CN106561671A - Tulathromycin-containing sterilization composition - Google Patents
Tulathromycin-containing sterilization composition Download PDFInfo
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- CN106561671A CN106561671A CN201610906065.1A CN201610906065A CN106561671A CN 106561671 A CN106561671 A CN 106561671A CN 201610906065 A CN201610906065 A CN 201610906065A CN 106561671 A CN106561671 A CN 106561671A
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- Prior art keywords
- tulathromycin
- phlorhizin
- weight
- ratio
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a tulathromycin-containing sterilization composition. The composition comprises tulathromycin and phlorizin, and a weight part ratio of the tulathromycin to the phlorizin is 12:1 to 11:1. The composition comprising the tulathromycin and the phlorizin according to a specific ratio has very good synergistic control effect on leaf spot of eggplants, and has very obvious synergistic effect when the part ratio of the tulathromycin to the phlorizin is 12:1 to 11:1.
Description
Technical field
The present invention relates to a kind of medicament, specifically a kind of bactericidal composition containing Tulathromycin, belong to agricultural technology field.
Background technology
Tulathromycin (No. CAS：280755-12-6) it is broad-spectrum sterilization medicine, to some gram positive bacterias and gram-negative
Property bacterium have bactericidal activity, especially sensitive to cattle and respiratory diseases in pigs pathogen, such as Actinobacillus pleuropneumoniae, hemolytic bar
This moral bacterium, Pasteurella multocida, sleep Histophilus (Haemophilus somnus), mycoplasma pneumoniae, haemophilus parasuises,
Bordetella Bordetella etc..
Phlorhizin (CAS accession number：It is 60-81-1) to extract from Fructus Mali pumilae, Fructus Mali pumilae bark and leaf etc. and obtain, it is apple tree
Internal aldehydes matter.Phlorhizin be by phloretin and glycocide be glucoside bound into glycosides, its catabolite phloroglucin,
Effect of microbial activitiess etc. can effectively be suppressed.
Actual pesticide experience have shown that, repeats and single-minded applies a kind of reactive compound to prevent and treat harmful fungoid very
To cause the fast selective of fungal bacterial strain in the case of many, be that reduction refractory fungal bacterial strain is selectively dangerous, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the way that the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance produce, reduce amount of application, reduce cost accounting.It is found by the applicant that Tulathromycin is carried out with phlorhizin
Compounding, for alternaria leaf spot of egg plant has significantly preventing and treating potentiation.
The content of the invention
For the problem that above-mentioned prior art is present, it is an object of the invention to provide the Bactericidal composite containing Tulathromycin
Thing, it is to be compounded the sterilization component of two kinds of different structures, the different mechanisms of action, is expanding prevention spectrum and raising drug effect
Effective way, it is often more important that avoid or delay generation of the disease to new composition resistance.To realize the purpose of the present invention, inventor
Tulathromycin and phlorhizin are compounded, for preventing and treating the disease of crop.
To achieve these goals, the technical solution used in the present invention is：One kind includes two kinds of principle active components：Tuo La
Rhzomorph and phlorhizin.
Described Tulathromycin is with the ratio of the parts by weight of phlorhizin, 20:1-1:1.
Described Tulathromycin accounts for the 1-30% of medicament gross weight with the weight sum of phlorhizin.
Also include pure water, methyl oleate Polyethylene oxide (30) dimerization hydroxy stearic acid fat.
The present invention under specific ratio by Tulathromycin and phlorhizin compatibility by having found there is collaboration preventing and treating well
The effect of alternaria leaf spot of egg plant, the particularly ratio in Tulathromycin and the parts by weight of phlorhizin are 14:1-13:Between 1, its collaboration
Preventing and treating alternaria leaf spot of egg plant effect is apparent, and whole reagent cost is relatively low, and toxicity is less.
Specific embodiment
Embodiment 1
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 20:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 2
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 14:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 3
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 13:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 4
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 8:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 5
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 5:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 6
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 2:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 7
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 1:1,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 8
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 1:2,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 9
Tulathromycin is with the ratio of the parts by weight of phlorhizin, 1:6,
Described Tulathromycin and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Laboratory test：
Subjects：Alternaria leaf spot of egg plant pathogenic bacteria
According to the incidence of the whole strain blade of test grade scale investigation Fructus Lycopersici esculenti, disease index and prevention effect are calculated.Will
Prevention effect is converted into niqueMin (y), and medicinal liquid does height (μ g/ml) and is converted into logarithm value (x), and with method of least square virulence is calculated
Concentration EC50 in equation and suppression, according to the abundant methods of Sun Yun toxicity index level co-toxicity coefficient (CTC) of medicament is calculated.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition co-toxicity coefficient (CTC) of middle B=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] *
100CTC≤80, compositionss show as antagonism, 80 ＜ CTC ＜ 120, and compositionss show as summation action, CTC >=120, group
Compound shows as potentiation.
Table 1 is Tulathromycin：Phlorhizin and its different ratio are compounded to alternaria leaf spot of egg plant toxicity test interpretation of result.
From the measurement result of table 1, work as Tulathromycin：Phlorhizin proportioning is 14:1-13:When between 1, co-toxicity coefficient is equal
It is much higher than 150, with obvious potentiation, and other ratios mix, and co-toxicity coefficient is not obvious.
Field efficacy checking test
Test method：At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each square meter of cell 20.10 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage rate of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-24% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
The field control effectiveness test of embodiment and matched group to leaf spot.
The proportioning under certain proportion cooperates with preventing and treating alternaria leaf spot of egg plant effect apparent to Tulathromycin with phlorhizin, and single
One Tulathromycin has certain prevention effect, single phlorhizin prevention and control capability is also effect on driving birds is not good.Tulathromycin and root
The ratio of the parts by weight of skin glycosides is 14:1-13:Synergy is most notable when 1, and effect is not very notable during other proportions.
Claims (4)
1. a kind of bactericidal composition containing Tulathromycin, it is characterised in that comprising two kinds of principle active components：Tulathromycin and root
Skin glycosides.
2. a kind of bactericidal composition containing Tulathromycin according to claim 1, described Tulathromycin and phlorhizin
The ratio of parts by weight is 20:1-1:1.
3. a kind of bactericidal composition containing Tulathromycin according to claim 1, it is characterised in that described Tulathromycin
The 1-30% of medicament gross weight is accounted for the weight sum of phlorhizin.
4. a kind of bactericidal composition containing Tulathromycin according to claim 1, it is characterised in that also including pure water,
Methyl oleate Polyethylene oxide (30) dimerization hydroxy stearic acid fat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906065.1A CN106561671A (en) | 2016-10-17 | 2016-10-17 | Tulathromycin-containing sterilization composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906065.1A CN106561671A (en) | 2016-10-17 | 2016-10-17 | Tulathromycin-containing sterilization composition |
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| Publication Number | Publication Date |
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| CN106561671A true CN106561671A (en) | 2017-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610906065.1A Pending CN106561671A (en) | 2016-10-17 | 2016-10-17 | Tulathromycin-containing sterilization composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107926972A (en) * | 2017-12-04 | 2018-04-20 | 刘志伟 | A kind of bactericidal composition containing Prochloraz |
| CN107950536A (en) * | 2017-12-04 | 2018-04-24 | 刘志伟 | A kind of bactericidal composition containing Bravo |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2402355A1 (en) * | 2010-07-01 | 2012-01-04 | Novartis AG | Crystalline anhydrous forms II and III of Tulathromycin |
| CN102762544A (en) * | 2010-02-17 | 2012-10-31 | 先正达参股股份有限公司 | Isoxazoline derivatives as insecticides |
| CN104351219A (en) * | 2014-10-30 | 2015-02-18 | 安徽省黄淮兽药有限公司 | Compound abamectin preparation for aquaculture, as well as preparation method and application of compound abamectin preparation |
-
2016
- 2016-10-17 CN CN201610906065.1A patent/CN106561671A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102762544A (en) * | 2010-02-17 | 2012-10-31 | 先正达参股股份有限公司 | Isoxazoline derivatives as insecticides |
| EP2402355A1 (en) * | 2010-07-01 | 2012-01-04 | Novartis AG | Crystalline anhydrous forms II and III of Tulathromycin |
| CN104351219A (en) * | 2014-10-30 | 2015-02-18 | 安徽省黄淮兽药有限公司 | Compound abamectin preparation for aquaculture, as well as preparation method and application of compound abamectin preparation |
Non-Patent Citations (1)
| Title |
|---|
| J.L.INGHAM: "Disease Resistance in Higher Plants The Concept of Pre-infectional Post-infectional Resistance", 《JOURNAL OF PHYTOPATHOLOGY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107926972A (en) * | 2017-12-04 | 2018-04-20 | 刘志伟 | A kind of bactericidal composition containing Prochloraz |
| CN107950536A (en) * | 2017-12-04 | 2018-04-24 | 刘志伟 | A kind of bactericidal composition containing Bravo |
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Application publication date: 20170419 |
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