses 50 tails.
1.2 test methods:
Water temperature: 25 DEG C
Drug concentration: 0.05ppm
The compound Avermectin preparation that experimental group adopts the embodiment of the present invention 1 to prepare, control group 1 and 2, with reference to embodiment 1, adopts active principle to be emamectin-benzoate and Tulathromycin respectively; Emamectin-benzoate and Sai La rhzomorph two kinds of Avermectin preparations, Pesticidal and sterilizing composition each active principle content proportioning that control group 1 and 2 adopts is with embodiment 1, and other components suitably increase and decrease.The insecticide on what control group 3 adopted Hubei Yu Yao company to produce can be used for shrimp, the crab pool-mixed kills peaceful, indicates consumption identical with the present invention.
1.3 results: experimental group and control group 1 ~ 3 kill cat head Sao effect in table 3.
Table 3 effect test
From table 3, experimental group effect is best, killing rate 100% after cat head Sao killing rate reaches 94%, 24h after medication 12h.Control group 1 and 3 effect is the poorest, and the insecticidal effect of experimental group is obviously better than control group.
2 compound Avermectin preparations of the present invention are used for the treatment of the effect test of red skin disease
Fish is used in 2.1 tests: grass carp 80 tail, the long 25cm of body, body weight 200g, purchased from fish farm, be divided into experimental group and control group 1 ~ 3 at random, often group chooses 20 tails.
2.2 test methods:
Water temperature: 32 DEG C
Drug concentration: 0.05ppm
The compound Avermectin preparation that experimental group adopts the embodiment of the present invention 2 to prepare, control group 1 and 2 is with reference to embodiment 2, active principle is adopted to be emamectin-benzoate and Tulathromycin, emamectin-benzoate and Sai La rhzomorph two kinds of compound Avermectin preparations respectively, compound Avermectin preparation each active principle content proportioning that control group 1 and 2 adopts is with embodiment 2, and other components suitably increase and decrease.The similar disinfection sanitizer that control group 3 adopts chinese carp pharmaceutical factory, Shanxi one to produce, indicate consumption identical with the present invention, whole experiment is all carry out when starting aerator.
2.3 result
Symptom before medication: every tail fish body surface has the red skin symptom of 5% ~ 8% substantially, and fish runs around on sinister errands, and does not eat food.
Symptom between the operating period: after medication 24h, experimental group is altered jumping phenomenon and is obviously alleviated, and it is not obvious that control group alleviates phenomenon; After medication 48h, experimental group is altered and is jumped phenomenon and disappear, and fish starts food, though control group 2 is altered and jumped phenomenon and have and obviously alleviate, but still does not eat food; It is not obvious that control group 1 and 3 alleviates phenomenon; Medication the 5th day, experimental group is eaten food and is recovered normal, and red skin symptom disappears substantially, and control group control group 2 just starts food, also has the red skin symptom of part, and control group 1 and 3 is altered jumping phenomenon and obviously alleviated, and start food, red skin symptom alleviates to some extent.Obviously control group can be better than by illustrative experiment group bactericidal effect by above-mentioned experimental result.
Claims (5)
1. the compound Avermectin preparation for aquaculture, it is characterized in that, be made up of the component of following weight percentage: abamectin benzoate 2.5 ~ 3.5%, Tulathromycin 2 ~ 4%, plug draw rhzomorph 3 ~ 6%, agriculture breast 0206-B 15 ~ 20%, azone 3 ~ 5%, absolute ethyl alcohol 40 ~ 60% and dimethylbenzene 25 ~ 40%.
2. compound Avermectin preparation according to claim 1, it is characterized in that, be made up of the component of following weight percentage: abamectin benzoate 2.5%, Tulathromycin 3%, plug draw rhzomorph 5%, agriculture breast 0206-B 11%, azone 3.5%, absolute ethyl alcohol 45% and dimethylbenzene 30%.
3. a preparation method for the compound Avermectin preparation of claim 1, it is characterized in that, step is as follows:
1) each raw material components is taken by proportioning;
2) abamectin benzoate is added in absolute ethyl alcohol, fully dissolve, for subsequent use;
3) Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, then step 2 is added) in solution, mix, add agriculture breast 0206-B, azone more successively, 20min is stirred at 25 ~ 30 DEG C, obtain a kind of light yellow clear liquid, be the compound Avermectin preparation of the present invention for aquaculture.
4. an application for the compound Avermectin preparation of claim 1, is characterized in that: have the parasite of aquiculture animal generation and well kill effect, also has good control efficiency to fish, shrimp, crab pool generation bacterial disease.
5. application according to claim 4, is characterized in that: the Chinese Sao, the anchor head Sao that occur for shrimp, the crab pool and fish pond, Dactylogyrus and killing of little melonworm have good effect.
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| CN201410594605.8A CN104351219B (en) | 2014-10-30 | 2014-10-30 | A kind of compound avilamycin preparation for aquaculture and its preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106561671A (en) * | 2016-10-17 | 2017-04-19 | 徐州得铸生物科技有限公司 | Tulathromycin-containing sterilization composition |
| CN107714712A (en) * | 2017-10-10 | 2018-02-23 | 王研 | A kind of HEXAFLUMURON composition for being used to prevent and treat anchor head Sao diseases |
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| CN1582953A (en) * | 2003-08-22 | 2005-02-23 | 王玉万 | Preparation containing avilamycin, etc. as medicines against parasites for fish |
| CN1947506A (en) * | 2006-05-19 | 2007-04-18 | 东北农业大学 | Method for preparing microemulsion, aqueous emulsion and suspending agent contg. Dola-mycetin and Sala-mycetin |
| CN101309587A (en) * | 2005-11-18 | 2008-11-19 | 凯米诺瓦有限公司 | Oil-in-water formulaion of avermectins |
| CN101933935A (en) * | 2010-06-30 | 2011-01-05 | 洛阳惠中兽药有限公司 | Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry |
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- 2014-10-30 CN CN201410594605.8A patent/CN104351219B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582953A (en) * | 2003-08-22 | 2005-02-23 | 王玉万 | Preparation containing avilamycin, etc. as medicines against parasites for fish |
| CN101309587A (en) * | 2005-11-18 | 2008-11-19 | 凯米诺瓦有限公司 | Oil-in-water formulaion of avermectins |
| CN1947506A (en) * | 2006-05-19 | 2007-04-18 | 东北农业大学 | Method for preparing microemulsion, aqueous emulsion and suspending agent contg. Dola-mycetin and Sala-mycetin |
| CN101933935A (en) * | 2010-06-30 | 2011-01-05 | 洛阳惠中兽药有限公司 | Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106561671A (en) * | 2016-10-17 | 2017-04-19 | 徐州得铸生物科技有限公司 | Tulathromycin-containing sterilization composition |
| CN107714712A (en) * | 2017-10-10 | 2018-02-23 | 王研 | A kind of HEXAFLUMURON composition for being used to prevent and treat anchor head Sao diseases |
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| CN104351219B (en) | 2016-07-06 |
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Address after: 234000 Xiaoxian Food Industrial Park, Suzhou City, Anhui Province Patentee after: Anhui Kaiqiang Biotechnology Co.,Ltd. Address before: 235200 Anhui city of Suzhou province Xiaoxian Dragon Town Xiao Taolu South (6 km east) Patentee before: ANHUI HUANGHUAI VETERINARY MEDICINE Co.,Ltd. |