CN107926960A - A kind of bactericidal composition of isothiazolone-containing - Google Patents
A kind of bactericidal composition of isothiazolone-containing Download PDFInfo
- Publication number
- CN107926960A CN107926960A CN201711258099.5A CN201711258099A CN107926960A CN 107926960 A CN107926960 A CN 107926960A CN 201711258099 A CN201711258099 A CN 201711258099A CN 107926960 A CN107926960 A CN 107926960A
- Authority
- CN
- China
- Prior art keywords
- isothiazolinone
- formoononetin
- weight
- ratio
- isothiazolone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition of isothiazolone-containing, isothiazolinone and formoononetin, the ratio between parts by weight of isothiazolinone and formoononetin are 1:1‑20:1.The present invention is 15 particularly in the ratio between isothiazolinone and the parts by weight of formoononetin by the way that isothiazolinone and formoononetin compatibility to be found to have the function that collaboration prevention tomato verticillium wilt well under specific ratio:1‑16:Between 1, its synergy is apparent.
Description
Technical field
The present invention relates to a kind of medicament, is specifically a kind of bactericidal composition of isothiazolone-containing, belongs to agricultural technology neck
Domain.
Background technology
Isothiazolinone (CAS:55965-84-9) mainly by 5-Chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-
Methyl -4- isothiazoline -3- ketone (MIT) forms.Isothiazolinone is to be killed by disconnecting the key of bacterium and algae protein matter to rise
Raw effect.After isothiazolinone is contacted with microorganism, it promptly can irreversibly suppress its growth, so as to cause microorganism thin
The death of born of the same parents, therefore there is very strong suppression and killing effect to common bacteria, fungi, algae etc..Kill livestock efficient, degradability
It is good, have the characteristics that not produce that residual, safe operation, compatibility are good, stability is strong, use cost is low.Formoononetin, pulse family
The inflorescence of plant red clover and wounded in the battle branches and leaves, ononis spinosa herb.With antitumaous effect, for prevention breast cancer, prostate
Cancer, colon cancer, improve osteoporosis and improvement Woman climacteric symptom etc. and have certain effect,【No. CAS】485-72-3 molecules
Formula is as follows：
It is the maximally efficient means of controlling plant diseases using chemical agent.But apply single long-term continuous high dose
Chemical bactericide, be easy to cause the problems such as residual of medicament, environmental pollution and resistance to resistance to the action of a drug fungi are developed.Rational chemistry
Bactericide compounded or mixture have expand fungicidal spectrum, improve prevention effect, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning,
Reduce residual, delay the positive feature such as Antifungal resistance and drug-fast generation and development, bactericide compounded is to solve above-mentioned ask
One of maximally efficient method of topic.Develop new product fungicide price is constantly soaring, and in contrast, exploitation with research efficiently,
Low toxicity, the compounding of low-residual and mixture have small investment, the lead time is short and is paid attention to both at home and abroad, and numerous and confused increase develops
Dynamics.We screen and on the basis of field trial, filter out nitre benzene bacterium ester and compounded with isothiazolinone indoors, have
Obvious synergistic effect, and there is no people at present on the bactericidal composition and application of isothiazolinone and the compounding of formoononetin
Reported.
The content of the invention
In view of the above-mentioned problems of the prior art, it is an object of the invention to provide the sterilization group containing isothiazolinone
Compound, it is to be compounded the sterilization component of two kinds of different structures, the different mechanisms of action, is to expand prevention spectrum and raising drug effect
Effective way, it is often more important that avoid or delay generation of the disease to new composition resistance.To achieve the object of the present invention, invention
People compounds isothiazolinone and formoononetin, for preventing the disease of crop.
To achieve these goals, the technical solution adopted by the present invention is：One kind includes two kinds of principle active components：Different thiophene
Oxazoline ketone and formoononetin.
The ratio between the isothiazolinone and the parts by weight of formoononetin are 20:1-1:1.
The sum of the isothiazolinone and the weight of formoononetin account for the 1-6% of herbicide gross weight.Further include pure
Water purification, three phenethyl phenol polyoxyethylene ether phosphate of methyl oleate.
Isothiazolinone and formoononetin compatibility by being found to have association well by the present invention under specific ratio
It is 15 particularly in the ratio between isothiazolinone and the parts by weight of formoononetin with the effect of prevention tomato verticillium wilt:1-20:
Between 1, it is cooperateed with, and prevention tomato verticillium wilt effect is apparent, and whole reagent cost is relatively low, and toxicity is smaller.
Embodiment：
Embodiment 1：
The ratio between isothiazolinone and the parts by weight of formoononetin are：20:1, the isothiazolinone is with piercing awns handle
The sum of weight of florigen accounts for the 4% of herbicide gross weight, methyl oleate 1%, three phenethyl phenol polyoxyethylene ether phosphates 1%,
Surplus is pure water.
Embodiment 2：
The ratio between isothiazolinone and the parts by weight of formoononetin are：16:1, the isothiazolinone is with piercing awns handle
The sum of weight of florigen accounts for the 4% of herbicide gross weight, methyl oleate 1%, three phenethyl phenol polyoxyethylene ether phosphates 1%,
Surplus is pure water.
Embodiment 3：
The ratio between isothiazolinone and the parts by weight of formoononetin are：15:1, the isothiazolinone is with piercing awns handle
The sum of weight of florigen accounts for the 4% of herbicide gross weight, methyl oleate 1%, three phenethyl phenol polyoxyethylene ether phosphates 1%,
Surplus is pure water.
Embodiment 4：
The ratio between isothiazolinone and the parts by weight of formoononetin are：10:1, the isothiazolinone is with piercing awns handle
The sum of weight of florigen accounts for the 4% of herbicide gross weight, methyl oleate 1%, three phenethyl phenol polyoxyethylene ether phosphates 1%,
Surplus is pure water.
Embodiment 5：
The ratio between isothiazolinone and the parts by weight of formoononetin are：5:1, the isothiazolinone and ononis spinosa
The sum of weight of element accounts for the 4% of herbicide gross weight, methyl oleate 1%, and three phenethyl phenol polyoxyethylene ether phosphates 1% are remaining
Measure as pure water.
Embodiment 6：
The ratio between isothiazolinone and the parts by weight of formoononetin are：2:1, the isothiazolinone and ononis spinosa
The sum of weight of element accounts for the 4% of herbicide gross weight, methyl oleate 1%, and three phenethyl phenol polyoxyethylene ether phosphates 1% are remaining
Measure as pure water.
Embodiment 7：
The ratio between isothiazolinone and the parts by weight of formoononetin are：1:1, the isothiazolinone and ononis spinosa
The sum of weight of element accounts for the 4% of herbicide gross weight, methyl oleate 1%, and three phenethyl phenol polyoxyethylene ether phosphates 1% are remaining
Measure as pure water.
Embodiment 8：
The ratio between isothiazolinone and the parts by weight of formoononetin are：1:2, the isothiazolinone and ononis spinosa
The sum of weight of element accounts for the 4% of herbicide gross weight, methyl oleate 1%, and three phenethyl phenol polyoxyethylene ether phosphates 1% are remaining
Measure as pure water.
Embodiment 9：
The ratio between isothiazolinone and the parts by weight of formoononetin are：1:6, the isothiazolinone and ononis spinosa
The sum of weight of element accounts for the 4% of herbicide gross weight, methyl oleate 1%, and three phenethyl phenol polyoxyethylene ether phosphates 1% are remaining
Measure as pure water.
Laboratory test：
First, indoor biometrics are tested
Mycelial growth rate method is used indoors, EC50 value of the different agents to bacterial strain is measured, by co-toxicity coefficient calculating side
Method, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, circular is as follows：
Using a certain single dose in mixture as standard agent (generally selecting EC50 juniors), calculated：
Single dose toxicity index=standard agent EC50/ single doses EC50 × 100
The toxicity index of theoretical toxicity index TTI=A single doses × A single doses virulence of proportion+B single doses in mixture refers to
Number × B single doses proportion in mixture
Survey EC50 value × 100 of EC50 values/mixture of toxicity index ATI=standard single doses
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：Mixture has synergetic when CTC is more than 120, is antagonism when CTC is less than 80, CTC exists
It is summation action between 80-120.
1 isothiazolinone of table：Indoor biometrics result of the formoononetin different ratio to tomato verticillium wilt.
From the measurement result of table 1, work as isothiazolinone：Formoononetin is matched 16:1-15:It is malicious altogether when between 1
Coefficient is above 150, has obvious synergistic effect, and other ratios mix, co-toxicity coefficient unobvious.
Field efficacy checking test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second of dispenser is carried out after 7 days, each handles 4
A cell, each 20 square meter of cell.10 days investigation statistics incidences, each 5 points of cell are random before medicine and after second of medicine
Sampling, 5 plants of crops of every investigation, investigates percentage and classification that the lesion area in whole strain per blade accounts for blade area, calculates
Disease index and prevention effect.
It is expected that preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
The field control effectiveness test of embodiment and control group to tomato verticillium wilt.
It can be seen that isothiazolinone is matched with formoononetin under certain proportion cooperates with prevention tomato verticillium wilt effect very
It is obvious, and single isothiazolinone has certain prevention effect, and single formoononetin ability is also ineffective.
The ratio between isothiazolinone and the parts by weight of formoononetin are 15:1-16:Synergy is most notable when 1, and other ratios are matched somebody with somebody
Than when effect be not very notable.
Claims (3)
1. a kind of bactericidal composition of isothiazolone-containing, it is characterised in that include two kinds of principle active components：Isothiazolinone
With formoononetin.
2. a kind of bactericidal composition of isothiazolone-containing according to claim 1, the isothiazolinone and thorn awns
The ratio between parts by weight of handle florigen are 20:1-1:1.
A kind of 3. bactericidal composition of isothiazolone-containing according to claim 1, it is characterised in that the isothiazole
The sum of weight of quinoline ketone and formoononetin accounts for the 1-6% of herbicide gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258099.5A CN107926960A (en) | 2017-12-04 | 2017-12-04 | A kind of bactericidal composition of isothiazolone-containing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258099.5A CN107926960A (en) | 2017-12-04 | 2017-12-04 | A kind of bactericidal composition of isothiazolone-containing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107926960A true CN107926960A (en) | 2018-04-20 |
Family
ID=61948451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711258099.5A Pending CN107926960A (en) | 2017-12-04 | 2017-12-04 | A kind of bactericidal composition of isothiazolone-containing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107926960A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843250A (en) * | 2010-06-21 | 2010-09-29 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing compound containing isothiazolin-ketone and kasugamycin |
| CN103585143A (en) * | 2013-11-08 | 2014-02-19 | 苏州市马尔泰新材料有限公司 | Application of formononetin in preparation of aspergillus fumigatus resistant medicament |
| CN106561674A (en) * | 2016-10-17 | 2017-04-19 | 徐州得铸生物科技有限公司 | Bactericidal composition containing isothiazolinone |
-
2017
- 2017-12-04 CN CN201711258099.5A patent/CN107926960A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843250A (en) * | 2010-06-21 | 2010-09-29 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing compound containing isothiazolin-ketone and kasugamycin |
| CN103585143A (en) * | 2013-11-08 | 2014-02-19 | 苏州市马尔泰新材料有限公司 | Application of formononetin in preparation of aspergillus fumigatus resistant medicament |
| CN106561674A (en) * | 2016-10-17 | 2017-04-19 | 徐州得铸生物科技有限公司 | Bactericidal composition containing isothiazolinone |
Non-Patent Citations (1)
| Title |
|---|
| 杨秀伟等: "《中药成分代谢分析》", 30 September 2003, 中国医药科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104094946A (en) | Sterilization composition with synergistic effect | |
| CN103518750B (en) | High-efficiency compound biological bactericide and application thereof | |
| CN104872205A (en) | Mixture for controlling soil-borne diseases of tobaccos, and using method of mixture | |
| CN103493818A (en) | Sterilization composition containing metconazole and JS399-19 | |
| CN104304325B (en) | A kind of kind Rhizoma Zingiberis Recens inorganic agent preventing bacterial wilt of ginger | |
| CN111771892B (en) | Weeding composition containing topramezone, mesotrione and terbuthylazine | |
| CN102388873A (en) | Downy mildew fungicide for promoting crop growth and application thereof | |
| CN103548849B (en) | Synergistic compound biological bactericide and application thereof | |
| CN107926960A (en) | A kind of bactericidal composition of isothiazolone-containing | |
| CN105409992B (en) | A kind of bactericidal composition and its application | |
| CN107455390A (en) | Composition pesticide of environment-protecting pesticide sterilization and preparation method thereof | |
| CN107897198A (en) | The complex composition and its application of Zhongshengmycin and eugenol | |
| CN104886122B (en) | Compound composition containing dufulin and pyrazole amide bactericide and bactericide | |
| CN107751210A (en) | A kind of bactericidal composition containing isopyrazam | |
| CN107279161A (en) | A kind of bactericidal composition containing folpet and fluopyram | |
| CN106538540A (en) | A kind of bactericidal composition containing volution bacterium amine | |
| CN108402061B (en) | Biopesticide composition for preventing and treating tea geometrid | |
| CN107306949A (en) | A kind of composition pesticide containing DCPTA | |
| CN112753702A (en) | Weeding composition containing oxaziclomefone, clomazone and pyrazosulfuron-ethyl | |
| CN104705332A (en) | Multifunctional bactericidal composition and application of multifunctional bactericidal composition | |
| CN104798794A (en) | Captan and imazalil compound composition and application thereof | |
| CN109588414A (en) | A kind of green tea tree special plant source composite pesticide and preparation method thereof | |
| CN107980777A (en) | A kind of bactericidal composition containing bromothalonil and eugenol | |
| CN106561674A (en) | Bactericidal composition containing isothiazolinone | |
| CN107926957A (en) | A kind of bactericidal composition containing ethirimol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180420 |