CN106818760A - A kind of bactericidal composition containing SelaginpulvilinA - Google Patents
A kind of bactericidal composition containing SelaginpulvilinA Download PDFInfo
- Publication number
- CN106818760A CN106818760A CN201710109759.7A CN201710109759A CN106818760A CN 106818760 A CN106818760 A CN 106818760A CN 201710109759 A CN201710109759 A CN 201710109759A CN 106818760 A CN106818760 A CN 106818760A
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- China
- Prior art keywords
- selaginpulvilina
- pilocarpine hydrochloride
- composition containing
- bactericidal composition
- weight
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing SelaginpulvilinA, SelaginpulvilinA and pilocarpine hydrochloride, the ratio between SelaginpulvilinA and the parts by weight of pilocarpine hydrochloride are, 15: 1 18: 1.The present invention cooperates with the effect for preventing and treating gray mold well by finding to have SelaginpulvilinA and pilocarpine hydrochloride compatibility under specific ratio, particularly between the ratio between the parts by weight of SelaginpulvilinA and pilocarpine hydrochloride are for 15: 1 18: 1, its synergy is apparent.
Description
Technical field
The present invention relates to a kind of medicament, specifically a kind of bactericidal composition containing SelaginpulvilinA belongs to agricultural
Technical field.
Background technology
Gray mold is open country, protecting field crop is common and compares a kind of fungal disease of difficult preventing and treating, belongs to low temperature and high relative humidity type
Disease, growth of pathogenic bacteria temperature is 20~30 DEG C, and it is the disease high-incidence season that 20~25 DEG C of temperature, humidity continue when more than 90%.Ash
Mildew belongs to fungal disease caused by the pathogen of Botrytis cinerea infects, and flower, fruit, leaf, stem can fall ill.Fruit is caught an illness, and Chinese olive is aggrieved heavy,
First infected more than the column cap or petal of residual, backward fruit extension causes pericarp in canescence, and have thick grey mould
Layer, in water corruption shape, blade is fallen ill since blade tip, inwardly extended into " V " shape along between vein, taupe, while there is the depth alternate
Line shape line, sick key has a common boundary clearly demarcated.The disease is a kind of typical aeroborne disease, can be propagated with air, current and farming operation.
During actual disease control, it is difficult to the thoroughly cut-out infection sources of adopting an effective measure；It is also difficult in the case where pathogen invades
To utterly destroy pathogen, such as medicament is sprayed, it is difficult to solve the pathogen in air and dew；And individually smoke canopy, it is impossible to emphasis
The pathogen of on the invalid bodies such as the sick leaf of solution, disease fruit or inside.
Actual agricultural chemicals experience have shown that, repeat and single-minded apply a kind of reactive compound to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of many, to reduce the danger of refractory fungal bacterial strain selectivity, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.Enter by by the reactive compound with the different mechanisms of action
Row combination, can delaying drug resistance generation, reduction amount of application, reduction cost accounting.Natural active compound is killed as a kind of emerging
Bacterium insecticide, particularly natural active compound compound the influence for pesticide-germicide, are current pesticide field primary studies
Direction..
Native compound SelaginpulvilinA, possesses brand-new framework types, is published in Org.Lett., 2014,16
(1), 282285, it is disclosed in a kind of Selaginella pulvinata extract of Chinese patent and its preparation method and application earlier,
201310492901.2, the compound possesses brand-new framework types, yet there are no on SelaginpulvilinA and
Pilocarpine hydrochloride particularly prevents and treats the report in terms of gray mold for sterilization.
The content of the invention
For the problem that above-mentioned prior art is present, it is an object of the invention to provide containing SelaginpulvilinA's
Bactericidal composition, prevents and treats gray mold effect good.
To realize the purpose of the present invention, SelaginpulvilinA and pilocarpine hydrochloride are compounded, are used for by inventor
Prevent and treat the disease of crop.
To achieve these goals, the technical solution adopted by the present invention is：One kind includes two kinds of principle active components：
SelaginpulvilinA and pilocarpine hydrochloride.
The ratio between described SelaginpulvilinA and parts by weight of pilocarpine hydrochloride are, 15: 1-18: 1.
Described SelaginpulvilinA accounts for the 1- of herbicide gross weight with the weight sum of pilocarpine hydrochloride
6%.
Also include pure water, methyl oleate polyoxyethylene (30) dimerization hydroxy stearic acid fat.
The present invention is by the way that SelaginpulvilinA and pilocarpine hydrochloride compatibility to be found tool under specific ratio
There is collaboration well and prevent and treat gray mold, particularly in SelaginpulvilinA and the weight portion of pilocarpine hydrochloride
For between 15: 1-18: 1, its collaboration prevents and treats that gray mold effect is apparent to the ratio between number, and whole reagent cost is relatively low, toxicity compared with
It is small.
Specific embodiment
The preparation method of compound SelaginpulvilinA involved in the present invention is referring to document：Org.Lett., 2014,
16 (1), 282285, it is disclosed in a kind of Selaginella pulvinata extract of Chinese patent and its preparation method and application earlier,
201310492901.2。
Pilocarpine hydrochloride, No. CAS：54-71-7.
Embodiment 1：
Active ingredient SelaginpulvilinA and pilocarpine hydrochloride, press with the customary adjuvant such as lignin, diatomite
More solito technique, is made the wettable powder that effective constituent concentration is 2%.
Embodiment 2：
Active ingredient SelaginpulvilinA and pilocarpine hydrochloride, with calcium dodecyl benzene sulfonate, phenethyl phenol
The customary adjuvants such as APEO, solvent naphtha are made the missible oil that effective constituent concentration is 2% according to common process.
Embodiment 3：
Active ingredient SelaginpulvilinA and pilocarpine hydrochloride, it is conventional with wooden sodium sulfonate, kaolin etc. auxiliary
Material is made the water dispersible granules that effective constituent concentration is 2% according to common process.
Embodiment 4：
Active ingredient SelaginpulvilinA and pilocarpine hydrochloride, with solvent naphtha, pyrrolidones, xanthans etc. is often
Rule auxiliary material is made the aqueous emulsion that effective constituent concentration is 2% according to common process.
Embodiment 5
The ratio between SelaginpulvilinA and parts by weight of pilocarpine hydrochloride are, 1: 6,
Active ingredient SelaginpulvilinA and pilocarpine hydrochloride, with methyl oleate, polyoxyethylene (30) dimerization
The customary adjuvants such as hydroxy stearic acid fat are made the aqueous emulsion that effective constituent concentration is 2% according to common process.
Laboratory test：
Subjects：Gray mold germ fauna
The incidence of the whole strain blade of cucumber is investigated according to experiment grade scale, disease index and prevention effect is calculated.Will
Prevention effect is converted into niqueMin (y), and liquid does height (μ g/ml) and is converted into logarithm value (x), and virulence is calculated with least square method
Concentration EC50 in equation and suppression, toxicity index level co-toxicity coefficient (CTC) of medicament is calculated according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition co-toxicity coefficient (CTC) of middle B=[mixture surveys toxicity index (ATI)/mixture theoretical toxicity index (TTI)] *
100CTC≤80, composition shows as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, CTC >=120, group
Compound shows as synergistic effect.
Table 1SelaginpulvilinA：Pilocarpine hydrochloride and its different ratio compounding are to gray mold toxicity test knot
Fruit is analyzed.
A is SelaginpulvilinA, and B is pilocarpine hydrochloride.
From the measurement result of table 1, work as SelaginpulvilinA：Pilocarpine hydrochloride is matched 15: 1-18: 1
Between when, co-toxicity coefficient is both significantly higher than 200, and with obvious synergistic effect, and other ratios mix, and co-toxicity coefficient is failed to understand
It is aobvious.
Field efficacy checking test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second dispenser is carried out after 7 days, each treatment 4
Individual cell, each square meter of cell 20.In 10 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of every investigation, investigates the lesion area in whole strain per blade and accounts for the percentage of blade area and be classified, and calculates
Disease index and prevention effect.
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-22% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and more than 50% or the full leaf that lesion area accounts for leaf area are withered.
The field control effectiveness test of embodiment and control group to gray mold.
It can be seen that SelaginpulvilinA is matched with pilocarpine hydrochloride under certain proportion cooperates with preventing and treating grey mold
Sick effect is apparent, and single SelaginpulvilinA has certain prevention effect, but effect is not notable, single
The one anti-gray mold ability of pilocarpine hydrochloride is also effect on driving birds is not good.SelaginpulvilinA and pilocarpine hydrochloride
Synergy is most notable when the ratio between parts by weight are 15: 1-18: 1, and effect is not very notable during other proportions.
Claims (3)
1. a kind of bactericidal composition containing SelaginpulvilinA, it is characterised in that comprising two kinds of principle active components：
SelaginpulvilinA and pilocarpine hydrochloride, SelaginpulvilinA structural formulas are as follows：
2. a kind of bactericidal composition containing SelaginpulvilinA according to claim 1, described
The ratio between parts by weight of SelaginpulvilinA and pilocarpine hydrochloride are 1: 1-20: 1.
3. a kind of bactericidal composition containing SelaginpulvilinA according to claim 1, it is characterised in that described
The 1-6% of the weight sum bactericide gross weight of SelaginpulvilinA and pilocarpine hydrochloride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710109759.7A CN106818760A (en) | 2017-02-27 | 2017-02-27 | A kind of bactericidal composition containing SelaginpulvilinA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710109759.7A CN106818760A (en) | 2017-02-27 | 2017-02-27 | A kind of bactericidal composition containing SelaginpulvilinA |
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| CN106818760A true CN106818760A (en) | 2017-06-13 |
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| CN201710109759.7A Pending CN106818760A (en) | 2017-02-27 | 2017-02-27 | A kind of bactericidal composition containing SelaginpulvilinA |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103588616A (en) * | 2013-10-18 | 2014-02-19 | 中山大学 | Selaginella pulvinata extract as well as preparation method and applications thereof |
| CN106359480A (en) * | 2016-09-05 | 2017-02-01 | 广东康绿宝科技实业有限公司 | Efficient insecticide disinfector |
-
2017
- 2017-02-27 CN CN201710109759.7A patent/CN106818760A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103588616A (en) * | 2013-10-18 | 2014-02-19 | 中山大学 | Selaginella pulvinata extract as well as preparation method and applications thereof |
| CN106359480A (en) * | 2016-09-05 | 2017-02-01 | 广东康绿宝科技实业有限公司 | Efficient insecticide disinfector |
Non-Patent Citations (2)
| Title |
|---|
| BIGG, D. C. H.等: "Muscarinic agonists provide a new class of acaricide", 《NATURE (LONDON, UNITED KINGDOM)》 * |
| YIYOU HUANG等: "The discovery, complex crystal structure, and recognition mechanism", 《BIOCHEMICAL PHARMACOLOGY》 * |
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