CN106561674A - Bactericidal composition containing isothiazolinone - Google Patents
Bactericidal composition containing isothiazolinone Download PDFInfo
- Publication number
- CN106561674A CN106561674A CN201610906121.1A CN201610906121A CN106561674A CN 106561674 A CN106561674 A CN 106561674A CN 201610906121 A CN201610906121 A CN 201610906121A CN 106561674 A CN106561674 A CN 106561674A
- Authority
- CN
- China
- Prior art keywords
- isothiazolone
- phlorhizin
- weight
- bactericidal composition
- ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a bactericidal composition containing isothiazolinone. Weight ratio of isothiazolinone to phlorizin is 12:1-11:1. At a specific ratio of isothiazolinone to phlorizin, the tomato leaf mould control effect can be greatly synergized. Especially at the weight ratio of 12:1-11:1, the synergistic effect is very obvious.
Description
Technical field
The present invention relates to a kind of medicament, specifically a kind of bactericidal composition of isothiazolone-containing, belong to agricultural technology neck
Domain.
Background technology
Isothiazolone (CAS:It is 55965-84-9) main by CMIT (CIT) and 2-
Methyl -4- isothiazolines -3- ketone (MIT) is constituted.Isothiazolone is risen and kills by disconnecting the key of antibacterial and algae protein matter
Raw effect.After isothiazolone is contacted with microorganism, it promptly can be irreversibly suppressed to grow, so as to cause microorganism thin
The death of born of the same parents, therefore to common bacteria, funguses, algae etc. with very strong suppression and killing action.Kill livestock efficiency high, degradability
Good, with not producing, residual, safe operation, compatibility are good, stability is strong, the low feature of use cost.Can be with chlorine and great majority
Anions and canons and nonionic surfactant are miscible.
Phlorhizin (CAS accession number:It is 60-81-1) to extract from Fructus Mali pumilae, Fructus Mali pumilae bark and leaf etc. and obtain, it is apple tree
Internal aldehydes matter.Phlorhizin be by phloretin and glycocide be glucoside bound into glycosides, its catabolite phloroglucin,
Effect of microbial activitiess etc. can effectively be suppressed.
Actual pesticide experience have shown that, repeats and single-minded applies a kind of reactive compound to prevent and treat harmful fungoid very
To cause the fast selective of fungal bacterial strain in the case of many, be that reduction refractory fungal bacterial strain is selectively dangerous, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the way that the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance produce, reduce amount of application, reduce cost accounting.It is found by the applicant that isothiazolone enters with phlorhizin
Row compounding, with obvious potentiation.
The content of the invention
For the problem that above-mentioned prior art is present, it is an object of the invention to provide the sterilization group containing isothiazolone
Compound, it is to be compounded the sterilization component of two kinds of different structures, the different mechanisms of action, is expanding prevention spectrum and raising drug effect
Effective way, it is often more important that avoid or delay generation of the disease to new composition resistance.To realize the purpose of the present invention, invention
People compounds isothiazolone and phlorhizin, for preventing and treating the disease of crop.
To achieve these goals, the technical solution used in the present invention is:One kind includes two kinds of principle active components:Different thiophene
Oxazoline ketone and phlorhizin.
Described isothiazolone is with the ratio of the parts by weight of phlorhizin, 20:1-1:1.
Described isothiazolone accounts for the 1-40% of medicament gross weight with the weight sum of phlorhizin.
Also include pure water, methyl oleate Polyethylene oxide (30) dimerization hydroxy stearic acid fat.
The present invention under specific ratio by isothiazolone and phlorhizin compatibility by having found have collaboration well anti-
It is 14 to control the effect of leaf spot, the particularly ratio in isothiazolone and the parts by weight of phlorhizin:1-13:Between 1, its collaboration
Prevent and treat leaf muld of tomato effect apparent, whole reagent cost is relatively low, and toxicity is less.
Specific embodiment
Embodiment 1
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 20:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 2
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 14:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 3
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 13:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 4
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 8:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 5
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 5:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 6
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 2:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 7
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 1:1,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 8
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 1:2,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 9
Isothiazolone is with the ratio of the parts by weight of phlorhizin, 1:6,
Described isothiazolone and the weight sum of phlorhizin account for the 4% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Laboratory test:
Subjects:Leaf muld of tomato pathogenic bacteria
According to the incidence of the whole strain blade of test grade scale investigation Fructus Lycopersici esculenti, disease index and prevention effect are calculated.Will
Prevention effect is converted into niqueMin (y), and medicinal liquid does height (μ g/ml) and is converted into logarithm value (x), and with method of least square virulence is calculated
Concentration EC50 in equation and suppression, according to the abundant methods of Sun Yun toxicity index level co-toxicity coefficient (CTC) of medicament is calculated.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition co-toxicity coefficient (CTC) of middle B=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] *
100CTC≤80, compositionss show as antagonism, 80 < CTC < 120, and compositionss show as summation action, CTC >=120, group
Compound shows as potentiation.
Table 1 is isothiazolone:Phlorhizin and its different ratio are compounded to leaf spot toxicity test interpretation of result.
From the measurement result of table 1, work as isothiazolone:Phlorhizin proportioning is 14:1-13:When between 1, co-toxicity coefficient
150 are both significantly higher than, with obvious potentiation, and other ratios mix, and co-toxicity coefficient is not obvious.
Field efficacy checking test
Test method:At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each square meter of cell 20.10 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage rate of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale:
0 grade:Disease-free spot;
1 grade:Leaf spot lesion is less than 5, and length is less than 1cm;
3 grades:Leaf spot lesion 6-10, part scab length is more than 1cm;
5 grades:Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-24% of leaf area;
7 grades:Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area;
9 grades:Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
The field control effectiveness test of embodiment and matched group to leaf spot.
It can be seen that isothiazolone is with phlorhizin, and the proportioning under certain proportion cooperates with that to prevent and treat leaf spot effect apparent, and
Single isothiazolone has certain prevention effect, single phlorhizin prevention and control capability is also effect on driving birds is not good.Isothiazoline
Ketone is 14 with the ratio of the parts by weight of phlorhizin:1-13:Synergy is most notable when 1, and effect is not during other proportions
It is very notable.
Claims (4)
1. a kind of bactericidal composition of isothiazolone-containing, it is characterised in that comprising two kinds of principle active components:Isothiazolone
With phlorhizin.
2. the bactericidal composition of a kind of isothiazolone-containing according to claim 1, described isothiazolone and root bark
The ratio of the parts by weight of glycosides is 20:1-1:1.
3. a kind of bactericidal composition of isothiazolone-containing according to claim 1, it is characterised in that described isothiazole
Quinoline ketone accounts for the 1-40% of medicament gross weight with the weight sum of phlorhizin.
4. the bactericidal composition of a kind of isothiazolone-containing according to claim 1, it is characterised in that also including pure
Water, methyl oleate Polyethylene oxide (30) dimerization hydroxy stearic acid fat.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610906121.1A CN106561674A (en) | 2016-10-17 | 2016-10-17 | Bactericidal composition containing isothiazolinone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610906121.1A CN106561674A (en) | 2016-10-17 | 2016-10-17 | Bactericidal composition containing isothiazolinone |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106561674A true CN106561674A (en) | 2017-04-19 |
Family
ID=58533170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610906121.1A Pending CN106561674A (en) | 2016-10-17 | 2016-10-17 | Bactericidal composition containing isothiazolinone |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106561674A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107926960A (en) * | 2017-12-04 | 2018-04-20 | 刘志伟 | A kind of bactericidal composition of isothiazolone-containing |
-
2016
- 2016-10-17 CN CN201610906121.1A patent/CN106561674A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107926960A (en) * | 2017-12-04 | 2018-04-20 | 刘志伟 | A kind of bactericidal composition of isothiazolone-containing |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103918681A (en) | Bactericide composition containing thiediazole copper | |
CN103563944A (en) | Bactericidal composition containing pyraclostrobin and tebuconazole and application thereof | |
CN101632371A (en) | Compound sterilization composition | |
CN105010357A (en) | Sterilization composition and application thereof | |
CN101653131B (en) | Bactericidal composition containing azoxystrobin | |
CN103461383B (en) | Bactericide composition and production process thereof | |
CN101690489A (en) | Bactericidal composition | |
CN106561674A (en) | Bactericidal composition containing isothiazolinone | |
CN106561671A (en) | Tulathromycin-containing sterilization composition | |
CN106577697A (en) | Pesticide composition for prevention and treatment of tomato late blight | |
CN101536699A (en) | Bactericidal composition | |
CN104886122B (en) | Compound composition containing dufulin and pyrazole amide bactericide and bactericide | |
CN106577696A (en) | Tetramycin-containing pesticidal composition | |
CN105831132A (en) | Sterilization composition containing benzothiostrobin and fluoride ether bacteria amide | |
CN106577698A (en) | Sterilizing composition for preventing and treating sclerotinia rot of colza | |
CN107751210A (en) | A kind of bactericidal composition containing isopyrazam | |
CN103598190B (en) | Sterilization composition containing thifluzamide and boscalid | |
CN106561684A (en) | Bactericidal composition containing podophyllotoxin | |
CN108719308A (en) | A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and tiger glue adipic acid copper | |
CN106538540A (en) | A kind of bactericidal composition containing volution bacterium amine | |
CN110063335A (en) | A kind of bactericidal composition for preventing and treating wheat scab | |
CN106550949A (en) | A kind of bactericidal composition containing Triadimenol | |
CN106818760A (en) | A kind of bactericidal composition containing SelaginpulvilinA | |
CN106879639A (en) | A kind of composition pesticide of the flavones of fruit containing ground | |
CN105900994A (en) | Sterilization composition containing carabrone and prothioconazole |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170419 |